IL287121B1 - Method for continuous production of an active ingredient nucleus - Google Patents

Method for continuous production of an active ingredient nucleus

Info

Publication number
IL287121B1
IL287121B1 IL287121A IL28712121A IL287121B1 IL 287121 B1 IL287121 B1 IL 287121B1 IL 287121 A IL287121 A IL 287121A IL 28712121 A IL28712121 A IL 28712121A IL 287121 B1 IL287121 B1 IL 287121B1
Authority
IL
Israel
Prior art keywords
active ingredient
particles
process space
granulate
tablet
Prior art date
Application number
IL287121A
Other languages
English (en)
Hebrew (he)
Other versions
IL287121A (en
Original Assignee
Add Advanced Drug Delivery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Add Advanced Drug Delivery Tech Ltd filed Critical Add Advanced Drug Delivery Tech Ltd
Publication of IL287121A publication Critical patent/IL287121A/en
Publication of IL287121B1 publication Critical patent/IL287121B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
IL287121A 2019-04-11 2021-10-10 Method for continuous production of an active ingredient nucleus IL287121B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19168685.6A EP3721871A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
PCT/EP2020/060278 WO2020208202A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (2)

Publication Number Publication Date
IL287121A IL287121A (en) 2022-01-01
IL287121B1 true IL287121B1 (en) 2026-01-01

Family

ID=66105207

Family Applications (1)

Application Number Title Priority Date Filing Date
IL287121A IL287121B1 (en) 2019-04-11 2021-10-10 Method for continuous production of an active ingredient nucleus

Country Status (13)

Country Link
US (1) US12551443B2 (https=)
EP (2) EP3721871A1 (https=)
JP (1) JP7602483B2 (https=)
CN (2) CN118649138A (https=)
AU (1) AU2020271280B2 (https=)
BR (1) BR112021020282A2 (https=)
CA (1) CA3144742A1 (https=)
DK (1) DK3952844T3 (https=)
ES (1) ES3053040T3 (https=)
IL (1) IL287121B1 (https=)
PL (1) PL3952844T3 (https=)
PT (1) PT3952844T (https=)
WO (1) WO2020208202A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102024107710A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Verfahren zur Herstellung von Tabletten
DE102024107712A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Vorrichtung zur Herstellung von Tabletten

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0739201T3 (da) 1994-01-14 2000-05-01 Ethypharm Lab Prod Ethiques Mikrogranuler af 5-nitro-imidazolderivater
DE19514187C1 (de) * 1995-04-21 1996-05-15 Degussa Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation
PT1117729E (pt) * 1998-07-21 2004-01-30 Vantico Ag Granulados escoaveis
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
NZ526720A (en) * 2000-12-28 2007-11-30 Altus Pharmaceuticals Inc Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
KR100592512B1 (ko) * 2002-11-22 2006-07-03 서울약품공업(주) 탐술로신 또는 약제학적으로 허용되는 이의 염을활성성분으로 하는 서방성 배뇨장애 치료제
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
ES2374191T3 (es) 2003-06-11 2012-02-14 Glatt Ingenieurtechnik Gmbh Procedimiento de preparación de granulados de enzimas y granulados de enzimas así obtenidos.
DE102005037630A1 (de) * 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
WO2010066385A1 (de) 2008-12-08 2010-06-17 Ratiopharm Gmbh Kompaktiertes moxifloxacin
WO2010106555A2 (en) 2009-03-17 2010-09-23 Shantilal, Doshi, Bimalkumar Directly compressible pre-granulated cellulose ether polymer and process for preparing the same
JP5922310B2 (ja) * 2013-07-25 2016-05-24 株式会社三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
EP3721870A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EUROPEAN MEDICINE AGENCY:, ASSESSMENT REPORT, DULOXETINE MYLAN, 10 April 2015 (2015-04-10) *

Also Published As

Publication number Publication date
IL287121A (en) 2022-01-01
JP2022528783A (ja) 2022-06-15
DK3952844T3 (da) 2025-11-17
WO2020208202A1 (de) 2020-10-15
CN118649138A (zh) 2024-09-17
AU2020271280B2 (en) 2025-07-24
JP7602483B2 (ja) 2024-12-18
ES3053040T3 (en) 2026-01-16
US20220280432A1 (en) 2022-09-08
PT3952844T (pt) 2025-11-21
EP3952844B1 (de) 2025-08-27
CN114302711A (zh) 2022-04-08
CA3144742A1 (en) 2020-10-15
PL3952844T3 (pl) 2026-01-19
EP3952844A1 (de) 2022-02-16
BR112021020282A2 (pt) 2021-12-14
US12551443B2 (en) 2026-02-17
EP3721871A1 (de) 2020-10-14
AU2020271280A1 (en) 2021-12-09

Similar Documents

Publication Publication Date Title
US9050254B2 (en) Method for production of particles of pharmaceutical substances and the use thereof
IL287126B1 (en) Process for continuous production of an active ingredient nucleus
BRPI0718761A2 (pt) "método para produzir grândulos a partir de um pó, massa de granulado, processo para preparar um tablete, tablete, aparelho para granulação a seco, dispositivo de fracionamento, e, uso de um aparelho ou dispositivo."
KR20030081506A (ko) Ｈ+, ｋ+ -ａｔｐ-아제 저해제를 함유하는 미립자의 제조방법
US12551443B2 (en) Method for continuously producing an active ingredient granulate
EP2285356B1 (en) Process for preparing a tablet comprising metformin
US20100080849A1 (en) Pellets containing a pharmaceutical substance, method for the production thereof and use of the same
JP4092587B2 (ja) 二軸混練機を用いた乾式コーティング
US20140163109A1 (en) Taste-masked ibupropen granules
JP2022540994A (ja) 実質的に水性環境中に溶解性のカンナビノイド顆粒を製造するための方法および装置
Rashid Centrifugal granulating process for preparing drug-layered pellets based on microcrystalline cellulose beads
Rashid ISSN 1239-9469 Yliopistopaino Helsinki 2001 Finland Toi32thei32souli32ofi32myi32heavenlyi32father