IL287049B2 - Trisubstituted piperidine compounds for inhibiting CBL-B, and use of a CBL-B inhibitor in combination with a cancer vaccine and/or oncolytic virus - Google Patents

Trisubstituted piperidine compounds for inhibiting CBL-B, and use of a CBL-B inhibitor in combination with a cancer vaccine and/or oncolytic virus

Info

Publication number
IL287049B2
IL287049B2 IL287049A IL28704921A IL287049B2 IL 287049 B2 IL287049 B2 IL 287049B2 IL 287049 A IL287049 A IL 287049A IL 28704921 A IL28704921 A IL 28704921A IL 287049 B2 IL287049 B2 IL 287049B2
Authority
IL
Israel
Prior art keywords
cell
alkyl
cbl
inhibitor
compound
Prior art date
Application number
IL287049A
Other languages
English (en)
Hebrew (he)
Other versions
IL287049A (en
IL287049B1 (en
Inventor
Arthur T Sands
Neil F Bence
Christoph W Zapf
Frederick Cohen
Chenbo Wang
Thomas Cummins
Hiroko Tanaka
Hunter Paul Shunatona
Mario Cardozo
Dahlia Weiss
Jennifa Gosling
Original Assignee
Nurix Therapeutics Inc
Arthur T Sands
Neil F Bence
Christoph W Zapf
Frederick Cohen
Chenbo Wang
Thomas Cummins
Hiroko Tanaka
Hunter Paul Shunatona
Mario Cardozo
Dahlia Weiss
Jennifa Gosling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nurix Therapeutics Inc, Arthur T Sands, Neil F Bence, Christoph W Zapf, Frederick Cohen, Chenbo Wang, Thomas Cummins, Hiroko Tanaka, Hunter Paul Shunatona, Mario Cardozo, Dahlia Weiss, Jennifa Gosling filed Critical Nurix Therapeutics Inc
Publication of IL287049A publication Critical patent/IL287049A/en
Publication of IL287049B1 publication Critical patent/IL287049B1/en
Publication of IL287049B2 publication Critical patent/IL287049B2/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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IL287049A 2019-04-09 2020-04-09 Trisubstituted piperidine compounds for inhibiting CBL-B, and use of a CBL-B inhibitor in combination with a cancer vaccine and/or oncolytic virus IL287049B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962831392P 2019-04-09 2019-04-09
US201962866909P 2019-06-26 2019-06-26
US201962880267P 2019-07-30 2019-07-30
US201962888870P 2019-08-19 2019-08-19
US201962888845P 2019-08-19 2019-08-19
PCT/US2020/027492 WO2020210508A1 (en) 2019-04-09 2020-04-09 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus

Publications (3)

Publication Number Publication Date
IL287049A IL287049A (en) 2021-12-01
IL287049B1 IL287049B1 (en) 2024-09-01
IL287049B2 true IL287049B2 (en) 2025-01-01

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IL287049A IL287049B2 (en) 2019-04-09 2020-04-09 Trisubstituted piperidine compounds for inhibiting CBL-B, and use of a CBL-B inhibitor in combination with a cancer vaccine and/or oncolytic virus

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US (3) US11464802B2 (enExample)
EP (1) EP3953346A1 (enExample)
JP (1) JP7580393B2 (enExample)
KR (1) KR102922115B1 (enExample)
CN (1) CN114364667B (enExample)
AU (1) AU2020272937B2 (enExample)
BR (1) BR112021019722A2 (enExample)
CA (1) CA3136348A1 (enExample)
IL (1) IL287049B2 (enExample)
MX (3) MX2021012285A (enExample)
WO (1) WO2020210508A1 (enExample)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
CN110790758A (zh) * 2018-08-01 2020-02-14 上海轶诺药业有限公司 一类具有免疫调节功能的含n杂环化合物的制备和应用
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