IL281569B2 - Use of tradipient in motion sickness - Google Patents
Use of tradipient in motion sicknessInfo
- Publication number
- IL281569B2 IL281569B2 IL281569A IL28156921A IL281569B2 IL 281569 B2 IL281569 B2 IL 281569B2 IL 281569 A IL281569 A IL 281569A IL 28156921 A IL28156921 A IL 28156921A IL 281569 B2 IL281569 B2 IL 281569B2
- Authority
- IL
- Israel
- Prior art keywords
- tradipitant
- motion sickness
- effective amount
- symptom
- dose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862737992P | 2018-09-28 | 2018-09-28 | |
| US201962874927P | 2019-07-16 | 2019-07-16 | |
| PCT/US2019/053107 WO2020069092A1 (en) | 2018-09-28 | 2019-09-26 | Use of tradipitant in motion sickness |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL281569A IL281569A (en) | 2021-05-31 |
| IL281569B1 IL281569B1 (en) | 2024-12-01 |
| IL281569B2 true IL281569B2 (en) | 2025-04-01 |
Family
ID=68165866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281569A IL281569B2 (en) | 2018-09-28 | 2019-09-26 | Use of tradipient in motion sickness |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20220249444A1 (https=) |
| EP (2) | EP3856338B1 (https=) |
| JP (1) | JP7468964B2 (https=) |
| KR (2) | KR102863233B1 (https=) |
| CN (1) | CN111918701B (https=) |
| AU (1) | AU2019348001B2 (https=) |
| BR (1) | BR112020015484A2 (https=) |
| CA (1) | CA3089238A1 (https=) |
| CL (1) | CL2020002165A1 (https=) |
| DK (1) | DK3856338T3 (https=) |
| ES (1) | ES3010832T3 (https=) |
| FI (1) | FI3856338T3 (https=) |
| HR (1) | HRP20250097T1 (https=) |
| HU (1) | HUE070000T2 (https=) |
| IL (1) | IL281569B2 (https=) |
| MX (1) | MX2020008456A (https=) |
| PT (1) | PT3856338T (https=) |
| SI (1) | SI3856338T1 (https=) |
| WO (1) | WO2020069092A1 (https=) |
| ZA (1) | ZA202004594B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2824552T3 (es) * | 2015-03-04 | 2021-05-12 | Vanda Pharmaceuticals Inc | Método de tratamiento con tradipitant |
| JP7791832B2 (ja) | 2020-03-26 | 2025-12-24 | バンダ・ファーマシューティカルズ・インコーポレイテッド | トラジピタントによる下気道感染症の治療 |
| WO2023019084A1 (en) * | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| US20240350469A1 (en) | 2021-08-31 | 2024-10-24 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| AU2023413130A1 (en) | 2022-12-21 | 2025-06-05 | Vanda Pharmaceuticals Inc. | Methods of treatment with tradipitant |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297375B1 (en) * | 1999-02-24 | 2001-10-02 | Hoffmann-La Roche Inc. | 4-phenyl-pyridine derivatives |
| EP1501809B1 (en) * | 2002-04-26 | 2008-01-16 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
| US20160136162A1 (en) * | 2009-11-18 | 2016-05-19 | Helsinn Healthcare Sa | Compositions and methods for treating centrally mediated nausea and vomiting |
| WO2016141341A1 (en) * | 2015-03-04 | 2016-09-09 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| WO2019099883A1 (en) * | 2017-11-17 | 2019-05-23 | Vanda Pharmaceuticals Inc. | Method of treatment of gastrointestinal diseases with tradipitant |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0415010B8 (pt) * | 2003-10-24 | 2021-05-25 | Lilly Co Eli | formas cristalinas iv e v de {2-[1-(3,5-bis-trifluorometilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il)-(2-clorofenil)-metanona, (2-clorofenil)-[2-(2-hidróxi-2-piridin-4-il-vinil)piridin-3-il]metanona, seus processos de preparação, e composição farmacêutica sólida |
-
2019
- 2019-09-26 HU HUE19783926A patent/HUE070000T2/hu unknown
- 2019-09-26 FI FIEP19783926.9T patent/FI3856338T3/fi active
- 2019-09-26 BR BR112020015484-9A patent/BR112020015484A2/pt unknown
- 2019-09-26 WO PCT/US2019/053107 patent/WO2020069092A1/en not_active Ceased
- 2019-09-26 JP JP2020568453A patent/JP7468964B2/ja active Active
- 2019-09-26 EP EP19783926.9A patent/EP3856338B1/en active Active
- 2019-09-26 KR KR1020207022180A patent/KR102863233B1/ko active Active
- 2019-09-26 SI SI201930892T patent/SI3856338T1/sl unknown
- 2019-09-26 IL IL281569A patent/IL281569B2/en unknown
- 2019-09-26 MX MX2020008456A patent/MX2020008456A/es unknown
- 2019-09-26 AU AU2019348001A patent/AU2019348001B2/en active Active
- 2019-09-26 DK DK19783926.9T patent/DK3856338T3/da active
- 2019-09-26 EP EP24197970.7A patent/EP4450126A3/en not_active Withdrawn
- 2019-09-26 CA CA3089238A patent/CA3089238A1/en active Pending
- 2019-09-26 KR KR1020257030873A patent/KR20250140634A/ko active Pending
- 2019-09-26 CN CN201980018140.2A patent/CN111918701B/zh active Active
- 2019-09-26 ES ES19783926T patent/ES3010832T3/es active Active
- 2019-09-26 PT PT197839269T patent/PT3856338T/pt unknown
- 2019-09-26 HR HRP20250097TT patent/HRP20250097T1/hr unknown
-
2020
- 2020-07-24 ZA ZA2020/04594A patent/ZA202004594B/en unknown
- 2020-08-21 CL CL2020002165A patent/CL2020002165A1/es unknown
-
2022
- 2022-04-28 US US17/731,831 patent/US20220249444A1/en not_active Abandoned
-
2024
- 2024-05-01 US US18/652,776 patent/US20240285588A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297375B1 (en) * | 1999-02-24 | 2001-10-02 | Hoffmann-La Roche Inc. | 4-phenyl-pyridine derivatives |
| EP1501809B1 (en) * | 2002-04-26 | 2008-01-16 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
| US20160136162A1 (en) * | 2009-11-18 | 2016-05-19 | Helsinn Healthcare Sa | Compositions and methods for treating centrally mediated nausea and vomiting |
| WO2016141341A1 (en) * | 2015-03-04 | 2016-09-09 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| WO2019099883A1 (en) * | 2017-11-17 | 2019-05-23 | Vanda Pharmaceuticals Inc. | Method of treatment of gastrointestinal diseases with tradipitant |
Non-Patent Citations (2)
| Title |
|---|
| DAVID G WARR ET AL,, EVALUATION OF RISK FACTORS PREDICTIVE OF NAUSEA AND VOMITING WITH CURRENT STANDARD-OF-CARE ANTIEMETIC TREATMENT: ANALYSIS OF PHASE 3 TRIAL OF APREPITANT IN PATIENTS RECEIVING ADRIAMYCIN-CYCLOPHOSPHAMIDE-BASED CHEMOTHERAPY, 13 May 2010 (2010-05-13) * |
| PASRICHA PANKAJ J ET AL,, APREPITANT HAS MIXED EFFECTS ON NAUSEA AND REDUCES OTHER SYMPTOMS IN PATIENTS WITH GASTROPARESIS AND RELATED DISORDERS, 28 October 2017 (2017-10-28) * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022511194A (ja) | 2022-01-31 |
| JP7468964B2 (ja) | 2024-04-16 |
| EP3856338B1 (en) | 2024-11-06 |
| CL2020002165A1 (es) | 2021-01-04 |
| HRP20250097T1 (hr) | 2025-03-28 |
| CN111918701B (zh) | 2024-08-02 |
| BR112020015484A2 (pt) | 2021-04-27 |
| EP3856338A1 (en) | 2021-08-04 |
| NZ766397A (en) | 2023-09-29 |
| KR20250140634A (ko) | 2025-09-25 |
| ES3010832T3 (en) | 2025-04-04 |
| CA3089238A1 (en) | 2020-04-02 |
| EP4450126A3 (en) | 2025-02-19 |
| SI3856338T1 (sl) | 2025-04-30 |
| US20240285588A1 (en) | 2024-08-29 |
| US20220249444A1 (en) | 2022-08-11 |
| IL281569A (en) | 2021-05-31 |
| HUE070000T2 (hu) | 2025-04-28 |
| AU2019348001A1 (en) | 2020-08-06 |
| AU2019348001B2 (en) | 2023-09-21 |
| EP4450126A2 (en) | 2024-10-23 |
| PT3856338T (pt) | 2025-01-31 |
| FI3856338T3 (fi) | 2025-02-03 |
| IL281569B1 (en) | 2024-12-01 |
| ZA202004594B (en) | 2024-12-18 |
| WO2020069092A1 (en) | 2020-04-02 |
| DK3856338T3 (da) | 2025-02-10 |
| CN111918701A (zh) | 2020-11-10 |
| MX2020008456A (es) | 2020-09-25 |
| KR20210067980A (ko) | 2021-06-08 |
| KR102863233B1 (ko) | 2025-09-22 |
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