IL276923A - Synthetic DNA vectors and methods of use - Google Patents
Synthetic DNA vectors and methods of useInfo
- Publication number
- IL276923A IL276923A IL276923A IL27692320A IL276923A IL 276923 A IL276923 A IL 276923A IL 276923 A IL276923 A IL 276923A IL 27692320 A IL27692320 A IL 27692320A IL 276923 A IL276923 A IL 276923A
- Authority
- IL
- Israel
- Prior art keywords
- methods
- synthetic dna
- dna vectors
- vectors
- synthetic
- Prior art date
Links
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643336P | 2018-03-15 | 2018-03-15 | |
| US201862749369P | 2018-10-23 | 2018-10-23 | |
| PCT/US2019/022511 WO2019178500A1 (en) | 2018-03-15 | 2019-03-15 | Synthetic dna vectors and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL276923A true IL276923A (en) | 2020-10-29 |
Family
ID=67908049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL276923A IL276923A (en) | 2018-03-15 | 2020-08-25 | Synthetic DNA vectors and methods of use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20210002667A1 (https=) |
| EP (1) | EP3765023A4 (https=) |
| JP (2) | JP2021516953A (https=) |
| KR (1) | KR20200132893A (https=) |
| CN (2) | CN117757842A (https=) |
| AU (1) | AU2019233901A1 (https=) |
| CA (1) | CA3092088A1 (https=) |
| IL (1) | IL276923A (https=) |
| MX (1) | MX2020009579A (https=) |
| WO (1) | WO2019178500A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| EP3474760B1 (en) | 2016-06-27 | 2023-01-11 | Galvanize Therapeutics, Inc. | Generator and a catheter with an electrode for treating a lung passageway |
| US20200048716A1 (en) * | 2017-11-03 | 2020-02-13 | Twister Biotech, Inc | Using minivectors to treat ovarian cancer |
| DK3731771T3 (da) | 2017-12-26 | 2023-08-28 | Galvanize Therapeutics Inc | V462033dk00 |
| SG11202103917VA (en) | 2018-10-16 | 2021-05-28 | Blueallele Llc | Methods for targeted insertion of dna in genes |
| CN118203401A (zh) | 2019-04-18 | 2024-06-18 | 盖能适治疗股份有限公司 | 用于治疗异常组织的装置、系统和方法 |
| KR20220128607A (ko) | 2019-09-18 | 2022-09-21 | 인터갈락틱 테라퓨틱스, 인크. | 합성 dna 벡터 및 사용 방법 |
| EP4192572A4 (en) | 2020-08-04 | 2024-08-21 | Galvanize Therapeutics, Inc. | TRANSFER OF MOLECULES BY PULSED ELECTRIC FIELD TO CELLS IN THE ORGANISM |
| CN116829691A (zh) | 2020-08-04 | 2023-09-29 | 盖能适治疗股份有限公司 | 分子到体内细胞的脉冲电场转移 |
| EP4298214A4 (en) * | 2021-02-23 | 2025-03-19 | Aldevron, LLC | NUCLEIC ACID VECTORS AND METHODS OF USE |
| CN118056012B (zh) * | 2021-08-24 | 2025-05-30 | 赛斯尔擎生物技术（上海）有限公司 | 一种修饰细胞的方法 |
| WO2023064934A1 (en) * | 2021-10-15 | 2023-04-20 | Intergalactic Therapeutics, Inc. | Respiratory delivery of therapeutic agents |
| EP4522758A4 (en) * | 2022-05-13 | 2026-05-06 | Ascidian Therapeutics Inc | Abca4 trans-splicing molecules |
| CA3262218A1 (en) | 2022-07-19 | 2024-01-25 | Rampart Bioscience, Inc. | CIRCULAR NON-IMMUNOGENEOUS NON-VIRAL DNA VECTORS |
| WO2024039652A1 (en) * | 2022-08-16 | 2024-02-22 | Aldevron, L.L.C. | Cell-free method of producing synthetic circular nucleic acid |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478745A (en) * | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US6825012B2 (en) * | 1995-02-23 | 2004-11-30 | Gencell S.A. | DNA molecules, preparation and use in gene therapy |
| RU2001135838A (ru) * | 1999-05-28 | 2004-01-20 | Камбрекс Байо Сайенс Инк. (Us) | Способы очистки ДНК и очищенная ДНК |
| EP1224313A1 (en) * | 1999-10-07 | 2002-07-24 | University of Iowa Research Foundation | Adeno-associated viruses and uses thereof |
| AU2001288839A1 (en) * | 2000-09-08 | 2002-03-22 | The General Hospital Corporation | Self-rearranging dna vectors |
| US20070196838A1 (en) * | 2000-12-08 | 2007-08-23 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| AU2002247014A1 (en) * | 2001-01-19 | 2002-07-30 | Genetica, Inc. | Methods and reagents for amplification and manipulation of vector and target nucleic acid sequences |
| AU2009231171A1 (en) * | 2008-04-02 | 2009-10-08 | Fondazione Telethon | Method of treating genetic disorders |
| US8236548B2 (en) * | 2008-07-03 | 2012-08-07 | The Board Of Trustees Of The Leland Stanford Junior University | Minicircle DNA vector preparations and methods of making and using the same |
| US8945885B2 (en) * | 2008-07-03 | 2015-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Minicircle DNA vector preparations and methods of making and using the same |
| EP2439276A1 (de) * | 2010-10-05 | 2012-04-11 | Rentschler Biotechnologie GmbH | Verfahren zur semi-synthetischen Herstellung hochreiner "MiniCircle" DNA-Vektoren aus Plasmiden |
| EP2500434A1 (en) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| US20140350087A9 (en) * | 2012-03-22 | 2014-11-27 | Halozyme, Inc. | Oncovector Nucleic Acid Molecules and Methods of Use |
| EP2994531B1 (en) * | 2013-05-10 | 2018-03-28 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| WO2016120186A1 (en) * | 2015-01-27 | 2016-08-04 | F. Hoffmann-La Roche Ag | Recombinant hbv cccdna, the method to generate thereof and the use thereof |
| EP3294309A4 (en) * | 2015-05-14 | 2019-01-16 | St. Jude Children's Research Hospital, Inc. | NUCLEIC ACID MOLECULES WITH SPACERS AND METHOD FOR USE THEREOF |
| CA3005474A1 (en) * | 2015-11-19 | 2017-05-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for correction of heritable ocular disease |
| MX2018010633A (es) * | 2016-03-03 | 2019-06-13 | Univ Massachusetts | Acido desoxirribonucleico (adn) lineal duplex de extremos cerrados para transferencia genica no viral. |
| KR20220128607A (ko) * | 2019-09-18 | 2022-09-21 | 인터갈락틱 테라퓨틱스, 인크. | 합성 dna 벡터 및 사용 방법 |
-
2019
- 2019-03-15 US US16/980,914 patent/US20210002667A1/en not_active Abandoned
- 2019-03-15 MX MX2020009579A patent/MX2020009579A/es unknown
- 2019-03-15 EP EP19766752.0A patent/EP3765023A4/en active Pending
- 2019-03-15 WO PCT/US2019/022511 patent/WO2019178500A1/en not_active Ceased
- 2019-03-15 CN CN202311181118.4A patent/CN117757842A/zh active Pending
- 2019-03-15 CA CA3092088A patent/CA3092088A1/en active Pending
- 2019-03-15 CN CN201980019118.XA patent/CN111954528A/zh active Pending
- 2019-03-15 AU AU2019233901A patent/AU2019233901A1/en not_active Abandoned
- 2019-03-15 KR KR1020207028218A patent/KR20200132893A/ko not_active Ceased
- 2019-03-15 JP JP2020545324A patent/JP2021516953A/ja active Pending
-
2020
- 2020-08-25 IL IL276923A patent/IL276923A/en unknown
-
2023
- 2023-12-28 JP JP2023222352A patent/JP2024041819A/ja active Pending
-
2024
- 2024-04-04 US US18/626,384 patent/US20240247284A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN117757842A (zh) | 2024-03-26 |
| AU2019233901A1 (en) | 2020-09-17 |
| JP2021516953A (ja) | 2021-07-15 |
| CA3092088A1 (en) | 2019-09-19 |
| CN111954528A (zh) | 2020-11-17 |
| JP2024041819A (ja) | 2024-03-27 |
| EP3765023A1 (en) | 2021-01-20 |
| EP3765023A4 (en) | 2022-01-19 |
| US20210002667A1 (en) | 2021-01-07 |
| WO2019178500A1 (en) | 2019-09-19 |
| KR20200132893A (ko) | 2020-11-25 |
| US20240247284A1 (en) | 2024-07-25 |
| MX2020009579A (es) | 2020-11-09 |
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