IL274405A - Combined pressure pathway modulators - Google Patents

Combined pressure pathway modulators

Info

Publication number
IL274405A
IL274405A IL274405A IL27440520A IL274405A IL 274405 A IL274405 A IL 274405A IL 274405 A IL274405 A IL 274405A IL 27440520 A IL27440520 A IL 27440520A IL 274405 A IL274405 A IL 274405A
Authority
IL
Israel
Prior art keywords
modulators
integrated stress
stress pathway
pathway
integrated
Prior art date
Application number
IL274405A
Other languages
English (en)
Hebrew (he)
Original Assignee
Abbvie Inc
Calico Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Calico Life Sciences Llc filed Critical Abbvie Inc
Publication of IL274405A publication Critical patent/IL274405A/en

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
CA3129609A1 (en) 2019-02-13 2020-08-20 Denali Therapeutics Inc. Eukaryotic initiation factor 2b modulators
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AU2020264485A1 (en) * 2019-04-30 2021-12-02 Abbvie Inc. Substituted cycloalkyls as modulators of the integrated stress pathway
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US12441720B2 (en) 2020-03-11 2025-10-14 Evotec International Gmbh Modulators of the integrated stress response pathway
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