IL273704B2 - Bi-layer pharmaceutical tablet formulations comprising lamivudine and dolutegravir sodium for use in treating hiv - Google Patents
Bi-layer pharmaceutical tablet formulations comprising lamivudine and dolutegravir sodium for use in treating hivInfo
- Publication number
- IL273704B2 IL273704B2 IL273704A IL27370420A IL273704B2 IL 273704 B2 IL273704 B2 IL 273704B2 IL 273704 A IL273704 A IL 273704A IL 27370420 A IL27370420 A IL 27370420A IL 273704 B2 IL273704 B2 IL 273704B2
- Authority
- IL
- Israel
- Prior art keywords
- tablet
- sodium
- hiv
- lamibordine
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762571863P | 2017-10-13 | 2017-10-13 | |
| US201862634317P | 2018-02-23 | 2018-02-23 | |
| PCT/US2018/054825 WO2019074826A2 (en) | 2017-10-13 | 2018-10-08 | FORMULATION OF BICOLET PHARMACEUTICAL TABLET |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL273704A IL273704A (en) | 2020-05-31 |
| IL273704B1 IL273704B1 (en) | 2024-02-01 |
| IL273704B2 true IL273704B2 (en) | 2024-06-01 |
Family
ID=66101717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL273704A IL273704B2 (en) | 2017-10-13 | 2018-10-08 | Bi-layer pharmaceutical tablet formulations comprising lamivudine and dolutegravir sodium for use in treating hiv |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20200230141A1 (https=) |
| EP (2) | EP4667003A3 (https=) |
| JP (2) | JP7774958B2 (https=) |
| KR (2) | KR20200070246A (https=) |
| CN (2) | CN117281788A (https=) |
| AU (1) | AU2018347990B2 (https=) |
| BR (1) | BR112020006783A2 (https=) |
| CA (1) | CA3078624A1 (https=) |
| CL (1) | CL2020000959A1 (https=) |
| ES (1) | ES3056013T3 (https=) |
| FI (1) | FI3694522T3 (https=) |
| IL (1) | IL273704B2 (https=) |
| MX (1) | MX2020003377A (https=) |
| PL (1) | PL3694522T3 (https=) |
| PT (1) | PT3694522T (https=) |
| TW (1) | TWI841539B (https=) |
| WO (1) | WO2019074826A2 (https=) |
| ZA (1) | ZA202002263B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3920927A1 (en) * | 2019-02-05 | 2021-12-15 | VIIV Healthcare Company | Method for treating hiv with dolutegravir and lamivudine |
| WO2021116244A1 (en) * | 2019-12-12 | 2021-06-17 | Sandoz Ag | Modulation of drug release and bioavailability of compositions containing dolutegravir sodium and other anti hiv drugs |
| CN111991558B (zh) * | 2020-08-28 | 2022-08-09 | 安徽贝克生物制药有限公司 | 一种抗逆转录病毒药物组合物及其制备方法 |
| CN114191404B (zh) * | 2022-01-10 | 2023-06-27 | 安徽贝克生物制药有限公司 | 一种多替拉韦片剂及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014064409A1 (en) * | 2012-10-23 | 2014-05-01 | Cipla Limited | Pharmaceutical antiretroviral composition |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744019C (en) | 2008-12-11 | 2017-03-14 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| US9713622B2 (en) * | 2009-11-20 | 2017-07-25 | Université Versailles Saint-Quentin-En-Yvelines | Schedules for administering combination therapies useful for treating persons afflicted with the human immunodeficiency virus (HIV) |
| PE20121524A1 (es) * | 2010-01-27 | 2012-12-03 | Viiv Healthcare Co | Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos |
| US20170189402A1 (en) * | 2012-03-28 | 2017-07-06 | Abbvie Inc. | Solid dosage forms |
| WO2014184553A1 (en) | 2013-05-15 | 2014-11-20 | Cipla Limited | Pharmaceutical antiretroviral compositions |
| US10189860B2 (en) * | 2014-07-29 | 2019-01-29 | Lek Pharmaceuticals D.D. | Hydrates of dolutegravir sodium |
| CN106860464A (zh) * | 2017-02-16 | 2017-06-20 | 江苏艾迪药业有限公司 | 用于联合抗病毒治疗的药物组合物及应用 |
-
2018
- 2018-10-08 FI FIEP18866268.8T patent/FI3694522T3/fi active
- 2018-10-08 KR KR1020207010456A patent/KR20200070246A/ko not_active Ceased
- 2018-10-08 MX MX2020003377A patent/MX2020003377A/es unknown
- 2018-10-08 AU AU2018347990A patent/AU2018347990B2/en active Active
- 2018-10-08 IL IL273704A patent/IL273704B2/en unknown
- 2018-10-08 PT PT188662688T patent/PT3694522T/pt unknown
- 2018-10-08 WO PCT/US2018/054825 patent/WO2019074826A2/en not_active Ceased
- 2018-10-08 KR KR1020247041200A patent/KR20250004136A/ko active Pending
- 2018-10-08 BR BR112020006783-0A patent/BR112020006783A2/pt unknown
- 2018-10-08 EP EP25212183.5A patent/EP4667003A3/en active Pending
- 2018-10-08 EP EP18866268.8A patent/EP3694522B1/en active Active
- 2018-10-08 CN CN202311269854.5A patent/CN117281788A/zh active Pending
- 2018-10-08 PL PL18866268.8T patent/PL3694522T3/pl unknown
- 2018-10-08 ES ES18866268T patent/ES3056013T3/es active Active
- 2018-10-08 CA CA3078624A patent/CA3078624A1/en active Pending
- 2018-10-08 CN CN201880066314.8A patent/CN111246851A/zh active Pending
- 2018-10-08 JP JP2020520646A patent/JP7774958B2/ja active Active
- 2018-10-08 US US16/652,768 patent/US20200230141A1/en active Pending
- 2018-10-11 TW TW107135747A patent/TWI841539B/zh active
-
2020
- 2020-04-09 CL CL2020000959A patent/CL2020000959A1/es unknown
- 2020-05-04 ZA ZA2020/02263A patent/ZA202002263B/en unknown
-
2025
- 2025-07-18 JP JP2025120922A patent/JP2025165977A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014064409A1 (en) * | 2012-10-23 | 2014-05-01 | Cipla Limited | Pharmaceutical antiretroviral composition |
Non-Patent Citations (1)
| Title |
|---|
| CAHN PEDRO ET AL,, DOLUTEGRAVIR-LAMIVUDINE AS INITIAL THERAPY IN HIV-1 INFECTED, ARV-NAIVE PATIENTS, 48-WEEK RESULTS OF THE PADDLE (PILOT ANTIRETROVIRAL DESIGN WITH DOLUTEGRAVIR LAMIVUDINE) STUDY, 1 January 2017 (2017-01-01) * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4667003A3 (en) | 2026-02-25 |
| KR20250004136A (ko) | 2025-01-07 |
| PL3694522T3 (pl) | 2026-03-02 |
| ZA202002263B (en) | 2024-10-30 |
| CN117281788A (zh) | 2023-12-26 |
| WO2019074826A2 (en) | 2019-04-18 |
| IL273704B1 (en) | 2024-02-01 |
| CN111246851A (zh) | 2020-06-05 |
| JP7774958B2 (ja) | 2025-11-25 |
| MX2020003377A (es) | 2020-09-28 |
| EP3694522A4 (en) | 2021-08-04 |
| TW201927290A (zh) | 2019-07-16 |
| BR112020006783A2 (pt) | 2020-10-06 |
| EP3694522A2 (en) | 2020-08-19 |
| CL2020000959A1 (es) | 2021-02-26 |
| TWI841539B (zh) | 2024-05-11 |
| AU2018347990A1 (en) | 2020-04-23 |
| KR20200070246A (ko) | 2020-06-17 |
| EP3694522B1 (en) | 2025-11-26 |
| PT3694522T (pt) | 2025-12-15 |
| WO2019074826A3 (en) | 2020-04-02 |
| JP2025165977A (ja) | 2025-11-05 |
| RU2020118376A3 (https=) | 2022-02-01 |
| FI3694522T3 (fi) | 2026-02-05 |
| CA3078624A1 (en) | 2019-04-18 |
| IL273704A (en) | 2020-05-31 |
| US20200230141A1 (en) | 2020-07-23 |
| EP4667003A2 (en) | 2025-12-24 |
| RU2020118376A (ru) | 2021-11-15 |
| AU2018347990B2 (en) | 2021-09-09 |
| JP2020536931A (ja) | 2020-12-17 |
| ES3056013T3 (en) | 2026-02-17 |
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