IL27321A - 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation - Google Patents

3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation

Info

Publication number
IL27321A
IL27321A IL27321A IL2732167A IL27321A IL 27321 A IL27321 A IL 27321A IL 27321 A IL27321 A IL 27321A IL 2732167 A IL2732167 A IL 2732167A IL 27321 A IL27321 A IL 27321A
Authority
IL
Israel
Prior art keywords
formula
acid
physiologically acceptable
alkoxy
quaternary ammonium
Prior art date
Application number
IL27321A
Other languages
English (en)
Hebrew (he)
Original Assignee
Merck Ag E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Ag E filed Critical Merck Ag E
Publication of IL27321A publication Critical patent/IL27321A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL27321A 1966-02-16 1967-01-25 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation IL27321A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0068414 1966-02-16

Publications (1)

Publication Number Publication Date
IL27321A true IL27321A (en) 1970-09-17

Family

ID=7312594

Family Applications (1)

Application Number Title Priority Date Filing Date
IL27321A IL27321A (en) 1966-02-16 1967-01-25 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation

Country Status (11)

Country Link
US (1) US3535344A (en:Method)
BE (1) BE694025A (en:Method)
CH (1) CH494222A (en:Method)
DE (1) DE1543749A1 (en:Method)
DK (1) DK118611B (en:Method)
ES (1) ES336869A1 (en:Method)
FR (1) FR6192M (en:Method)
GB (1) GB1103094A (en:Method)
IL (1) IL27321A (en:Method)
NL (1) NL6702140A (en:Method)
SE (1) SE328301B (en:Method)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053626A (en) * 1973-03-13 1977-10-11 Merck Patent Gesellschaft Mit Beschrankter Haftung Cholesterol level-lowering phenoxyacetic acids
US5830887A (en) * 1992-05-19 1998-11-03 Novogen Research Pty. Ltd. Health supplements containing phyto-oestrogens, analogues or metabolites thereof
US5446061A (en) * 1993-11-05 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US5446071A (en) * 1994-11-18 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
CZ212397A3 (en) * 1995-01-13 1997-11-12 Novo Nordisk As Use of 3,4-diphenylchromans for preparing pharmaceutical preparations for treating or prophylaxis of hyperlipoproteinaemia, hypertriacylglycerolaemia, hyperlipidaemia, hypercholesterolaemia, arteriosclerosis and reduction of blood sedimentation
BE1010487A6 (nl) 1996-06-11 1998-10-06 Unilin Beheer Bv Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen.
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US5985306A (en) * 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
US6316494B1 (en) 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979642B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US6043269A (en) * 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979648B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
AU4772297A (en) * 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ATE229519T1 (de) * 1996-10-28 2002-12-15 Novo Nordisk As Neue cis-3,4-chromanderivate zur vorbeugung oder behandlung von oestrogenbezogenen krankheiten oder syndromen
US5994390A (en) * 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
JP2001502706A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連病あるいは症候群の予防または治療に有用な新規トランス―３，４クロマン誘導体
US5958967A (en) * 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ATE229518T1 (de) * 1996-10-28 2002-12-15 Novo Nordisk As Cis-3,4-chromanderivate zur vorbeugung oder behandlungvon oestrogenbezogenen krankheiten oder syndromen
AU4699997A (en) * 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979644B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
DK0937057T3 (da) * 1996-10-28 2003-05-05 Novo Nordisk As Hidtil ukendte (-)-enantiomerer af cis-3,4-chromanderivater anvendelige i forebyggelse eller behandling af østrogenrelaterede sygdomme eller syndromer
US6146668A (en) 1997-04-28 2000-11-14 Novogen, Inc. Preparation of isoflavones from legumes
JP2001523258A (ja) * 1997-05-01 2001-11-20 ノボゲン インコーポレイテッド 更年期症状および骨粗鬆症の治療または予防
AUPP112497A0 (en) * 1997-12-24 1998-01-22 Novogen Research Pty Ltd Compositions and method for protecting skin from UV induced immunosupression and skin damage
AUPP260798A0 (en) 1998-03-26 1998-04-23 Novogen Research Pty Ltd Treatment of medical related conditions with isoflavone containing extracts of clover
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
AUPP868599A0 (en) * 1999-02-15 1999-03-11 Novogen Research Pty Ltd Production of isoflavone derivatives
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
US20090233999A1 (en) * 1999-09-06 2009-09-17 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPQ520300A0 (en) * 2000-01-21 2000-02-17 Novogen Research Pty Ltd Food product and process
JP4896335B2 (ja) 2000-03-01 2012-03-14 ナームローゼ・フエンノートチヤツプ・オルガノン エストロゲン化合物としてのクロマン誘導体
AUPR363301A0 (en) * 2001-03-08 2001-04-05 Novogen Research Pty Ltd Dimeric isoflavones
US20050119301A1 (en) * 2001-03-16 2005-06-02 Alan Husband Treatment of restenosis
EP1685140A4 (en) * 2003-11-18 2009-02-25 Novogen Res Pty Ltd PRODRUGS BASED ON ISOFLAVONOIDS, COMPOSITIONS THEREOF AND THERAPEUTIC PROCESSES INVOLVING THEM
AU2004290613B2 (en) * 2003-11-18 2010-03-25 Novogen Research Pty Ltd Isoflavonoid prodrugs, compositions thereof and therapeutic methods involving same
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
ATE532777T1 (de) 2004-09-21 2011-11-15 Marshall Edwards Inc Substituierte chromanderivate, medikamente und anwendungen in der therapie
WO2012061409A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
CN107427003B (zh) 2015-02-02 2023-01-31 梅制药公司 联合治疗

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) * 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
CH471113A (de) * 1965-01-29 1969-04-15 Merck Ag E Verfahren zur Herstellung von wasserlöslichen Flavanoidderivaten
US3436393A (en) * 1965-12-27 1969-04-01 Parke Davis & Co 4'-methoxy-2,2,4-trialkyl-delta**3-isoflavan compounds

Also Published As

Publication number Publication date
DE1543749A1 (de) 1969-12-11
US3535344A (en) 1970-10-20
BE694025A (en:Method) 1967-08-14
NL6702140A (en:Method) 1967-08-17
CH494222A (de) 1970-07-31
GB1103094A (en) 1968-02-14
SE328301B (en:Method) 1970-09-14
FR6192M (en:Method) 1968-07-22
ES336869A1 (es) 1968-05-01
DK118611B (da) 1970-09-14

Similar Documents

Publication Publication Date Title
IL27321A (en) 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation
Jurd The selective alkylation of polyphenols. II. Methylation of 7-, 4'-, and 3'-hydroxyl groups in flavonols
DE1518002A1 (de) Verfahren zur Herstellung von 4-Aryl-isoflavanoiden
Hay et al. 453. Bergenin, a C-glycopyranosyl derivative of 4-O-methylgallic acid
Arkley et al. 241. Griseofulvin analogues. Part I. Modification of the aromatic ring
Wolfrom et al. D-Xylosamine1
Yates et al. Photodimeric cage compounds. I. The structure of the photodimer of 2, 6-dimethyl-4-pyrone
Swan 318. The constitution of yohimbine and related alkaloids. Part IV. A synthesis of yohimbone
US3502660A (en) 2-((5'-(3' and/or 4'-substituted)isoxazoyl) methylidene)-3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes
Rogers et al. 2-Acylcyclohexane-1: 3-diones. Part II. 2-Formyl-, 2-propionyl-, 2-iso-butyryl-, and 2-phenylcarbamoyl-cyclo hexane-1: 3-dione, and their conversion into phenanthridines
Bycroft et al. The structure and synthesis of barakol: a novel dioxaphenalene derivative from Cassia siamea
US2175843A (en) Polyene carboxylic acids and esters and manufacture thereof
Culvenor et al. The Alkaloids of Senecio mikanioides Otto. Sarracine and Sarracine N-Oxide1
US3585214A (en) Hydroxyl derivatives of coumarine and processes for the preparation thereof
Battersby et al. 347. Ipecacuanha alkaloids. Part II. The structure of protoemetine and a partial synthesis of (–)-emetine
IL28366A (en) History of Flaban and their preparation
Birch et al. 719. The structure of alphitonin
Jones Preparation and Cyclization of Diethyl α, α-Diethoxy-α'-ethoxalylglutarate and Diethyl α, α-Diethoxy-α'-formylglutarate
Baker et al. Synthesis of (±)-di-O-methylcurvularin
HAYES et al. The preparation of 1-(2-furyl)-2-amino-1, 3-propanediol and derivatives
US2681340A (en) Amino esters
Wenkert et al. 1076. 2-Cyclohexylidenecyclohexanone and 2-cyclohex-1′-enylcyclohexanone, and the condensation of the latter with diethyl oxalate
Grundon et al. Degradation Studies on Apo-and Dehydro-apo-β-erythroidine1, 2
AT252241B (de) Verfahren zur Herstellung von neuen 4-Aryl-isoflavanoiden
NO742160L (en:Method)