IL270654B2 - Formulations of homotaurines and salts thereof - Google Patents
Formulations of homotaurines and salts thereofInfo
- Publication number
- IL270654B2 IL270654B2 IL270654A IL27065419A IL270654B2 IL 270654 B2 IL270654 B2 IL 270654B2 IL 270654 A IL270654 A IL 270654A IL 27065419 A IL27065419 A IL 27065419A IL 270654 B2 IL270654 B2 IL 270654B2
- Authority
- IL
- Israel
- Prior art keywords
- formulation
- hpmc
- release
- weight
- pellets
- Prior art date
Links
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- 230000036269 ulceration Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507532P | 2017-05-17 | 2017-05-17 | |
| US201862660690P | 2018-04-20 | 2018-04-20 | |
| PCT/US2018/033205 WO2018213589A1 (en) | 2017-05-17 | 2018-05-17 | Formulations of homotaurines and salts thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL270654A IL270654A (en) | 2020-01-30 |
| IL270654B1 IL270654B1 (en) | 2024-03-01 |
| IL270654B2 true IL270654B2 (en) | 2024-07-01 |
Family
ID=64274653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL270654A IL270654B2 (en) | 2017-05-17 | 2018-05-17 | Formulations of homotaurines and salts thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12042566B2 (enExample) |
| EP (1) | EP3624788A4 (enExample) |
| JP (2) | JP2020519669A (enExample) |
| KR (1) | KR20200005576A (enExample) |
| AU (2) | AU2018269557B2 (enExample) |
| CA (1) | CA3062834A1 (enExample) |
| IL (1) | IL270654B2 (enExample) |
| WO (1) | WO2018213589A1 (enExample) |
| ZA (1) | ZA201908264B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL270654B2 (en) | 2017-05-17 | 2024-07-01 | Confluence Pharmaceuticals Llc | Formulations of homotaurines and salts thereof |
| WO2025163673A1 (en) * | 2024-01-29 | 2025-08-07 | Micro Labs Limited | Dose-dumping resistant tablets of acamprosate calcium |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01280192A (ja) | 1988-10-25 | 1989-11-10 | Nichibei Co Ltd | ブラインド内装サッシ |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| PE57198A1 (es) | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
| US6514530B2 (en) | 1997-09-09 | 2003-02-04 | Alza Corporation | Dosage form comprising means for changing drug delivery shape |
| FR2775188B1 (fr) * | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
| CA2328197C (en) | 1998-04-14 | 2007-11-20 | The General Hospital Corporation | Methods for treating neuropsychiatric disorders |
| WO2000018374A1 (en) | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
| ES2168043B1 (es) | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
| US20050142191A1 (en) | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| RU2375048C2 (ru) | 2003-07-17 | 2009-12-10 | Д-Р Редди'С Лабораторис Инк. | Фармацевтическая композиция с набухающим покрытием |
| DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| CA2504471A1 (en) * | 2004-06-18 | 2005-12-18 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| JP2010532331A (ja) | 2007-07-05 | 2010-10-07 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 抗痙攣医薬組成物 |
| US9463172B2 (en) | 2009-02-12 | 2016-10-11 | Indiana University Research & Technology Corporation | Material and methods for treating developmental disorders including comorbid and idiopathic autism |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US9195775B2 (en) | 2009-06-26 | 2015-11-24 | Iii Holdings 2, Llc | System and method for managing and/or rendering internet multimedia content in a network |
| US20110142889A1 (en) | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| CA2850468C (en) * | 2010-09-28 | 2019-08-13 | Depomed, Inc. | Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract |
| ES2665569T3 (es) | 2011-03-01 | 2018-04-26 | Pharnext | Tratamiento de la isquemia cerebral |
| MX2021000431A (es) | 2011-03-23 | 2022-10-28 | Ironshore Pharmaceuticals & Dev Inc | Metodos y composiciones para el tratamiento de trastorno por deficit de atencion. |
| KR20130002292A (ko) | 2011-06-28 | 2013-01-07 | 주식회사 비보존 | 다중 타겟팅의 상승 효과를 유발하는 유효물질의 조합 및 그 용도 |
| US20130143867A1 (en) * | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| AU2013293167B2 (en) | 2012-07-22 | 2019-04-18 | Indiana University Research And Technology Corporation | Modulation sAPP, sAPP alpha and BDNF levels in individuals diagnosed with FXS and ASD |
| US20140073678A1 (en) | 2012-09-12 | 2014-03-13 | Monosol Rx, Llc | Anti-pain and anti-nausea and/or vomiting combinatorial compositions |
| CN105431144A (zh) | 2013-06-05 | 2016-03-23 | 思康脑侒股份有限公司 | 阿坎酸制剂、使用阿坎酸制剂的方法以及包含阿坎酸制剂的组合 |
| SG11201606275WA (en) * | 2014-02-11 | 2016-08-30 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
| IL255343B2 (en) * | 2015-05-04 | 2024-10-01 | Confluence Pharmaceuticals Llc | Sprinkle formulations of acamprosate |
| EP3331518A4 (en) | 2015-08-04 | 2019-04-03 | Confluence Pharmaceuticals, LLC | COMBINATION THERAPY WITH ACAMPROSATE AND D-CYCLOSERIN |
| JP6066009B1 (ja) | 2016-06-16 | 2017-01-25 | 富士電機株式会社 | ガス絶縁開閉装置用操作器及びそれを用いたガス絶縁開閉装置 |
| IL270654B2 (en) | 2017-05-17 | 2024-07-01 | Confluence Pharmaceuticals Llc | Formulations of homotaurines and salts thereof |
-
2018
- 2018-05-17 IL IL270654A patent/IL270654B2/en unknown
- 2018-05-17 EP EP18802495.4A patent/EP3624788A4/en active Pending
- 2018-05-17 KR KR1020197035170A patent/KR20200005576A/ko not_active Ceased
- 2018-05-17 CA CA3062834A patent/CA3062834A1/en active Pending
- 2018-05-17 AU AU2018269557A patent/AU2018269557B2/en active Active
- 2018-05-17 US US16/612,877 patent/US12042566B2/en active Active
- 2018-05-17 JP JP2019563191A patent/JP2020519669A/ja active Pending
- 2018-05-17 WO PCT/US2018/033205 patent/WO2018213589A1/en not_active Ceased
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2019
- 2019-12-11 ZA ZA2019/08264A patent/ZA201908264B/en unknown
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2021
- 2021-08-31 AU AU2021225172A patent/AU2021225172B2/en active Active
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2023
- 2023-04-27 JP JP2023073242A patent/JP7499539B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021225172A1 (en) | 2021-09-30 |
| US20200163895A1 (en) | 2020-05-28 |
| EP3624788A4 (en) | 2021-03-03 |
| AU2021225172B2 (en) | 2023-04-06 |
| JP2023099100A (ja) | 2023-07-11 |
| KR20200005576A (ko) | 2020-01-15 |
| JP2020519669A (ja) | 2020-07-02 |
| AU2018269557A1 (en) | 2019-11-28 |
| EP3624788A1 (en) | 2020-03-25 |
| WO2018213589A1 (en) | 2018-11-22 |
| JP7499539B2 (ja) | 2024-06-14 |
| CA3062834A1 (en) | 2018-11-22 |
| AU2018269557B2 (en) | 2021-06-03 |
| IL270654A (en) | 2020-01-30 |
| US12042566B2 (en) | 2024-07-23 |
| ZA201908264B (en) | 2022-03-30 |
| IL270654B1 (en) | 2024-03-01 |
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