IL270505B2 - Compounds, preparations and methods - Google Patents

Info

Publication number

IL270505B2

IL270505B2 IL270505A IL27050519A IL270505B2 IL 270505 B2 IL270505 B2 IL 270505B2 IL 270505 A IL270505 A IL 270505A IL 27050519 A IL27050519 A IL 27050519A IL 270505 B2 IL270505 B2 IL 270505B2

Authority

IL

Israel

Prior art keywords

optionally substituted

compound

alkyl

heterocyclyl

halo

Prior art date

2017-05-17

Links

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• 150000001875 compounds Chemical class 0.000 title claims description 337
• 239000000203 mixture Substances 0.000 title claims description 162
• 238000000034 method Methods 0.000 title description 132
• 125000000623 heterocyclic group Chemical group 0.000 claims description 146
• 125000005843 halogen group Chemical group 0.000 claims description 125
• -1 amino, hydroxyl Chemical group 0.000 claims description 99
• 125000001072 heteroaryl group Chemical group 0.000 claims description 96
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 94
• 150000003839 salts Chemical class 0.000 claims description 79
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 77
• 125000000217 alkyl group Chemical group 0.000 claims description 73
• 125000003118 aryl group Chemical group 0.000 claims description 69
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 66
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 64
• 201000010099 disease Diseases 0.000 claims description 61
• 229910052739 hydrogen Inorganic materials 0.000 claims description 60
• 239000001257 hydrogen Chemical group 0.000 claims description 53
• 125000003342 alkenyl group Chemical group 0.000 claims description 51
• 125000000304 alkynyl group Chemical group 0.000 claims description 49
• 125000004432 carbon atom Chemical group C* 0.000 claims description 48
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• 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 claims description 41
• 125000003107 substituted aryl group Chemical group 0.000 claims description 41
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 37
• 208000035475 disorder Diseases 0.000 claims description 33
• 125000004043 oxo group Chemical group O=* 0.000 claims description 33
• 125000005017 substituted alkenyl group Chemical group 0.000 claims description 33
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 32
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 30
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• 229910052799 carbon Inorganic materials 0.000 claims description 25
• 239000008194 pharmaceutical composition Substances 0.000 claims description 25
• 125000004429 atom Chemical group 0.000 claims description 23
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 22
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
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• 125000001424 substituent group Chemical group 0.000 claims description 14
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• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 11
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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• 125000003282 alkyl amino group Chemical group 0.000 claims description 2
• 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
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• QVEMDBXTQXHHAB-UHFFFAOYSA-N 3-(3-fluorophenyl)-6,6-dimethyl-1,2,3,7,8,9-hexahydropyrazolo[1,2-a]diazepin-5-one Chemical compound CC1(C)CCCN2CCC(N2C1=O)c1cccc(F)c1 QVEMDBXTQXHHAB-UHFFFAOYSA-N 0.000 claims 1
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• NYPLMFCBARDUKW-UHFFFAOYSA-N 4-(6,6-dimethyl-5-oxo-1,2,3,7,8,9-hexahydropyrazolo[1,2-a]diazepin-3-yl)benzonitrile Chemical compound CC1(C)CCCN2CCC(N2C1=O)c1ccc(cc1)C#N NYPLMFCBARDUKW-UHFFFAOYSA-N 0.000 claims 1
• HOQNVOWDNPNTOE-UHFFFAOYSA-N 4-ethyl-7-(3-fluorophenyl)-4-methyl-1,3,7,8,9,9a-hexahydropyrrolo[2,1-c][1,4]oxazepin-5-one Chemical compound CCC1(C)COCC2CCC(N2C1=O)C1=CC(F)=CC=C1 HOQNVOWDNPNTOE-UHFFFAOYSA-N 0.000 claims 1
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