IL269036B2 - tyk2 inhibitors, uses and methods for their production - Google Patents

tyk2 inhibitors, uses and methods for their production

Info

Publication number
IL269036B2
IL269036B2 IL269036A IL26903619A IL269036B2 IL 269036 B2 IL269036 B2 IL 269036B2 IL 269036 A IL269036 A IL 269036A IL 26903619 A IL26903619 A IL 26903619A IL 269036 B2 IL269036 B2 IL 269036B2
Authority
IL
Israel
Prior art keywords
compound
disorder
compounds
disease
peaks
Prior art date
Application number
IL269036A
Other languages
English (en)
Hebrew (he)
Other versions
IL269036B (en
IL269036A (en
Original Assignee
Nimbus Lakshmi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nimbus Lakshmi Inc filed Critical Nimbus Lakshmi Inc
Publication of IL269036A publication Critical patent/IL269036A/en
Publication of IL269036B publication Critical patent/IL269036B/en
Publication of IL269036B2 publication Critical patent/IL269036B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL269036A 2017-03-08 2018-03-07 tyk2 inhibitors, uses and methods for their production IL269036B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762468688P 2017-03-08 2017-03-08
PCT/US2018/021265 WO2018165240A1 (en) 2017-03-08 2018-03-07 Tyk2 inhibitors, uses, and methods for production thereof

Publications (3)

Publication Number Publication Date
IL269036A IL269036A (en) 2019-10-31
IL269036B IL269036B (en) 2022-11-01
IL269036B2 true IL269036B2 (en) 2023-03-01

Family

ID=63446346

Family Applications (1)

Application Number Title Priority Date Filing Date
IL269036A IL269036B2 (en) 2017-03-08 2018-03-07 tyk2 inhibitors, uses and methods for their production

Country Status (10)

Country Link
US (2) US10336752B2 (zh)
EP (2) EP3592746B1 (zh)
JP (2) JP7160824B2 (zh)
CN (1) CN110582501B (zh)
AR (1) AR111233A1 (zh)
AU (2) AU2018230737B2 (zh)
CA (1) CA3055209A1 (zh)
IL (1) IL269036B2 (zh)
TW (2) TWI783978B (zh)
WO (1) WO2018165240A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2930585T3 (es) 2015-02-27 2022-12-19 Nimbus Lakshmi Inc Inhibidores de TYK2 y usos de los mismos
US10023571B2 (en) 2015-09-02 2018-07-17 Nimbus Lakshimi, Inc. TYK2 inhibitors and uses thereof
US10647713B2 (en) * 2016-10-21 2020-05-12 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
BR112020001714A2 (pt) 2017-07-28 2020-07-21 Nimbus Lakshmi, Inc. inibidores de tyk2 e usos dos mesmos
JP6557436B1 (ja) 2018-03-12 2019-08-07 アッヴィ・インコーポレイテッド チロシンキナーゼ2媒介性シグナル伝達の阻害剤
WO2020081508A1 (en) 2018-10-15 2020-04-23 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
WO2020086616A1 (en) 2018-10-22 2020-04-30 Fronthera U.S. Pharmaceuticals Llc Tyk2 inhibitors and uses thereof
EP3920931A4 (en) * 2019-02-07 2022-08-10 Ventyx Biosciences, Inc. TYK2 PSEUDOKINALIGANDS
KR20220004641A (ko) 2019-03-26 2022-01-11 벤틱스 바이오사이언스, 인크. Tyk2 슈도키나아제 리간드
MX2021013317A (es) * 2019-04-30 2022-01-18 Celgene Corp Terapias de combinacion que comprenden inhibidores de apremilast y tyk2.
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
WO2021092246A1 (en) 2019-11-08 2021-05-14 Ventyx Biosciences, Inc. Tyk2 pseudokinase ligands
AU2022350509A1 (en) * 2021-09-23 2024-04-04 Bristol-Myers Squibb Company Methods of treating hair-loss disorders with tyk2 inhibitors
IL312330A (en) 2021-10-25 2024-06-01 Kymera Therapeutics Inc TYK2 joints and their uses
WO2023183910A1 (en) * 2022-03-25 2023-09-28 Nimbus Lakshmi, Inc. Solid forms of tyk2 inhibitors and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015131080A1 (en) * 2014-02-28 2015-09-03 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

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CN1195755C (zh) 1999-12-10 2005-04-06 辉瑞产品公司 吡咯并[2,3-d]嘧啶化合物
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ES2280530T3 (es) 2001-04-27 2007-09-16 Zenyaku Kogyo Kabushiki Kaisha Compuesto heterociclico y agente antitumoral que contiene el mismo como principio activo.
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
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PT1951684T (pt) 2005-11-01 2016-10-13 Targegen Inc Inibidores de cinases de tipo biaril-meta-pirimidina
PT3184526T (pt) 2005-12-13 2018-12-19 Incyte Holdings Corp Derivados de pirrolo[2,3-d]pirimidina como inibidores da cinase janus
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DK2634185T3 (en) 2012-03-02 2016-03-21 Sareum Ltd Tyk2 kinase inhibitors
US9296725B2 (en) 2012-05-24 2016-03-29 Cellzome Limited Heterocyclyl pyrimidine analogues as TYK2 inhibitors
ES2914793T3 (es) 2012-11-08 2022-06-16 Bristol Myers Squibb Co Compuestos heterocíclicos sustituidos con amida, útiles como moduladores de la respuesta de IL-12, IL-23 y/o IFN-alfa
MX2015005272A (es) 2012-11-08 2015-07-14 Squibb Bristol Myers Co Compuestos de piridilo sustituidos con alquilamida utiles como moduladores de las respuestas de interleucina 12 (il-12), interleucina 23 (il-23) y/o interferon alfa (ifnalfa).
ES2702126T3 (es) 2013-12-10 2019-02-27 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
ES2930585T3 (es) * 2015-02-27 2022-12-19 Nimbus Lakshmi Inc Inhibidores de TYK2 y usos de los mismos
US10023571B2 (en) 2015-09-02 2018-07-17 Nimbus Lakshimi, Inc. TYK2 inhibitors and uses thereof
JP7082130B2 (ja) 2016-10-14 2022-06-07 ニンバス ラクシュミ, インコーポレイテッド Tyk2阻害剤およびその使用
US10647713B2 (en) 2016-10-21 2020-05-12 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015131080A1 (en) * 2014-02-28 2015-09-03 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

Also Published As

Publication number Publication date
TW202321243A (zh) 2023-06-01
CA3055209A1 (en) 2018-09-13
AU2022256121A1 (en) 2022-11-17
CN110582501A (zh) 2019-12-17
JP2020511438A (ja) 2020-04-16
EP3592746B1 (en) 2024-01-24
IL269036B (en) 2022-11-01
EP3592746A4 (en) 2020-11-25
US11040967B2 (en) 2021-06-22
TW201840559A (zh) 2018-11-16
AR111233A1 (es) 2019-06-19
US20180258086A1 (en) 2018-09-13
CN110582501B (zh) 2022-09-23
IL269036A (en) 2019-10-31
AU2018230737A1 (en) 2019-09-19
JP7160824B2 (ja) 2022-10-25
EP4338802A2 (en) 2024-03-20
EP3592746A1 (en) 2020-01-15
TWI783978B (zh) 2022-11-21
JP2022185139A (ja) 2022-12-13
US10336752B2 (en) 2019-07-02
WO2018165240A1 (en) 2018-09-13
AU2018230737B2 (en) 2022-09-22
US20190337941A1 (en) 2019-11-07

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