IL262846B2 - Mutant cd200 and its uses - Google Patents
Mutant cd200 and its usesInfo
- Publication number
- IL262846B2 IL262846B2 IL262846A IL26284618A IL262846B2 IL 262846 B2 IL262846 B2 IL 262846B2 IL 262846 A IL262846 A IL 262846A IL 26284618 A IL26284618 A IL 26284618A IL 262846 B2 IL262846 B2 IL 262846B2
- Authority
- IL
- Israel
- Prior art keywords
- protein
- seq
- wild
- mutated
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1608197.8A GB201608197D0 (en) | 2016-05-10 | 2016-05-10 | Novel proteins |
| PCT/GB2017/051303 WO2017194941A1 (en) | 2016-05-10 | 2017-05-10 | Cd200 mutant and its uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL262846A IL262846A (en) | 2018-12-31 |
| IL262846B IL262846B (en) | 2022-10-01 |
| IL262846B2 true IL262846B2 (en) | 2023-02-01 |
Family
ID=56297468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL262846A IL262846B2 (en) | 2016-05-10 | 2018-11-07 | Mutant cd200 and its uses |
Country Status (14)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201608197D0 (en) | 2016-05-10 | 2016-06-22 | Ducentis Biotherapeutics Ltd | Novel proteins |
| KR102186780B1 (ko) | 2019-02-18 | 2020-12-04 | 박주현 | 비행부와 탑승부를 분리하여 축으로 결합한 유인드론 |
| CN110859951A (zh) * | 2019-09-23 | 2020-03-06 | 中国药科大学 | Cd200蛋白和cd200融合蛋白在制备治疗银屑病药物中的应用 |
| GB202115803D0 (en) * | 2021-11-03 | 2021-12-15 | Ducentis Biotherapeutics Ltd | Novel proteins |
| EP4519297A1 (en) * | 2022-05-06 | 2025-03-12 | Ducentis Biotherapeutics Limited | Novel cd200 fusion proteins |
| CN119522234A (zh) * | 2022-05-06 | 2025-02-25 | 杜森蒂斯生物治疗有限公司 | 新型cd200融合蛋白 |
| GB2626300A (en) * | 2022-12-08 | 2024-07-24 | Ducentis Biotherapeutics Ltd | Mutated CD200 proteins and methods of use therof |
| GB202303291D0 (en) | 2023-03-07 | 2023-04-19 | Secr Defence | Medicament and medicament combination for use in the treatment of infectious disease |
| GB202306711D0 (en) * | 2023-05-05 | 2023-06-21 | Ducentis Biotherapeutics Ltd | Novel proteins |
| WO2025106841A1 (en) * | 2023-11-15 | 2025-05-22 | The University Of Chicago | Methods and compositions for inducing antigen specific tolerance |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1032662E (pt) * | 1997-11-07 | 2006-07-31 | Trillium Therapeutics Inc | Metodos e composicoes para imunomodulacao. |
| US7223729B2 (en) | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
| EP1171154A2 (en) * | 1999-04-13 | 2002-01-16 | Schering Corporation | Uses of mammalian ox2 protein and related reagents |
| CA2402293A1 (en) * | 2000-03-07 | 2001-09-13 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2002223338B2 (en) * | 2000-11-22 | 2007-06-07 | Trillium Therapeutics Inc. | Truncated CD200 |
| KR20140053410A (ko) * | 2005-08-19 | 2014-05-07 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| WO2008089022A2 (en) * | 2007-01-11 | 2008-07-24 | Boehringer Ingelheim International Gmbh | Cd200 and its receptor, cd200r, modulate bone mass via the differentiation of osteoclasts |
| CN102448982B (zh) * | 2009-03-31 | 2018-04-20 | 华盛顿大学 | 用于调节靶细胞上补体调节蛋白的活性的组合物和方法 |
| JP6012473B2 (ja) * | 2010-01-11 | 2016-10-25 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｃｄ２００抗体を用いたヒトの処置における免疫調節効果のバイオマーカー |
| GB201608197D0 (en) | 2016-05-10 | 2016-06-22 | Ducentis Biotherapeutics Ltd | Novel proteins |
-
2016
- 2016-05-10 GB GBGB1608197.8A patent/GB201608197D0/en not_active Ceased
-
2017
- 2017-05-10 CN CN201780028505.0A patent/CN109219614B/zh active Active
- 2017-05-10 MX MX2018013778A patent/MX386295B/es unknown
- 2017-05-10 AU AU2017264825A patent/AU2017264825B2/en active Active
- 2017-05-10 KR KR1020187035514A patent/KR102498901B1/ko active Active
- 2017-05-10 EA EA201892554A patent/EA201892554A1/ru unknown
- 2017-05-10 CA CA3023601A patent/CA3023601A1/en active Pending
- 2017-05-10 JP JP2019511816A patent/JP6997767B2/ja active Active
- 2017-05-10 EP EP17724607.1A patent/EP3455247A1/en active Pending
- 2017-05-10 WO PCT/GB2017/051303 patent/WO2017194941A1/en not_active Ceased
- 2017-05-10 SG SG11201809677XA patent/SG11201809677XA/en unknown
- 2017-05-10 US US16/300,382 patent/US11203628B2/en active Active
- 2017-05-10 KR KR1020237004504A patent/KR102689460B1/ko active Active
-
2018
- 2018-10-24 ZA ZA2018/07079A patent/ZA201807079B/en unknown
- 2018-11-07 IL IL262846A patent/IL262846B2/en unknown
Non-Patent Citations (1)
| Title |
|---|
| HATHERLEY, DEBORAH, ET AL., STRUCTURES OF CD200/CD200 RECEPTOR FAMILY AND IMPLICATIONS FOR TOPOLOGY, REGULATION, AND EVOLUTION., 31 December 2013 (2013-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102689460B1 (ko) | 2024-07-26 |
| KR20230025937A (ko) | 2023-02-23 |
| BR112018073280A2 (pt) | 2019-03-19 |
| IL262846B (en) | 2022-10-01 |
| NZ747665A (en) | 2025-10-31 |
| AU2017264825B2 (en) | 2021-04-08 |
| ZA201807079B (en) | 2019-07-31 |
| CN109219614A (zh) | 2019-01-15 |
| SG11201809677XA (en) | 2018-11-29 |
| MX386295B (es) | 2025-03-18 |
| US20190367580A1 (en) | 2019-12-05 |
| EA201892554A1 (ru) | 2019-04-30 |
| JP6997767B2 (ja) | 2022-03-04 |
| EP3455247A1 (en) | 2019-03-20 |
| KR20190003761A (ko) | 2019-01-09 |
| KR102498901B1 (ko) | 2023-02-10 |
| JP2019518788A (ja) | 2019-07-04 |
| CN109219614B (zh) | 2022-05-24 |
| US11203628B2 (en) | 2021-12-21 |
| GB201608197D0 (en) | 2016-06-22 |
| IL262846A (en) | 2018-12-31 |
| AU2017264825A1 (en) | 2018-11-15 |
| WO2017194941A1 (en) | 2017-11-16 |
| CA3023601A1 (en) | 2017-11-16 |
| MX2018013778A (es) | 2019-08-01 |
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