IL262713B1 - Cannibidol for steroid dose reduction and treatment of inflammatory and autoimmune diseases - Google Patents

Cannibidol for steroid dose reduction and treatment of inflammatory and autoimmune diseases

Info

Publication number
IL262713B1
IL262713B1 IL262713A IL26271318A IL262713B1 IL 262713 B1 IL262713 B1 IL 262713B1 IL 262713 A IL262713 A IL 262713A IL 26271318 A IL26271318 A IL 26271318A IL 262713 B1 IL262713 B1 IL 262713B1
Authority
IL
Israel
Prior art keywords
steroid
cbd
dose
subject
functional derivative
Prior art date
Application number
IL262713A
Other languages
English (en)
Hebrew (he)
Other versions
IL262713A (en
Inventor
Moshe Yeshurun
Sari Prutchi Sagiv
Original Assignee
Stero Biotechs Ltd
Moshe Yeshurun
Sari Prutchi Sagiv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/143,694 external-priority patent/US9889100B2/en
Application filed by Stero Biotechs Ltd, Moshe Yeshurun, Sari Prutchi Sagiv filed Critical Stero Biotechs Ltd
Publication of IL262713A publication Critical patent/IL262713A/en
Publication of IL262713B1 publication Critical patent/IL262713B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL262713A 2016-05-02 2017-05-01 Cannibidol for steroid dose reduction and treatment of inflammatory and autoimmune diseases IL262713B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/143,694 US9889100B2 (en) 2013-05-02 2016-05-02 Cannabidiol for treatment of severe and refractory graft-versus-host disease
PCT/IL2017/050483 WO2017191630A1 (en) 2016-05-02 2017-05-01 Cannabidiol for reducing a steroid dose and treating inflammatory and autoimmune diseases

Publications (2)

Publication Number Publication Date
IL262713A IL262713A (en) 2018-12-31
IL262713B1 true IL262713B1 (en) 2024-03-01

Family

ID=60203614

Family Applications (1)

Application Number Title Priority Date Filing Date
IL262713A IL262713B1 (en) 2016-05-02 2017-05-01 Cannibidol for steroid dose reduction and treatment of inflammatory and autoimmune diseases

Country Status (7)

Country Link
EP (1) EP3452046A4 (ko)
KR (1) KR102537990B1 (ko)
CN (2) CN109414443A (ko)
AU (1) AU2017260873B2 (ko)
CA (1) CA3022900A1 (ko)
IL (1) IL262713B1 (ko)
WO (1) WO2017191630A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220347096A1 (en) 2019-10-03 2022-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Liposomal cannabinoids and uses thereof
WO2021117016A1 (en) * 2019-12-13 2021-06-17 Buzzelet Development And Technologies Ltd. Compositions and methods for treatment of inflammation with steroids and a modulator
JP2023516284A (ja) * 2020-02-19 2023-04-19 マーチャント,シュリーマ カンナビジオールの組成物および治療的使用
EP4208164A1 (en) * 2020-09-06 2023-07-12 Medicane Research & Development Ltd. Composition comprising cannabinoids, and/or terpens, and methods of using same
CN113398104B (zh) * 2021-07-14 2022-04-08 北京森宏健康科技有限公司 大麻二酚在治疗胆红素脑病中的用途
WO2023058016A1 (en) * 2021-10-04 2023-04-13 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) Non-steroidal anti-inflammatory drugs and cannabinoids and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274635B1 (en) * 1999-03-22 2001-08-14 Immugen Pharmaceuticals Inc. Alkylated resorcinol derivatives for the treatment of immune diseases
US20090005461A1 (en) * 2007-06-18 2009-01-01 University Of South Carolina Use of Cannabidiol in the Treatment of Hepatitis
US20110195096A1 (en) * 2008-07-31 2011-08-11 Dekel Pharmaceuticals Ltd. Compositions and methods for treating inflammatory disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070060638A1 (en) * 2005-08-26 2007-03-15 Olmstead Mary C Methods and therapies for potentiating therapeutic activities of a cannabinoid receptor agonist via administration of a cannabinoid receptor antagonist

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274635B1 (en) * 1999-03-22 2001-08-14 Immugen Pharmaceuticals Inc. Alkylated resorcinol derivatives for the treatment of immune diseases
US20090005461A1 (en) * 2007-06-18 2009-01-01 University Of South Carolina Use of Cannabidiol in the Treatment of Hepatitis
US20110195096A1 (en) * 2008-07-31 2011-08-11 Dekel Pharmaceuticals Ltd. Compositions and methods for treating inflammatory disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEGDE VENKATESH L. ET AL.,, ROLE OF MYELOID-DERIVED SUPPRESSOR CELLS IN AMELIORATION OF EXPERIMENTAL AUTOIMMUNE HEPATITIS FOLLOWING ACTIVATION OF TRPV1 RECEPTORS BY CANNABIDIOL., 1 April 2011 (2011-04-01) *

Also Published As

Publication number Publication date
AU2017260873A1 (en) 2018-11-29
IL262713A (en) 2018-12-31
WO2017191630A1 (en) 2017-11-09
KR20190016952A (ko) 2019-02-19
CA3022900A1 (en) 2017-11-09
AU2017260873B2 (en) 2023-03-02
KR102537990B1 (ko) 2023-05-30
CN117017998A (zh) 2023-11-10
CN109414443A (zh) 2019-03-01
EP3452046A1 (en) 2019-03-13
EP3452046A4 (en) 2020-02-19

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