IL262646B - Modulation of lipid metabolism for protein production - Google Patents
Modulation of lipid metabolism for protein productionInfo
- Publication number
- IL262646B IL262646B IL262646A IL26264618A IL262646B IL 262646 B IL262646 B IL 262646B IL 262646 A IL262646 A IL 262646A IL 26264618 A IL26264618 A IL 26264618A IL 262646 B IL262646 B IL 262646B
- Authority
- IL
- Israel
- Prior art keywords
- cell
- lmm
- fold
- product
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL262646A IL262646A (en) | 2018-12-31 |
| IL262646B true IL262646B (en) | 2022-08-01 |
Family
ID=58745198
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL262646A IL262646B (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
| IL294241A IL294241B2 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein synthesis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL294241A IL294241B2 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein synthesis |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (https=) |
| EP (1) | EP3452608B1 (https=) |
| JP (1) | JP6959942B2 (https=) |
| KR (1) | KR102536221B1 (https=) |
| CN (1) | CN109415748A (https=) |
| AU (1) | AU2017259010B2 (https=) |
| CA (1) | CA3023038C (https=) |
| EA (1) | EA201892503A1 (https=) |
| ES (1) | ES2938626T3 (https=) |
| IL (2) | IL262646B (https=) |
| MX (1) | MX2018013499A (https=) |
| SG (1) | SG11201809626PA (https=) |
| WO (1) | WO2017191165A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017191165A1 (en) | 2016-05-03 | 2017-11-09 | Lonza Ltd | Modulation of lipid metabolism for protein production |
| US20210324366A1 (en) * | 2018-07-11 | 2021-10-21 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20230193341A1 (en) * | 2018-10-24 | 2023-06-22 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| EP3942048A1 (en) | 2019-03-20 | 2022-01-26 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors |
| CN110317799B (zh) * | 2019-07-18 | 2026-04-03 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| US20220403398A1 (en) | 2019-11-14 | 2022-12-22 | Lonza Ltd | Methods of cell selection |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
| WO2026062080A1 (en) | 2024-09-17 | 2026-03-26 | Ares Trading S.A. | Cell having increased secretion capabilities and method of use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002095008A2 (en) | 2001-02-02 | 2002-11-28 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| US20050106222A1 (en) | 2003-06-11 | 2005-05-19 | Ailor Eric N. | Method to increase protein production in culture |
| EP1776461A2 (en) | 2004-04-16 | 2007-04-25 | DSMIP Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| EP1915394B1 (en) * | 2005-05-20 | 2021-01-27 | Lonza Biologics plc. | High-level expression of recombinant antibody in a mammalian host cell |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| US20110281301A1 (en) * | 2007-11-13 | 2011-11-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | The secretory capacity in host cells |
| NO2358882T3 (https=) * | 2008-11-18 | 2017-12-23 | ||
| FI3536797T3 (fi) * | 2013-02-01 | 2023-03-23 | Selexis Sa | Siirtogeenin tehostettu ilmentäminen ja prosessointi |
| JP6676526B2 (ja) * | 2013-08-06 | 2020-04-08 | ロンザ バイオロジクス ピーエルシー | 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法 |
| WO2017191165A1 (en) * | 2016-05-03 | 2017-11-09 | Lonza Ltd | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en not_active Ceased
- 2017-05-03 ES ES17724770T patent/ES2938626T3/es active Active
- 2017-05-03 EA EA201892503A patent/EA201892503A1/ru unknown
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/es unknown
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/zh active Pending
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/ko active Active
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/ja active Active
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| HUA, XIANXIN, ET AL., STEROL RESISTANCE IN CHO CELLS TRACED TO POINT MUTATION IN SREBP CLEAVAGE–ACTIVATING PROTEIN., 31 December 1996 (1996-12-31) * |
| LU, YUANSHAN, ET AL., OVEREXPRESSION OF STEAROYL-COA DESATURASE 1 IN BONE MARROW MESENCHYMAL STEM CELLS ENHANCE THE EXPRESSION OF INDUCED ENDOTHELIAL CELLS., 31 December 2014 (2014-12-31) * |
| WANG, JIAN, ET AL., CHARACTERIZATION OF HSCD5, A NOVEL HUMAN STEAROYL-COA DESATURASE UNIQUE TO PRIMATES., 31 December 2005 (2005-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190003651A (ko) | 2019-01-09 |
| IL262646A (en) | 2018-12-31 |
| WO2017191165A1 (en) | 2017-11-09 |
| EP3452608B1 (en) | 2022-11-30 |
| US20230047838A1 (en) | 2023-02-16 |
| CA3023038C (en) | 2023-03-14 |
| JP6959942B2 (ja) | 2021-11-05 |
| IL294241B1 (en) | 2023-06-01 |
| SG11201809626PA (en) | 2018-11-29 |
| EA201892503A1 (ru) | 2019-09-30 |
| US20170321194A1 (en) | 2017-11-09 |
| CA3023038A1 (en) | 2017-11-09 |
| EP3452608A1 (en) | 2019-03-13 |
| US10655111B2 (en) | 2020-05-19 |
| US11434474B2 (en) | 2022-09-06 |
| MX2018013499A (es) | 2019-09-11 |
| IL294241A (en) | 2022-08-01 |
| JP2019514399A (ja) | 2019-06-06 |
| ES2938626T3 (es) | 2023-04-13 |
| CN109415748A (zh) | 2019-03-01 |
| AU2017259010B2 (en) | 2021-04-22 |
| US20200231944A1 (en) | 2020-07-23 |
| BR112018072434A2 (pt) | 2019-02-19 |
| AU2017259010A1 (en) | 2018-11-22 |
| KR102536221B1 (ko) | 2023-05-23 |
| IL294241B2 (en) | 2023-10-01 |
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