IL261266B2 - Peptides, combination of peptides, and cell based medicaments for use in immunotherapy against urinary bladder cancer and other cancers - Google Patents

Info

Publication number

IL261266B2

IL261266B2 IL261266A IL26126618A IL261266B2 IL 261266 B2 IL261266 B2 IL 261266B2 IL 261266 A IL261266 A IL 261266A IL 26126618 A IL26126618 A IL 26126618A IL 261266 B2 IL261266 B2 IL 261266B2

Authority

IL

Israel

Prior art keywords

peptide

cancer

cell

peptides

cells

Prior art date

2016-03-01

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 title claims description 510
• 102000004196 processed proteins & peptides Human genes 0.000 title claims description 276
• 206010028980 Neoplasm Diseases 0.000 title claims description 217
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 title claims description 86
• 201000005112 urinary bladder cancer Diseases 0.000 title claims description 85
• 201000011510 cancer Diseases 0.000 title claims description 64
• 239000003814 drug Substances 0.000 title claims description 30
• 206010005003 Bladder cancer Diseases 0.000 title description 51
• 238000009169 immunotherapy Methods 0.000 title description 16
• 229940079593 drug Drugs 0.000 title description 6
• 210000004027 cell Anatomy 0.000 claims description 187
• 108091008874 T cell receptors Proteins 0.000 claims description 131
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 131
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 121
• 238000000034 method Methods 0.000 claims description 108
• 108090000623 proteins and genes Proteins 0.000 claims description 108
• 239000000427 antigen Substances 0.000 claims description 82
• 210000001519 tissue Anatomy 0.000 claims description 81
• 108091007433 antigens Proteins 0.000 claims description 80
• 102000036639 antigens Human genes 0.000 claims description 80
• 230000014509 gene expression Effects 0.000 claims description 65
• 238000011282 treatment Methods 0.000 claims description 64
• 241000282414 Homo sapiens Species 0.000 claims description 60
• 201000001441 melanoma Diseases 0.000 claims description 59
• 102000004169 proteins and genes Human genes 0.000 claims description 59
• 230000027455 binding Effects 0.000 claims description 57
• 229920001184 polypeptide Polymers 0.000 claims description 56
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 55
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 51
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 51
• 150000007523 nucleic acids Chemical class 0.000 claims description 50
• 102000039446 nucleic acids Human genes 0.000 claims description 45
• 108020004707 nucleic acids Proteins 0.000 claims description 45
• 208000002495 Uterine Neoplasms Diseases 0.000 claims description 43
• 206010046766 uterine cancer Diseases 0.000 claims description 43
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 41
• 206010041067 Small cell lung cancer Diseases 0.000 claims description 39
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 39
• 208000000587 small cell lung carcinoma Diseases 0.000 claims description 39
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 39
• 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 38
• 201000010175 gallbladder cancer Diseases 0.000 claims description 38
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 35
• 229960005486 vaccine Drugs 0.000 claims description 35
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 33
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 33
• 201000004101 esophageal cancer Diseases 0.000 claims description 33
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 31
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 30
• 210000000612 antigen-presenting cell Anatomy 0.000 claims description 30
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 30
• 239000013604 expression vector Substances 0.000 claims description 30
• 206010009944 Colon cancer Diseases 0.000 claims description 29
• 208000006990 cholangiocarcinoma Diseases 0.000 claims description 29
• 108091054437 MHC class I family Proteins 0.000 claims description 28
• 239000002671 adjuvant Substances 0.000 claims description 26
• -1 and optionally Substances 0.000 claims description 26
• 239000008194 pharmaceutical composition Substances 0.000 claims description 23
• 150000003839 salts Chemical class 0.000 claims description 23
• 208000006265 Renal cell carcinoma Diseases 0.000 claims description 22
• 238000000338 in vitro Methods 0.000 claims description 22
• 238000004519 manufacturing process Methods 0.000 claims description 22
• 239000003446 ligand Substances 0.000 claims description 21
• 102000043129 MHC class I family Human genes 0.000 claims description 19
• 230000005847 immunogenicity Effects 0.000 claims description 19
• 206010060862 Prostate cancer Diseases 0.000 claims description 16
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 16
• 230000035772 mutation Effects 0.000 claims description 16
• 208000026310 Breast neoplasm Diseases 0.000 claims description 15
• 230000005867 T cell response Effects 0.000 claims description 15
• 238000001727 in vivo Methods 0.000 claims description 15
• 210000004443 dendritic cell Anatomy 0.000 claims description 14
• 206010006187 Breast cancer Diseases 0.000 claims description 13
• 102000004127 Cytokines Human genes 0.000 claims description 11
• 108090000695 Cytokines Proteins 0.000 claims description 11
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 11
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 11
• 239000012636 effector Substances 0.000 claims description 11
• 206010017758 gastric cancer Diseases 0.000 claims description 11
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 11
• 201000002528 pancreatic cancer Diseases 0.000 claims description 11
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 11
• 201000011549 stomach cancer Diseases 0.000 claims description 11
• 206010033128 Ovarian cancer Diseases 0.000 claims description 9
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 9
• 238000001514 detection method Methods 0.000 claims description 9
• 230000002018 overexpression Effects 0.000 claims description 9
• 238000003745 diagnosis Methods 0.000 claims description 8
• 239000003085 diluting agent Substances 0.000 claims description 8
• 108020001507 fusion proteins Proteins 0.000 claims description 8
• 102000037865 fusion proteins Human genes 0.000 claims description 8
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 7
• 201000010989 colorectal carcinoma Diseases 0.000 claims description 7
• 150000001875 compounds Chemical class 0.000 claims description 7
• 239000012931 lyophilized formulation Substances 0.000 claims description 7
• 238000004949 mass spectrometry Methods 0.000 claims description 7
• 238000012163 sequencing technique Methods 0.000 claims description 7
• 102000006354 HLA-DR Antigens Human genes 0.000 claims description 6
• 108010058597 HLA-DR Antigens Proteins 0.000 claims description 6
• 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 6
• 238000010195 expression analysis Methods 0.000 claims description 6
• 230000006698 induction Effects 0.000 claims description 6
• 230000003211 malignant effect Effects 0.000 claims description 6
• 230000004936 stimulating effect Effects 0.000 claims description 6
• 239000003053 toxin Substances 0.000 claims description 6
• 231100000765 toxin Toxicity 0.000 claims description 6
• 108700012359 toxins Proteins 0.000 claims description 6
• 238000003556 assay Methods 0.000 claims description 5
• 238000002659 cell therapy Methods 0.000 claims description 5
• 238000012258 culturing Methods 0.000 claims description 5
• 239000001963 growth medium Substances 0.000 claims description 5
• 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 5
• 230000002147 killing effect Effects 0.000 claims description 5
• 108010002350 Interleukin-2 Proteins 0.000 claims description 4
• 102000000588 Interleukin-2 Human genes 0.000 claims description 4
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 4
• 239000000872 buffer Substances 0.000 claims description 4
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
• 108010028930 invariant chain Proteins 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
• 239000004480 active ingredient Substances 0.000 claims description 3
• 239000003937 drug carrier Substances 0.000 claims description 3
• 210000000822 natural killer cell Anatomy 0.000 claims description 3
• 229920002477 rna polymer Polymers 0.000 claims description 3
• 102000003812 Interleukin-15 Human genes 0.000 claims description 2
• 108090000172 Interleukin-15 Proteins 0.000 claims description 2
• 102000015696 Interleukins Human genes 0.000 claims description 2
• 108010063738 Interleukins Proteins 0.000 claims description 2
• 229940022399 cancer vaccine Drugs 0.000 claims description 2
• 230000001413 cellular effect Effects 0.000 claims description 2
• 208000005017 glioblastoma Diseases 0.000 claims description 2
• 238000012070 whole genome sequencing analysis Methods 0.000 claims description 2
• 239000012528 membrane Substances 0.000 claims 2
• 238000002493 microarray Methods 0.000 claims 2
• 238000010186 staining Methods 0.000 claims 2
• 238000011510 Elispot assay Methods 0.000 claims 1
• 206010027406 Mesothelioma Diseases 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 229940038309 personalized vaccine Drugs 0.000 claims 1
• 239000003381 stabilizer Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 70
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 69
• 235000018102 proteins Nutrition 0.000 description 55
• 235000001014 amino acid Nutrition 0.000 description 52
• 208000014018 liver neoplasm Diseases 0.000 description 52
• 229940024606 amino acid Drugs 0.000 description 51
• 150000001413 amino acids Chemical class 0.000 description 50
• 108020004414 DNA Proteins 0.000 description 41
• 239000000523 sample Substances 0.000 description 37
• 239000013598 vector Substances 0.000 description 31
• 239000000203 mixture Substances 0.000 description 29
• 206010004593 Bile duct cancer Diseases 0.000 description 28
• 208000026900 bile duct neoplasm Diseases 0.000 description 28
• 208000003174 Brain Neoplasms Diseases 0.000 description 26
• 235000002639 sodium chloride Nutrition 0.000 description 24
• 239000012634 fragment Substances 0.000 description 22
• 230000028993 immune response Effects 0.000 description 22
• 125000000539 amino acid group Chemical group 0.000 description 20
• 108091054438 MHC class II family Proteins 0.000 description 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
• 230000000875 corresponding effect Effects 0.000 description 17
• 201000010099 disease Diseases 0.000 description 17
• 102000040430 polynucleotide Human genes 0.000 description 17
• 108091033319 polynucleotide Proteins 0.000 description 17
• 239000002157 polynucleotide Substances 0.000 description 17
• 210000004881 tumor cell Anatomy 0.000 description 17
• 210000003932 urinary bladder Anatomy 0.000 description 17
• 108091023037 Aptamer Proteins 0.000 description 16
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 16
• 230000006870 function Effects 0.000 description 16
• 208000019465 refractory cytopenia of childhood Diseases 0.000 description 16
• 108700028369 Alleles Proteins 0.000 description 15
• 230000004048 modification Effects 0.000 description 15
• 238000012986 modification Methods 0.000 description 15
• 238000002560 therapeutic procedure Methods 0.000 description 15
• 241001467552 Mycobacterium bovis BCG Species 0.000 description 14
• 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 14
• 238000009472 formulation Methods 0.000 description 14
• 230000001105 regulatory effect Effects 0.000 description 14
• 238000006467 substitution reaction Methods 0.000 description 14
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 13
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 13
• 108010075704 HLA-A Antigens Proteins 0.000 description 13
• 102100034523 Histone H4 Human genes 0.000 description 13
• 101001067880 Homo sapiens Histone H4 Proteins 0.000 description 13
• 238000013459 approach Methods 0.000 description 13
• 210000000056 organ Anatomy 0.000 description 13
• 239000000047 product Substances 0.000 description 13
• 102000043131 MHC class II family Human genes 0.000 description 12
• 238000002512 chemotherapy Methods 0.000 description 12
• 230000000694 effects Effects 0.000 description 12
• 230000004044 response Effects 0.000 description 12
• 239000000243 solution Substances 0.000 description 12
• 230000001225 therapeutic effect Effects 0.000 description 12
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 11
• 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 11
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 11
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 11
• 238000011161 development Methods 0.000 description 11
• 230000018109 developmental process Effects 0.000 description 11
• 238000002360 preparation method Methods 0.000 description 11
• 101001125931 Arabidopsis thaliana Plastidial pyruvate kinase 2 Proteins 0.000 description 10
• 101001125939 Homo sapiens Plakophilin-1 Proteins 0.000 description 10
• 108060003951 Immunoglobulin Proteins 0.000 description 10
• 108010038807 Oligopeptides Proteins 0.000 description 10
• 102000015636 Oligopeptides Human genes 0.000 description 10
• 102100029331 Plakophilin-1 Human genes 0.000 description 10
• 210000000013 bile duct Anatomy 0.000 description 10
• 210000000987 immune system Anatomy 0.000 description 10
• 102000018358 immunoglobulin Human genes 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• 238000007920 subcutaneous administration Methods 0.000 description 10
• 230000004083 survival effect Effects 0.000 description 10
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 9
• 108091028043 Nucleic acid sequence Proteins 0.000 description 9
• 239000000090 biomarker Substances 0.000 description 9
• 239000003795 chemical substances by application Substances 0.000 description 9
• 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 9
• 230000002163 immunogen Effects 0.000 description 9
• 238000002347 injection Methods 0.000 description 9
• 239000007924 injection Substances 0.000 description 9
• 108010016281 ADP-Ribosylation Factor 1 Proteins 0.000 description 8
• 102100034341 ADP-ribosylation factor 1 Human genes 0.000 description 8
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 8
• 241000700605 Viruses Species 0.000 description 8
• 238000004458 analytical method Methods 0.000 description 8
• 239000002585 base Substances 0.000 description 8
• 230000015572 biosynthetic process Effects 0.000 description 8
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 8
• 230000001939 inductive effect Effects 0.000 description 8
• 210000004698 lymphocyte Anatomy 0.000 description 8
• 239000003550 marker Substances 0.000 description 8
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
• 238000012360 testing method Methods 0.000 description 8
• 241000238631 Hexapoda Species 0.000 description 7
• 241000699666 Mus <mouse, genus> Species 0.000 description 7
• 108091034117 Oligonucleotide Proteins 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
• 238000006243 chemical reaction Methods 0.000 description 7
• 239000002299 complementary DNA Substances 0.000 description 7
• 210000002443 helper t lymphocyte Anatomy 0.000 description 7
• 230000008685 targeting Effects 0.000 description 7
• 201000009030 Carcinoma Diseases 0.000 description 6
• 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 description 6
• 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 description 6
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 6
• 208000002030 Merkel cell carcinoma Diseases 0.000 description 6
• 206010027476 Metastases Diseases 0.000 description 6
• 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 6
• 102100037272 T cell receptor beta constant 1 Human genes 0.000 description 6
• 102100037298 T cell receptor beta constant 2 Human genes 0.000 description 6
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
• 239000002253 acid Substances 0.000 description 6
• 230000000890 antigenic effect Effects 0.000 description 6
• 239000003153 chemical reaction reagent Substances 0.000 description 6
• 230000000295 complement effect Effects 0.000 description 6
• 235000018417 cysteine Nutrition 0.000 description 6
• 230000004927 fusion Effects 0.000 description 6
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 6
• 230000001024 immunotherapeutic effect Effects 0.000 description 6
• 230000001965 increasing effect Effects 0.000 description 6
• 238000007912 intraperitoneal administration Methods 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 238000009801 radical cystectomy Methods 0.000 description 6
• 229950010550 resiquimod Drugs 0.000 description 6
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 description 6
• 238000001356 surgical procedure Methods 0.000 description 6
• 238000002626 targeted therapy Methods 0.000 description 6
• 238000012546 transfer Methods 0.000 description 6
• 108091026890 Coding region Proteins 0.000 description 5
• 108020004705 Codon Proteins 0.000 description 5
• 102100024338 Collagen alpha-3(VI) chain Human genes 0.000 description 5
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
• 101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 description 5
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 5
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 5
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 5
• 241001465754 Metazoa Species 0.000 description 5
• 241001529936 Murinae Species 0.000 description 5
• 108700026244 Open Reading Frames Proteins 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
• 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 description 5
• 230000001580 bacterial effect Effects 0.000 description 5
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 5
• 229960004316 cisplatin Drugs 0.000 description 5
• 229960004397 cyclophosphamide Drugs 0.000 description 5
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
• 230000001419 dependent effect Effects 0.000 description 5
• 230000002068 genetic effect Effects 0.000 description 5
• 210000004602 germ cell Anatomy 0.000 description 5
• 229960002751 imiquimod Drugs 0.000 description 5
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 5
• 210000001165 lymph node Anatomy 0.000 description 5
• 210000004962 mammalian cell Anatomy 0.000 description 5
• 238000002823 phage display Methods 0.000 description 5
• 102000005962 receptors Human genes 0.000 description 5
• 108020003175 receptors Proteins 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 208000015347 renal cell adenocarcinoma Diseases 0.000 description 5
• 230000028327 secretion Effects 0.000 description 5
• 230000000638 stimulation Effects 0.000 description 5
• 239000000126 substance Substances 0.000 description 5
• 230000009466 transformation Effects 0.000 description 5
• 206010044412 transitional cell carcinoma Diseases 0.000 description 5
• 239000000439 tumor marker Substances 0.000 description 5
• 238000002255 vaccination Methods 0.000 description 5
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
• 102100023826 ADP-ribosylation factor 4 Human genes 0.000 description 4
• 241000894006 Bacteria Species 0.000 description 4
• 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 description 4
• 101000684189 Homo sapiens ADP-ribosylation factor 4 Proteins 0.000 description 4
• 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 description 4
• 101001107586 Homo sapiens Nuclear pore complex protein Nup107 Proteins 0.000 description 4
• 101000598781 Homo sapiens Oxidative stress-responsive serine-rich protein 1 Proteins 0.000 description 4
• 101000613717 Homo sapiens Protein odd-skipped-related 1 Proteins 0.000 description 4
• 101001098464 Homo sapiens Serine/threonine-protein kinase OSR1 Proteins 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 108010047761 Interferon-alpha Proteins 0.000 description 4
• 102000006992 Interferon-alpha Human genes 0.000 description 4
• 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 description 4
• 239000004472 Lysine Substances 0.000 description 4
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
• 241000699670 Mus sp. Species 0.000 description 4
• 102100021976 Nuclear pore complex protein Nup107 Human genes 0.000 description 4
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
• 102100040551 Protein odd-skipped-related 1 Human genes 0.000 description 4
• 108020004511 Recombinant DNA Proteins 0.000 description 4
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 4
• 102000002689 Toll-like receptor Human genes 0.000 description 4
• 108020000411 Toll-like receptor Proteins 0.000 description 4
• 102100033117 Toll-like receptor 9 Human genes 0.000 description 4
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
• 230000004913 activation Effects 0.000 description 4
• 230000005975 antitumor immune response Effects 0.000 description 4
• 230000006907 apoptotic process Effects 0.000 description 4
• 210000004369 blood Anatomy 0.000 description 4
• 239000008280 blood Substances 0.000 description 4
• 210000004899 c-terminal region Anatomy 0.000 description 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
• 230000029087 digestion Effects 0.000 description 4
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 4
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 4
• 229960005277 gemcitabine Drugs 0.000 description 4
• 238000007918 intramuscular administration Methods 0.000 description 4
• 210000004185 liver Anatomy 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 210000002540 macrophage Anatomy 0.000 description 4
• 230000001394 metastastic effect Effects 0.000 description 4
• 206010061289 metastatic neoplasm Diseases 0.000 description 4
• 239000000178 monomer Substances 0.000 description 4
• 239000002773 nucleotide Substances 0.000 description 4
• 125000003729 nucleotide group Chemical group 0.000 description 4
• 238000012545 processing Methods 0.000 description 4
• 230000002062 proliferating effect Effects 0.000 description 4
• 238000000746 purification Methods 0.000 description 4
• 238000002271 resection Methods 0.000 description 4
• BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 238000003786 synthesis reaction Methods 0.000 description 4
• 238000013518 transcription Methods 0.000 description 4
• 230000035897 transcription Effects 0.000 description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
• 102100023818 ADP-ribosylation factor 3 Human genes 0.000 description 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
• 210000003359 CD4-positive helper T lymphocyte Anatomy 0.000 description 3
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 3
• 108010078791 Carrier Proteins Proteins 0.000 description 3
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 3
• 241000588724 Escherichia coli Species 0.000 description 3
• 208000032612 Glial tumor Diseases 0.000 description 3
• 206010018338 Glioma Diseases 0.000 description 3
• 101000684275 Homo sapiens ADP-ribosylation factor 3 Proteins 0.000 description 3
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
• 108090000526 Papain Proteins 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 230000024932 T cell mediated immunity Effects 0.000 description 3
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
• 230000000735 allogeneic effect Effects 0.000 description 3
• 230000000259 anti-tumor effect Effects 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 238000002619 cancer immunotherapy Methods 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 230000036755 cellular response Effects 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000010367 cloning Methods 0.000 description 3
• 208000029742 colonic neoplasm Diseases 0.000 description 3
• 230000008878 coupling Effects 0.000 description 3
• 238000005859 coupling reaction Methods 0.000 description 3
• 238000004132 cross linking Methods 0.000 description 3
• 238000009799 cystectomy Methods 0.000 description 3
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 238000002474 experimental method Methods 0.000 description 3
• 230000013595 glycosylation Effects 0.000 description 3
• 238000006206 glycosylation reaction Methods 0.000 description 3
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 238000003384 imaging method Methods 0.000 description 3
• 210000002865 immune cell Anatomy 0.000 description 3
• 230000003053 immunization Effects 0.000 description 3
• 238000003364 immunohistochemistry Methods 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 238000001990 intravenous administration Methods 0.000 description 3
• 230000009545 invasion Effects 0.000 description 3
• 238000005304 joining Methods 0.000 description 3
• 125000005647 linker group Chemical group 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 230000001404 mediated effect Effects 0.000 description 3
• 230000009401 metastasis Effects 0.000 description 3
• 239000011859 microparticle Substances 0.000 description 3
• 210000003205 muscle Anatomy 0.000 description 3
• 231100000590 oncogenic Toxicity 0.000 description 3
• 230000002246 oncogenic effect Effects 0.000 description 3
• 229940055729 papain Drugs 0.000 description 3
• 235000019834 papain Nutrition 0.000 description 3
• 201000010198 papillary carcinoma Diseases 0.000 description 3
• 238000009800 partial cystectomy Methods 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 239000000825 pharmaceutical preparation Substances 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 230000005855 radiation Effects 0.000 description 3
• 150000003254 radicals Chemical class 0.000 description 3
• 239000011347 resin Substances 0.000 description 3
• 229920005989 resin Polymers 0.000 description 3
• 230000001177 retroviral effect Effects 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 239000007790 solid phase Substances 0.000 description 3
• 210000000130 stem cell Anatomy 0.000 description 3
• DTMHTVJOHYTUHE-UHFFFAOYSA-N thiocyanogen Chemical compound N#CSSC#N DTMHTVJOHYTUHE-UHFFFAOYSA-N 0.000 description 3
• 230000004614 tumor growth Effects 0.000 description 3
• 230000002485 urinary effect Effects 0.000 description 3
• DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 description 2
• NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 2
• JVJFIQYAHPMBBX-UHFFFAOYSA-N 4-hydroxynonenal Chemical compound CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 description 2
• 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
• 208000036764 Adenocarcinoma of the esophagus Diseases 0.000 description 2
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
• 102100027314 Beta-2-microglobulin Human genes 0.000 description 2
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
• 208000009458 Carcinoma in Situ Diseases 0.000 description 2
• 241000282693 Cercopithecidae Species 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
• 102000007644 Colony-Stimulating Factors Human genes 0.000 description 2
• 108010071942 Colony-Stimulating Factors Proteins 0.000 description 2
• JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
• 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 description 2
• 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical compound CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• 108010083068 Dual Oxidases Proteins 0.000 description 2
• 238000002965 ELISA Methods 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 108010040721 Flagellin Proteins 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 2
• 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 2
• 108010058607 HLA-B Antigens Proteins 0.000 description 2
• 108010052199 HLA-C Antigens Proteins 0.000 description 2
• 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 2
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 2
• 101000798076 Homo sapiens T cell receptor delta constant Proteins 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 2
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 2
• 108090000467 Interferon-beta Proteins 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 102000008070 Interferon-gamma Human genes 0.000 description 2
• 108010065805 Interleukin-12 Proteins 0.000 description 2
• 102000013462 Interleukin-12 Human genes 0.000 description 2
• 108091092195 Intron Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 239000007836 KH2PO4 Substances 0.000 description 2
• 150000008575 L-amino acids Chemical class 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• 239000002147 L01XE04 - Sunitinib Substances 0.000 description 2
• 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 description 2
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 2
• 239000007832 Na2SO4 Substances 0.000 description 2
• 206010030137 Oesophageal adenocarcinoma Diseases 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
• 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• 102100035703 Prostatic acid phosphatase Human genes 0.000 description 2
• LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
• 230000004570 RNA-binding Effects 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 241000283984 Rodentia Species 0.000 description 2
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• 241000713880 Spleen focus-forming virus Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 102100032272 T cell receptor delta constant Human genes 0.000 description 2
• 108700042076 T-Cell Receptor alpha Genes Proteins 0.000 description 2
• 108700042077 T-Cell Receptor beta Genes Proteins 0.000 description 2
• 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 2
• 108700019146 Transgenes Proteins 0.000 description 2
• 108090000631 Trypsin Proteins 0.000 description 2
• 102000004142 Trypsin Human genes 0.000 description 2
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 2
• 150000001242 acetic acid derivatives Chemical class 0.000 description 2
• PAAZCQANMCYGAW-UHFFFAOYSA-N acetic acid;2,2,2-trifluoroacetic acid Chemical class CC(O)=O.OC(=O)C(F)(F)F PAAZCQANMCYGAW-UHFFFAOYSA-N 0.000 description 2
• 239000008186 active pharmaceutical agent Substances 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 125000001931 aliphatic group Chemical group 0.000 description 2
• 125000003368 amide group Chemical group 0.000 description 2
• 150000001408 amides Chemical class 0.000 description 2
• RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
• 239000005557 antagonist Substances 0.000 description 2
• 230000005875 antibody response Effects 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
• 235000009582 asparagine Nutrition 0.000 description 2
• 229960001230 asparagine Drugs 0.000 description 2
• 230000001363 autoimmune Effects 0.000 description 2
• TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• 108010081355 beta 2-Microglobulin Proteins 0.000 description 2
• 229960000397 bevacizumab Drugs 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 229960002685 biotin Drugs 0.000 description 2
• 235000020958 biotin Nutrition 0.000 description 2
• 239000011616 biotin Substances 0.000 description 2
• 201000001531 bladder carcinoma Diseases 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 239000008364 bulk solution Substances 0.000 description 2
• LYQFWZFBNBDLEO-UHFFFAOYSA-M caesium bromide Chemical compound [Br-].[Cs+] LYQFWZFBNBDLEO-UHFFFAOYSA-M 0.000 description 2
• AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 2
• FLJPGEWQYJVDPF-UHFFFAOYSA-L caesium sulfate Chemical compound [Cs+].[Cs+].[O-]S([O-])(=O)=O FLJPGEWQYJVDPF-UHFFFAOYSA-L 0.000 description 2
• 239000001110 calcium chloride Substances 0.000 description 2
• 235000011148 calcium chloride Nutrition 0.000 description 2
• 229910001628 calcium chloride Inorganic materials 0.000 description 2
• ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
• 230000021235 carbamoylation Effects 0.000 description 2
• 231100000504 carcinogenesis Toxicity 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 230000012292 cell migration Effects 0.000 description 2
• 238000012512 characterization method Methods 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• 238000007385 chemical modification Methods 0.000 description 2
• 230000000973 chemotherapeutic effect Effects 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 229910001914 chlorine tetroxide Inorganic materials 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 229940047120 colony stimulating factors Drugs 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 2
• 230000009089 cytolysis Effects 0.000 description 2
• 230000001086 cytosolic effect Effects 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 230000002950 deficient Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 239000005547 deoxyribonucleotide Substances 0.000 description 2
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
• OQALFHMKVSJFRR-UHFFFAOYSA-N dityrosine Chemical compound OC(=O)C(N)CC1=CC=C(O)C(C=2C(=CC=C(CC(N)C(O)=O)C=2)O)=C1 OQALFHMKVSJFRR-UHFFFAOYSA-N 0.000 description 2
• 229960003668 docetaxel Drugs 0.000 description 2
• 229940126534 drug product Drugs 0.000 description 2
• 230000009977 dual effect Effects 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 230000007705 epithelial mesenchymal transition Effects 0.000 description 2
• 208000028653 esophageal adenocarcinoma Diseases 0.000 description 2
• 238000000684 flow cytometry Methods 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 238000013467 fragmentation Methods 0.000 description 2
• 238000006062 fragmentation reaction Methods 0.000 description 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• 229920001519 homopolymer Polymers 0.000 description 2
• 210000004408 hybridoma Anatomy 0.000 description 2
• 125000001165 hydrophobic group Chemical group 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 229940124452 immunizing agent Drugs 0.000 description 2
• 230000016784 immunoglobulin production Effects 0.000 description 2
• 229940072221 immunoglobulins Drugs 0.000 description 2
• 239000000568 immunological adjuvant Substances 0.000 description 2
• 230000008676 import Effects 0.000 description 2
• 201000004933 in situ carcinoma Diseases 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 238000010348 incorporation Methods 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 229960003130 interferon gamma Drugs 0.000 description 2
• 238000011835 investigation Methods 0.000 description 2
• PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 2
• KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
• IIPYXGDZVMZOAP-UHFFFAOYSA-N lithium nitrate Chemical compound [Li+].[O-][N+]([O-])=O IIPYXGDZVMZOAP-UHFFFAOYSA-N 0.000 description 2
• INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Chemical compound [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 description 2
• 201000005249 lung adenocarcinoma Diseases 0.000 description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 229910001629 magnesium chloride Inorganic materials 0.000 description 2
• 235000011147 magnesium chloride Nutrition 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 210000002752 melanocyte Anatomy 0.000 description 2
• 229960000485 methotrexate Drugs 0.000 description 2
• 229960004857 mitomycin Drugs 0.000 description 2
• 108091005601 modified peptides Proteins 0.000 description 2
• 210000001616 monocyte Anatomy 0.000 description 2
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
• 235000019796 monopotassium phosphate Nutrition 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 201000004686 non-invasive bladder papillary urothelial neoplasm Diseases 0.000 description 2
• 238000010606 normalization Methods 0.000 description 2
• 238000011275 oncology therapy Methods 0.000 description 2
• 239000002245 particle Substances 0.000 description 2
• 238000010647 peptide synthesis reaction Methods 0.000 description 2
• 229940023041 peptide vaccine Drugs 0.000 description 2
• VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Chemical compound [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 2
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 2
• OJUGVDODNPJEEC-UHFFFAOYSA-N phenylglyoxal Chemical compound O=CC(=O)C1=CC=CC=C1 OJUGVDODNPJEEC-UHFFFAOYSA-N 0.000 description 2
• 108700002563 poly ICLC Proteins 0.000 description 2
• 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 description 2
• 230000004481 post-translational protein modification Effects 0.000 description 2
• 235000011164 potassium chloride Nutrition 0.000 description 2
• 239000001103 potassium chloride Substances 0.000 description 2
• GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
• FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 238000004393 prognosis Methods 0.000 description 2
• 108010043671 prostatic acid phosphatase Proteins 0.000 description 2
• 125000006239 protecting group Chemical group 0.000 description 2
• 230000009145 protein modification Effects 0.000 description 2
• 230000006337 proteolytic cleavage Effects 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 230000000306 recurrent effect Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 238000004007 reversed phase HPLC Methods 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 210000003705 ribosome Anatomy 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 108010038379 sargramostim Proteins 0.000 description 2
• 229960002530 sargramostim Drugs 0.000 description 2
• 238000009094 second-line therapy Methods 0.000 description 2
• 230000019491 signal transduction Effects 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 229960003310 sildenafil Drugs 0.000 description 2
• JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
• VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
• 229910052938 sodium sulfate Inorganic materials 0.000 description 2
• 235000011152 sodium sulphate Nutrition 0.000 description 2
• 241000894007 species Species 0.000 description 2
• 230000009870 specific binding Effects 0.000 description 2
• 230000003595 spectral effect Effects 0.000 description 2
• 206010041823 squamous cell carcinoma Diseases 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 238000011272 standard treatment Methods 0.000 description 2
• WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 2
• 229960001796 sunitinib Drugs 0.000 description 2
• 230000009897 systematic effect Effects 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• 210000001541 thymus gland Anatomy 0.000 description 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 230000001131 transforming effect Effects 0.000 description 2
• 238000011830 transgenic mouse model Methods 0.000 description 2
• 238000013519 translation Methods 0.000 description 2
• 230000001960 triggered effect Effects 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• 239000012588 trypsin Substances 0.000 description 2
• 108010060175 trypsinogen activation peptide Proteins 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 208000010570 urinary bladder carcinoma Diseases 0.000 description 2
• 210000003741 urothelium Anatomy 0.000 description 2
• 229960003048 vinblastine Drugs 0.000 description 2
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 2
• 230000003612 virological effect Effects 0.000 description 2
• 239000000277 virosome Substances 0.000 description 2
• 210000005253 yeast cell Anatomy 0.000 description 2
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• YUXKOWPNKJSTPQ-AXWWPMSFSA-N (2s,3r)-2-amino-3-hydroxybutanoic acid;(2s)-2-amino-3-hydroxypropanoic acid Chemical compound OC[C@H](N)C(O)=O.C[C@@H](O)[C@H](N)C(O)=O YUXKOWPNKJSTPQ-AXWWPMSFSA-N 0.000 description 1
• FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• DMQYDVBIPXAAJA-VHXPQNKSSA-N (3z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)-(5-methyl-1h-imidazol-2-yl)methylidene]-1h-indol-2-one Chemical compound C1CN(CC)CCC1NC1=CC=C(NC(=O)\C2=C(/C=3NC=C(C)N=3)C=3C=C(F)C=CC=3)C2=C1 DMQYDVBIPXAAJA-VHXPQNKSSA-N 0.000 description 1
• 229910019670 (NH4)H2PO4 Inorganic materials 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• DHBXNPKRAUYBTH-UHFFFAOYSA-N 1,1-ethanedithiol Chemical compound CC(S)S DHBXNPKRAUYBTH-UHFFFAOYSA-N 0.000 description 1
• ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
• DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical class CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
• 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 description 1
• KFDPCYZHENQOBV-UHFFFAOYSA-N 2-(bromomethyl)-4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1CBr KFDPCYZHENQOBV-UHFFFAOYSA-N 0.000 description 1
• VUCNQOPCYRJCGQ-UHFFFAOYSA-N 2-[4-(hydroxymethyl)phenoxy]acetic acid Chemical class OCC1=CC=C(OCC(O)=O)C=C1 VUCNQOPCYRJCGQ-UHFFFAOYSA-N 0.000 description 1
• IOJUJUOXKXMJNF-UHFFFAOYSA-N 2-acetyloxybenzoic acid [3-(nitrooxymethyl)phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC1=CC=CC(CO[N+]([O-])=O)=C1 IOJUJUOXKXMJNF-UHFFFAOYSA-N 0.000 description 1
• IZQAUUVBKYXMET-UHFFFAOYSA-N 2-bromoethanamine Chemical compound NCCBr IZQAUUVBKYXMET-UHFFFAOYSA-N 0.000 description 1
• JQPFYXFVUKHERX-UHFFFAOYSA-N 2-hydroxy-2-cyclohexen-1-one Natural products OC1=CCCCC1=O JQPFYXFVUKHERX-UHFFFAOYSA-N 0.000 description 1
• MWOOKDULMBMMPN-UHFFFAOYSA-N 3-(2-ethyl-1,2-oxazol-2-ium-5-yl)benzenesulfonate Chemical compound O1[N+](CC)=CC=C1C1=CC=CC(S([O-])(=O)=O)=C1 MWOOKDULMBMMPN-UHFFFAOYSA-N 0.000 description 1
• LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical compound NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 description 1
• HXHAJRMTJXHJJZ-UHFFFAOYSA-N 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=CC(Br)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1CCCC1 HXHAJRMTJXHJJZ-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 1
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
• XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 description 1
• 108091007504 ADAM10 Proteins 0.000 description 1
• 102100033347 AP-2 complex subunit beta Human genes 0.000 description 1
• 102100025339 ATP-dependent DNA helicase DDX11 Human genes 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 206010069754 Acquired gene mutation Diseases 0.000 description 1
• 102100024092 Aldo-keto reductase family 1 member C4 Human genes 0.000 description 1
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
• 108010049777 Ankyrins Proteins 0.000 description 1
• 102000008102 Ankyrins Human genes 0.000 description 1
• 241000272478 Aquila Species 0.000 description 1
• 101001107584 Arabidopsis thaliana Nuclear pore complex protein NUP107 Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 241000228212 Aspergillus Species 0.000 description 1
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 1
• BXTVQNYQYUTQAZ-UHFFFAOYSA-N BNPS-skatole Chemical compound N=1C2=CC=CC=C2C(C)(Br)C=1SC1=CC=CC=C1[N+]([O-])=O BXTVQNYQYUTQAZ-UHFFFAOYSA-N 0.000 description 1
• 244000063299 Bacillus subtilis Species 0.000 description 1
• 235000014469 Bacillus subtilis Nutrition 0.000 description 1
• 108020000946 Bacterial DNA Proteins 0.000 description 1
• 108020004513 Bacterial RNA Proteins 0.000 description 1
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
• 208000023514 Barrett esophagus Diseases 0.000 description 1
• 208000023665 Barrett oesophagus Diseases 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• 102000015735 Beta-catenin Human genes 0.000 description 1
• 108060000903 Beta-catenin Proteins 0.000 description 1
• 229920002498 Beta-glucan Polymers 0.000 description 1
• 102100027990 Beta/gamma crystallin domain-containing protein 2 Human genes 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• 210000001239 CD8-positive, alpha-beta cytotoxic T lymphocyte Anatomy 0.000 description 1
• 101150028732 CHMP4B gene Proteins 0.000 description 1
• 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 description 1
• UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 description 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 229940123587 Cell cycle inhibitor Drugs 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 102100038274 Charged multivesicular body protein 4b Human genes 0.000 description 1
• 102100038216 Charged multivesicular body protein 4c Human genes 0.000 description 1
• 101150055427 Chmp4c gene Proteins 0.000 description 1
• 108090000317 Chymotrypsin Proteins 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• 101100007328 Cocos nucifera COS-1 gene Proteins 0.000 description 1
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 241000723655 Cowpea mosaic virus Species 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• 239000004971 Cross linker Substances 0.000 description 1
• 108010058546 Cyclin D1 Proteins 0.000 description 1
• 241000701022 Cytomegalovirus Species 0.000 description 1
• 102100031635 Cytoplasmic dynein 1 heavy chain 1 Human genes 0.000 description 1
• 150000008574 D-amino acids Chemical class 0.000 description 1
• YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
• 108091008102 DNA aptamers Proteins 0.000 description 1
• 230000004543 DNA replication Effects 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 101100327868 Danio rerio chmp4c gene Proteins 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 1
• 102100039673 Disintegrin and metalloproteinase domain-containing protein 10 Human genes 0.000 description 1
• 102100021218 Dual oxidase 1 Human genes 0.000 description 1
• 102100021217 Dual oxidase 2 Human genes 0.000 description 1
• 102100021820 E3 ubiquitin-protein ligase RNF4 Human genes 0.000 description 1
• 102100034596 E3 ubiquitin-protein ligase TRIM23 Human genes 0.000 description 1
• 102000001301 EGF receptor Human genes 0.000 description 1
• 108060006698 EGF receptor Proteins 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 108010059378 Endopeptidases Proteins 0.000 description 1
• 102000005593 Endopeptidases Human genes 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 102100025496 F-box and WD repeat domain containing protein 10B Human genes 0.000 description 1
• 108091008794 FGF receptors Proteins 0.000 description 1
• 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 description 1
• 240000008168 Ficus benjamina Species 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 1
• 229910052688 Gadolinium Inorganic materials 0.000 description 1
• 241001663880 Gammaretrovirus Species 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
• 108060005986 Granzyme Proteins 0.000 description 1
• 102000001398 Granzyme Human genes 0.000 description 1
• 101150009006 HIS3 gene Proteins 0.000 description 1
• 108010008553 HLA-B*07 antigen Proteins 0.000 description 1
• 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
• 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
• 102100027738 Heterogeneous nuclear ribonucleoprotein H Human genes 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000732341 Homo sapiens AP-2 complex subunit beta Proteins 0.000 description 1
• 101000722210 Homo sapiens ATP-dependent DNA helicase DDX11 Proteins 0.000 description 1
• 101000859450 Homo sapiens Beta/gamma crystallin domain-containing protein 2 Proteins 0.000 description 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
• 101000866326 Homo sapiens Cytoplasmic dynein 1 heavy chain 1 Proteins 0.000 description 1
• 101001107086 Homo sapiens E3 ubiquitin-protein ligase RNF4 Proteins 0.000 description 1
• 101000848625 Homo sapiens E3 ubiquitin-protein ligase TRIM23 Proteins 0.000 description 1
• 101000914283 Homo sapiens F-box and WD repeat domain containing protein 10B Proteins 0.000 description 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 101001081149 Homo sapiens Heterogeneous nuclear ribonucleoprotein H Proteins 0.000 description 1
• 101001008527 Homo sapiens Laminin subunit alpha-5 Proteins 0.000 description 1
• 101000619663 Homo sapiens Leucine-rich repeat-containing protein 1 Proteins 0.000 description 1
• 101000608935 Homo sapiens Leukosialin Proteins 0.000 description 1
• 101000972291 Homo sapiens Lymphoid enhancer-binding factor 1 Proteins 0.000 description 1
• 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
• 101000573526 Homo sapiens Membrane protein MLC1 Proteins 0.000 description 1
• 101000794228 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 1
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 1
• 101000863978 Homo sapiens Protein downstream neighbor of Son Proteins 0.000 description 1
• 101000836190 Homo sapiens SNRPN upstream reading frame protein Proteins 0.000 description 1
• 101100260585 Homo sapiens SPOCK1 gene Proteins 0.000 description 1
• 101000898985 Homo sapiens Seipin Proteins 0.000 description 1
• 101000657845 Homo sapiens Small nuclear ribonucleoprotein-associated proteins B and B' Proteins 0.000 description 1
• 101000753197 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-2 Proteins 0.000 description 1
• 101000800055 Homo sapiens Testican-1 Proteins 0.000 description 1
• 101000795793 Homo sapiens Tetratricopeptide repeat protein 28 Proteins 0.000 description 1
• 101000807344 Homo sapiens Ubiquitin-conjugating enzyme E2 A Proteins 0.000 description 1
• 101000955093 Homo sapiens WD repeat-containing protein 3 Proteins 0.000 description 1
• 101000964759 Homo sapiens Zinc finger protein 573 Proteins 0.000 description 1
• 108090000144 Human Proteins Proteins 0.000 description 1
• 102000003839 Human Proteins Human genes 0.000 description 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
• 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
• 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 102100026720 Interferon beta Human genes 0.000 description 1
• 102000003996 Interferon-beta Human genes 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 102000000589 Interleukin-1 Human genes 0.000 description 1
• 102000003816 Interleukin-13 Human genes 0.000 description 1
• 108090000176 Interleukin-13 Proteins 0.000 description 1
• 102100030703 Interleukin-22 Human genes 0.000 description 1
• 102000013264 Interleukin-23 Human genes 0.000 description 1
• 108010065637 Interleukin-23 Proteins 0.000 description 1
• 108090000978 Interleukin-4 Proteins 0.000 description 1
• 102000004388 Interleukin-4 Human genes 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 102000000704 Interleukin-7 Human genes 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• 239000005511 L01XE05 - Sorafenib Substances 0.000 description 1
• 239000003798 L01XE11 - Pazopanib Substances 0.000 description 1
• 102100027450 Laminin subunit alpha-5 Human genes 0.000 description 1
• 241000134253 Lanka Species 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102100022237 Leucine-rich repeat-containing protein 1 Human genes 0.000 description 1
• 102100039564 Leukosialin Human genes 0.000 description 1
• 102100022699 Lymphoid enhancer-binding factor 1 Human genes 0.000 description 1
• 108091054455 MAP kinase family Proteins 0.000 description 1
• 102000043136 MAP kinase family Human genes 0.000 description 1
• 108010010995 MART-1 Antigen Proteins 0.000 description 1
• 102100024997 MOB kinase activator 1B Human genes 0.000 description 1
• 101700059339 MOB1A Proteins 0.000 description 1
• PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 229910021380 Manganese Chloride Inorganic materials 0.000 description 1
• GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
• 229920000057 Mannan Polymers 0.000 description 1
• 102100026290 Membrane protein MLC1 Human genes 0.000 description 1
• 229910019445 Mg(ClO4) Inorganic materials 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• 102100030144 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Human genes 0.000 description 1
• 102100034256 Mucin-1 Human genes 0.000 description 1
• 206010057269 Mucoepidermoid carcinoma Diseases 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 101100096028 Mus musculus Smok1 gene Proteins 0.000 description 1
• 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
• 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
• 241000186366 Mycobacterium bovis Species 0.000 description 1
• 241000187481 Mycobacterium phlei Species 0.000 description 1
• GUVMFDICMFQHSZ-UHFFFAOYSA-N N-(1-aminoethenyl)-1-[4-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[hydroxy-[[3-[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-[[[2-[[[2-[[[5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[5-(4-amino-2-oxopyrimidin-1-yl)-2-[[hydroxy-[2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphinothioyl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]oxolan-2-yl]-5-methylimidazole-4-carboxamide Chemical compound CC1=C(C(=O)NC(N)=C)N=CN1C1OC(COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)CO)C(OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)O)C1 GUVMFDICMFQHSZ-UHFFFAOYSA-N 0.000 description 1
• VIHYIVKEECZGOU-UHFFFAOYSA-N N-acetylimidazole Chemical compound CC(=O)N1C=CN=C1 VIHYIVKEECZGOU-UHFFFAOYSA-N 0.000 description 1
• 108010084333 N-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysine Proteins 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 108090000163 Nuclear pore complex proteins Proteins 0.000 description 1
• 102000003789 Nuclear pore complex proteins Human genes 0.000 description 1
• 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 1
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
• 108700006640 OspA Proteins 0.000 description 1
• 239000012648 POLY-ICLC Substances 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 101800001442 Peptide pr Proteins 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 102100033237 Pro-epidermal growth factor Human genes 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 102100029926 Protein downstream neighbor of Son Human genes 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 108020005067 RNA Splice Sites Proteins 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 206010062237 Renal impairment Diseases 0.000 description 1
• 108020005091 Replication Origin Proteins 0.000 description 1
• 101100394989 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) hisI gene Proteins 0.000 description 1
• 101150117369 SPOCK1 gene Proteins 0.000 description 1
• 206010039491 Sarcoma Diseases 0.000 description 1
• 102100021463 Seipin Human genes 0.000 description 1
• 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 1
• 108020004459 Small interfering RNA Proteins 0.000 description 1
• 102100034683 Small nuclear ribonucleoprotein-associated proteins B and B' Human genes 0.000 description 1
• 102100021955 Sodium/potassium-transporting ATPase subunit alpha-2 Human genes 0.000 description 1
• 208000035518 Squamous cell carcinoma of the oropharynx Diseases 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 108010002687 Survivin Proteins 0.000 description 1
• 108700005078 Synthetic Genes Proteins 0.000 description 1
• 230000037453 T cell priming Effects 0.000 description 1
• 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 description 1
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 108010017842 Telomerase Proteins 0.000 description 1
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
• CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 1
• 102100033390 Testican-1 Human genes 0.000 description 1
• NYTOUQBROMCLBJ-UHFFFAOYSA-N Tetranitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)([N+]([O-])=O)[N+]([O-])=O NYTOUQBROMCLBJ-UHFFFAOYSA-N 0.000 description 1
• 102100031744 Tetratricopeptide repeat protein 28 Human genes 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
• 208000007536 Thrombosis Diseases 0.000 description 1
• 102000008236 Toll-Like Receptor 7 Human genes 0.000 description 1
• 108010060825 Toll-Like Receptor 7 Proteins 0.000 description 1
• 102000008208 Toll-Like Receptor 8 Human genes 0.000 description 1
• 108010060752 Toll-Like Receptor 8 Proteins 0.000 description 1
• 102000040945 Transcription factor Human genes 0.000 description 1
• 108091023040 Transcription factor Proteins 0.000 description 1
• 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
• 108020004566 Transfer RNA Proteins 0.000 description 1
• UATJOMSPNYCXIX-UHFFFAOYSA-N Trinitrobenzene Chemical compound [O-][N+](=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 UATJOMSPNYCXIX-UHFFFAOYSA-N 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 102100039094 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• 102100023345 Tyrosine-protein kinase ITK/TSK Human genes 0.000 description 1
• 108090000848 Ubiquitin Proteins 0.000 description 1
• 102000044159 Ubiquitin Human genes 0.000 description 1
• 102100037261 Ubiquitin-conjugating enzyme E2 A Human genes 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 108091008605 VEGF receptors Proteins 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 description 1
• 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 108010067390 Viral Proteins Proteins 0.000 description 1
• 108020000999 Viral RNA Proteins 0.000 description 1
• 102100038964 WD repeat-containing protein 3 Human genes 0.000 description 1
• 108700020467 WT1 Proteins 0.000 description 1
• 101150084041 WT1 gene Proteins 0.000 description 1
• 241001492404 Woodchuck hepatitis virus Species 0.000 description 1
• 102100040656 Zinc finger protein 573 Human genes 0.000 description 1
• 210000001015 abdomen Anatomy 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
• 238000005903 acid hydrolysis reaction Methods 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 230000003044 adaptive effect Effects 0.000 description 1
• 230000002730 additional effect Effects 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 210000000577 adipose tissue Anatomy 0.000 description 1
• 238000011226 adjuvant chemotherapy Methods 0.000 description 1
• 210000004100 adrenal gland Anatomy 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 229940060265 aldara Drugs 0.000 description 1
• 150000001447 alkali salts Chemical class 0.000 description 1
• 239000013566 allergen Substances 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• 150000003862 amino acid derivatives Chemical class 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
• 235000019270 ammonium chloride Nutrition 0.000 description 1
• 239000000908 ammonium hydroxide Substances 0.000 description 1
• UKFWSNCTAHXBQN-UHFFFAOYSA-N ammonium iodide Chemical compound [NH4+].[I-] UKFWSNCTAHXBQN-UHFFFAOYSA-N 0.000 description 1
• 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
• 235000019289 ammonium phosphates Nutrition 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 239000004037 angiogenesis inhibitor Substances 0.000 description 1
• 150000008064 anhydrides Chemical class 0.000 description 1
• 229910052925 anhydrite Inorganic materials 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 230000003042 antagnostic effect Effects 0.000 description 1
• 230000003527 anti-angiogenesis Effects 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 230000005809 anti-tumor immunity Effects 0.000 description 1
• 230000006023 anti-tumor response Effects 0.000 description 1
• 210000000628 antibody-producing cell Anatomy 0.000 description 1
• 230000030741 antigen processing and presentation Effects 0.000 description 1
• 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 1
• 230000008349 antigen-specific humoral response Effects 0.000 description 1
• 239000008365 aqueous carrier Substances 0.000 description 1
• 239000008346 aqueous phase Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 229910001620 barium bromide Inorganic materials 0.000 description 1
• NKQIMNKPSDEDMO-UHFFFAOYSA-L barium bromide Chemical compound [Br-].[Br-].[Ba+2] NKQIMNKPSDEDMO-UHFFFAOYSA-L 0.000 description 1
• 229910001626 barium chloride Inorganic materials 0.000 description 1
• WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
• 229910001638 barium iodide Inorganic materials 0.000 description 1
• IWOUKMZUPDVPGQ-UHFFFAOYSA-N barium nitrate Inorganic materials [Ba+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O IWOUKMZUPDVPGQ-UHFFFAOYSA-N 0.000 description 1
• WAKZZMMCDILMEF-UHFFFAOYSA-H barium(2+);diphosphate Chemical compound [Ba+2].[Ba+2].[Ba+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O WAKZZMMCDILMEF-UHFFFAOYSA-H 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 238000002306 biochemical method Methods 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 238000005422 blasting Methods 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 210000001185 bone marrow Anatomy 0.000 description 1
• 201000008275 breast carcinoma Diseases 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
• NLSCHDZTHVNDCP-UHFFFAOYSA-N caesium nitrate Inorganic materials [Cs+].[O-][N+]([O-])=O NLSCHDZTHVNDCP-UHFFFAOYSA-N 0.000 description 1
• YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
• 229910001622 calcium bromide Inorganic materials 0.000 description 1
• WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 description 1
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
• 239000000920 calcium hydroxide Substances 0.000 description 1
• 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
• 229910001640 calcium iodide Inorganic materials 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• 230000009400 cancer invasion Effects 0.000 description 1
• 239000012830 cancer therapeutic Substances 0.000 description 1
• 238000009566 cancer vaccine Methods 0.000 description 1
• 238000005251 capillar electrophoresis Methods 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 229920006317 cationic polymer Polymers 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 229960002412 cediranib Drugs 0.000 description 1
• 229940047495 celebrex Drugs 0.000 description 1
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
• 230000025084 cell cycle arrest Effects 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 230000022534 cell killing Effects 0.000 description 1
• 239000002771 cell marker Substances 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 229940030156 cell vaccine Drugs 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 230000017455 cell-cell adhesion Effects 0.000 description 1
• 210000002230 centromere Anatomy 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 230000004745 cervical carcinogenesis Effects 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• QUPYHCHUQVNFJW-UHFFFAOYSA-M cesium;thiocyanate Chemical compound [Cs+].[S-]C#N QUPYHCHUQVNFJW-UHFFFAOYSA-M 0.000 description 1
• 230000002925 chemical effect Effects 0.000 description 1
• 125000003636 chemical group Chemical group 0.000 description 1
• 230000006328 chemical modification of amino acids Effects 0.000 description 1
• VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
• 150000001805 chlorine compounds Chemical class 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 229960002376 chymotrypsin Drugs 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 239000013599 cloning vector Substances 0.000 description 1
• 238000011260 co-administration Methods 0.000 description 1
• 238000009096 combination chemotherapy Methods 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 238000002591 computed tomography Methods 0.000 description 1
• 238000004624 confocal microscopy Methods 0.000 description 1
• 210000002808 connective tissue Anatomy 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 229910001431 copper ion Inorganic materials 0.000 description 1
• 229910000336 copper(I) sulfate Inorganic materials 0.000 description 1
• WIVXEZIMDUGYRW-UHFFFAOYSA-L copper(i) sulfate Chemical compound [Cu+].[Cu+].[O-]S([O-])(=O)=O WIVXEZIMDUGYRW-UHFFFAOYSA-L 0.000 description 1
• XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
• OILAIQUEIWYQPH-UHFFFAOYSA-N cyclohexane-1,2-dione Chemical compound O=C1CCCCC1=O OILAIQUEIWYQPH-UHFFFAOYSA-N 0.000 description 1
• 210000000172 cytosol Anatomy 0.000 description 1
• 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 230000007423 decrease Effects 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 230000004041 dendritic cell maturation Effects 0.000 description 1
• 229940029030 dendritic cell vaccine Drugs 0.000 description 1
• 108010017271 denileukin diftitox Proteins 0.000 description 1
• 238000010511 deprotection reaction Methods 0.000 description 1
• 229950006137 dexfosfoserine Drugs 0.000 description 1
• 125000004386 diacrylate group Chemical group 0.000 description 1
• 150000004985 diamines Chemical class 0.000 description 1
• MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
• 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
• 235000019838 diammonium phosphate Nutrition 0.000 description 1
• 125000004989 dicarbonyl group Chemical group 0.000 description 1
• FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 238000006471 dimerization reaction Methods 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 229910000397 disodium phosphate Inorganic materials 0.000 description 1
• 235000019800 disodium phosphate Nutrition 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 230000006334 disulfide bridging Effects 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 210000003162 effector t lymphocyte Anatomy 0.000 description 1
• 229940056913 eftilagimod alfa Drugs 0.000 description 1
• 230000005611 electricity Effects 0.000 description 1
• 238000001493 electron microscopy Methods 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 238000000132 electrospray ionisation Methods 0.000 description 1
• 238000001437 electrospray ionisation time-of-flight quadrupole detection Methods 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 230000012202 endocytosis Effects 0.000 description 1
• 229940066758 endopeptidases Drugs 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 229940088598 enzyme Drugs 0.000 description 1
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
• 229960001904 epirubicin Drugs 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 210000001508 eye Anatomy 0.000 description 1
• 238000010265 fast atom bombardment Methods 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 230000003328 fibroblastic effect Effects 0.000 description 1
• 239000010408 film Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 108700014844 flt3 ligand Proteins 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 238000001215 fluorescent labelling Methods 0.000 description 1
• 238000002594 fluoroscopy Methods 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 235000011087 fumaric acid Nutrition 0.000 description 1
• UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 238000003500 gene array Methods 0.000 description 1
• 238000003197 gene knockdown Methods 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 230000004077 genetic alteration Effects 0.000 description 1
• 231100000118 genetic alteration Toxicity 0.000 description 1
• 102000054766 genetic haplotypes Human genes 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 230000036449 good health Effects 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 159000000011 group IA salts Chemical class 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 210000002216 heart Anatomy 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 description 1
• 229920000140 heteropolymer Polymers 0.000 description 1
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
• 229920001600 hydrophobic polymer Polymers 0.000 description 1
• 230000007124 immune defense Effects 0.000 description 1
• 230000008105 immune reaction Effects 0.000 description 1
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 230000001571 immunoadjuvant effect Effects 0.000 description 1
• 238000011532 immunohistochemical staining Methods 0.000 description 1
• 239000002955 immunomodulating agent Substances 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 230000002584 immunomodulator Effects 0.000 description 1
• 230000003308 immunostimulating effect Effects 0.000 description 1
• 230000002637 immunotoxin Effects 0.000 description 1
• 239000002596 immunotoxin Substances 0.000 description 1
• 229940051026 immunotoxin Drugs 0.000 description 1
• 231100000608 immunotoxin Toxicity 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 229940117681 interleukin-12 Drugs 0.000 description 1
• 108010074108 interleukin-21 Proteins 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 230000002601 intratumoral effect Effects 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 208000030776 invasive breast carcinoma Diseases 0.000 description 1
• JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 210000003292 kidney cell Anatomy 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
• 229910052747 lanthanoid Inorganic materials 0.000 description 1
• 150000002602 lanthanoids Chemical class 0.000 description 1
• 210000002429 large intestine Anatomy 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 239000002960 lipid emulsion Substances 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 239000012669 liquid formulation Substances 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Inorganic materials [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 description 1
• MHCFAGZWMAWTNR-UHFFFAOYSA-M lithium perchlorate Chemical compound [Li+].[O-]Cl(=O)(=O)=O MHCFAGZWMAWTNR-UHFFFAOYSA-M 0.000 description 1
• 229910001486 lithium perchlorate Inorganic materials 0.000 description 1
• 229910001386 lithium phosphate Inorganic materials 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 230000001926 lymphatic effect Effects 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 description 1
• 239000011654 magnesium acetate Substances 0.000 description 1
• 235000011285 magnesium acetate Nutrition 0.000 description 1
• 229910001623 magnesium bromide Inorganic materials 0.000 description 1
• OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
• 229910001641 magnesium iodide Inorganic materials 0.000 description 1
• BLQJIBCZHWBKSL-UHFFFAOYSA-L magnesium iodide Chemical compound [Mg+2].[I-].[I-] BLQJIBCZHWBKSL-UHFFFAOYSA-L 0.000 description 1
• YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Inorganic materials [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 1
• 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
• 238000002595 magnetic resonance imaging Methods 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 230000036210 malignancy Effects 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 239000011565 manganese chloride Substances 0.000 description 1
• 235000002867 manganese chloride Nutrition 0.000 description 1
• 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 230000008099 melanin synthesis Effects 0.000 description 1
• 210000003716 mesoderm Anatomy 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
• UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
• ZCQGVFNHUATAJY-UHFFFAOYSA-N methyl 2-[methyl(prop-2-enoyl)amino]acetate Chemical compound COC(=O)CN(C)C(=O)C=C ZCQGVFNHUATAJY-UHFFFAOYSA-N 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• 230000011987 methylation Effects 0.000 description 1
• 238000007069 methylation reaction Methods 0.000 description 1
• 239000011325 microbead Substances 0.000 description 1
• 230000000813 microbial effect Effects 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 239000011259 mixed solution Substances 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
• 235000019785 monomagnesium phosphate Nutrition 0.000 description 1
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 1
• 235000019799 monosodium phosphate Nutrition 0.000 description 1
• 230000004899 motility Effects 0.000 description 1
• 229940035036 multi-peptide vaccine Drugs 0.000 description 1
• 229940055036 mycobacterium phlei Drugs 0.000 description 1
• CMWYAOXYQATXSI-UHFFFAOYSA-N n,n-dimethylformamide;piperidine Chemical compound CN(C)C=O.C1CCNCC1 CMWYAOXYQATXSI-UHFFFAOYSA-N 0.000 description 1
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 239000005445 natural material Substances 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
• 238000009099 neoadjuvant therapy Methods 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 230000001613 neoplastic effect Effects 0.000 description 1
• 230000010309 neoplastic transformation Effects 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 210000000440 neutrophil Anatomy 0.000 description 1
• FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
• VXAPDXVBDZRZKP-UHFFFAOYSA-N nitric acid phosphoric acid Chemical compound O[N+]([O-])=O.OP(O)(O)=O VXAPDXVBDZRZKP-UHFFFAOYSA-N 0.000 description 1
• 231100000956 nontoxicity Toxicity 0.000 description 1
• 231100001221 nontumorigenic Toxicity 0.000 description 1
• 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
• 210000004492 nuclear pore Anatomy 0.000 description 1
• 230000005937 nuclear translocation Effects 0.000 description 1
• 230000000269 nucleophilic effect Effects 0.000 description 1
• 239000002751 oligonucleotide probe Substances 0.000 description 1
• 230000006548 oncogenic transformation Effects 0.000 description 1
• 229940100027 ontak Drugs 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 208000010655 oral cavity squamous cell carcinoma Diseases 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 235000006408 oxalic acid Nutrition 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 238000009116 palliative therapy Methods 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 208000003154 papilloma Diseases 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 230000005298 paramagnetic effect Effects 0.000 description 1
• 210000002990 parathyroid gland Anatomy 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 description 1
• 229960000639 pazopanib Drugs 0.000 description 1
• 210000004197 pelvis Anatomy 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 229940125667 peptide vaccine candidate Drugs 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• 229930192851 perforin Natural products 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 210000004303 peritoneum Anatomy 0.000 description 1
• 229940124531 pharmaceutical excipient Drugs 0.000 description 1
• 229940127557 pharmaceutical product Drugs 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical group OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
• 238000002428 photodynamic therapy Methods 0.000 description 1
• 230000001817 pituitary effect Effects 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 239000013600 plasmid vector Substances 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 210000004224 pleura Anatomy 0.000 description 1
• 229940115270 poly iclc Drugs 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 102000054765 polymorphisms of proteins Human genes 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 231100000857 poor renal function Toxicity 0.000 description 1
• 210000003240 portal vein Anatomy 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 238000002600 positron emission tomography Methods 0.000 description 1
• 230000001124 posttranscriptional effect Effects 0.000 description 1
• IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Inorganic materials [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 1
• GKKCIDNWFBPDBW-UHFFFAOYSA-M potassium cyanate Chemical compound [K]OC#N GKKCIDNWFBPDBW-UHFFFAOYSA-M 0.000 description 1
• 235000010333 potassium nitrate Nutrition 0.000 description 1
• 229910001487 potassium perchlorate Inorganic materials 0.000 description 1
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
• 229910052939 potassium sulfate Inorganic materials 0.000 description 1
• ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 230000037452 priming Effects 0.000 description 1
• 230000002250 progressing effect Effects 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 229940021993 prophylactic vaccine Drugs 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 235000019260 propionic acid Nutrition 0.000 description 1
• 238000000159 protein binding assay Methods 0.000 description 1
• 230000016434 protein splicing Effects 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 229940107700 pyruvic acid Drugs 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 239000002516 radical scavenger Substances 0.000 description 1
• 238000007347 radical substitution reaction Methods 0.000 description 1
• 239000000941 radioactive substance Substances 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 238000006722 reduction reaction Methods 0.000 description 1
• 238000005932 reductive alkylation reaction Methods 0.000 description 1
• 230000012385 regulation of binding Effects 0.000 description 1
• 230000022983 regulation of cell cycle Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 229910000344 rubidium sulfate Inorganic materials 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 210000003079 salivary gland Anatomy 0.000 description 1
• 229930182490 saponin Natural products 0.000 description 1
• 150000007949 saponins Chemical class 0.000 description 1
• 238000004621 scanning probe microscopy Methods 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 238000011519 second-line treatment Methods 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 229960000714 sipuleucel-t Drugs 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 238000001542 size-exclusion chromatography Methods 0.000 description 1
• 229940074386 skatole Drugs 0.000 description 1
• 210000002027 skeletal muscle Anatomy 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 208000000649 small cell carcinoma Diseases 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
• 235000010344 sodium nitrate Nutrition 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
• PUZPDOWCWNUUKD-ULWFUOSBSA-M sodium;fluorine-18(1-) Chemical compound [18F-].[Na+] PUZPDOWCWNUUKD-ULWFUOSBSA-M 0.000 description 1
• 238000010532 solid phase synthesis reaction Methods 0.000 description 1
• 239000006104 solid solution Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 230000037439 somatic mutation Effects 0.000 description 1
• 229960003787 sorafenib Drugs 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 230000010473 stable expression Effects 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 210000002536 stromal cell Anatomy 0.000 description 1
• BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
• 208000014794 superficial urinary bladder carcinoma Diseases 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 229960000835 tadalafil Drugs 0.000 description 1
• IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 description 1
• 108010010186 talactoferrin alfa Proteins 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• 229960004964 temozolomide Drugs 0.000 description 1
• QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 1
• 229960000235 temsirolimus Drugs 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 230000004797 therapeutic response Effects 0.000 description 1
• 229940021747 therapeutic vaccine Drugs 0.000 description 1
• 238000004809 thin layer chromatography Methods 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 210000003437 trachea Anatomy 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 230000009261 transgenic effect Effects 0.000 description 1
• 230000010474 transient expression Effects 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 description 1
• 125000001814 trioxo-lambda(7)-chloranyloxy group Chemical group *OCl(=O)(=O)=O 0.000 description 1
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
• 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
• 235000019798 tripotassium phosphate Nutrition 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
• 235000019801 trisodium phosphate Nutrition 0.000 description 1
• 238000001665 trituration Methods 0.000 description 1
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 1
• 230000002100 tumorsuppressive effect Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 241000701447 unidentified baculovirus Species 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 210000001635 urinary tract Anatomy 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 208000023747 urothelial carcinoma Diseases 0.000 description 1
• 239000012646 vaccine adjuvant Substances 0.000 description 1
• 229940124931 vaccine adjuvant Drugs 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 238000010200 validation analysis Methods 0.000 description 1
• 229960000653 valrubicin Drugs 0.000 description 1
• ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
• 229960002381 vardenafil Drugs 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 238000012800 visualization Methods 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• 208000022752 well-differentiated liposarcoma Diseases 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1