IL261146B - Methods and compositions for treating cancers and neoplasms - Google Patents

Methods and compositions for treating cancers and neoplasms

Info

Publication number
IL261146B
IL261146B IL261146A IL26114618A IL261146B IL 261146 B IL261146 B IL 261146B IL 261146 A IL261146 A IL 261146A IL 26114618 A IL26114618 A IL 26114618A IL 261146 B IL261146 B IL 261146B
Authority
IL
Israel
Prior art keywords
asc
cells
cancer
cell
tumor
Prior art date
Application number
IL261146A
Other languages
English (en)
Hebrew (he)
Other versions
IL261146A (en
Inventor
Gilert Ariel
Yissachar Allen Hoshea
SHRAGA HELED Niva
Ofir Rachel
Aberman Zami
Original Assignee
Pluristem Ltd
Gilert Ariel
Yissachar Allen Hoshea
SHRAGA HELED Niva
Ofir Rachel
Aberman Zami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pluristem Ltd, Gilert Ariel, Yissachar Allen Hoshea, SHRAGA HELED Niva, Ofir Rachel, Aberman Zami filed Critical Pluristem Ltd
Publication of IL261146A publication Critical patent/IL261146A/en
Publication of IL261146B publication Critical patent/IL261146B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062General methods for three-dimensional culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL261146A 2016-02-18 2017-02-16 Methods and compositions for treating cancers and neoplasms IL261146B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662296621P 2016-02-18 2016-02-18
PCT/IB2017/050868 WO2017141181A1 (en) 2016-02-18 2017-02-16 Methods and compositions for treating cancers and neoplasms

Publications (2)

Publication Number Publication Date
IL261146A IL261146A (en) 2018-10-31
IL261146B true IL261146B (en) 2022-07-01

Family

ID=58266008

Family Applications (1)

Application Number Title Priority Date Filing Date
IL261146A IL261146B (en) 2016-02-18 2017-02-16 Methods and compositions for treating cancers and neoplasms

Country Status (7)

Country Link
US (1) US20210205370A1 (https=)
EP (1) EP3416662B1 (https=)
JP (1) JP6884792B2 (https=)
AU (1) AU2017220148A1 (https=)
CA (1) CA3012741A1 (https=)
IL (1) IL261146B (https=)
WO (1) WO2017141181A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018191619A1 (en) 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US20210000882A1 (en) * 2018-02-28 2021-01-07 Crown Scientific, LLC Production and use of extracellular vesicles
US20210115395A1 (en) * 2018-03-28 2021-04-22 Pluristem Ltd. Methods for expanding adherent stromal cells and cells obtained thereby
JP7538044B2 (ja) * 2018-04-30 2024-08-21 ザ チルドレンズ メディカル センター コーポレーション 間葉系間質細胞エキソソームおよびそれらの使用
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
AU2019359890B2 (en) * 2018-10-17 2024-10-24 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US20220323412A1 (en) * 2019-09-06 2022-10-13 Chi-Chih Kang Extracellular vesicle-fenretinide compositions, extracellular vesicle-c-kit inhibitor compositions, methods of making and uses thereof
WO2022059026A1 (en) * 2020-09-21 2022-03-24 Mestastop Solutions Private Limited Systems and methods for predicting cancer metastasis and screening of drugs
JP7849911B2 (ja) * 2021-09-27 2026-04-22 金湧長生醫學生物科技股▲ふん▼有限公司 脱落膜胎盤間葉系幹細胞及び血管新生促進医薬組成物の製造におけるその用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008019148A2 (en) * 2006-08-04 2008-02-14 Anthrogenesis Corporation Tumor suppression using placental stem cells
WO2009045360A2 (en) * 2007-09-28 2009-04-09 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
WO2010026575A2 (en) * 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
WO2011094181A1 (en) * 2010-01-26 2011-08-04 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
JPS6410979A (en) 1987-07-03 1989-01-13 Mitsubishi Chem Ind Microcarrier for cultivating cell
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
DE69903800T2 (de) 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
EP1261694B1 (en) 2000-02-26 2008-01-16 Artecel, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
WO2007011693A2 (en) * 2005-07-14 2007-01-25 Medistem Laboratories, Inc. Compositions of placentally-derived stem cells for the treatment of cancer
EP2366775B1 (en) 2006-03-23 2015-04-22 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US7531334B2 (en) 2006-04-14 2009-05-12 Xerox Corporation Polymeric microcarriers for cell culture functions
MX2010003019A (es) * 2007-09-19 2010-04-30 Pluristem Ltd Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia.
US8828720B2 (en) 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
EP3150703A1 (en) 2009-07-09 2017-04-05 TiGenix, S.A.U. Cells for use in a method for treating inflammatory and/or immune disorders
EP2977445B1 (en) 2009-11-30 2018-07-25 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
EP2561066B1 (en) * 2010-04-23 2016-03-30 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
CN103476924A (zh) 2011-04-15 2013-12-25 普拉里斯坦有限公司 收获细胞的方法和系统
RU2615179C2 (ru) 2012-09-06 2017-04-04 Плуристем Лтд. Устройства и способы культивирования клеток
WO2014066122A1 (en) * 2012-10-24 2014-05-01 The Texas A&M University System Treatment of tumors with activated mesenchymal stem cells
US10258652B2 (en) 2014-12-18 2019-04-16 Pluristem Ltd. Methods and compositions for treating and preventing muscle wasting disorders
US20180015125A1 (en) 2015-03-23 2018-01-18 Pluristem Ltd. Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008019148A2 (en) * 2006-08-04 2008-02-14 Anthrogenesis Corporation Tumor suppression using placental stem cells
WO2009045360A2 (en) * 2007-09-28 2009-04-09 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
WO2010026575A2 (en) * 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
WO2011094181A1 (en) * 2010-01-26 2011-08-04 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GONZ?LEZ, PAZ L., ET AL., CHORION MESENCHYMAL STEM CELLS SHOW SUPERIOR DIFFERENTIATION, IMMUNOSUPPRESSIVE, AND ANGIOGENIC POTENTIALS IN COMPARISON WITH HAPLOIDENTICAL MATERNAL PLACENTAL CELLS., 13 August 2015 (2015-08-13) *
SPEES, JEFFREY L., RYANG HWA LEE, AND CARL A. GREGORY., MECHANISMS OF MESENCHYMAL STEM/STROMAL CELL FUNCTION., 31 August 2016 (2016-08-31) *

Also Published As

Publication number Publication date
JP6884792B2 (ja) 2021-06-09
EP3416662B1 (en) 2020-07-29
CA3012741A1 (en) 2017-08-24
WO2017141181A1 (en) 2017-08-24
EP3416662A1 (en) 2018-12-26
US20210205370A1 (en) 2021-07-08
AU2017220148A1 (en) 2018-07-19
IL261146A (en) 2018-10-31
JP2019509999A (ja) 2019-04-11

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