IL260750B2 - Clinical assessment of m-protein response in multiple myeloma - Google Patents
Clinical assessment of m-protein response in multiple myelomaInfo
- Publication number
- IL260750B2 IL260750B2 IL260750A IL26075018A IL260750B2 IL 260750 B2 IL260750 B2 IL 260750B2 IL 260750 A IL260750 A IL 260750A IL 26075018 A IL26075018 A IL 26075018A IL 260750 B2 IL260750 B2 IL 260750B2
- Authority
- IL
- Israel
- Prior art keywords
- seq
- amino acid
- acid sequence
- albumin
- idiotypic antibody
- Prior art date
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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| PCT/EP2017/055011 WO2017149122A1 (en) | 2016-03-04 | 2017-03-03 | Clinical assessment of m-protein response in multiple myeloma |
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| IL305540A IL305540B2 (en) | 2016-03-04 | 2017-03-03 | Clinical evaluation of protein-M response in multiple myeloma |
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| WO2019209730A1 (en) | 2018-04-24 | 2019-10-31 | Helena Laboratories Corporation | Removal of interfering factors from serum protein electrophoresis profiles |
| EP3851456A4 (en) | 2018-09-11 | 2022-06-08 | Jiangsu Hengrui Medicine Co., Ltd. | ANTI-CD38 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND PHARMACEUTICAL APPLICATION |
| CN113574071B (zh) | 2019-03-15 | 2025-03-25 | 莫佛塞斯公司 | 用于治疗自身抗体介导的自身免疫疾病的抗-cd38抗体及其药物组合物 |
| WO2023094696A1 (en) * | 2021-11-29 | 2023-06-01 | Morphosys Ag | Methods for reducing anti-cd38 mab drug interference in serological assays |
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| US6936464B1 (en) * | 1992-10-02 | 2005-08-30 | Cancer Research Technology Limited | Immune responses to fusion proteins |
| WO2009032128A1 (en) * | 2007-08-28 | 2009-03-12 | Abbott Biotechnology Ltd. | Compositions and methods comprising binding proteins for adalimumab |
| US20090130089A9 (en) * | 2006-10-10 | 2009-05-21 | Vaccinex, Inc. | Anti-cd20 antibodies and methods of use |
| US20130302318A1 (en) * | 2010-09-27 | 2013-11-14 | Lisa Rojkjaer | Anti-CD38 Antibody and Lenalidomide or Bortezomib for the Treatment of Multipe Myeloma and NHL |
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| US4661586A (en) * | 1981-11-17 | 1987-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal anti-idiotype antibodies |
| US4578350A (en) * | 1983-09-23 | 1986-03-25 | Syntex (U.S.A.) Inc. | Immunoassays employing protected labels |
| US20020164788A1 (en) | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
| CA2329940A1 (en) | 1998-06-05 | 1999-12-09 | Mayo Foundation For Medical Education And Research | Use of genetically engineered antibodies to cd38 to treat multiple myeloma |
| EP1174440A1 (en) | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
| US7348139B1 (en) * | 2001-04-13 | 2008-03-25 | The Johns Hopkins University School Of Medicine | SOCS-1 gene methylation in cancer |
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| EP1544215A1 (en) | 2003-12-17 | 2005-06-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Human anti-idiotypic antibody fragments that mimic HER-2/neu |
| SI2511297T1 (sl) * | 2004-02-06 | 2015-07-31 | Morphosys Ag | Proti -CD38 humana protitelesa in njihova uporaba |
| EP1720907B1 (en) | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-cd38 human antibodies and uses therefor |
| KR101335798B1 (ko) * | 2005-02-15 | 2013-12-02 | 듀크 유니버시티 | 항-ｃｄ19 항체 및 종양학에서 이의 용도 |
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| TW200745162A (en) | 2005-05-24 | 2007-12-16 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 |
| CN103554260A (zh) | 2005-10-12 | 2014-02-05 | 莫佛塞斯公司 | 特异性针对人CD38的完全人HuCAL GOLD-衍生治疗抗体的生成和鉴定 |
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| EP3105317B1 (en) * | 2014-02-14 | 2018-09-19 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
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- 2017-03-03 SG SG11201806214RA patent/SG11201806214RA/en unknown
- 2017-03-03 EP EP17708766.5A patent/EP3423498A1/en active Pending
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2022
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| US6936464B1 (en) * | 1992-10-02 | 2005-08-30 | Cancer Research Technology Limited | Immune responses to fusion proteins |
| US20090130089A9 (en) * | 2006-10-10 | 2009-05-21 | Vaccinex, Inc. | Anti-cd20 antibodies and methods of use |
| WO2009032128A1 (en) * | 2007-08-28 | 2009-03-12 | Abbott Biotechnology Ltd. | Compositions and methods comprising binding proteins for adalimumab |
| US20130302318A1 (en) * | 2010-09-27 | 2013-11-14 | Lisa Rojkjaer | Anti-CD38 Antibody and Lenalidomide or Bortezomib for the Treatment of Multipe Myeloma and NHL |
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