IL258478B - Extended use zirconium silicate compositions and methods of use thereof - Google Patents

Extended use zirconium silicate compositions and methods of use thereof

Info

Publication number
IL258478B
IL258478B IL258478A IL25847818A IL258478B IL 258478 B IL258478 B IL 258478B IL 258478 A IL258478 A IL 258478A IL 25847818 A IL25847818 A IL 25847818A IL 258478 B IL258478 B IL 258478B
Authority
IL
Israel
Prior art keywords
methods
zirconium compounds
silicon zirconium
extended
extended use
Prior art date
Application number
IL258478A
Other languages
English (en)
Hebrew (he)
Other versions
IL258478A (en
Original Assignee
Zs Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58227650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL258478(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zs Pharma Inc filed Critical Zs Pharma Inc
Publication of IL258478A publication Critical patent/IL258478A/en
Publication of IL258478B publication Critical patent/IL258478B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/02—Processes using inorganic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/14—Base exchange silicates, e.g. zeolites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C01B39/06—Preparation of isomorphous zeolites characterised by measures to replace the aluminium or silicon atoms in the lattice framework by atoms of other elements, i.e. by direct or secondary synthesis
    • C01B39/08—Preparation of isomorphous zeolites characterised by measures to replace the aluminium or silicon atoms in the lattice framework by atoms of other elements, i.e. by direct or secondary synthesis the aluminium atoms being wholly replaced
    • C01B39/085—Group IVB- metallosilicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL258478A 2015-10-14 2018-04-01 Extended use zirconium silicate compositions and methods of use thereof IL258478B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/883,428 US9592253B1 (en) 2015-10-14 2015-10-14 Extended use zirconium silicate compositions and methods of use thereof
PCT/US2016/056286 WO2017066128A1 (en) 2015-10-14 2016-10-10 Extended use zirconium silicate compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
IL258478A IL258478A (en) 2018-05-31
IL258478B true IL258478B (en) 2020-09-30

Family

ID=58227650

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258478A IL258478B (en) 2015-10-14 2018-04-01 Extended use zirconium silicate compositions and methods of use thereof

Country Status (19)

Country Link
US (4) US9592253B1 (https=)
EP (1) EP3362456A4 (https=)
JP (1) JP6546700B2 (https=)
KR (1) KR102667566B1 (https=)
CN (2) CN108137620B (https=)
AR (1) AR106369A1 (https=)
AU (1) AU2016338753C1 (https=)
CA (1) CA3000950C (https=)
CL (1) CL2018000916A1 (https=)
CR (1) CR20180276A (https=)
EA (2) EA035890B1 (https=)
HK (1) HK1254808A1 (https=)
IL (1) IL258478B (https=)
MX (1) MX2018004440A (https=)
MY (1) MY187088A (https=)
PH (1) PH12018500786B1 (https=)
TW (1) TWI742004B (https=)
WO (1) WO2017066128A1 (https=)
ZA (1) ZA201803095B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101896732B1 (ko) 2011-02-11 2018-09-07 제트에스 파마, 인코포레이티드 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄
US9592253B1 (en) * 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof
WO2019092179A1 (en) * 2017-11-10 2019-05-16 Sandoz Ag Pharmaceutical compositions comprising zs-9
SG11202109834XA (en) 2019-03-13 2021-10-28 Astrazeneca Ab Potassium-binding agents for use in hemodialysis patients
CN117342570B (zh) * 2023-09-04 2026-02-10 杭州国瑞生物科技有限公司 一种环硅酸锆钠的a晶型及其制备方法
CN117735564B (zh) * 2023-12-19 2025-12-19 杭州国瑞生物科技有限公司 一种环硅酸锆钠的b晶型及其制备方法与应用
CN120172420B (zh) * 2025-03-21 2025-12-23 时森海(杭州)医药科技有限公司 控制粒径分布的环硅酸锆钠及其制备方法
CN120984211A (zh) * 2025-06-13 2025-11-21 时森海(杭州)医药科技有限公司 生产环硅酸锆钠的反应器和方法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE21224E (en) 1939-10-03 Coherent zirconium silicates
US2809943A (en) * 1952-09-11 1957-10-15 Dow Chemical Co Weighted ion exchange resin granules and method of making same
US3492092A (en) * 1966-04-04 1970-01-27 Chem Separations Corp Ion exchange process for treating crude mineral solutions
US3947279A (en) 1971-12-23 1976-03-30 Owens-Illinois, Inc. Thermally crystallizable glasses possessing precision controlled crystallization and flow properties and process of producing same
US4581141A (en) 1978-02-27 1986-04-08 Purdue Research Foundation Dialysis material and method for removing uremic substances
FR2444005A1 (fr) 1978-12-15 1980-07-11 Ugine Kuhlmann Procede industriel de fabrication en semi-continu de zeolithe a
US4943545A (en) 1987-06-08 1990-07-24 Mobil Oil Corporation Activation of zeolites
US5015453A (en) 1989-04-28 1991-05-14 W. R. Grace & Co.-Conn. Crystalline group IVA metal-containing molecular sieve compositions
US5099737A (en) 1991-02-22 1992-03-31 Curletto Giorgio F Double chambered bassboard housing for electronic M.I.D.I. accordion with retractable keyboard
US5338527A (en) 1992-08-20 1994-08-16 Uop Zirconium silicate composition, method of preparation and uses thereof
ATE142170T1 (de) 1992-10-28 1996-09-15 Crosfield Joseph & Sons Kieselsäuren
US5518707A (en) 1994-10-24 1996-05-21 Uop Metallo germanates
IT1283284B1 (it) 1996-03-21 1998-04-16 Eniricerche Spa Zeolite ers-10 e procedimento per la sua preparazione
FR2750893B1 (fr) 1996-07-12 1998-10-30 Elf Aquitaine Procede de synthese de zeolithe avec agitation homogene du milieu, dispositif et application
US5888472A (en) 1997-04-08 1999-03-30 Uop Llc Zirconium silicate molecular sieves and process using the same
US5891417A (en) 1997-04-08 1999-04-06 Uop Llc Zirconium silicate and zirconium germanate molecular sieves and process using the same
CA2268888A1 (en) 1997-05-12 1998-11-19 Itsuki Uehara Separator for battery and alkali secondary battery using the same
US6007790A (en) 1998-08-13 1999-12-28 Uop Llc Family of microporous indium silicate compositions
US6332985B1 (en) 1999-03-29 2001-12-25 Uop Llc Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
US6099737A (en) 1999-03-29 2000-08-08 Uop Llc Process for removing toxins from blood using zirconium metallate or titanium metallate compositions
US7041274B2 (en) 1999-10-22 2006-05-09 Intevep, S.A. Aluminosilicate compositions, preparation and use
US20020061521A1 (en) 2000-01-31 2002-05-23 Rosen Craig A. Nucleic acids, proteins, and antibodies
US6379641B1 (en) 2000-05-01 2002-04-30 Uop Llc Microporous rare earth silicates and method of producing same
US6596254B1 (en) 2000-06-12 2003-07-22 Sandia Corporation Niobate-based octahedral molecular sieves
WO2002062356A2 (en) 2001-02-06 2002-08-15 Ash Medical Systems, Inc. Monovalent-selective cation exchangers as oral sorbent therapy
US6579460B1 (en) 2001-03-13 2003-06-17 Uop Llc Process and composition for removing toxins from bodily fluids
US6814871B1 (en) 2001-07-13 2004-11-09 Uop Llc Process for removing pollutants from aqueous streams
US6689335B1 (en) 2002-12-19 2004-02-10 Eastman Kodak Company Silver ion sequester and release agent
US8597778B2 (en) 2003-12-15 2013-12-03 Asahi Kasei Chemicals Corporation Porous formed article and method for production thereof
BRPI0509331B8 (pt) 2004-03-30 2021-05-25 Ilypsa Inc uso de uma composição de ligação de sódio
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
JP5328152B2 (ja) 2004-12-28 2013-10-30 レナル ソリューションズ，インク． リン酸ジルコニウム粒子の合成法
WO2006134915A1 (ja) 2005-06-14 2006-12-21 Asahi Kasei Chemicals Corporation 水処理装置及び水処理方法
GB2446077B (en) 2005-09-30 2010-10-13 Ilypsa Inc Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
CA2624112A1 (en) 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
US7297318B2 (en) * 2005-11-17 2007-11-20 J.M. Huber Corporation Method of removing heavy metals from silicate sources during silicate manufacturing
US7201885B1 (en) * 2005-11-17 2007-04-10 J.M. Huber Corporation Method of removing heavy metals from silicate sources during silicate manufacturing
US8367112B2 (en) 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
WO2007127390A2 (en) 2006-04-28 2007-11-08 Biolife, L.L.C. Materials and methods for wound treatment
EP2079660B1 (en) 2007-01-03 2017-01-11 Insilico Co., Ltd. Coordination polymer crystal with porous metal-organic frameworks and preperation method thereof
ES2304890B1 (es) 2007-04-03 2009-10-30 Universidad De Zaragoza Procedimiento de obtencion de esferas de titanosilicato.
CN101980983B (zh) 2008-02-26 2014-04-16 康宁股份有限公司 用于硅酸盐玻璃的澄清剂
US20100104527A1 (en) 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
MX389664B (es) 2008-08-22 2025-03-20 Vifor Int Ltd Polimeros reticulados de intercambio cationico, composiciones y su uso en el tratamiento de la hipercalcemia
US8865121B2 (en) 2009-06-18 2014-10-21 Basf Se Organotemplate-free synthetic process for the production of a zeolitic material
GB0913525D0 (en) * 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
US20120070468A1 (en) 2010-09-16 2012-03-22 Uop Llc Removal of toxins from gastrointestinal fluids
KR101896732B1 (ko) * 2011-02-11 2018-09-07 제트에스 파마, 인코포레이티드 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄
WO2012137132A1 (en) 2011-04-08 2012-10-11 Basf Se Process for producing acylation catalyst
US9527751B2 (en) 2011-11-11 2016-12-27 Basf Se Organotemplate-free synthetic process for the production of a zeolitic material of the CHA-type structure
WO2013118063A1 (en) 2012-02-06 2013-08-15 Basf Se Iron- and copper-containing zeolite beta from organotemplate-free synthesis and use thereof in the selective catalytic reduction of nox
US9475041B2 (en) 2012-04-24 2016-10-25 Basf Se Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds
HK1215861A1 (zh) * 2012-07-11 2016-09-23 Zs Pharma, Inc 用於治疗高钙血症患者高钾血症的微孔硅酸锆以及用於治疗高钾血症的改进的含钙组合物
KR102184602B1 (ko) * 2012-10-22 2020-11-30 제트에스 파마, 인코포레이티드 고칼륨혈증의 치료를 위한 미세다공성 지르코늄 실리케이트
US20150290242A1 (en) * 2013-11-08 2015-10-15 ZS Pharma, Inc. Microporous Zirconium Silicate for the Treatment of Hyperkalemia
US20140302175A1 (en) * 2013-04-05 2014-10-09 ZS Pharma, Inc. Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease
EP3079706A4 (en) * 2013-12-10 2017-12-27 ZS Pharma, Inc Zirconium silicate for treating hyperkalemia without co-administering lithium
US9592253B1 (en) * 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof

Also Published As

Publication number Publication date
US20190365800A1 (en) 2019-12-05
TW201717972A (zh) 2017-06-01
IL258478A (en) 2018-05-31
AU2016338753C1 (en) 2019-08-08
BR112018007189A2 (en) 2018-10-16
CN113143958A (zh) 2021-07-23
MX2018004440A (es) 2018-07-06
KR102667566B1 (ko) 2024-05-22
PH12018500786B1 (en) 2022-09-07
CN108137620A (zh) 2018-06-08
JP2018530596A (ja) 2018-10-18
HK1254808A1 (zh) 2019-07-26
NZ740931A (en) 2024-12-20
US10300087B2 (en) 2019-05-28
JP6546700B2 (ja) 2019-07-17
EP3362456A4 (en) 2019-05-15
CL2018000916A1 (es) 2018-08-17
US12582673B2 (en) 2026-03-24
CN108137620B (zh) 2021-05-18
US11738044B2 (en) 2023-08-29
PH12018500786A1 (en) 2018-10-29
US20240009229A1 (en) 2024-01-11
ZA201803095B (en) 2019-11-27
AU2016338753B2 (en) 2019-04-18
EA202091273A1 (ru) 2021-02-03
WO2017066128A1 (en) 2017-04-20
CA3000950C (en) 2023-10-31
EA035890B1 (ru) 2020-08-27
CA3000950A1 (en) 2017-04-20
CR20180276A (es) 2018-09-19
AR106369A1 (es) 2018-01-10
US20170151279A1 (en) 2017-06-01
EA201890875A1 (ru) 2018-11-30
US9592253B1 (en) 2017-03-14
EP3362456A1 (en) 2018-08-22
AU2016338753A1 (en) 2018-04-12
TWI742004B (zh) 2021-10-11
MY187088A (en) 2021-08-30
KR20180067614A (ko) 2018-06-20

Similar Documents

Publication Publication Date Title
IL285101A (en) Antibodies targeting g-protein coupled receptor and methods of use
EP4212536C0 (en) BENZOXAZEPINE OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
IL259747A (en) Antibodies targeting fc receptor-like 5 and methods of use
IL254039A0 (en) Anti-pvrig antibodies and methods of use
HUE046000T2 (hu) Antiproferatív vegyületek és alkalmazásuk módszerei
PT3548033T (pt) Compostos e respectivos métodos de utilização
IL251970B (en) Anti-cd79b antibodies and methods of use
PL3353210T3 (pl) Przeciwciała anty-TIGIT i sposoby stosowania
IL251972B (en) Analyzing and utilizing landscapes
HRP20251095T1 (hr) Neoantigeni i metode njihove uporabe
IL258768A (en) Glycan-interacting compounds and methods of use
PL3215532T3 (pl) Przeciwciała anty-TIM3 i sposoby ich zastosowania
IL252602B (en) Oral care compositions and methods of use
PL3250610T3 (pl) Przeciwciała anty-FcRn i sposoby ich stosowania
IL258478B (en) Extended use zirconium silicate compositions and methods of use thereof
PT3319612T (pt) Oxisteróis e métodos de utilização dos mesmos
BR112016020889A2 (pt) variantes de hppd e métodos de uso
EP3406336A4 (en) NANO FOIL OF CORE CASE STRUCTURE TYPE
IL272851A (en) Methods of using dipivefrin
PL3457851T3 (pl) Pochodne sobetiromu
DK3569166T3 (da) Indretning til akut behandling af hjertestop
BR112016026046A2 (pt) Uso de compostos de tienotriazolodiazepina
IL248223A0 (en) Vaccine compositions
IL313083A (en) Terlipressin compositions and their methods of use
DK3137873T3 (da) Viscometer and methods of use thereof

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed