IL250744A0 - שיטה להכנת פלבוציקליב והכנות רוקחיות שלו - Google Patents

שיטה להכנת פלבוציקליב והכנות רוקחיות שלו

Info

Publication number
IL250744A0
IL250744A0 IL250744A IL25074417A IL250744A0 IL 250744 A0 IL250744 A0 IL 250744A0 IL 250744 A IL250744 A IL 250744A IL 25074417 A IL25074417 A IL 25074417A IL 250744 A0 IL250744 A0 IL 250744A0
Authority
IL
Israel
Prior art keywords
palbociclib
producing
same
pharmaceutical compositions
pharmaceutical
Prior art date
Application number
IL250744A
Other languages
English (en)
Inventor
Ludovic Coutable
Original Assignee
Ratiopharm Gmbh
Ludovic Coutable
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh, Ludovic Coutable filed Critical Ratiopharm Gmbh
Publication of IL250744A0 publication Critical patent/IL250744A0/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL250744A 2014-08-28 2017-02-23 שיטה להכנת פלבוציקליב והכנות רוקחיות שלו IL250744A0 (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043354P 2014-08-28 2014-08-28
PCT/EP2015/069588 WO2016030439A1 (en) 2014-08-28 2015-08-27 Method of producing palbociclib and pharmaceutical compositions comprising the same

Publications (1)

Publication Number Publication Date
IL250744A0 true IL250744A0 (he) 2017-04-30

Family

ID=54007718

Family Applications (1)

Application Number Title Priority Date Filing Date
IL250744A IL250744A0 (he) 2014-08-28 2017-02-23 שיטה להכנת פלבוציקליב והכנות רוקחיות שלו

Country Status (3)

Country Link
EP (1) EP3186252A1 (he)
IL (1) IL250744A0 (he)
WO (1) WO2016030439A1 (he)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105616418A (zh) * 2014-11-07 2016-06-01 江苏豪森药业集团有限公司 含有细胞周期蛋白抑制剂的药物制剂及其制备方法
CN105748435B (zh) * 2016-04-21 2019-03-29 石家庄海瑞药物科技有限公司 一种帕布昔利布药物组合物及其制备方法
EP3255048A1 (en) * 2016-06-07 2017-12-13 K.H.S. Pharma Holding GmbH Non-crystalline form of palbociclib
WO2018007927A1 (en) * 2016-07-04 2018-01-11 Dr. Reddy's Laboratories Limited Process for preparation of palbociclib
CN106220627A (zh) * 2016-07-31 2016-12-14 合肥远志医药科技开发有限公司 一种高纯度帕布昔利布的工业化制备方法
CN106018655B (zh) * 2016-08-01 2018-01-19 南京臣功制药股份有限公司 一种帕布昔利布原料有关物质的检测方法
KR101893879B1 (ko) 2017-03-31 2018-09-03 한국화학연구원 신규한 cdk 저해 화합물, 이의 제조방법, 및 이를 유효성분으로 함유하는 cdk 관련 질환의 예방 또는 치료용 약학적 조성물
CN109206373B (zh) * 2017-07-07 2022-02-15 上海医药工业研究院 一种帕博昔布中间体5-溴-2-氯-4-环戊基氨基嘧啶的制备工艺
EP3658119A1 (en) * 2017-07-28 2020-06-03 Synthon B.V. Pharmaceutical composition comprising palbociclib
CN111386272B (zh) 2017-10-27 2023-01-06 费森尤斯卡比肿瘤学有限公司 一种改进的瑞博西尼及其盐的制备方法
CN108299422B (zh) * 2018-02-28 2019-10-25 杭州福斯特药业有限公司 一种帕泊昔利布中间体的制备方法
US11858928B2 (en) 2018-05-24 2024-01-02 Synthon B.V. Process for making palbociclib
CN108822026A (zh) * 2018-09-21 2018-11-16 湖北大学 一种抗癌药帕博昔布重要中间体的合成工艺
CN109867673B (zh) * 2019-04-16 2021-03-16 淮海工学院 一种合成帕布昔利布的方法
CN110256424A (zh) * 2019-07-03 2019-09-20 武汉工程大学 一种帕博西尼关键中间体v的合成方法
EP4089092A4 (en) * 2020-01-10 2024-03-06 Hangzhou Innogate Pharma Co., Ltd. POLYCYCLIC COMPOUND ACTING AS A KINASE INHIBITOR
CN111362939B (zh) * 2020-04-26 2021-08-03 山东梅奥华卫科技有限公司 一种帕布昔利布母核结构化合物的制备方法
WO2021220295A1 (en) * 2020-04-29 2021-11-04 Natco Pharma Limited Immediate release pharmaceutical compositions comprising palbociclib
WO2022091001A1 (en) * 2020-10-29 2022-05-05 Pfizer Ireland Pharmaceuticals Process for preparation of palbociclib
CN112457311B (zh) * 2020-12-04 2022-07-12 江苏豪森药业集团有限公司 一种含有氯溴吡咯嘧啶酮结构化合物的制备方法
CN112552297A (zh) * 2020-12-12 2021-03-26 江西国药有限责任公司 一种哌柏西利的制备方法与流程
CN112898299B (zh) * 2021-01-26 2021-11-26 山东铂源药业有限公司 一种帕布昔利布中间体的制备方法
CN113683612B (zh) * 2021-09-07 2022-06-17 山东铂源药业股份有限公司 一种帕布昔利布的制备方法
CN113999227A (zh) * 2021-11-26 2022-02-01 常州大学 一种帕博西尼中间体的制备方法
WO2023194870A1 (en) * 2022-04-06 2023-10-12 Glenmark Life Sciences Limited Process for the preparation of palbociclib

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716880A2 (pt) * 2006-09-08 2013-10-15 Pfizer Prod Inc Síntese de 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas
SI2958916T1 (sl) * 2013-02-21 2018-11-30 Pfizer Inc. Trdne oblike selektivnih zaviralcev CDK4/6

Also Published As

Publication number Publication date
WO2016030439A1 (en) 2016-03-03
EP3186252A1 (en) 2017-07-05

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