IL235521A - Polymorphic form of the oxalate salt 6 - o - (4-dimethylaminoethoxy) cinnamoyl pomgilol and methods of preparation and use - Google Patents

Polymorphic form of the oxalate salt 6 - o - (4-dimethylaminoethoxy) cinnamoyl pomgilol and methods of preparation and use

Info

Publication number
IL235521A
IL235521A IL235521A IL23552114A IL235521A IL 235521 A IL235521 A IL 235521A IL 235521 A IL235521 A IL 235521A IL 23552114 A IL23552114 A IL 23552114A IL 235521 A IL235521 A IL 235521A
Authority
IL
Israel
Prior art keywords
dimethylaminoethoxy
making
methods
same
polymorphic form
Prior art date
Application number
IL235521A
Other languages
English (en)
Hebrew (he)
Other versions
IL235521A0 (en
Inventor
Crawford Thomas
Original Assignee
Zafgen Inc
Crawford Thomas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zafgen Inc, Crawford Thomas filed Critical Zafgen Inc
Publication of IL235521A0 publication Critical patent/IL235521A0/en
Publication of IL235521A publication Critical patent/IL235521A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL235521A 2012-05-07 2014-11-05 Polymorphic form of the oxalate salt 6 - o - (4-dimethylaminoethoxy) cinnamoyl pomgilol and methods of preparation and use IL235521A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261643586P 2012-05-07 2012-05-07
PCT/US2013/039877 WO2013169727A1 (en) 2012-05-07 2013-05-07 Polymorphic salt of the oxalate salt of 6 - o - ( 4 - dimethylaminoethoxy) cinnarnoyl fumagillol and methods of making and using same

Publications (2)

Publication Number Publication Date
IL235521A0 IL235521A0 (en) 2015-02-01
IL235521A true IL235521A (en) 2017-02-28

Family

ID=48446683

Family Applications (1)

Application Number Title Priority Date Filing Date
IL235521A IL235521A (en) 2012-05-07 2014-11-05 Polymorphic form of the oxalate salt 6 - o - (4-dimethylaminoethoxy) cinnamoyl pomgilol and methods of preparation and use

Country Status (10)

Country Link
US (1) US9260419B2 (enExample)
EP (1) EP2847176A1 (enExample)
JP (1) JP2015516425A (enExample)
KR (1) KR20150016303A (enExample)
AU (1) AU2013259760A1 (enExample)
BR (1) BR112014027808A2 (enExample)
CA (1) CA2872649A1 (enExample)
IL (1) IL235521A (enExample)
MX (1) MX2014013525A (enExample)
WO (1) WO2013169727A1 (enExample)

Families Citing this family (8)

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WO2013055385A2 (en) 2011-10-03 2013-04-18 Zafgen Corporation Methods of treating age related disorders
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
EP2846792B1 (en) 2012-05-08 2018-08-15 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
CN104364251B (zh) 2012-05-09 2017-02-22 扎夫根股份有限公司 烟曲霉醇型化合物及其制备和使用方法
KR20150126924A (ko) 2013-03-14 2015-11-13 자프겐 인크. 신장 질환 및 기타 장애의 치료 방법
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso

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ATE153854T1 (de) 1992-12-16 1997-06-15 Takeda Chemical Industries Ltd Stabile pharmazeutische zubereitung mit fumagillolderivaten
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Also Published As

Publication number Publication date
EP2847176A1 (en) 2015-03-18
BR112014027808A2 (pt) 2017-06-27
AU2013259760A1 (en) 2014-11-20
US9260419B2 (en) 2016-02-16
CA2872649A1 (en) 2013-11-14
IL235521A0 (en) 2015-02-01
MX2014013525A (es) 2015-10-22
WO2013169727A1 (en) 2013-11-14
JP2015516425A (ja) 2015-06-11
CN104350046A (zh) 2015-02-11
US20150111964A1 (en) 2015-04-23
KR20150016303A (ko) 2015-02-11

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