IL227490A0 - מעכבים quinazolinone של dynein - Google Patents
מעכבים quinazolinone של dyneinInfo
- Publication number
- IL227490A0 IL227490A0 IL227490A IL22749013A IL227490A0 IL 227490 A0 IL227490 A0 IL 227490A0 IL 227490 A IL227490 A IL 227490A IL 22749013 A IL22749013 A IL 22749013A IL 227490 A0 IL227490 A0 IL 227490A0
- Authority
- IL
- Israel
- Prior art keywords
- dynein
- quinazolinone
- inhibitors
- quinazolinone inhibitors
- Prior art date
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical compound C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 102000013035 dynein heavy chain Human genes 0.000 title 1
- 108060002430 dynein heavy chain Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161434545P | 2011-01-20 | 2011-01-20 | |
| PCT/US2012/021639 WO2012099916A1 (en) | 2011-01-20 | 2012-01-18 | Quinazolinone inhibitors of dynein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL227490A0 true IL227490A0 (he) | 2013-09-30 |
Family
ID=45774309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL227490A IL227490A0 (he) | 2011-01-20 | 2013-07-15 | מעכבים quinazolinone של dynein |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9145376B2 (he) |
| EP (1) | EP2665712A1 (he) |
| JP (1) | JP2014506565A (he) |
| AU (1) | AU2012207393A1 (he) |
| CA (1) | CA2824925A1 (he) |
| IL (1) | IL227490A0 (he) |
| WO (1) | WO2012099916A1 (he) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015221969A1 (de) * | 2015-11-09 | 2017-05-11 | Technische Universität Dresden | Verfahren zur automatisierten Detektion einer Aktivität von Wirkstoffen in einer Lösung |
| KR102672900B1 (ko) * | 2016-09-01 | 2024-06-10 | (주)아모레퍼시픽 | 2,4-디클로로-a-(3,4-디하이드로-4-옥소-2(1H)-퀴나졸리닐리덴)-β-옥소-벤젠프로판니트릴을 포함하는 멜라닌 증진용 조성물 |
| WO2018213712A1 (en) * | 2017-05-18 | 2018-11-22 | Kapoor Tarun M | Pyrazoloquinazolinone antitumor agents |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0995485A (ja) * | 1995-03-16 | 1997-04-08 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および剤 |
| US20050080138A1 (en) | 1999-09-16 | 2005-04-14 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2003074497A1 (en) * | 2002-03-01 | 2003-09-12 | Pintex Pharmaceutical, Inc. | Pin1-modulating compounds and methods of use thereof |
| AU2003291761A1 (en) * | 2002-11-04 | 2004-06-07 | Nps Pharmaceuticals, Inc. | Quinazolinone compounds as calcilytics |
| EP1911425B1 (en) | 2003-02-12 | 2014-01-15 | The Procter and Gamble Company | Absorbent core for an absorbent article |
| WO2007124171A2 (en) * | 2006-04-20 | 2007-11-01 | Massachusetts Institute Of Technology | Compositions and methods for treating trinucleotide repeat disorders |
| AR062200A1 (es) * | 2006-08-04 | 2008-10-22 | Aeterna Zentaris Gmbh | Derivados de antraceno y su uso para el tratamiento de emfermedades tumorales bengnas y malingnas |
| US8686102B2 (en) | 2007-11-02 | 2014-04-01 | Momentive Performance Materials Inc. | Textiles treated with copolymers of epoxy compounds and amino silanes having enhanced wet-strength |
| US20090118421A1 (en) | 2007-11-02 | 2009-05-07 | Momentive Performance Materials Inc. | Copolymer of epoxy compounds and amino silanes |
| WO2009102864A1 (en) * | 2008-02-12 | 2009-08-20 | Stanford University | Hedgehog pathway antagonists and methods of use |
| US9040508B2 (en) * | 2008-12-08 | 2015-05-26 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
-
2012
- 2012-01-18 CA CA2824925A patent/CA2824925A1/en not_active Abandoned
- 2012-01-18 US US13/980,527 patent/US9145376B2/en not_active Expired - Fee Related
- 2012-01-18 AU AU2012207393A patent/AU2012207393A1/en not_active Abandoned
- 2012-01-18 EP EP12706722.1A patent/EP2665712A1/en not_active Withdrawn
- 2012-01-18 JP JP2013550547A patent/JP2014506565A/ja active Pending
- 2012-01-18 WO PCT/US2012/021639 patent/WO2012099916A1/en not_active Ceased
-
2013
- 2013-07-15 IL IL227490A patent/IL227490A0/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012099916A1 (en) | 2012-07-26 |
| JP2014506565A (ja) | 2014-03-17 |
| AU2012207393A1 (en) | 2013-08-08 |
| CA2824925A1 (en) | 2012-07-26 |
| EP2665712A1 (en) | 2013-11-27 |
| US9145376B2 (en) | 2015-09-29 |
| US20130296349A1 (en) | 2013-11-07 |
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