IL226397B - Bifunctional molecules with antibody-mobilizing and fusion-inhibiting activity against human immunodeficiency virus - Google Patents
Bifunctional molecules with antibody-mobilizing and fusion-inhibiting activity against human immunodeficiency virusInfo
- Publication number
- IL226397B IL226397B IL226397A IL22639713A IL226397B IL 226397 B IL226397 B IL 226397B IL 226397 A IL226397 A IL 226397A IL 22639713 A IL22639713 A IL 22639713A IL 226397 B IL226397 B IL 226397B
- Authority
- IL
- Israel
- Prior art keywords
- recruiting
- antibody
- inhibitory activity
- activity against
- immunodeficiency virus
- Prior art date
Links
- 241000725303 Human immunodeficiency virus Species 0.000 title 1
- 230000001588 bifunctional effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41497710P | 2010-11-18 | 2010-11-18 | |
US201161522518P | 2011-08-11 | 2011-08-11 | |
PCT/US2011/061174 WO2012068366A2 (fr) | 2010-11-18 | 2011-11-17 | Molécules bifonctionnelles dotées d'une activité de recrutement d'anticorps et d'inhibition de l'entrée du virus dirigées contre le virus de l'immunodéficience humaine |
Publications (2)
Publication Number | Publication Date |
---|---|
IL226397A0 IL226397A0 (en) | 2013-07-31 |
IL226397B true IL226397B (en) | 2018-02-28 |
Family
ID=46084646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL226397A IL226397B (en) | 2010-11-18 | 2013-05-16 | Bifunctional molecules with antibody-mobilizing and fusion-inhibiting activity against human immunodeficiency virus |
Country Status (16)
Country | Link |
---|---|
US (5) | US9562038B2 (fr) |
EP (1) | EP2640720B1 (fr) |
JP (2) | JP6155193B2 (fr) |
KR (1) | KR20140000275A (fr) |
CN (2) | CN107011333B (fr) |
AU (1) | AU2011329829B2 (fr) |
BR (1) | BR112013012309A2 (fr) |
CA (1) | CA2818308A1 (fr) |
CL (1) | CL2013001429A1 (fr) |
CO (1) | CO6801635A2 (fr) |
EA (1) | EA201390726A1 (fr) |
IL (1) | IL226397B (fr) |
MX (1) | MX350974B (fr) |
PE (1) | PE20140406A1 (fr) |
SG (2) | SG190829A1 (fr) |
WO (1) | WO2012068366A2 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20030329A1 (es) | 2001-08-08 | 2003-05-12 | Takeda Chemical Industries Ltd | Compuesto biciclico con actividad antagonista de ccr5 y produccion del mismo |
WO2011046946A2 (fr) * | 2009-10-13 | 2011-04-21 | Yale University | Molécules bifonctionnelles à activité de recrutement d'anticorps et d'inhibition d'entrée dirigées contre le virus de l'immunodéficience humaine |
JP6155193B2 (ja) | 2010-11-18 | 2017-06-28 | イェール ユニバーシティーYale University | ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 |
US20140308342A1 (en) | 2011-11-11 | 2014-10-16 | Yale University | Reprogramming urokinase into an antibody-recruiting anticancer agent |
EP4005600A1 (fr) | 2012-04-26 | 2022-06-01 | Yale University | Molécule de délivrance de médicament sous forme cytotoxique ciblant le vih (cdm-h), activité cytotoxique contre le virus de l'immunodéficience humaine et leurs méthodes d'utilisation |
WO2013166110A1 (fr) | 2012-05-02 | 2013-11-07 | Yale University | Molécules de recrutement d'anticorps conjugués à un agoniste de tlr) |
JP6473138B2 (ja) | 2013-05-03 | 2019-02-20 | イェール ユニバーシティーYale University | 癌、特に前立腺癌を標的とする合成抗体模倣化合物(SyAM) |
CA2971093A1 (fr) * | 2014-12-23 | 2016-06-30 | Tobira Therapeutics, Inc. | Procede de preparation de cenicriviroc et d'analogues apparentes |
WO2017023994A1 (fr) | 2015-08-06 | 2017-02-09 | Yale University | Composés de recrutement d'anticorps à base de petites molécules pour le traitement du cancer |
LT3390441T (lt) | 2015-12-15 | 2021-11-10 | Gilead Sciences, Inc. | Žmogaus imunodeficito virusą neutralizuojantys antikūnai |
US20190151464A1 (en) * | 2016-03-18 | 2019-05-23 | Rutgers, The State University Of New Jersey | Targeting tumor cells with chemotherapeutic agents conjugated to anti-matriptase antibodies by in vivo cleavable linking moieties |
US10407411B2 (en) | 2016-06-21 | 2019-09-10 | Tobira Therapeutics, Inc. | Purified cenicriviroc and purified intermediates for making cenicriviroc |
WO2018026997A1 (fr) | 2016-08-03 | 2018-02-08 | Yale University | Molécules de recrutement d'anticorps pour le traitement du cancer |
WO2018045043A1 (fr) | 2016-08-31 | 2018-03-08 | Tobira Therapeutics, Inc. | Formes solides de mésylate de cenicriviroc et procédés de fabrication de formes solides de mésylate de cenicriviroc |
CN107056762B (zh) * | 2016-12-22 | 2020-08-28 | 四川百利药业有限责任公司 | 一种用作抗流感病毒的双羰基类似物 |
JP7009517B2 (ja) | 2017-06-21 | 2022-01-25 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv gp120およびcd3を標的とする多重特異性抗体 |
WO2021151391A1 (fr) * | 2020-01-30 | 2021-08-05 | 沈阳福洋医药科技有限公司 | Application du composé isovalérylspiramycine et sa composition pour la préparation d'un médicament antiviral |
CN111995622B (zh) * | 2020-08-20 | 2022-04-15 | 复旦大学 | 化合物及其用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
ZA893284B (en) * | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
ATE210464T1 (de) * | 1992-06-09 | 2001-12-15 | Neorx Corp | BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN |
JP3319073B2 (ja) * | 1993-08-24 | 2002-08-26 | 和光純薬工業株式会社 | 免疫学的測定方法 |
US6140505A (en) * | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US6469006B1 (en) * | 1999-06-15 | 2002-10-22 | Bristol-Myers Squibb Company | Antiviral indoleoxoacetyl piperazine derivatives |
US6573262B2 (en) * | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
DE60113543T2 (de) * | 2000-07-10 | 2006-07-13 | Bristol-Myers Squibb Co. | Zusammensetzung und antivirale wirkung von substituierten indol-oxo-aceto-piperidin-derivaten |
US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
HUP0401523A3 (en) * | 2004-07-29 | 2007-05-02 | Richter Gedeon Vegyeszet | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
EP3564674B1 (fr) * | 2006-11-01 | 2021-08-25 | Ventana Medical Systems, Inc. | Haptènes, conjugués de haptènes, leurs compositions et leur procédé de préparation et d'utilisation |
PL2291659T3 (pl) * | 2008-05-13 | 2016-04-29 | Univ Yale | Małe cząsteczki chimerowe do rekrutacji przeciwciał do komórek nowotworowych |
WO2010008519A2 (fr) * | 2008-07-14 | 2010-01-21 | Andrew Metters | Marqueurs diagnostiques in vitro comprenant des nanoparticules de carbone et trousses |
EP2395992A2 (fr) * | 2009-02-10 | 2011-12-21 | The Scripps Research Institute | Vaccination programmée chimiquement |
WO2011046946A2 (fr) | 2009-10-13 | 2011-04-21 | Yale University | Molécules bifonctionnelles à activité de recrutement d'anticorps et d'inhibition d'entrée dirigées contre le virus de l'immunodéficience humaine |
US8450361B2 (en) * | 2010-08-06 | 2013-05-28 | Bristol-Myers Squibb Company | Substituted indole and azaindole oxoacetyl piperazinamide derivatives |
JP6155193B2 (ja) | 2010-11-18 | 2017-06-28 | イェール ユニバーシティーYale University | ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 |
-
2011
- 2011-11-17 JP JP2013540011A patent/JP6155193B2/ja active Active
- 2011-11-17 BR BR112013012309A patent/BR112013012309A2/pt not_active Application Discontinuation
- 2011-11-17 CN CN201611167953.2A patent/CN107011333B/zh active Active
- 2011-11-17 US US13/988,251 patent/US9562038B2/en active Active
- 2011-11-17 CA CA2818308A patent/CA2818308A1/fr not_active Abandoned
- 2011-11-17 KR KR1020137015098A patent/KR20140000275A/ko not_active Application Discontinuation
- 2011-11-17 PE PE2013001206A patent/PE20140406A1/es not_active Application Discontinuation
- 2011-11-17 CN CN201180065404.3A patent/CN103402998B/zh active Active
- 2011-11-17 SG SG2013038344A patent/SG190829A1/en unknown
- 2011-11-17 SG SG10201510402WA patent/SG10201510402WA/en unknown
- 2011-11-17 EA EA201390726A patent/EA201390726A1/ru unknown
- 2011-11-17 MX MX2013005462A patent/MX350974B/es active IP Right Grant
- 2011-11-17 WO PCT/US2011/061174 patent/WO2012068366A2/fr active Application Filing
- 2011-11-17 AU AU2011329829A patent/AU2011329829B2/en active Active
- 2011-11-17 EP EP11842404.3A patent/EP2640720B1/fr active Active
-
2013
- 2013-05-16 IL IL226397A patent/IL226397B/en active IP Right Grant
- 2013-05-17 CL CL2013001429A patent/CL2013001429A1/es unknown
- 2013-06-07 CO CO13138546A patent/CO6801635A2/es not_active Application Discontinuation
-
2016
- 2016-11-04 JP JP2016215788A patent/JP6567486B2/ja active Active
- 2016-12-15 US US15/379,969 patent/US10030008B2/en active Active
-
2018
- 2018-07-17 US US16/037,678 patent/US10703743B2/en active Active
-
2020
- 2020-06-05 US US16/894,362 patent/US11136316B2/en active Active
-
2021
- 2021-09-09 US US17/470,393 patent/US11858917B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL226397A0 (en) | Bi-functional molecules with antibody recruitment and inhibition activity | |
IL252398A0 (en) | cd37-binding molecules and their immunoconjugates | |
IT1402653B1 (it) | Composito fotocatalizzatore e prodotto funzionale fotocatalitico usante lo stesso. | |
EP2799540A4 (fr) | Arginase humaine et arginase humaine pégylée, et leur application | |
EP2712384A4 (fr) | Élément de coupe novateur et structure de coupe le mettant en uvre | |
ME02672B (fr) | Phényl-3-aza-bicyclo[3.1.0]hex-3-yl-méthanones et leur utilisation en tant que médicament | |
HK1187527A1 (en) | N-carboxyalkyl auristatins and the use thereof | |
ZA201209595B (en) | N-acetyl-dl-leucine, neuroprotective and retinoprotective medicament | |
EP2771008A4 (fr) | Macrocycles augmentant l'activité p53 et leurs utilisations | |
IL222835A0 (en) | Bifunictional molecules for inactivating hiv and blocking hiv entry | |
PL2855506T3 (pl) | Peptydy i ich zastosowanie | |
ZA201207416B (en) | Cdca5 peptides and vaccines including the same | |
EP2636737A4 (fr) | Facteur contrôlant la couleur de la peau et des cheveux | |
EP2515939A4 (fr) | Virus inactivé sous l'effet de la lumière, systèmes et procédés d'utilisation de ceux-ci | |
EP2646546A4 (fr) | Peptides tomm34 et vaccins les comprenant | |
EP2659891A4 (fr) | Médicament ayant une activité contre la famille des herpès-virus | |
IL221474A0 (en) | Hjurp peptides and vaccines including the same | |
GB201012941D0 (en) | Determining the extent of a structure on or in the skin of a subject | |
HK1213978A1 (zh) | 流感病毒和 型糖尿病 | |
EP2630238A4 (fr) | Peptides wdhd1 et vaccins les contenant | |
EP2630237A4 (fr) | Peptides c18orf54 et vaccins les contenant | |
TWM390691U (en) | Caster device and luggage having the caster device | |
PT2356993T (pt) | Medicamento para a redução da colesterolemia e da trigliceridemia | |
GB201015789D0 (en) | Peptides and their use in the treatment | |
ZA201205434B (en) | Coffins, sarcophagi, cinerary urns and the like |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |