IL202666A0 - Substituted piperazines - Google Patents

Substituted piperazines

Info

Publication number
IL202666A0
IL202666A0 IL202666A IL20266609A IL202666A0 IL 202666 A0 IL202666 A0 IL 202666A0 IL 202666 A IL202666 A IL 202666A IL 20266609 A IL20266609 A IL 20266609A IL 202666 A0 IL202666 A0 IL 202666A0
Authority
IL
Israel
Prior art keywords
substituted piperazines
piperazines
substituted
Prior art date
Application number
IL202666A
Other languages
English (en)
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of IL202666A0 publication Critical patent/IL202666A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL202666A 2007-06-13 2009-12-10 Substituted piperazines IL202666A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94373107P 2007-06-13 2007-06-13
PCT/US2008/066730 WO2008157240A1 (fr) 2007-06-13 2008-06-12 Pipérazines substituées

Publications (1)

Publication Number Publication Date
IL202666A0 true IL202666A0 (en) 2010-06-30

Family

ID=39609397

Family Applications (1)

Application Number Title Priority Date Filing Date
IL202666A IL202666A0 (en) 2007-06-13 2009-12-10 Substituted piperazines

Country Status (9)

Country Link
US (2) US20080312247A1 (fr)
EP (1) EP2155697B1 (fr)
JP (1) JP2010529994A (fr)
KR (1) KR20100047190A (fr)
CN (1) CN101835761A (fr)
AU (1) AU2008266124A1 (fr)
CA (1) CA2690379A1 (fr)
IL (1) IL202666A0 (fr)
WO (1) WO2008157240A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139877B1 (fr) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
MX2012003770A (es) 2009-09-30 2012-08-03 Harvard College Metodos para la modulacion de autofagia a traves de la modulacion de productos de genes que aumentan la autofagia.
CN101811941A (zh) * 2010-03-12 2010-08-25 重庆欣欣向荣精细化工有限公司 邻羟基苯基烷基醚的制备方法
CN102295622A (zh) 2010-06-25 2011-12-28 上海冠杰生物医药科技有限公司 一种雷诺嗪的制备方法
EP2524688B1 (fr) * 2011-05-11 2013-05-01 ratiopharm GmbH Composition de libération modifiée comportant de la ranolazine
JP2014516080A (ja) * 2011-06-08 2014-07-07 エスティーアイ ファーマ， エルエルシー 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤
CA2905751A1 (fr) 2013-03-13 2014-10-09 Forma Therapeutics, Inc. Nouveaux composes et compositions pour l'inhibition de fasn
EP2968327A4 (fr) * 2013-03-14 2016-09-28 Celgene Avilomics Res Inc Composés hétéroaryle et utilisations de ceux-ci
EP3049084A4 (fr) * 2013-09-25 2017-03-15 Cortendo AB (publ) Nouveaux analogues de 5-(phénoxyméthyl)-1,3-dioxane fonctionnalisés présentant une action inhibitrice du cytochrome p450
KR20160117596A (ko) 2014-02-07 2016-10-10 오스펙스 파마슈티칼스, 인코포레이티드 신규 제약 제제
WO2020092395A1 (fr) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. Formes solides de (4-(2-fluoro-4-(1-méthyl-1h-benzo[d]imidazol-5-yl)benzoyl)pipérazin-1-yl)(1-hydroxycyclopropyl)méthanone
CN116251072B (zh) * 2023-03-14 2023-09-15 郑州大学第一附属医院 一种吲哚布芬片及其制备方法、用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
EP1104760B1 (fr) * 1999-12-03 2003-03-12 Pfizer Products Inc. Composés de sulfamoylhétéroaryl-pyrazole comme analgésiques et agents anti-inflammatoires
US6396062B1 (en) * 1999-12-03 2002-05-28 Cymer, Inc. Portable laser beam monitor
EP1134290A3 (fr) * 2000-03-14 2004-01-02 Pfizer Products Inc. Modèles pharmacophores pour l'identification de l'efficacité inhibitoire à CYP2D6 des inhibiteurs sélectifs de récaptage de sérotonine
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
WO2006008753A1 (fr) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Forme cristalline et amorphe de ranolazine et son processus de fabrication
AR054583A1 (es) * 2005-07-26 2007-06-27 Altana Pharma Ag Pantoprazol isotopicamente sustituido
US20080033011A1 (en) * 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
EA014432B1 (ru) * 2005-07-29 2010-12-30 Консерт Фармасьютикалс Инк. Дейтерированные производные 1,3-бензодиоксола
WO2007041630A1 (fr) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Inhibiteurs deutériés d'atpase h+,k+ gastrique ayant des propriétés thérapeutiques renforcées
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
EP2139877B1 (fr) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux

Also Published As

Publication number Publication date
EP2155697B1 (fr) 2012-11-28
US20080312247A1 (en) 2008-12-18
WO2008157240A1 (fr) 2008-12-24
JP2010529994A (ja) 2010-09-02
CA2690379A1 (fr) 2008-12-24
CN101835761A (zh) 2010-09-15
KR20100047190A (ko) 2010-05-07
EP2155697A1 (fr) 2010-02-24
US20110160154A1 (en) 2011-06-30
AU2008266124A1 (en) 2008-12-24

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