IL202270A0 - Therapeutic pyrazoloquinoline derivatives - Google Patents
Therapeutic pyrazoloquinoline derivativesInfo
- Publication number
- IL202270A0 IL202270A0 IL202270A IL20227009A IL202270A0 IL 202270 A0 IL202270 A0 IL 202270A0 IL 202270 A IL202270 A IL 202270A IL 20227009 A IL20227009 A IL 20227009A IL 202270 A0 IL202270 A0 IL 202270A0
- Authority
- IL
- Israel
- Prior art keywords
- formula
- gabaa
- animal
- compound
- pyrazoloquinoline derivatives
- Prior art date
Links
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94300507P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/066201 WO2008154438A1 (en) | 2007-06-08 | 2008-06-06 | Therapeutic pyrazoloquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL202270A0 true IL202270A0 (en) | 2010-06-16 |
Family
ID=40096440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202270A IL202270A0 (en) | 2007-06-08 | 2009-11-22 | Therapeutic pyrazoloquinoline derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7872002B2 (https=) |
| EP (1) | EP2166852B1 (https=) |
| JP (1) | JP2010529143A (https=) |
| KR (1) | KR20100039331A (https=) |
| CN (1) | CN101742908A (https=) |
| AT (1) | ATE544344T1 (https=) |
| AU (1) | AU2008261884A1 (https=) |
| BR (1) | BRPI0812366A2 (https=) |
| CA (1) | CA2688395A1 (https=) |
| ES (1) | ES2386168T3 (https=) |
| IL (1) | IL202270A0 (https=) |
| MX (1) | MX2009013202A (https=) |
| WO (1) | WO2008154438A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2689934A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazolonaphthyridine derivatives |
| WO2008154442A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
| WO2008154438A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline derivatives |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| JP2018537450A (ja) | 2015-11-16 | 2018-12-20 | ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダＦｕｎｄａｃｉｏｎ Ｐａｒａ Ｌａ Ｉｎｖｅｓｔｉｇａｓｉｏｎ Ｍｅｄｉｃａ Ａｐｌｉｃａｄａ | Ｄｎａメチルトランスフェラーゼ阻害剤としての新規化合物 |
| CN105294648B (zh) * | 2015-11-30 | 2017-11-28 | 山东罗欣药业集团股份有限公司 | 一种西他沙星的制备方法 |
| WO2022037631A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204126A1 (de) * | 1982-02-06 | 1983-08-11 | Bayer Ag, 5090 Leverkusen | Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4814450A (en) | 1984-07-09 | 1989-03-21 | Ciba-Geigy Corporation | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives |
| JPS61112075A (ja) | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US5334595A (en) | 1992-10-23 | 1994-08-02 | Sterling Winthrop Inc. | Pyrazoloquinolones as anticancer agents |
| GB9716347D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
| GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| JP3896309B2 (ja) | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| US7674906B2 (en) | 2002-12-16 | 2010-03-09 | Active Biotech Ab | Tetracyclic immunomodulatory compounds |
| TW200508233A (en) | 2003-05-29 | 2005-03-01 | Millennium Pharm Inc | Chk-1 inhibitors |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| JP2009507081A (ja) | 2005-09-07 | 2009-02-19 | ブレインセルス，インコーポレイティド | ＨＤａｃ阻害による神経発生の調整 |
| JP2008047893A (ja) * | 2006-08-11 | 2008-02-28 | Samsung Electronics Co Ltd | 薄膜トランジスタ表示板及びその製造方法 |
| WO2008154438A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline derivatives |
-
2008
- 2008-06-06 WO PCT/US2008/066201 patent/WO2008154438A1/en not_active Ceased
- 2008-06-06 JP JP2010511387A patent/JP2010529143A/ja active Pending
- 2008-06-06 MX MX2009013202A patent/MX2009013202A/es active IP Right Grant
- 2008-06-06 KR KR1020107000330A patent/KR20100039331A/ko not_active Withdrawn
- 2008-06-06 CA CA002688395A patent/CA2688395A1/en not_active Abandoned
- 2008-06-06 CN CN200880024823A patent/CN101742908A/zh active Pending
- 2008-06-06 AT AT08770402T patent/ATE544344T1/de active
- 2008-06-06 US US12/135,036 patent/US7872002B2/en not_active Expired - Fee Related
- 2008-06-06 AU AU2008261884A patent/AU2008261884A1/en not_active Abandoned
- 2008-06-06 ES ES08770402T patent/ES2386168T3/es active Active
- 2008-06-06 BR BRPI0812366A patent/BRPI0812366A2/pt not_active IP Right Cessation
- 2008-06-06 EP EP08770402A patent/EP2166852B1/en not_active Not-in-force
-
2009
- 2009-11-22 IL IL202270A patent/IL202270A0/en unknown
-
2010
- 2010-11-18 US US12/949,655 patent/US8598159B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080306049A1 (en) | 2008-12-11 |
| ES2386168T3 (es) | 2012-08-10 |
| KR20100039331A (ko) | 2010-04-15 |
| BRPI0812366A2 (pt) | 2016-08-02 |
| CN101742908A (zh) | 2010-06-16 |
| ATE544344T1 (de) | 2012-02-15 |
| EP2166852A4 (en) | 2010-07-07 |
| US20110065693A1 (en) | 2011-03-17 |
| MX2009013202A (es) | 2010-04-09 |
| JP2010529143A (ja) | 2010-08-26 |
| US8598159B2 (en) | 2013-12-03 |
| HK1142775A1 (en) | 2010-12-17 |
| AU2008261884A1 (en) | 2008-12-18 |
| US7872002B2 (en) | 2011-01-18 |
| EP2166852B1 (en) | 2012-02-08 |
| CA2688395A1 (en) | 2008-12-18 |
| EP2166852A1 (en) | 2010-03-31 |
| WO2008154438A1 (en) | 2008-12-18 |
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