IL192852A - Compounds for the treatment of metabolic disorders - Google Patents
Compounds for the treatment of metabolic disordersInfo
- Publication number
- IL192852A IL192852A IL192852A IL19285208A IL192852A IL 192852 A IL192852 A IL 192852A IL 192852 A IL192852 A IL 192852A IL 19285208 A IL19285208 A IL 19285208A IL 192852 A IL192852 A IL 192852A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- reaction
- diabetes
- carbon atoms
- Prior art date
Links
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- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
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- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
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- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
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- 239000012279 sodium borohydride Substances 0.000 description 1
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- 238000013222 sprague-dawley male rat Methods 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
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- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
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- 238000002054 transplantation Methods 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/12—Ophthalmic agents for cataracts
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Diabetes (AREA)
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- Obesity (AREA)
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- Hematology (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76206806P | 2006-01-25 | 2006-01-25 | |
| PCT/US2007/060833 WO2007087506A2 (en) | 2006-01-25 | 2007-01-22 | Compounds for the treatment of metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL192852A0 IL192852A0 (en) | 2009-02-11 |
| IL192852A true IL192852A (en) | 2012-03-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| IL192852A IL192852A (en) | 2006-01-25 | 2008-07-16 | Compounds for the treatment of metabolic disorders |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7947735B2 (enExample) |
| EP (1) | EP1976378A4 (enExample) |
| JP (1) | JP2009528275A (enExample) |
| KR (1) | KR20080086523A (enExample) |
| CN (1) | CN101374415A (enExample) |
| AU (1) | AU2007208127A1 (enExample) |
| CA (1) | CA2636290A1 (enExample) |
| IL (1) | IL192852A (enExample) |
| NZ (1) | NZ569729A (enExample) |
| WO (1) | WO2007087506A2 (enExample) |
| ZA (1) | ZA200805645B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05008600A (es) * | 2003-02-13 | 2005-11-04 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
| SI1633340T1 (sl) * | 2003-04-15 | 2011-02-28 | Wellstat Therapeutics Corp | Spojine za zdravljenje metaboličnih motenj |
| US7442796B2 (en) * | 2003-04-30 | 2008-10-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| EP1978948A4 (en) * | 2006-02-02 | 2010-06-16 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER |
| NZ571118A (en) | 2006-03-31 | 2011-12-22 | Wellstat Therapeutics Corp | Combination treatment of metabolic disorders |
| EP2019673A4 (en) * | 2006-05-18 | 2010-06-16 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER |
| NZ573031A (en) * | 2006-06-09 | 2011-11-25 | Wellstat Therapeutics Corp | Compounds for the treatment of metabolic disorders |
| MX2009001763A (es) * | 2006-08-17 | 2009-02-25 | Wellstat Therapeutics Corp | Tratamiento combinado para trastornos metabolicos. |
| DE102007058842A1 (de) * | 2007-12-05 | 2009-06-10 | Grünenthal GmbH | Arzneimittel |
| WO2009091732A1 (en) * | 2008-01-15 | 2009-07-23 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| BRPI0909299B1 (pt) * | 2008-03-13 | 2021-11-23 | Wellstat Therapeutics Corporation | Compostos e métodos para redução de ácido úrico |
| US20130331452A1 (en) | 2010-09-08 | 2013-12-12 | Wellstat Therapeutics Corporation | Benzoic acid compounds for reducing uric acid |
Family Cites Families (11)
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| BE667498A (enExample) | 1964-07-28 | 1965-11-16 | ||
| US4080335A (en) * | 1975-07-28 | 1978-03-21 | Beecham Group Limited | Anorexic chromans |
| FR2653119B1 (fr) | 1989-10-18 | 1994-08-05 | Lipha | Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
| CZ20033394A3 (cs) * | 2001-06-12 | 2005-03-16 | Wellstat Therapeutics Corporation | Sloučeniny pro léčení metabolických poruch a způsob jejich přípravy |
| JP2006507303A (ja) * | 2002-11-01 | 2006-03-02 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の処置のための化合物 |
| MXPA05008600A (es) * | 2003-02-13 | 2005-11-04 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
| SI1633340T1 (sl) | 2003-04-15 | 2011-02-28 | Wellstat Therapeutics Corp | Spojine za zdravljenje metaboličnih motenj |
| EP1618086B1 (en) * | 2003-04-22 | 2009-12-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| US7442796B2 (en) * | 2003-04-30 | 2008-10-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| MXPA06001963A (es) * | 2003-08-20 | 2006-05-31 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de trastornos metabolicos. |
| CA2547430A1 (en) | 2003-11-26 | 2005-06-09 | Takeda Pharmaceutical Company Limited | Receptor function regulating agent |
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2007
- 2007-01-22 CN CNA2007800035511A patent/CN101374415A/zh active Pending
- 2007-01-22 CA CA002636290A patent/CA2636290A1/en not_active Abandoned
- 2007-01-22 US US12/160,858 patent/US7947735B2/en not_active Expired - Fee Related
- 2007-01-22 NZ NZ569729A patent/NZ569729A/en not_active IP Right Cessation
- 2007-01-22 JP JP2008552537A patent/JP2009528275A/ja not_active Withdrawn
- 2007-01-22 KR KR1020087018398A patent/KR20080086523A/ko not_active Ceased
- 2007-01-22 EP EP07717341A patent/EP1976378A4/en not_active Withdrawn
- 2007-01-22 AU AU2007208127A patent/AU2007208127A1/en not_active Abandoned
- 2007-01-22 WO PCT/US2007/060833 patent/WO2007087506A2/en not_active Ceased
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2008
- 2008-06-27 ZA ZA200805645A patent/ZA200805645B/xx unknown
- 2008-07-16 IL IL192852A patent/IL192852A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL192852A0 (en) | 2009-02-11 |
| JP2009528275A (ja) | 2009-08-06 |
| US20080306150A1 (en) | 2008-12-11 |
| AU2007208127A1 (en) | 2007-08-02 |
| CN101374415A (zh) | 2009-02-25 |
| CA2636290A1 (en) | 2007-08-02 |
| WO2007087506A2 (en) | 2007-08-02 |
| EP1976378A4 (en) | 2010-06-09 |
| EP1976378A2 (en) | 2008-10-08 |
| KR20080086523A (ko) | 2008-09-25 |
| NZ569729A (en) | 2011-07-29 |
| ZA200805645B (en) | 2009-09-30 |
| WO2007087506A3 (en) | 2007-11-22 |
| US7947735B2 (en) | 2011-05-24 |
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| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |