IL183153A0 - 8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - Google Patents
8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTSInfo
- Publication number
- IL183153A0 IL183153A0 IL183153A IL18315307A IL183153A0 IL 183153 A0 IL183153 A0 IL 183153A0 IL 183153 A IL183153 A IL 183153A IL 18315307 A IL18315307 A IL 18315307A IL 183153 A0 IL183153 A0 IL 183153A0
- Authority
- IL
- Israel
- Prior art keywords
- sub
- formula
- compounds
- provides
- isothiazolo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 229960005475 antiinfective agent Drugs 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108020000946 Bacterial DNA Proteins 0.000 abstract 1
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 241000206602 Eukaryota Species 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62696104P | 2004-11-11 | 2004-11-11 | |
| PCT/US2005/040725 WO2006118605A2 (en) | 2004-11-11 | 2005-11-10 | 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL183153A0 true IL183153A0 (en) | 2007-09-20 |
Family
ID=36980341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL183153A IL183153A0 (en) | 2004-11-11 | 2007-05-13 | 8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060100215A1 (enExample) |
| EP (1) | EP1809639B1 (enExample) |
| JP (1) | JP2008519842A (enExample) |
| KR (1) | KR20070085791A (enExample) |
| CN (1) | CN101120004A (enExample) |
| AT (1) | ATE445623T1 (enExample) |
| AU (1) | AU2005331275A1 (enExample) |
| CA (1) | CA2587485A1 (enExample) |
| DE (1) | DE602005017178D1 (enExample) |
| IL (1) | IL183153A0 (enExample) |
| MX (1) | MX2007005731A (enExample) |
| WO (1) | WO2006118605A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006017082D1 (de) | 2005-07-27 | 2010-11-04 | Achillion Pharmaceuticals Inc | 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dione und verwandte verbindungen als antiinfektive mittel |
| CA2695072A1 (en) | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) * | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| CA2001203C (en) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| FR2645862B1 (fr) * | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| US5071848A (en) * | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| EP0541086A1 (en) * | 1991-11-08 | 1993-05-12 | Kaken Pharmaceutical Co., Ltd. | Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7 |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| JP2004515548A (ja) * | 2000-12-14 | 2004-05-27 | ザ プロクター アンド ギャンブル カンパニー | 抗微生物キノロン |
| JP5147237B2 (ja) * | 2003-08-12 | 2013-02-20 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗感染剤としてのイソチアゾロキノロン類および関連化合物 |
-
2005
- 2005-11-10 MX MX2007005731A patent/MX2007005731A/es not_active Application Discontinuation
- 2005-11-10 AT AT05857829T patent/ATE445623T1/de not_active IP Right Cessation
- 2005-11-10 US US11/271,556 patent/US20060100215A1/en not_active Abandoned
- 2005-11-10 EP EP05857829A patent/EP1809639B1/en not_active Expired - Lifetime
- 2005-11-10 CN CNA2005800461026A patent/CN101120004A/zh active Pending
- 2005-11-10 AU AU2005331275A patent/AU2005331275A1/en not_active Abandoned
- 2005-11-10 WO PCT/US2005/040725 patent/WO2006118605A2/en not_active Ceased
- 2005-11-10 DE DE602005017178T patent/DE602005017178D1/de not_active Expired - Fee Related
- 2005-11-10 JP JP2007541310A patent/JP2008519842A/ja not_active Withdrawn
- 2005-11-10 KR KR1020077012701A patent/KR20070085791A/ko not_active Withdrawn
- 2005-11-10 CA CA002587485A patent/CA2587485A1/en not_active Abandoned
-
2007
- 2007-05-13 IL IL183153A patent/IL183153A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006118605A3 (en) | 2006-12-21 |
| KR20070085791A (ko) | 2007-08-27 |
| CN101120004A (zh) | 2008-02-06 |
| EP1809639A2 (en) | 2007-07-25 |
| DE602005017178D1 (de) | 2009-11-26 |
| WO2006118605A2 (en) | 2006-11-09 |
| MX2007005731A (es) | 2007-07-19 |
| ATE445623T1 (de) | 2009-10-15 |
| JP2008519842A (ja) | 2008-06-12 |
| AU2005331275A1 (en) | 2006-11-09 |
| CA2587485A1 (en) | 2006-11-09 |
| US20060100215A1 (en) | 2006-05-11 |
| EP1809639B1 (en) | 2009-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL189017A (en) | Derivatives of 8-methoxy-9 h-isothiazolo [4,5- b] quinoline-4,3-diones as bactericides | |
| IL185164A0 (en) | New isothiazoloquinolones and related compounds as anti-infective agents | |
| UA84879C2 (ru) | Изотиазолохинолоны и родственные соединения с противомикробным действием | |
| WO2004062601A3 (en) | Antibacterial agents | |
| MY140638A (en) | New heterocyclic compounds, which are active as inhibitors of beta-lactamases | |
| WO2007023507A3 (en) | Oxazolidinones bearing antimicrobial activity composition and methods of preparation | |
| WO2010115184A3 (en) | Hydroxythienoquinolones and related compounds as anti-infective agents | |
| WO2010047737A3 (en) | Antimicrobial indoline compounds for treatment of bacterial infections | |
| AP2003002942A0 (en) | New derivatives of oxazolidinones as bacterial agents | |
| DE602004008959D1 (de) | Benzoäbüä1,4üdioxepinderivate | |
| WO2008038092A3 (en) | Substituted piperidinophenyl oxazolidinones | |
| ATE339424T1 (de) | 3-substituierte 7-alkylidene-3-cephem-4- carbonsäuren als beta-lactamase inhibitoren | |
| WO2006120563A3 (en) | Antibacterial agents | |
| WO2002100327A3 (en) | Substituted 1-benzazepines and derivatives thereof | |
| IL183153A0 (en) | 8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | |
| MXPA05010783A (es) | Derivados antimicrobianos de [3.1.0] biciclohexilfenil-oxazolidinona y analogos. | |
| TW200637861A (en) | Novel diazabicyclononene derivative | |
| ATE417052T1 (de) | Oxazaborolidine als bakterielle effektoren | |
| WO2008036420A3 (en) | 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents | |
| WO2002018353A3 (en) | Oxazolidinone chemotherapeutic agents | |
| PT1175429E (pt) | Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a | |
| DK1340756T3 (da) | Hidtil ukendte beta-lactamforbindelser og fremgangsmåde til fremstilling deraf | |
| TW200634014A (en) | Novel diazabicyclononene derivative | |
| WO2006009907A3 (en) | Isoxazolidine compounds for treatment of bacterial infections | |
| WO2007079173A3 (en) | Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents |