CN101120004A - 用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物 - Google Patents

用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物 Download PDF

Info

Publication number
CN101120004A
CN101120004A CNA2005800461026A CN200580046102A CN101120004A CN 101120004 A CN101120004 A CN 101120004A CN A2005800461026 A CNA2005800461026 A CN A2005800461026A CN 200580046102 A CN200580046102 A CN 200580046102A CN 101120004 A CN101120004 A CN 101120004A
Authority
CN
China
Prior art keywords
alkyl
amino
group
salt
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800461026A
Other languages
English (en)
Chinese (zh)
Inventor
B·J·布拉德伯里
M·德士潘德
M·J·普斯
王秋萍
J·A·威尔斯
宋永胜
桥本明广
E·卢西恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achillion Pharmaceuticals Inc
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of CN101120004A publication Critical patent/CN101120004A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2005800461026A 2004-11-11 2005-11-10 用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物 Pending CN101120004A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62696104P 2004-11-11 2004-11-11
US60/626,961 2004-11-11

Publications (1)

Publication Number Publication Date
CN101120004A true CN101120004A (zh) 2008-02-06

Family

ID=36980341

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800461026A Pending CN101120004A (zh) 2004-11-11 2005-11-10 用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物

Country Status (12)

Country Link
US (1) US20060100215A1 (enExample)
EP (1) EP1809639B1 (enExample)
JP (1) JP2008519842A (enExample)
KR (1) KR20070085791A (enExample)
CN (1) CN101120004A (enExample)
AT (1) ATE445623T1 (enExample)
AU (1) AU2005331275A1 (enExample)
CA (1) CA2587485A1 (enExample)
DE (1) DE602005017178D1 (enExample)
IL (1) IL183153A0 (enExample)
MX (1) MX2007005731A (enExample)
WO (1) WO2006118605A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101272263B1 (ko) * 2005-07-27 2013-06-13 아칠리온 파르마세우티칼스 인코포레이티드 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물
CA2695072A1 (en) 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
FR2645862B1 (fr) * 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
US5071848A (en) * 1989-10-23 1991-12-10 Abbott Laboratories Tricyclic quinoline antineoplastic agents
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
EP0541086A1 (en) * 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
HUP0303410A3 (en) * 2000-12-14 2005-12-28 Procter & Gamble Antimicrobial quinolones, pharmaceutical compositions containing them and their use
WO2005019228A1 (en) * 2003-08-12 2005-03-03 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents

Also Published As

Publication number Publication date
KR20070085791A (ko) 2007-08-27
IL183153A0 (en) 2007-09-20
ATE445623T1 (de) 2009-10-15
JP2008519842A (ja) 2008-06-12
MX2007005731A (es) 2007-07-19
EP1809639B1 (en) 2009-10-14
WO2006118605A3 (en) 2006-12-21
WO2006118605A2 (en) 2006-11-09
US20060100215A1 (en) 2006-05-11
AU2005331275A1 (en) 2006-11-09
EP1809639A2 (en) 2007-07-25
CA2587485A1 (en) 2006-11-09
DE602005017178D1 (de) 2009-11-26

Similar Documents

Publication Publication Date Title
US8946422B2 (en) 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
US20110223132A1 (en) Isothiazoloquinolones and related compounds as anti-infective agents
US20120114601A1 (en) New isothiazoloquinolones and related compounds as anti-infective agents
US7199128B2 (en) 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
CN101120004A (zh) 用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物
WO2024153250A1 (zh) 作为usp1抑制剂的化合物
US7659399B2 (en) 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
JP2008519842A5 (enExample)
MX2008001344A (es) 8-metoxi-9h-isotiazolo[5,4-b]quinolin-3,4-dionas y compuestos relacionados como agentes anti-infecciosos
HK1122024B (en) 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20080206