IL174195A - Isolated nucleic acid sequence encoding a polypeptide having ghrelin splice variant activity, an expression vector comprising the same, a host cell transfected with the expression vector and methods associated therewith - Google Patents

Isolated nucleic acid sequence encoding a polypeptide having ghrelin splice variant activity, an expression vector comprising the same, a host cell transfected with the expression vector and methods associated therewith

Info

Publication number
IL174195A
IL174195A IL174195A IL17419506A IL174195A IL 174195 A IL174195 A IL 174195A IL 174195 A IL174195 A IL 174195A IL 17419506 A IL17419506 A IL 17419506A IL 174195 A IL174195 A IL 174195A
Authority
IL
Israel
Prior art keywords
seq
nucleic acid
sequence
obesity
variant
Prior art date
Application number
IL174195A
Other languages
English (en)
Other versions
IL174195A0 (en
Original Assignee
Liat Mintz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liat Mintz filed Critical Liat Mintz
Publication of IL174195A0 publication Critical patent/IL174195A0/en
Publication of IL174195A publication Critical patent/IL174195A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL174195A 2003-09-11 2006-03-09 Isolated nucleic acid sequence encoding a polypeptide having ghrelin splice variant activity, an expression vector comprising the same, a host cell transfected with the expression vector and methods associated therewith IL174195A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/659,782 US7176292B2 (en) 2003-09-11 2003-09-11 Ghrelin variant protein
PCT/US2004/029230 WO2005026392A2 (en) 2003-09-11 2004-09-09 Compositions, reagents and kits for and methods of diagnosing, monitoring and treating obesity and/or diabetes

Publications (2)

Publication Number Publication Date
IL174195A0 IL174195A0 (en) 2006-08-01
IL174195A true IL174195A (en) 2012-08-30

Family

ID=34273528

Family Applications (2)

Application Number Title Priority Date Filing Date
IL174195A IL174195A (en) 2003-09-11 2006-03-09 Isolated nucleic acid sequence encoding a polypeptide having ghrelin splice variant activity, an expression vector comprising the same, a host cell transfected with the expression vector and methods associated therewith
IL200120A IL200120A0 (en) 2003-09-11 2009-07-28 Compositions, reagents and kits for and methods of diagnosing, monitoring and treating obesity and/or diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL200120A IL200120A0 (en) 2003-09-11 2009-07-28 Compositions, reagents and kits for and methods of diagnosing, monitoring and treating obesity and/or diabetes

Country Status (15)

Country Link
US (2) US7176292B2 (ja)
EP (1) EP1664346B1 (ja)
JP (2) JP2007504825A (ja)
KR (1) KR101081040B1 (ja)
CN (1) CN101023184A (ja)
AT (1) ATE480641T1 (ja)
AU (2) AU2004273053B2 (ja)
BR (1) BRPI0414365A (ja)
CA (1) CA2538514C (ja)
DE (1) DE602004029061D1 (ja)
HK (1) HK1092841A1 (ja)
IL (2) IL174195A (ja)
NZ (1) NZ546488A (ja)
RU (1) RU2420583C2 (ja)
WO (1) WO2005026392A2 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512971B2 (en) * 2002-12-10 2013-08-20 Echelon Biosciences, Inc. Compounds and methods of use thereof for assaying lysophospholipase D activity
US20050208658A1 (en) * 2003-11-21 2005-09-22 The University Of Maryland RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
WO2005113747A2 (de) 2004-05-21 2005-12-01 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Multizelluläre gewebe- und organkultursysteme
WO2005119525A1 (en) * 2004-06-04 2005-12-15 Pfizer Products Inc. 11βHSD1 CRYSTAL STRUCTURES FOR STRUCTURE BASED DRUG DESIGN
CN101321779A (zh) * 2005-11-03 2008-12-10 利亚特·明茨 诊断、监测和治疗激素失调的组合物、试剂、试剂盒及方法
EP1999146B1 (en) * 2006-03-13 2012-05-30 Liat Mintz Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite stimulation
US7763707B2 (en) * 2006-03-13 2010-07-27 Liat Mintz Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation
EP2021365B1 (en) * 2006-03-28 2012-05-30 Liat Mintz A ghrelin splice variant for use in the prevention or treatment of high cholesterol levels
WO2009048903A1 (en) * 2007-10-08 2009-04-16 Bristol-Myers Squibb Company 11 beta hydroxysteroid dehydrogenase type 1
AU2009224114B2 (en) * 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
ES2372337B1 (es) * 2010-06-10 2013-01-18 Servicio Andaluz De Salud Variante de la ghrelina y sus usos.
EP2809339A2 (en) * 2012-02-03 2014-12-10 Zealand Pharma A/S Ghrelin analogues
CN102721819B (zh) * 2012-06-28 2014-08-13 广州瑞博奥生物科技有限公司 一种脂联素的竞争抑制性酶联免疫检测试剂盒及方法
US20190316204A1 (en) * 2015-07-24 2019-10-17 Korea University Research And Business Foundation Biomarker for determining aging, determining obesity, and diagnosing cancer and diagnosing kit using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291653B1 (en) * 1997-03-24 2001-09-18 Zymogenetics, Inc. Antibodies to motilin homologs
US20040023874A1 (en) * 2002-03-15 2004-02-05 Burgess Catherine E. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CA2411667A1 (en) * 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
AU2002328630B2 (en) * 2001-08-17 2005-09-01 Fujirebio Inc. Method of diagnosing or monitoring saccharometabolic error
EP1997829A1 (en) * 2001-12-21 2008-12-03 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002358467A1 (en) * 2001-12-21 2003-07-15 Maxygen Aps Adiponectin fragments and conjugates
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN1886423A (zh) * 2002-01-18 2006-12-27 普罗特米克斯公司 脂联素的糖基同工型及其用途
JPWO2003063894A1 (ja) * 2002-01-31 2005-05-26 独立行政法人科学技術振興機構 インスリン抵抗性改善剤
EP1999146B1 (en) * 2006-03-13 2012-05-30 Liat Mintz Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite stimulation

Also Published As

Publication number Publication date
HK1092841A1 (en) 2007-02-16
RU2420583C2 (ru) 2011-06-10
WO2005026392A3 (en) 2005-08-11
ATE480641T1 (de) 2010-09-15
AU2004273053A1 (en) 2005-03-24
CN101023184A (zh) 2007-08-22
IL174195A0 (en) 2006-08-01
US20070086997A1 (en) 2007-04-19
JP2011182776A (ja) 2011-09-22
US7176292B2 (en) 2007-02-13
EP1664346A2 (en) 2006-06-07
BRPI0414365A (pt) 2006-11-14
AU2004273053B2 (en) 2010-05-20
US20050059015A1 (en) 2005-03-17
JP2007504825A (ja) 2007-03-08
IL200120A0 (en) 2011-08-01
JP5314658B2 (ja) 2013-10-16
CA2538514C (en) 2014-04-08
KR101081040B1 (ko) 2011-11-09
US8088730B2 (en) 2012-01-03
NZ546488A (en) 2009-01-31
RU2006111720A (ru) 2007-10-20
AU2010212460A1 (en) 2010-09-09
EP1664346B1 (en) 2010-09-08
DE602004029061D1 (de) 2010-10-21
KR20060083208A (ko) 2006-07-20
WO2005026392A2 (en) 2005-03-24
CA2538514A1 (en) 2005-03-24

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