IL166535A0 - Modified adamts4 molecules and method of use thereof - Google Patents

Modified adamts4 molecules and method of use thereof

Info

Publication number
IL166535A0
IL166535A0 IL16653505A IL16653505A IL166535A0 IL 166535 A0 IL166535 A0 IL 166535A0 IL 16653505 A IL16653505 A IL 16653505A IL 16653505 A IL16653505 A IL 16653505A IL 166535 A0 IL166535 A0 IL 166535A0
Authority
IL
Israel
Prior art keywords
molecules
modified adamts4
adamts4
modified
adamts4 molecules
Prior art date
Application number
IL16653505A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of IL166535A0 publication Critical patent/IL166535A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL16653505A 2002-07-29 2005-01-27 Modified adamts4 molecules and method of use thereof IL166535A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872102P 2002-07-29 2002-07-29
PCT/US2003/023484 WO2004011637A2 (fr) 2002-07-29 2003-07-29 Molecules adamts4 modifiees et procede d'utilisation de ces molecules

Publications (1)

Publication Number Publication Date
IL166535A0 true IL166535A0 (en) 2006-01-15

Family

ID=31188463

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16653505A IL166535A0 (en) 2002-07-29 2005-01-27 Modified adamts4 molecules and method of use thereof

Country Status (10)

Country Link
US (2) US7118902B2 (fr)
EP (1) EP1525307A2 (fr)
JP (1) JP2005534308A (fr)
CN (1) CN1681920A (fr)
AU (1) AU2003261269A1 (fr)
BR (1) BR0313083A (fr)
CA (1) CA2492444A1 (fr)
IL (1) IL166535A0 (fr)
MX (1) MXPA05000959A (fr)
WO (1) WO2004011637A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9677829B2 (en) 2001-06-01 2017-06-13 Mitsubishi Paper Mills Limited Total heat exchanging element paper
KR20040088059A (ko) 2002-02-05 2004-10-15 와이어쓰 절두된 아그레카나제 분자
CA2492444A1 (fr) * 2002-07-29 2004-02-05 Wyeth Molecules adamts4 modifiees et procede d'utilisation de ces molecules
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
MXPA06011970A (es) * 2004-04-16 2006-12-15 Wyeth Corp Moleculas de una desintegrina y metaloproteinasa truncadas.
US7625731B2 (en) 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
AU2006282798A1 (en) * 2005-08-25 2007-03-01 Wyeth Aggrecanase structure
GB0601976D0 (en) * 2006-02-01 2006-03-15 Merck Sharp & Dohme Proteins
EP2027284A2 (fr) * 2006-05-18 2009-02-25 Sanofi-Aventis Utilisation du gène adamts4 et de polymorphismes de protéines
ATE550648T1 (de) * 2007-06-22 2012-04-15 Genera Istrazivanja D O O Adamts4 als blut-biomarker und therapeutisches ziel bei chronischem nierenversagen
EP2174661B1 (fr) 2007-06-29 2012-12-19 National University Corporation Nagoya University Agent pour le traitement de la douleur d'origine neuropathique
EP2420250A1 (fr) 2010-08-13 2012-02-22 Universitätsklinikum Münster Anticorps anti-syndecan-4
AU2014335251B2 (en) 2013-10-15 2020-04-30 Genefrontier Corporation Human antibody against aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451575A (en) * 1967-09-15 1969-06-24 Geza Petro Jr Conveyor bucket with hydraulically-operated grille-like lid
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
WO1986000639A1 (fr) 1984-07-06 1986-01-30 Sandoz Ag Production et purification de lymphokine
EP0177343B1 (fr) 1984-10-05 1992-07-22 Genentech, Inc. ADN, cultures de cellules et méthodes pour sécréter des protéines hétérologiques et récupérer des protéines périplasmiques
US6069229A (en) * 1997-03-07 2000-05-30 Schering Corporation Mammalian proteinases; oxidoreductases; related reagents
EP0998572A2 (fr) * 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Metalloproteases decomposant l'aggrecan
US6842704B2 (en) * 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
AU3622600A (en) 1999-03-08 2000-09-28 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
EP1136547A3 (fr) 2000-03-22 2002-09-25 Pfizer Products Inc. Polypeptides Adamts, acides nucléiques codant pour ces polypeptides et leurs utilisations
US6458552B1 (en) * 2000-06-06 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Metalloprotease peptide substrates and methods
US20020151702A1 (en) * 2000-10-18 2002-10-17 Genetics Institute, Inc. Aggrecanase molecules
SE0102298D0 (sv) * 2001-06-27 2001-06-27 Astrazeneca Ab Crystal structure of enzyme and uses thereof
WO2003004607A2 (fr) * 2001-07-05 2003-01-16 Wyeth Molecules d'aggrecanase
WO2003016492A2 (fr) 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Genes, proteines et variants adamts13, et utilisations de ceux-ci
US20030105313A1 (en) * 2001-10-16 2003-06-05 American Home Products Corporation Aggrecanase molecules
WO2003064622A2 (fr) * 2002-01-31 2003-08-07 Wyeth Molecules d'aggrecanase
KR20040088059A (ko) * 2002-02-05 2004-10-15 와이어쓰 절두된 아그레카나제 분자
CA2492444A1 (fr) * 2002-07-29 2004-02-05 Wyeth Molecules adamts4 modifiees et procede d'utilisation de ces molecules

Also Published As

Publication number Publication date
EP1525307A2 (fr) 2005-04-27
CN1681920A (zh) 2005-10-12
BR0313083A (pt) 2007-07-17
AU2003261269A1 (en) 2004-02-16
WO2004011637A3 (fr) 2004-04-08
CA2492444A1 (fr) 2004-02-05
US7118902B2 (en) 2006-10-10
US20060228354A1 (en) 2006-10-12
MXPA05000959A (es) 2005-05-16
JP2005534308A (ja) 2005-11-17
WO2004011637A2 (fr) 2004-02-05
US20040142863A1 (en) 2004-07-22

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