IL166362A0 - Gene therapy for critical limb ischemia with wild type or mutant enos - Google Patents

Gene therapy for critical limb ischemia with wild type or mutant enos

Info

Publication number
IL166362A0
IL166362A0 IL16636205A IL16636205A IL166362A0 IL 166362 A0 IL166362 A0 IL 166362A0 IL 16636205 A IL16636205 A IL 16636205A IL 16636205 A IL16636205 A IL 16636205A IL 166362 A0 IL166362 A0 IL 166362A0
Authority
IL
Israel
Prior art keywords
wild type
gene therapy
limb ischemia
critical limb
mutant enos
Prior art date
Application number
IL16636205A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL166362A0 publication Critical patent/IL166362A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL16636205A 2002-08-16 2005-01-18 Gene therapy for critical limb ischemia with wild type or mutant enos IL166362A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40363702P 2002-08-16 2002-08-16
PCT/US2003/025626 WO2004016761A2 (en) 2002-08-16 2003-08-15 Gene therapy for critical limb ischemia with wild type or mutant enos

Publications (1)

Publication Number Publication Date
IL166362A0 true IL166362A0 (en) 2006-01-16

Family

ID=31888259

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16636205A IL166362A0 (en) 2002-08-16 2005-01-18 Gene therapy for critical limb ischemia with wild type or mutant enos

Country Status (15)

Country Link
US (1) US20040120930A1 (ko)
EP (1) EP1536689A4 (ko)
JP (1) JP2005539031A (ko)
KR (1) KR20050042162A (ko)
CN (2) CN100408101C (ko)
AU (1) AU2003263844A1 (ko)
BR (1) BR0313515A (ko)
CA (1) CA2494845A1 (ko)
IL (1) IL166362A0 (ko)
MX (1) MXPA05001763A (ko)
NO (1) NO20051351L (ko)
PL (1) PL375446A1 (ko)
RU (1) RU2005107414A (ko)
WO (1) WO2004016761A2 (ko)
ZA (1) ZA200502181B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014123749A1 (en) * 2013-01-30 2014-08-14 Board Of Regents Of The University Of Nebraska Compositions and methods for treating complications associated with diabetes
US20190284263A1 (en) * 2016-04-29 2019-09-19 Inovio Pharmaceuticals, Inc. In vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
CN105944243A (zh) * 2016-05-12 2016-09-21 段俊丽 一种eNOS表达与活化的调控装置及周围动脉疾病的治疗装置
CN107802826B (zh) * 2017-10-26 2020-02-18 首都医科大学宣武医院 eNOS突变体在促进血管生成中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU766238B2 (en) * 1998-03-09 2003-10-09 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Compositions and methods for modulating vascularization
EP1016726A1 (en) * 1998-12-30 2000-07-05 Introgene B.V. Gene therapy to promote angiogenesis
IL145760A0 (en) * 1999-04-16 2002-07-25 Univ Yale eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING

Also Published As

Publication number Publication date
EP1536689A4 (en) 2006-09-06
WO2004016761A2 (en) 2004-02-26
CN1688197A (zh) 2005-10-26
WO2004016761A3 (en) 2005-03-17
PL375446A1 (en) 2005-11-28
JP2005539031A (ja) 2005-12-22
AU2003263844A1 (en) 2004-03-03
CN101391105A (zh) 2009-03-25
ZA200502181B (en) 2006-09-27
BR0313515A (pt) 2005-10-18
NO20051351L (no) 2005-04-28
KR20050042162A (ko) 2005-05-04
US20040120930A1 (en) 2004-06-24
EP1536689A2 (en) 2005-06-08
RU2005107414A (ru) 2006-01-27
CA2494845A1 (en) 2004-02-26
MXPA05001763A (es) 2005-08-19
CN100408101C (zh) 2008-08-06

Similar Documents

Publication Publication Date Title
IL166511A0 (en) Enos mutants useful for gene therapy
AU2003215065A8 (en) Method for treating diseases associated with abnormal kinase activity
EP1572075A3 (en) Method for treating diseases associated with abnormal kinase activity
PL378879A1 (pl) Terapia skojarzona z czynnikami kostymulującymi
IL164352A0 (en) Methods for treating tweak-related conditions
EP1578782A3 (en) Combination therapy with co-stimulatory factors
AU2003281299A8 (en) Methods for specifically inhibiting histone deacetylase-7 and 8
EP1490074A4 (en) MIXED CELL GENE THERAPY
IL166362A0 (en) Gene therapy for critical limb ischemia with wild type or mutant enos
AU2003272204A8 (en) Neuronal and retinal gene expression patterns
AU2003256526A1 (en) Arrangements and methods for treating a subject
AU2003249054A8 (en) Neuronal gene expression patterns
GB2389535B (en) Incubator
AU2003215375A1 (en) Analog scrambler
AU2003214701A1 (en) Mattress with adjustable hardness
EP1616182A4 (en) REPLACEMENT ENZYMOTHERAPY WITH 17-BETA-HYDROXYSTEROID DESHYDROGENASE TYPE 2
AU2003302893A1 (en) METHODS FOR SUSTAINING eNOS ACTIVITY
AU2003227841A1 (en) Detachable computer with detachable elements
AU2003217037A8 (en) Stem cell therapy
AU2003294705A8 (en) Ntsm gene
GB0201624D0 (en) Furnace
GB0221777D0 (en) T s valve arrangement
GB0212655D0 (en) Antistatic treatment
PL356071A1 (en) Mutbar 1 gene
GB0230027D0 (en) Therapy