IL166010A0 - Piperidine derivatives and their use as selective inhibitors of MIP-1alpha binding to its receptor CCR1 - Google Patents
Piperidine derivatives and their use as selective inhibitors of MIP-1alpha binding to its receptor CCR1Info
- Publication number
- IL166010A0 IL166010A0 IL16601004A IL16601004A IL166010A0 IL 166010 A0 IL166010 A0 IL 166010A0 IL 16601004 A IL16601004 A IL 16601004A IL 16601004 A IL16601004 A IL 16601004A IL 166010 A0 IL166010 A0 IL 166010A0
- Authority
- IL
- Israel
- Prior art keywords
- mip
- selective inhibitors
- piperidine derivatives
- receptor ccr1
- 1alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39710802P | 2002-07-18 | 2002-07-18 | |
PCT/IB2003/002876 WO2004009550A1 (en) | 2002-07-18 | 2003-07-07 | Piperidine derivatives and their use as selective inhibitors of mip-1alpha binding to its receptor ccr1 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL166010A0 true IL166010A0 (en) | 2006-01-15 |
Family
ID=30770997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16601004A IL166010A0 (en) | 2002-07-18 | 2004-12-27 | Piperidine derivatives and their use as selective inhibitors of MIP-1alpha binding to its receptor CCR1 |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040063759A1 (de) |
EP (1) | EP1534677A1 (de) |
JP (1) | JP2005537279A (de) |
KR (1) | KR20050021497A (de) |
CN (1) | CN1668592A (de) |
AP (1) | AP2005003200A0 (de) |
AR (1) | AR040583A1 (de) |
AU (1) | AU2003242941A1 (de) |
BR (1) | BR0312946A (de) |
CA (1) | CA2492651A1 (de) |
EC (1) | ECSP055547A (de) |
HN (1) | HN2003000222A (de) |
IL (1) | IL166010A0 (de) |
IS (1) | IS7614A (de) |
MA (1) | MA27326A1 (de) |
MX (1) | MXPA05000380A (de) |
OA (1) | OA12885A (de) |
PA (1) | PA8575901A1 (de) |
PE (1) | PE20040666A1 (de) |
TN (1) | TNSN05014A1 (de) |
TW (1) | TW200402416A (de) |
UY (1) | UY27897A1 (de) |
WO (1) | WO2004009550A1 (de) |
ZA (1) | ZA200500067B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399790B2 (en) | 2001-02-28 | 2008-07-15 | Konowalchuk Thomas W | Virucidal compositions |
CN1867336B (zh) | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-芳基-4-取代的哌嗪衍生物及其制药用途 |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
BR0312699A (pt) * | 2002-07-18 | 2005-04-26 | Pfizer Prod Inc | Derivados de piperidina bicìclica como antagonistas de receptor de quimiocina ccr1 |
US8261062B2 (en) | 2003-03-27 | 2012-09-04 | Microsoft Corporation | Non-cryptographic addressing |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
CN1950082B (zh) | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | 双环和桥连的含氮杂环化物 |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7929689B2 (en) | 2004-06-30 | 2011-04-19 | Microsoft Corporation | Call signs |
US20060167044A1 (en) * | 2004-12-20 | 2006-07-27 | Arnaiz Damian O | Piperidine derivatives and their use as anti-inflammatory agents |
US7620902B2 (en) | 2005-04-20 | 2009-11-17 | Microsoft Corporation | Collaboration spaces |
US7617281B2 (en) | 2005-04-25 | 2009-11-10 | Microsoft Corporation | System and method for collaboration with serverless presence |
US7660851B2 (en) | 2005-07-06 | 2010-02-09 | Microsoft Corporation | Meetings near me |
SI1907374T1 (sl) | 2005-07-26 | 2012-11-30 | Glaxo Group Ltd | Derivati benzilpiperazina uporabni za zdravljenje gastrointestinalnih motenj |
US7576218B2 (en) | 2005-10-11 | 2009-08-18 | Chemocentryx, Inc. | 4-phenylpiperdine-pyrazole CCR1 antagonists |
US8069208B2 (en) | 2006-04-21 | 2011-11-29 | Microsoft Corporation | Peer-to-peer buddy request and response |
US8086842B2 (en) | 2006-04-21 | 2011-12-27 | Microsoft Corporation | Peer-to-peer contact exchange |
EP2202223B1 (de) * | 2007-10-18 | 2017-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclische verbindung als blut-rbp4 senkende agent |
WO2010077915A1 (en) * | 2008-12-17 | 2010-07-08 | Forest Laboratories Holdings Limited | Novel compounds useful as cc chemokine receptor ligands |
WO2015091645A1 (en) | 2013-12-18 | 2015-06-25 | Basf Se | Azole compounds carrying an imine-derived substituent |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE640616A (de) * | 1962-12-19 | |||
US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
WO1997024325A1 (en) * | 1995-12-28 | 1997-07-10 | Takeda Chemical Industries, Ltd. | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS |
NZ515374A (en) * | 1999-05-18 | 2004-09-24 | Teijin Ltd | Remedies or prophylactics for diseases in association with chemokines |
AR028947A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
MXPA04000737A (es) * | 2001-07-24 | 2004-07-08 | Richter Gedeon Vegyeszet | Derivados de piperidina como antagonistas receptores de nmda. |
-
2003
- 2003-06-17 PA PA20038575901A patent/PA8575901A1/es unknown
- 2003-07-07 AU AU2003242941A patent/AU2003242941A1/en not_active Abandoned
- 2003-07-07 EP EP03765230A patent/EP1534677A1/de not_active Withdrawn
- 2003-07-07 BR BR0312946-2A patent/BR0312946A/pt not_active Application Discontinuation
- 2003-07-07 CN CNA038170922A patent/CN1668592A/zh active Pending
- 2003-07-07 MX MXPA05000380A patent/MXPA05000380A/es unknown
- 2003-07-07 AP AP2005003200A patent/AP2005003200A0/xx unknown
- 2003-07-07 KR KR10-2005-7000849A patent/KR20050021497A/ko not_active Application Discontinuation
- 2003-07-07 CA CA002492651A patent/CA2492651A1/en not_active Abandoned
- 2003-07-07 JP JP2004522601A patent/JP2005537279A/ja active Pending
- 2003-07-07 OA OA1200500010A patent/OA12885A/en unknown
- 2003-07-07 WO PCT/IB2003/002876 patent/WO2004009550A1/en not_active Application Discontinuation
- 2003-07-08 US US10/616,844 patent/US20040063759A1/en not_active Abandoned
- 2003-07-15 PE PE2003000705A patent/PE20040666A1/es not_active Application Discontinuation
- 2003-07-16 AR AR20030102555A patent/AR040583A1/es unknown
- 2003-07-16 UY UY27897A patent/UY27897A1/es not_active Application Discontinuation
- 2003-07-17 HN HN2003000222A patent/HN2003000222A/es unknown
- 2003-07-17 TW TW092119550A patent/TW200402416A/zh unknown
-
2004
- 2004-12-23 IS IS7614A patent/IS7614A/is unknown
- 2004-12-27 IL IL16601004A patent/IL166010A0/xx unknown
-
2005
- 2005-01-04 ZA ZA200500067A patent/ZA200500067B/en unknown
- 2005-01-18 EC EC2005005547A patent/ECSP055547A/es unknown
- 2005-01-18 TN TNP2005000014A patent/TNSN05014A1/fr unknown
- 2005-01-18 MA MA28049A patent/MA27326A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
TW200402416A (en) | 2004-02-16 |
WO2004009550A1 (en) | 2004-01-29 |
PA8575901A1 (es) | 2004-07-20 |
US20040063759A1 (en) | 2004-04-01 |
TNSN05014A1 (fr) | 2007-05-14 |
JP2005537279A (ja) | 2005-12-08 |
MA27326A1 (fr) | 2005-05-02 |
UY27897A1 (es) | 2004-02-27 |
ZA200500067B (en) | 2005-11-02 |
BR0312946A (pt) | 2005-07-12 |
HN2003000222A (es) | 2004-11-23 |
IS7614A (is) | 2004-12-23 |
ECSP055547A (es) | 2005-03-10 |
PE20040666A1 (es) | 2004-09-25 |
CN1668592A (zh) | 2005-09-14 |
AP2005003200A0 (en) | 2005-03-31 |
AR040583A1 (es) | 2005-04-13 |
AU2003242941A1 (en) | 2004-02-09 |
KR20050021497A (ko) | 2005-03-07 |
OA12885A (en) | 2006-09-15 |
MXPA05000380A (es) | 2005-03-31 |
CA2492651A1 (en) | 2004-01-29 |
EP1534677A1 (de) | 2005-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL166010A0 (en) | Piperidine derivatives and their use as selective inhibitors of MIP-1alpha binding to its receptor CCR1 | |
ZA200500680B (en) | Quinoline derivatives and their use as mycrobacterial inhibitors | |
HK1094203A1 (en) | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | |
AU2003298514A8 (en) | Methods and compositions using cholinesterase inhibitors | |
IL173398A0 (en) | Pyridyl derivatives and their use as therapeutic agents | |
IL174334A0 (en) | Use of chk1 inhibitors to control cell proliferation | |
EP1601357A4 (de) | Heterocyclische kinase-hemmer: verfahren zur verwendung und synthese | |
IL182527A0 (en) | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity | |
EP1656378A4 (de) | Verbindungen und zusammensetzungen als inhibitoren von rezeptor-tyrosinkinase-aktivität | |
PL375877A1 (en) | Hydantoine derivatives and their use as tace inhibitors | |
IL175179A0 (en) | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | |
EP1603567A4 (de) | Tetracyclische benzamid-derivate und anwendungsverfahren dafür | |
AU2003302919A1 (en) | Pyridine derivatives as jnk inhibitors and their use | |
IL174497A0 (en) | Pyridine derivatives and use thereof as urotensin ii antagonists | |
IL176772A0 (en) | Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors | |
EP1763346A4 (de) | Zusammensetzungen und verfahren in zusammenhang mit pyrimidinsynthesehemmern | |
AU2003232848A8 (en) | Phenylaminopyrimidines and their use as rho-kinase inhibitors | |
ZA200606070B (en) | Substituted quinolines and their use as mycrobacterial inhibitors | |
AU2003215756A8 (en) | Benzimidazoles and their use as mitogen-activated- and rho-kinase inhibitors | |
EP1703907A4 (de) | Zusammensetzungen und verfahren zur behandlung von rezidivierenden krankheiten | |
EP1638565A4 (de) | Substituierte piperidin-verbindungen und anwendungsverfahren dafür | |
IL179038A0 (en) | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases | |
EP1627048A4 (de) | Zusammensetzungen zur herunterregulierung der ccr5-expression und verwendungsverfahren dafür | |
AU2003218715A8 (en) | Azepane derivatives and their use as atk1 inhibitors | |
GB0611789D0 (en) | Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation |