IL165858A - Pharmaceutical preparation for treating human malignancies with arginine deprivation and uses thereof - Google Patents

Pharmaceutical preparation for treating human malignancies with arginine deprivation and uses thereof

Info

Publication number
IL165858A
IL165858A IL165858A IL16585804A IL165858A IL 165858 A IL165858 A IL 165858A IL 165858 A IL165858 A IL 165858A IL 16585804 A IL16585804 A IL 16585804A IL 165858 A IL165858 A IL 165858A
Authority
IL
Israel
Prior art keywords
pharmaceutical preparation
treating human
human malignancies
arginine deprivation
pharmaceutical composition
Prior art date
Application number
IL165858A
Other languages
English (en)
Other versions
IL165858A0 (en
Original Assignee
Bio Cancer Treatment Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30000613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL165858(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/GB2003/002665 external-priority patent/WO2004000349A1/en
Application filed by Bio Cancer Treatment Int Ltd filed Critical Bio Cancer Treatment Int Ltd
Publication of IL165858A0 publication Critical patent/IL165858A0/xx
Publication of IL165858A publication Critical patent/IL165858A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL165858A 2002-06-20 2004-12-19 Pharmaceutical preparation for treating human malignancies with arginine deprivation and uses thereof IL165858A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39075702P 2002-06-20 2002-06-20
PCT/CN2002/000635 WO2004001048A1 (en) 2002-06-20 2002-09-09 Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation
PCT/GB2003/002665 WO2004000349A1 (en) 2002-06-20 2003-06-20 Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation

Publications (2)

Publication Number Publication Date
IL165858A0 IL165858A0 (en) 2006-01-15
IL165858A true IL165858A (en) 2010-12-30

Family

ID=30000613

Family Applications (1)

Application Number Title Priority Date Filing Date
IL165858A IL165858A (en) 2002-06-20 2004-12-19 Pharmaceutical preparation for treating human malignancies with arginine deprivation and uses thereof

Country Status (12)

Country Link
US (4) US7951366B2 (pt)
EP (1) EP1517699B1 (pt)
JP (2) JP5307042B2 (pt)
CN (2) CN1918298B (pt)
AT (2) ATE385807T1 (pt)
AU (1) AU2002325782A1 (pt)
DE (2) DE60331871D1 (pt)
HK (3) HK1053577A2 (pt)
IL (1) IL165858A (pt)
MX (1) MXPA04012970A (pt)
NZ (1) NZ537774A (pt)
WO (1) WO2004001048A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9789169B2 (en) 2014-04-29 2017-10-17 Bio-Cancer Treatment International Limited Methods and compositions for modulating the immune system with arginase I

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745847A (zh) * 2004-09-08 2006-03-15 康达医药科技有限公司 用精氨酸酶治疗肝炎的药物组合物和方法
CN101002945B (zh) * 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
RU2008137226A (ru) * 2006-03-17 2010-04-27 Байо-Кэнсер Тритмент Интернэшнл Лимитид (Cn) Способ и композиция для защиты от радиации
US20080138858A1 (en) * 2006-12-12 2008-06-12 Bio-Cancer Treatment International Ltd. Expression System for Recombinant Human Arginase I
WO2010023195A2 (en) * 2008-08-26 2010-03-04 Kyon Biotech Ag Compositions and methods for treating cancer
LT3778885T (lt) 2008-10-31 2023-06-12 Aerase, Inc. Dirbtinai sukurtų žmogaus arginazių kompozicijos ir vėžio gydymo metodai
US8507245B2 (en) 2009-03-26 2013-08-13 The Hong Kong Polytechnic University Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
WO2011008495A2 (en) * 2009-06-29 2011-01-20 The Board Of Regents Of The University Of Texas System Arginase formulations and methods
CN103184208B (zh) * 2011-12-27 2015-09-16 拜奥生物科技（上海）有限公司 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用
JP2016117702A (ja) * 2014-12-22 2016-06-30 武輝 山田 ガン細胞の死滅法
CN105062941B (zh) * 2015-08-25 2019-03-05 江南大学 一种利用重组枯草芽孢杆菌全细胞转化生产l-鸟氨酸的方法
US20180271960A1 (en) * 2015-09-21 2018-09-27 Bio-Cancer Treatment International Ltd. Method to treat cancer using arginine delpetor and ornithine decarboxylase (odc) inhibitor
CN105112391B (zh) * 2015-09-22 2018-07-06 浙江道尔生物科技有限公司 一种人源精氨酸酶突变体及其制备方法和用途
HRP20220406T1 (hr) 2016-08-08 2022-05-27 Aerase, Inc. Pripravci i metode za liječenje raka deplecijom arginina i imunoonkološkim sredstvima
KR20200122298A (ko) 2017-12-05 2020-10-27 에어레이즈, 인크. 아르기나제 1 결핍을 치료하기 위한 방법 및 조성물
JP2021525749A (ja) * 2018-05-31 2021-09-27 ザ ホンコン ポリテクニック ユニバーシティ 癌、肥満、代謝障害及び関連する合併症と併存症のためのアルギニン枯渇剤の組成と応用
EP4069280A4 (en) * 2019-12-02 2024-01-03 The Hong Kong Polytechnic University METHODS FOR INDUCING INTERMITTENT FASTING AND MODULATING AUTOPHAGY
CN115804845A (zh) * 2022-12-02 2023-03-17 华东理工大学 精氨酸剥夺在延缓衰老与联合化疗药物治疗肿瘤中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780286A (en) * 1996-03-14 1998-07-14 Smithkline Beecham Corporation Arginase II
US5851985A (en) 1996-08-16 1998-12-22 Tepic; Slobodan Treatment of tumors by arginine deprivation
AU5192498A (en) * 1996-12-03 1998-06-29 Kyowa Hakko Kogyo Co. Ltd. Tissue fibrosis inhibitor
AU3305999A (en) 1998-02-26 1999-09-15 Beth Israel Deaconess Medical Center Amino acid degrading enzymes modulate cell death
US6413757B1 (en) * 2000-02-28 2002-07-02 Millennium Pharmaceuticals, Inc. 25312, a novel human agmatinase-like homolog
CN1324945A (zh) * 2000-05-19 2001-12-05 上海博德基因开发有限公司 一种新的多肽——精氨酸酶12和编码这种多肽的多核苷酸
CN1324942A (zh) * 2000-05-19 2001-12-05 上海博德基因开发有限公司 一种新的多肽——人精氨酸酶9和编码这种多肽的多核苷酸
KR100396983B1 (ko) 2000-07-29 2003-09-02 이강춘 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
DE10047204A1 (de) 2000-09-23 2002-04-25 Henkel Kgaa Topische Hautbehandlungsmittel mit Arginase
CN1345966A (zh) * 2000-09-26 2002-04-24 上海博德基因开发有限公司 一种新的多肽——人精氨酸酶35.42和编码这种多肽的多核苷酸
CN1345970A (zh) * 2000-09-29 2002-04-24 上海博德基因开发有限公司 一种新的多肽——含精氨酸酶结构域的蛋白质9.35和编码这种多肽的多核苷酸
KR20040004449A (ko) 2000-11-28 2004-01-13 휘닉스 파머컬러직스, 인크. 변형된 아르기닌 데이미나제
WO2003063780A2 (en) 2002-01-25 2003-08-07 Cancer Treatments International Therapeutic composition for treatment of cancer by arginine depletion

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9789169B2 (en) 2014-04-29 2017-10-17 Bio-Cancer Treatment International Limited Methods and compositions for modulating the immune system with arginase I
US9867875B2 (en) 2014-04-29 2018-01-16 Bio-Cancer Treatment International Limited Methods and compositions for modulating the immune system with Arginase I
US10532086B2 (en) 2014-04-29 2020-01-14 Bio-Cancer Treatment International Limited Methods and compositions for modulating the immune system with arginase I

Also Published As

Publication number Publication date
CN1918298B (zh) 2011-06-29
US20050244398A1 (en) 2005-11-03
DE60331871D1 (de) 2010-05-06
IL165858A0 (en) 2006-01-15
US8679810B2 (en) 2014-03-25
NZ537774A (en) 2007-01-26
HK1071687A1 (en) 2005-07-29
US7951366B2 (en) 2011-05-31
JP2010148509A (ja) 2010-07-08
MXPA04012970A (es) 2005-08-18
EP1517699A1 (en) 2005-03-30
US20080248018A1 (en) 2008-10-09
JP5307042B2 (ja) 2013-10-02
US20090123450A1 (en) 2009-05-14
DE60319083T2 (de) 2009-02-05
WO2004001048A1 (en) 2003-12-31
CN1918298A (zh) 2007-02-21
ATE385807T1 (de) 2008-03-15
EP1517699B1 (en) 2008-02-13
US20080226617A1 (en) 2008-09-18
DE60319083D1 (de) 2008-03-27
HK1109876A1 (en) 2008-06-27
HK1053577A2 (en) 2003-10-10
ATE461707T1 (de) 2010-04-15
AU2002325782A1 (en) 2004-01-06
CN101433714A (zh) 2009-05-20
JP2013172743A (ja) 2013-09-05

Similar Documents

Publication Publication Date Title
HK1109876A1 (en) Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
RU2006145899A (ru) Ферменты для фармацевтического применения
MXPA03006771A (es) Anticuerpos modificados y metodos de uso.
TR201903587T4 (tr) Telomeraz aktivitesinin artırılması için bileşimler.
DE60115842D1 (de) Ventilanordnung
TW200503996A (en) Novel hydroxamates as therapeutic agents
MX344587B (es) Metodo para incrementar la estabilidad in vitro e in vivo de enzimas asociadas al transtorno lisosomal.
SG146666A1 (en) Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
SG169224A1 (en) Method for treatment of tumors using nordihydrogualaretic acid derivatives
CY1116164T1 (el) Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμου
NZ623123A (en) A process for concentration of a polypeptide
IL192181A0 (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of mania and bipolar disorder
MX365007B (es) Uso de acido lipasa lisosomal para tratar la dificiencia de acido lipasa lisosomal en pacientes.
WO2004046309A3 (en) Methods for inhibiting viral replication in vivo
DE60122672D1 (de) Zusammensetzung zur intestinalen verabreichung
MXPA05008704A (es) Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas.
ATE368455T1 (de) Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
EP1543158A4 (en) REGULATED APTAMER THERAPEUTICS
WO2003063780A3 (en) Therapeutic composition for treatment of cancer by arginine depletion
MXPA05013226A (es) Carbamatos de piperidina sustituidos, para el uso como inhibidores de la lipasa sensible a hormonas.
DE60330888D1 (de) Verwendung von drospirenon zur behandlung von hypertension
RS102304A (en) Composition for therapeutic use comprising a vitamin, a metal salt and insulin or a growth hormone
HUP0101602A2 (hu) Termékenységet javító készítmény, és annak alkalmazása
UA36490A (uk) Спосіб лікування гнійно-септичних захворювань м'яких тканин

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed