IL163884A0 - Treatment of central nervous systemdamage - Google Patents

Treatment of central nervous systemdamage

Info

Publication number
IL163884A0
IL163884A0 IL16388403A IL16388403A IL163884A0 IL 163884 A0 IL163884 A0 IL 163884A0 IL 16388403 A IL16388403 A IL 16388403A IL 16388403 A IL16388403 A IL 16388403A IL 163884 A0 IL163884 A0 IL 163884A0
Authority
IL
Israel
Prior art keywords
systemdamage
treatment
central nervous
cns
mammal
Prior art date
Application number
IL16388403A
Other languages
English (en)
Original Assignee
King S College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King S College London filed Critical King S College London
Publication of IL163884A0 publication Critical patent/IL163884A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
IL16388403A 2002-03-04 2003-03-04 Treatment of central nervous systemdamage IL163884A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0205022.7A GB0205022D0 (en) 2002-03-04 2002-03-04 Materials and methods for the treatment of cns damage
PCT/GB2003/000901 WO2003074080A1 (en) 2002-03-04 2003-03-04 Treatment of central nervous system damage

Publications (1)

Publication Number Publication Date
IL163884A0 true IL163884A0 (en) 2005-12-18

Family

ID=9932221

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16388403A IL163884A0 (en) 2002-03-04 2003-03-04 Treatment of central nervous systemdamage
IL163884A IL163884A (en) 2002-03-04 2004-09-02 Preparation of medicaments to promote neuronal plasticity
IL223875A IL223875A (en) 2002-03-04 2012-12-25 Use of chondroitinase in the preparation of a drug for use in a method of promoting neural flexibility

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL163884A IL163884A (en) 2002-03-04 2004-09-02 Preparation of medicaments to promote neuronal plasticity
IL223875A IL223875A (en) 2002-03-04 2012-12-25 Use of chondroitinase in the preparation of a drug for use in a method of promoting neural flexibility

Country Status (15)

Country Link
US (1) US20050118157A1 (de)
EP (2) EP2277531A1 (de)
JP (2) JP5112607B2 (de)
AT (1) ATE490786T1 (de)
AU (2) AU2003208466B2 (de)
CA (1) CA2478645C (de)
DE (1) DE60335244D1 (de)
DK (1) DK1480674T3 (de)
ES (1) ES2357227T3 (de)
GB (1) GB0205022D0 (de)
IL (3) IL163884A0 (de)
MX (1) MXPA04008598A (de)
PT (1) PT1480674E (de)
SI (1) SI1480674T1 (de)
WO (1) WO2003074080A1 (de)

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AU5340801A (en) * 2000-04-13 2001-10-30 Thomas N Wight Therapeutic compounds and methods
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
EP1575548B1 (de) * 2002-05-04 2011-03-09 Acorda Therapeutics, Inc. Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
CA2493509C (en) 2002-06-03 2010-03-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
EP1530643B1 (de) * 2002-08-15 2011-05-04 Acorda Therapeutics, Inc. Chimärisches protein
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
WO2004094592A2 (en) 2003-04-18 2004-11-04 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
US7429375B2 (en) 2003-05-16 2008-09-30 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for the treatment of CNS
AU2004247025B8 (en) * 2003-05-16 2011-06-30 Acorda Therapeutics, Inc. Fusion proteins for the treatment of CNS
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
MXPA05012305A (es) * 2003-05-16 2006-04-18 Acorda Therapeutics Inc Composiciones y metodos para el tratamiento de lesiones del snc.
US7507570B2 (en) * 2004-03-10 2009-03-24 Massachusetts Institute Of Technology Recombinant chondroitinase ABC I and uses thereof
ES2411504T3 (es) 2004-05-18 2013-07-05 Acorda Therapeutics, Inc. Métodos de purificación de condroitinasa y formulaciones estables de la misma
KR101241551B1 (ko) * 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
KR101215697B1 (ko) * 2004-08-19 2012-12-28 바이오겐 아이덱 엠에이 인코포레이티드 뉴블라스틴 변형체
US20070031397A1 (en) * 2005-05-25 2007-02-08 Schnaar Ronald L Compositions and methods for enhancing axon regeneration
WO2007038548A2 (en) 2005-09-26 2007-04-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
JP4147264B2 (ja) * 2006-09-08 2008-09-10 株式会社ステリック再生医科学研究所 神経線維性変性抑制剤
EP2450442B1 (de) 2006-10-10 2017-07-19 Acorda Therapeutics, Inc. Zusammensetzungen und verfahren zur verwendung von chondroitinase-abci-mutanten
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
WO2008149428A1 (ja) * 2007-06-05 2008-12-11 Glycoscience Laboratories, Inc. 自己免疫疾患、炎症及び神経疾患の治療剤及び予防剤
WO2009020964A2 (en) * 2007-08-08 2009-02-12 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
EP2217249A4 (de) * 2007-11-06 2011-10-12 Benaroya Res Inst Hemmung von versican mit sirna und anderen molekülen
GB0723825D0 (en) * 2007-12-05 2008-01-23 Ucl Business Plc Composition
JP5636536B2 (ja) * 2008-04-14 2014-12-10 国立大学法人名古屋大学 神経因性疼痛の改善剤
EP2153844A1 (de) * 2008-08-14 2010-02-17 HAUBECK, Hans-Dieter Humane Hyaluronidasen zum erneuten axonalen Wachstum
WO2010100247A1 (en) 2009-03-06 2010-09-10 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Novel therapy for anxiety
US20110124706A1 (en) * 2009-11-25 2011-05-26 Zhigang He SOCS3 Inhibition Promotes CNS Neuron Regeneration
JP5885136B2 (ja) * 2011-01-31 2016-03-15 学校法人 愛知医科大学 高硫酸化コンドロイチン硫酸類の合成方法、高硫酸化コンドロイチン硫酸類、および解析用試薬
WO2012136768A1 (en) 2011-04-08 2012-10-11 Hans-Dieter Haubeck Use of mutants of human hyaluronidase ph-20 with increased chondroitinase activity for axonal regrowth
WO2013067125A1 (en) 2011-11-01 2013-05-10 Children's Medical Center Corporation Co-activation of mtor and stat3 pathways to promote neuronal survival and regeneration
WO2014052461A1 (en) * 2012-09-25 2014-04-03 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Treatment of central nervous system (cns) injury
WO2014065669A1 (en) * 2012-10-26 2014-05-01 Stichting Vu-Vumc Methods of treatment and diagnosis for cognitive decline and memory impairment
EP3033416A4 (de) * 2013-08-12 2017-02-08 Benaroya Research Institute at Virginia Mason 4-methylumbelliferon-behandlung zur immunmodulation
WO2018029685A1 (en) * 2016-08-11 2018-02-15 Technion Research & Development Foundation Limited Compositions and methods for treating a fear memory

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
AU6872691A (en) * 1989-10-27 1991-05-31 Case Western Reserve University Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
JPH06502840A (ja) * 1989-10-27 1994-03-31 ケース ウェスタン リザーブ ユニバーシティ ケラタン硫酸、コンドロイチン硫酸、デルマタン硫酸及び他のグリカンによる細胞成長の阻害
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
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US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5773277A (en) 1992-06-26 1998-06-30 Seikagaku Kogyo Kabushiki Kaisha Crystalline chondroitinase isolated from Proteus vulgaris ATCC 6896
US5496718A (en) 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
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US5716617A (en) 1994-04-22 1998-02-10 American Cyanamid Company Compositions of proteus vulgaris chondroitinase I and chondroitinase II
US6093563A (en) 1994-07-08 2000-07-25 Ibex Technologies R And D, Inc. Chondroitin lyase enzymes
US5997863A (en) 1994-07-08 1999-12-07 Ibex Technologies R And D, Inc. Attenuation of wound healing processes
JPH09194502A (ja) * 1995-11-13 1997-07-29 Seikagaku Kogyo Co Ltd 新規コンドロイチン硫酸プロテオグリカン、そのコア蛋白質、それをコードするｄｎａおよびそれに対する抗体
EP0875253B1 (de) * 1997-05-02 2005-04-06 Seikagaku Corporation Chondroitinase enthaltende Zusammensetzungen
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JP4749667B2 (ja) * 2001-08-13 2011-08-17 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 神経組織の修復を促進するための材料および方法
US7199110B2 (en) * 2002-12-30 2007-04-03 Purdue Research Foundation Method of treatment for spinal cord injury

Also Published As

Publication number Publication date
DE60335244D1 (de) 2011-01-20
CA2478645A1 (en) 2003-09-12
US20050118157A1 (en) 2005-06-02
EP1480674A1 (de) 2004-12-01
AU2003208466B2 (en) 2008-10-02
JP2010132682A (ja) 2010-06-17
AU2003208466A1 (en) 2003-09-16
AU2009200025A1 (en) 2009-02-05
SI1480674T1 (sl) 2011-04-29
PT1480674E (pt) 2011-03-15
ATE490786T1 (de) 2010-12-15
JP2005526740A (ja) 2005-09-08
CA2478645C (en) 2011-11-29
WO2003074080A1 (en) 2003-09-12
AU2009200025B2 (en) 2010-11-18
DK1480674T3 (da) 2011-03-28
EP2277531A1 (de) 2011-01-26
ES2357227T3 (es) 2011-04-20
JP5112607B2 (ja) 2013-01-09
EP1480674B1 (de) 2010-12-08
IL223875A (en) 2017-02-28
HK1073430A1 (en) 2005-10-07
GB0205022D0 (en) 2002-04-17
IL163884A (en) 2013-01-31
MXPA04008598A (es) 2005-09-08

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