IL163658A0 - Assay for activity of the actriib kinase - Google Patents
Assay for activity of the actriib kinaseInfo
- Publication number
- IL163658A0 IL163658A0 IL16365803A IL16365803A IL163658A0 IL 163658 A0 IL163658 A0 IL 163658A0 IL 16365803 A IL16365803 A IL 16365803A IL 16365803 A IL16365803 A IL 16365803A IL 163658 A0 IL163658 A0 IL 163658A0
- Authority
- IL
- Israel
- Prior art keywords
- assay
- activity
- actriib
- kinase
- actriib kinase
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36060702P | 2002-02-28 | 2002-02-28 | |
| PCT/IB2003/000638 WO2003072808A1 (fr) | 2002-02-28 | 2003-02-17 | Essai de determination de l'activite de la actriib kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL163658A0 true IL163658A0 (en) | 2005-12-18 |
Family
ID=27734775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16365803A IL163658A0 (en) | 2002-02-28 | 2003-02-17 | Assay for activity of the actriib kinase |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030219846A1 (fr) |
| EP (1) | EP1340817A1 (fr) |
| JP (1) | JP2003250537A (fr) |
| KR (1) | KR20040084942A (fr) |
| CN (1) | CN1643161A (fr) |
| AU (1) | AU2003206033A1 (fr) |
| CA (1) | CA2476942A1 (fr) |
| HR (1) | HRP20040786A2 (fr) |
| IL (1) | IL163658A0 (fr) |
| NO (1) | NO20044051L (fr) |
| RU (1) | RU2004126254A (fr) |
| WO (1) | WO2003072808A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050137147A1 (en) * | 2003-12-22 | 2005-06-23 | Alcon, Inc. | Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration |
| ATE523208T1 (de) * | 2003-12-22 | 2011-09-15 | Novartis Ag | Mittel zur behandlung von glaukomatöser retinopathie und optischer neuropathie |
| TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| US20060115870A1 (en) * | 2004-03-30 | 2006-06-01 | Alcon, Inc. | High throughput assay for human Rho kinase activity |
| WO2005102345A1 (fr) * | 2004-03-30 | 2005-11-03 | Alcon, Inc. | Utilisation d'inhibiteurs de kinase rho dans le traitement de deficits auditifs, d'acouphenes et dans l'amelioration de l'equilibre corporel |
| US20080096238A1 (en) * | 2004-03-30 | 2008-04-24 | Alcon, Inc. | High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio |
| EP3059245B1 (fr) | 2004-07-23 | 2018-11-07 | Acceleron Pharma Inc. | Anticorps antagonistes du récepteur actrii |
| KR20180030264A (ko) | 2005-11-23 | 2018-03-21 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| KR101803620B1 (ko) * | 2006-12-18 | 2017-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒｉｉ 길항물질과 적혈구 수준을 증가시키기 위한 이의 용도 |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| JP5237970B2 (ja) | 2007-02-01 | 2013-07-17 | アクセルロン ファーマ， インコーポレイテッド | 乳癌を治療または予防するためのアクチビンＡｃｔＲＩＩａアンタゴニストおよび使用 |
| TW202021980A (zh) | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| EP2120999B1 (fr) | 2007-02-09 | 2012-08-29 | Acceleron Pharma, Inc. | Compositions comprenant des antagonistes Activin-ActRIIA et leur utilisation dans la prévention ou le traitement du myélome multiple |
| CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| PL3494986T3 (pl) | 2008-08-14 | 2020-11-16 | Acceleron Pharma Inc. | Pułapki GDF |
| WO2010083034A1 (fr) * | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Procédés permettant d'augmenter l'adiponectine |
| EP3345921A1 (fr) | 2009-06-08 | 2018-07-11 | Acceleron Pharma Inc. | Utilisation d'anticorps anti-actriib pour l'augmentation d'adipocytes thermogènes |
| CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| WO2011063018A1 (fr) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Protéines actriib et variants et utilisations de celles-ci se rapportant à l'induction de l'utrophine pour une thérapie de la dystrophie musculaire |
| JP2014502260A (ja) | 2010-11-08 | 2014-01-30 | アクセルロン ファーマ， インコーポレイテッド | Ａｃｔｒｉｉａ結合剤およびその使用 |
| JP6214537B2 (ja) * | 2012-08-21 | 2017-10-25 | 国立大学法人九州大学 | 貧血患者の貧血の要因を検出するためのバイオマーカー |
| EP3308796B1 (fr) | 2012-11-02 | 2021-07-14 | Celgene Corporation | Antagonistes d'activine-actrii et utilisations pour le traitement de troubles osseux et autres |
| AP2017009674A0 (en) | 2014-06-13 | 2017-01-31 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| MD4801C1 (ro) | 2014-12-03 | 2022-10-31 | Celgene Corporation | Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL142828A0 (en) * | 1998-09-25 | 2002-03-10 | Childrens Medical Center | Short peptides which selectively modulate the activity of protein kinases |
| GB9923208D0 (en) * | 1999-10-01 | 1999-12-08 | Cambridge Drug Discovery Ltd | Assay |
| US20020115173A1 (en) * | 2000-12-11 | 2002-08-22 | Children's Medical Center Corporation | Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity |
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
-
2003
- 2003-02-14 US US10/367,241 patent/US20030219846A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000638 patent/WO2003072808A1/fr not_active Application Discontinuation
- 2003-02-17 IL IL16365803A patent/IL163658A0/xx unknown
- 2003-02-17 CN CNA038065827A patent/CN1643161A/zh active Pending
- 2003-02-17 CA CA002476942A patent/CA2476942A1/fr not_active Abandoned
- 2003-02-17 KR KR10-2004-7013380A patent/KR20040084942A/ko not_active Application Discontinuation
- 2003-02-17 AU AU2003206033A patent/AU2003206033A1/en not_active Abandoned
- 2003-02-17 RU RU2004126254/13A patent/RU2004126254A/ru not_active Application Discontinuation
- 2003-02-19 EP EP03251012A patent/EP1340817A1/fr not_active Withdrawn
- 2003-02-28 JP JP2003052729A patent/JP2003250537A/ja not_active Withdrawn
-
2004
- 2004-08-27 HR HRP20040786 patent/HRP20040786A2/hr not_active Application Discontinuation
- 2004-09-24 NO NO20044051A patent/NO20044051L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040084942A (ko) | 2004-10-06 |
| AU2003206033A1 (en) | 2003-09-09 |
| CN1643161A (zh) | 2005-07-20 |
| WO2003072808A1 (fr) | 2003-09-04 |
| US20030219846A1 (en) | 2003-11-27 |
| HRP20040786A2 (en) | 2004-12-31 |
| RU2004126254A (ru) | 2005-04-10 |
| CA2476942A1 (fr) | 2003-09-04 |
| NO20044051L (no) | 2004-09-24 |
| JP2003250537A (ja) | 2003-09-09 |
| EP1340817A1 (fr) | 2003-09-03 |
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