IL163608A0 - Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders - Google Patents

Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders

Info

Publication number
IL163608A0
IL163608A0 IL16360803A IL16360803A IL163608A0 IL 163608 A0 IL163608 A0 IL 163608A0 IL 16360803 A IL16360803 A IL 16360803A IL 16360803 A IL16360803 A IL 16360803A IL 163608 A0 IL163608 A0 IL 163608A0
Authority
IL
Israel
Prior art keywords
derivatives
amino
proliferative disorders
treating proliferative
sulfonanilides
Prior art date
Application number
IL16360803A
Other languages
English (en)
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Publication of IL163608A0 publication Critical patent/IL163608A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL16360803A 2002-02-28 2003-02-28 Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders IL163608A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36071002P 2002-02-28 2002-02-28
PCT/US2003/006358 WO2003072063A2 (en) 2002-02-28 2003-02-28 Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders

Publications (1)

Publication Number Publication Date
IL163608A0 true IL163608A0 (en) 2005-12-18

Family

ID=27766241

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16360803A IL163608A0 (en) 2002-02-28 2003-02-28 Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
IL163608A IL163608A (en) 2002-02-28 2004-08-18 Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL163608A IL163608A (en) 2002-02-28 2004-08-18 Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders

Country Status (8)

Country Link
US (1) US7161031B2 (de)
EP (1) EP1534284B1 (de)
JP (1) JP4538233B2 (de)
AT (1) ATE517626T1 (de)
AU (1) AU2003213661A1 (de)
CA (1) CA2477236C (de)
IL (2) IL163608A0 (de)
WO (1) WO2003072063A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767926B1 (en) * 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
WO2003072062A2 (en) * 2002-02-28 2003-09-04 Temple University-Of The Commonwealth System Of Higher Education Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
KR101274524B1 (ko) * 2004-03-16 2013-06-19 온코노바 테라퓨틱스, 인코포레이티드 증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체
CA2574491C (en) * 2004-07-19 2011-05-24 Onconova Therapeutics, Inc. Formulations for parenteral administration of (e)-2,6-dialkoxystryryl 4-substituted benzylsulfones
US20090306207A1 (en) * 2005-01-05 2009-12-10 Reddy M V Ramana Treatment of Drug-Resistant Proliferative Disorders
EP2007716A1 (de) * 2006-04-13 2008-12-31 Glaxo Group Limited Aryl- und heteroarylsulfonamide als agonisten am wachstumshormonsekretagogum-rezeptor
EP2046322A4 (de) * 2006-08-02 2010-10-06 Univ Temple Aryl-vinyl-sulfide, -sulfone, -sulfoxide und -sulfonamide, derivate davon und therapeutische anwendungen davon
JP5278968B2 (ja) * 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
GB0617865D0 (en) * 2006-09-11 2006-10-18 Glaxo Group Ltd Novel use
CA2663375A1 (en) * 2006-09-15 2008-03-20 Onconova Therapeutics, Inc. Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions
KR101992929B1 (ko) 2012-09-20 2019-06-25 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 알킬 디아릴 유도체, 제조방법 및 용도
US10383831B2 (en) * 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2531367A (en) * 1947-07-15 1950-11-21 Sharp & Dohme Inc N-(substituted sulfonyl)-aminobenzoic acids
DE2118493C3 (de) 1971-04-16 1980-04-30 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Aminostilbenen
US4035421A (en) * 1976-03-19 1977-07-12 Morton-Norwich Products, Inc. N-(3,4,-dichlorophenyl)-2-phenylethenesulfonamide
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
NZ238911A (en) * 1990-07-17 1993-10-26 Lilly Co Eli Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor
JPH04202173A (ja) 1990-11-30 1992-07-22 Zeria Pharmaceut Co Ltd スルホンアミド誘導体及びそれを含有する５―リポキシゲナーゼ阻害剤
WO1995024190A2 (en) 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
JPH11503110A (ja) * 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体拮抗剤
PT896533E (pt) * 1996-02-22 2004-02-27 Tularik Inc Pentafluorobenzenosulfonamidas e analogos
US6262113B1 (en) * 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6548553B2 (en) * 1997-10-03 2003-04-15 Temple University-Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
AU741042B2 (en) * 1997-10-03 2001-11-22 Temple University - Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
US6191170B1 (en) * 1998-01-13 2001-02-20 Tularik Inc. Benzenesulfonamides and benzamides as therapeutic agents
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
DE69908156T2 (de) 1998-09-23 2003-12-24 Tularik, Inc. Arylsulfonanilid-harnstoffe
US6762207B1 (en) * 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
US6586617B1 (en) * 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
US6767926B1 (en) * 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
GB9924522D0 (en) * 1999-10-15 1999-12-15 Arrow Therapeutics Ltd Enzyme inhibitors
US6541475B2 (en) * 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
US6486210B2 (en) * 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
WO2002028828A1 (en) * 2000-10-05 2002-04-11 Temple University - Of The Commonwealth System Of Higher Education Substituted (e)-styryl benzylsulfones for treating proliferative disorders
AU2002305942B2 (en) * 2001-02-28 2006-10-26 Onconova Therapeutics, Inc. Method for protecting cells and tissues from ionizing radiation toxicity with Alpha, Beta unsaturated aryl sulfones
US6646009B2 (en) * 2001-02-28 2003-11-11 Temple University — Of Commonwealth System of Higher Education N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof
EP1406884A1 (de) * 2001-05-11 2004-04-14 Biovitrum Ab Arylsulfonamid verbindungen zur behandlung von obesitas, typ-ii-diabetes und erkrankungen des zns
WO2003072062A2 (en) * 2002-02-28 2003-09-04 Temple University-Of The Commonwealth System Of Higher Education Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders

Also Published As

Publication number Publication date
EP1534284A4 (de) 2006-08-16
WO2003072063A3 (en) 2005-04-07
US20050096484A1 (en) 2005-05-05
US7161031B2 (en) 2007-01-09
EP1534284B1 (de) 2011-07-27
AU2003213661A8 (en) 2003-09-09
EP1534284A2 (de) 2005-06-01
ATE517626T1 (de) 2011-08-15
JP4538233B2 (ja) 2010-09-08
CA2477236C (en) 2013-08-13
AU2003213661A1 (en) 2003-09-09
JP2005528345A (ja) 2005-09-22
WO2003072063A2 (en) 2003-09-04
IL163608A (en) 2013-12-31
CA2477236A1 (en) 2003-09-04

Similar Documents

Publication Publication Date Title
MXPA04005456A (es) Derivados de acetileno que tienen actividad antagonistica de mglur5.
AU7779900A (en) Trifluoromethyl-substituted spirocyclic ketoenols
YU63202A (sh) Derivati 2-okso-1-pirolidina, postupci za njihovo dobijanje i njihove upotrebe
AU2002239344A1 (en) Pyrazolopyridines
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
AU2003228674A1 (en) Muscarinic antagonists
CA2356300A1 (en) 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
MXPA04004107A (es) Moleculas pequenas para el tratamiento del crecimiento celular anormal.
WO2003072062A3 (en) Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
DE60112330D1 (en) Pyrazolopyridinderivate
CA2453917A1 (en) Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
AU2003213661A8 (en) Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
SE0301320D0 (sv) Positive modulators of nicotinic acetylcholine receptors
BRPI0409376A (pt) derivados de indeno como agentes farmacêuticos
WO2002010152A3 (de) Neue indolderivate und deren verwendung als arzneimittel
HRP20010969B1 (en) Novel piperazinylalkylthiopyrimidine derivatives,
IL157050A0 (en) 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
WO2004033423A3 (en) Anticancer compounds
MXPA02009549A (es) Imidazopiridinas triciclicas.
AU2002357740A1 (en) Pyrazolo-pyridine derivatives as antiherpes agents
BR0309996A (pt) Composto, composição farmacêutica, método de tratar ou melhorar doenças ou condições proliferativas, uso de um composto, e, método de tratar ou melhorar doenças inflamatórias
AU2002248531A1 (en) Pyrazolopyriadine derivatives
ATE232081T1 (de) Orale zusammensetzung enthaltend perlit