IL162604A0 - Conformationally constrained c-backbone cyclic peptides - Google Patents
Conformationally constrained c-backbone cyclic peptidesInfo
- Publication number
- IL162604A0 IL162604A0 IL16260403A IL16260403A IL162604A0 IL 162604 A0 IL162604 A0 IL 162604A0 IL 16260403 A IL16260403 A IL 16260403A IL 16260403 A IL16260403 A IL 16260403A IL 162604 A0 IL162604 A0 IL 162604A0
- Authority
- IL
- Israel
- Prior art keywords
- cyclic peptides
- conformationally constrained
- backbone cyclic
- backbone
- conformationally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34403702P | 2002-01-03 | 2002-01-03 | |
PCT/IL2003/000006 WO2003059933A2 (en) | 2002-01-03 | 2003-01-02 | Conformationally constrained c-backbone cyclic peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL162604A0 true IL162604A0 (en) | 2005-11-20 |
Family
ID=23348766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16260403A IL162604A0 (en) | 2002-01-03 | 2003-01-02 | Conformationally constrained c-backbone cyclic peptides |
Country Status (5)
Country | Link |
---|---|
US (1) | US20050267017A1 (xx) |
EP (1) | EP1468013A4 (xx) |
AU (1) | AU2003207940A1 (xx) |
IL (1) | IL162604A0 (xx) |
WO (1) | WO2003059933A2 (xx) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2284459C (en) | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery |
WO2005123761A1 (en) * | 2004-06-21 | 2005-12-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION |
CA2609951A1 (en) * | 2005-05-31 | 2006-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Backbone cyclized melanocortin stimulating hormone (.alpha.s) analogs |
CN105061577A (zh) | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 安定化させたp53ペプチドおよびその使用法 |
BRPI0807578A2 (pt) | 2007-02-23 | 2021-06-15 | Aileron Therapeutics, Inc. | macrociclo peptidomimético, composto, kit e métodos para sintetizar um macrociclo peptidomimético |
KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
JP2012515172A (ja) | 2009-01-14 | 2012-07-05 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
CN108570097A (zh) | 2010-08-13 | 2018-09-25 | 爱勒让治疗公司 | 拟肽大环化合物 |
WO2012170969A2 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
EP2914256B1 (en) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
CN112972378A (zh) | 2014-09-24 | 2021-06-18 | 艾瑞朗医疗公司 | 拟肽大环化合物及其制剂 |
JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
EP3294318A4 (en) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF |
US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2830442A1 (de) * | 1978-07-11 | 1980-01-24 | Max Planck Gesellschaft | Verfahren zur herstellung von polypeptiden |
IL99628A (en) * | 1991-10-02 | 2004-07-25 | Yissum Res Dev Co | Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them |
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
US6407059B1 (en) * | 1994-06-08 | 2002-06-18 | Peptor Limited | Conformationally constrained backbone cyclized peptide analogs |
EP1037904A2 (en) * | 1997-12-15 | 2000-09-27 | Peptor Ltd | Branched building units for synthesizing cyclic peptides |
-
2003
- 2003-01-02 WO PCT/IL2003/000006 patent/WO2003059933A2/en not_active Application Discontinuation
- 2003-01-02 IL IL16260403A patent/IL162604A0/xx unknown
- 2003-01-02 AU AU2003207940A patent/AU2003207940A1/en not_active Abandoned
- 2003-01-02 EP EP03704944A patent/EP1468013A4/en not_active Withdrawn
-
2005
- 2005-03-21 US US11/085,906 patent/US20050267017A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003207940A1 (en) | 2003-07-30 |
EP1468013A4 (en) | 2005-03-16 |
AU2003207940A8 (en) | 2003-07-30 |
US20050267017A1 (en) | 2005-12-01 |
WO2003059933A2 (en) | 2003-07-24 |
WO2003059933A3 (en) | 2004-01-15 |
EP1468013A2 (en) | 2004-10-20 |
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