IL161300A0 - Methods of screening for toxicity of test compounds - Google Patents

Methods of screening for toxicity of test compounds

Info

Publication number
IL161300A0
IL161300A0 IL16130002A IL16130002A IL161300A0 IL 161300 A0 IL161300 A0 IL 161300A0 IL 16130002 A IL16130002 A IL 16130002A IL 16130002 A IL16130002 A IL 16130002A IL 161300 A0 IL161300 A0 IL 161300A0
Authority
IL
Israel
Prior art keywords
toxicity
screening
methods
test compounds
compounds
Prior art date
Application number
IL16130002A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL161300A0 publication Critical patent/IL161300A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL16130002A 2001-10-31 2002-10-31 Methods of screening for toxicity of test compounds IL161300A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33650901P 2001-10-31 2001-10-31
PCT/US2002/034894 WO2003050297A1 (fr) 2001-10-31 2002-10-31 Procede de criblage de composes de test pour determiner leur toxicite

Publications (1)

Publication Number Publication Date
IL161300A0 true IL161300A0 (en) 2004-09-27

Family

ID=23316423

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16130002A IL161300A0 (en) 2001-10-31 2002-10-31 Methods of screening for toxicity of test compounds

Country Status (8)

Country Link
US (1) US7041501B2 (fr)
EP (1) EP1446497A4 (fr)
JP (1) JP2005511093A (fr)
AU (1) AU2002364692B2 (fr)
CA (1) CA2465262A1 (fr)
IL (1) IL161300A0 (fr)
MX (1) MXPA04004018A (fr)
WO (1) WO2003050297A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US7776021B2 (en) * 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
EP1589814B1 (fr) 2003-01-16 2009-08-12 The General Hospital Corporation Utilisation de systemes microfabriques tridimensionnels du genie tissulaire pour applications pharmacologiques
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7452678B2 (en) * 2003-06-24 2008-11-18 Bristol-Myers Squibb Company Identification of biomarkers for liver toxicity
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) * 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
EP2029766A4 (fr) * 2006-06-08 2010-02-10 Univ North Carolina Impulsions de compartiments biliaires dans des hépatocytes cultivés en sandwich
WO2012031057A1 (fr) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms-582949 pour le traitement d'une maladie rhumatismale résistante
JP2017035081A (ja) * 2015-08-13 2017-02-16 サントリーホールディングス株式会社 動物細胞毒性又は抗酸化能の試験方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356806A (en) 1987-06-05 1994-10-18 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450
US5164313A (en) 1987-06-05 1992-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant vaccinia virus encoding cytochromes P-450
US5506131A (en) * 1987-06-05 1996-04-09 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450 genes
US5529920A (en) 1988-12-14 1996-06-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human liver epithelial cell line and culture media therefor
AU621972B2 (en) 1988-12-14 1992-03-26 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cell culture medium for human liver epithelial cell line
US5665589A (en) 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
JPH0749923B2 (ja) * 1989-05-31 1995-05-31 大日本スクリーン製造株式会社 レーザ測長器のための単位変換装置
US5457187A (en) * 1993-12-08 1995-10-10 Board Of Regents University Of Nebraska Oligonucleotides containing 5-fluorouracil
US5759782A (en) * 1995-06-07 1998-06-02 The United States Of America Cellular apoptosis susceptibility protein (CSP) and antisense CSP
US5869243A (en) 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
TW471968B (en) * 1999-08-25 2002-01-11 Committee On Chinese Medicine Solamargine pharmaceutical composition for killing cancer cells
US6852845B1 (en) * 1999-11-22 2005-02-08 Curagen Corporation Method of identifying toxic agents using NSAID-induced differential gene expression in liver
US7700822B2 (en) * 2002-07-12 2010-04-20 Cancer Research Technology Limited Modulation of cytochrome P450 reductase activity

Also Published As

Publication number Publication date
CA2465262A1 (fr) 2003-06-19
JP2005511093A (ja) 2005-04-28
US20030113708A1 (en) 2003-06-19
EP1446497A4 (fr) 2004-12-29
AU2002364692A1 (en) 2003-06-23
WO2003050297A1 (fr) 2003-06-19
MXPA04004018A (es) 2004-07-23
US7041501B2 (en) 2006-05-09
EP1446497A1 (fr) 2004-08-18
AU2002364692B2 (en) 2006-11-23

Similar Documents

Publication Publication Date Title
EP1363880A4 (fr) Synthese destinee a la preparation de composes de criblage utilises comme agents de fixation a la tubuline
HK1080549A1 (zh) 有關 調節者的篩選方法
GB0127553D0 (en) Provision of data for analysis
EP1378749A4 (fr) Procede de criblage
EP1414491A4 (fr) Procedes inhibant la toxicite amyloide
GB0111108D0 (en) Testing apparatus
EP1463820A4 (fr) Procede de criblage de composes
IL161300A0 (en) Methods of screening for toxicity of test compounds
GB0216762D0 (en) Wireless test fixture for PCBs
EP1546317A4 (fr) Procedes de quantification de metabolites de methotrexate
EP1660671A4 (fr) Procedes de detection et d'identification de composes
GB0111004D0 (en) Screening method
EP1556400A4 (fr) Procede de preparation de composes de 2-halo-2'-deoxyadenosine a partir de 2'-deoxyguanosine
GB0303936D0 (en) Method of testing
AU2002347337A1 (en) Method of screening forpotential anti-bacterial agents
GB0200721D0 (en) Toxicity test
GB0108133D0 (en) Substituted polycyclic compounds
AU2003254579A8 (en) Methods of screening for schizophrenia
GB2379276B (en) Imapct testing apparatus
AU2002365426A8 (en) Methods for screening osteogenic compounds
GB0115763D0 (en) Testing apparatus
GB0009503D0 (en) Screening method for compounds
IL155231A0 (en) New nmr screening method
EP1259635A4 (fr) Procedes de criblage de composes antimicrobiens
AU2002216285A1 (en) Multiple target test useful for pre-donation screening of blood