IL157766A0 - Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses - Google Patents
Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their usesInfo
- Publication number
- IL157766A0 IL157766A0 IL15776602A IL15776602A IL157766A0 IL 157766 A0 IL157766 A0 IL 157766A0 IL 15776602 A IL15776602 A IL 15776602A IL 15776602 A IL15776602 A IL 15776602A IL 157766 A0 IL157766 A0 IL 157766A0
- Authority
- IL
- Israel
- Prior art keywords
- sps
- proteins
- chaperone
- protease resistant
- polynucleotides encoding
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 230000001876 chaperonelike Effects 0.000 title abstract 2
- 239000003398 denaturant Substances 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27277101P | 2001-03-05 | 2001-03-05 | |
| PCT/IL2002/000174 WO2002070647A2 (en) | 2001-03-05 | 2002-03-05 | Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL157766A0 true IL157766A0 (en) | 2004-03-28 |
Family
ID=23041210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15776602A IL157766A0 (en) | 2001-03-05 | 2002-03-05 | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050074763A1 (de) |
| EP (1) | EP1481061B1 (de) |
| AT (1) | ATE513043T1 (de) |
| AU (1) | AU2002234863A1 (de) |
| CA (1) | CA2440358C (de) |
| ES (1) | ES2365602T3 (de) |
| IL (1) | IL157766A0 (de) |
| WO (1) | WO2002070647A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090253125A9 (en) * | 2001-03-05 | 2009-10-08 | Wangxia Wang | Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof |
| US7253341B2 (en) * | 2001-03-05 | 2007-08-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof |
| AR051866A1 (es) * | 2004-12-24 | 2007-02-14 | Cropdesign Nv | Plantas con aumento del rendimiento y metodo de prepracion |
| US9051379B2 (en) * | 2005-07-07 | 2015-06-09 | Fulcrum Sp Ltd. | Sp1 polypeptides, modified Sp1 polypeptides and uses thereof |
| JP5863191B2 (ja) | 2009-09-03 | 2016-02-16 | エスピー ナノ リミテッド | 多数の部位で改変されたｓｐ１ポリペプチドおよびその使用 |
| CA2798517C (en) | 2010-05-17 | 2016-07-05 | The Procter & Gamble Company | Systems and methods of detecting and demonstrating hair damage via evaluation of protein fragments |
| WO2012160565A1 (en) | 2011-05-26 | 2012-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Biomolecular electronic device and process of use |
| CN104704120A (zh) * | 2012-09-20 | 2015-06-10 | 诺维信公司 | 针对编码功能蛋白的变体筛选多核苷酸文库 |
| US10179933B2 (en) | 2013-02-07 | 2019-01-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Hybrid nanopores and uses thereof for detection of analytes |
| RU2692258C2 (ru) | 2014-01-31 | 2019-06-24 | Когнишн Терапьютикс, Инк. | Композиции изоиндолина и способы лечения нейродегенеративного заболевания |
| EP3194589B1 (de) | 2014-07-31 | 2022-07-27 | Primordial Genetics Inc. | Zusammensetzungen zur verbesserung von zellen und organismen |
| IL243838A (en) | 2016-01-28 | 2017-07-31 | Sp Nano Ltd | The composition containing sp1 protein and carbon nanoparticles and its uses |
| IL243839B (en) | 2016-01-28 | 2018-01-31 | Sp Nano Ltd | Conductive wires |
| WO2017165464A1 (en) * | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| DK3634394T3 (da) | 2017-05-15 | 2026-03-02 | Cognition Therapeutics Inc | Sammensætninger til behandling af neurogenerative sygdomme |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| EP3765517A1 (de) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | An calreticulin bindende multifunktionsmoleküle und ihre verwendungen |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0748398A (ja) | 1993-08-03 | 1995-02-21 | Nippon Oil Co Ltd | 変性蛋白質の再生方法及び変性蛋白質再生剤 |
| JPH09173078A (ja) * | 1995-09-14 | 1997-07-08 | Tadayuki Imanaka | 分子シャペロンを用いる蛋白質の製造方法 |
-
2002
- 2002-03-05 ES ES02701532T patent/ES2365602T3/es not_active Expired - Lifetime
- 2002-03-05 IL IL15776602A patent/IL157766A0/xx not_active IP Right Cessation
- 2002-03-05 AT AT02701532T patent/ATE513043T1/de not_active IP Right Cessation
- 2002-03-05 EP EP02701532A patent/EP1481061B1/de not_active Expired - Lifetime
- 2002-03-05 CA CA2440358A patent/CA2440358C/en not_active Expired - Fee Related
- 2002-03-05 WO PCT/IL2002/000174 patent/WO2002070647A2/en not_active Ceased
- 2002-03-05 US US10/468,841 patent/US20050074763A1/en not_active Abandoned
- 2002-03-05 AU AU2002234863A patent/AU2002234863A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002070647A2 (en) | 2002-09-12 |
| EP1481061B1 (de) | 2011-06-15 |
| ES2365602T3 (es) | 2011-10-07 |
| AU2002234863A1 (en) | 2002-09-19 |
| ATE513043T1 (de) | 2011-07-15 |
| WO2002070647A8 (en) | 2003-11-27 |
| CA2440358A1 (en) | 2002-09-12 |
| US20050074763A1 (en) | 2005-04-07 |
| CA2440358C (en) | 2013-08-20 |
| EP1481061A2 (de) | 2004-12-01 |
| WO2002070647A3 (en) | 2004-10-07 |
| EP1481061A4 (de) | 2005-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |