IL157669A0 - Nitrogen-based camptothecin derivatives - Google Patents

Nitrogen-based camptothecin derivatives

Info

Publication number
IL157669A0
IL157669A0 IL15766902A IL15766902A IL157669A0 IL 157669 A0 IL157669 A0 IL 157669A0 IL 15766902 A IL15766902 A IL 15766902A IL 15766902 A IL15766902 A IL 15766902A IL 157669 A0 IL157669 A0 IL 157669A0
Authority
IL
Israel
Prior art keywords
nitrogen
camptothecin derivatives
camptothecin
based camptothecin
esters
Prior art date
Application number
IL15766902A
Other languages
English (en)
Original Assignee
Catholic Healthcare West
California Pacific Med Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catholic Healthcare West, California Pacific Med Center filed Critical Catholic Healthcare West
Publication of IL157669A0 publication Critical patent/IL157669A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL15766902A 2001-03-01 2002-02-06 Nitrogen-based camptothecin derivatives IL157669A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/797,765 US6403604B1 (en) 2001-03-01 2001-03-01 Nitrogen-based camptothecin derivatives
PCT/US2002/003798 WO2002070525A2 (fr) 2001-03-01 2002-02-06 Derives de camptothecine azotes

Publications (1)

Publication Number Publication Date
IL157669A0 true IL157669A0 (en) 2004-03-28

Family

ID=25171748

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15766902A IL157669A0 (en) 2001-03-01 2002-02-06 Nitrogen-based camptothecin derivatives
IL157669A IL157669A (en) 2001-03-01 2003-08-31 Nitrogen-based camptothecin derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157669A IL157669A (en) 2001-03-01 2003-08-31 Nitrogen-based camptothecin derivatives

Country Status (13)

Country Link
US (2) US6403604B1 (fr)
EP (1) EP1383772B1 (fr)
JP (1) JP4584538B2 (fr)
KR (1) KR100853141B1 (fr)
CN (1) CN1246323C (fr)
AT (1) ATE338047T1 (fr)
CA (1) CA2439787C (fr)
DE (1) DE60214359T2 (fr)
ES (1) ES2274020T3 (fr)
IL (2) IL157669A0 (fr)
MX (1) MXPA03007896A (fr)
NZ (1) NZ528115A (fr)
WO (1) WO2002070525A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
AU2003243397A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Homo-camptothecin derivatives
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20080058403A (ko) 2005-09-15 2008-06-25 페인셉터 파마 코포레이션 뉴로트로핀 매개 활성 조절 방법
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN100586952C (zh) * 2006-11-10 2010-02-03 中国药科大学 噁唑骈喜树碱酯衍生物及其制备方法和用途
WO2009089537A2 (fr) 2008-01-11 2009-07-16 Northwestern University Composés anticancéreux
CN104622809B (zh) * 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物
WO2010148138A2 (fr) * 2009-06-17 2010-12-23 Threshold Pharmaceuticals, Inc. Dérivés de camptothécine
US10391056B2 (en) 2011-11-03 2019-08-27 Taiwan Lipsome Company, LTD. Pharmaceutical compositions of hydrophobic camptothecin derivatives
US10980798B2 (en) 2011-11-03 2021-04-20 Taiwan Liposome Company, Ltd. Pharmaceutical compositions of hydrophobic camptothecin derivatives
CN109575044A (zh) * 2018-12-21 2019-04-05 西安交通大学 2-（喜树碱-10-氧基）乙酰胺类化合物和应用
EP4176904A1 (fr) * 2019-03-29 2023-05-10 MedImmune Limited Composés et leurs conjugués
WO2021173773A1 (fr) 2020-02-25 2021-09-02 Mediboston, Inc. Dérivés de camptothécine et leurs utilisations

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
GB9320781D0 (en) 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
GB9504065D0 (en) 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
JPH08333370A (ja) * 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
US6339091B1 (en) 1995-06-21 2002-01-15 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
AU7732996A (en) 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US6096336A (en) 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
CN1107678C (zh) 1996-08-19 2003-05-07 比奥纽默里克药物公司 高亲脂性喜树碱衍生物，其制备方法及其用途
AU739028B2 (en) 1996-09-27 2001-10-04 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
ATE210673T1 (de) 1996-09-30 2001-12-15 Bayer Ag Glycokonjugate von modifizierten camptothecin- derivaten (20-o-verknüpfung)
SG104284A1 (en) 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
UA57757C2 (uk) 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
ID23424A (id) 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6057303A (en) 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000066127A1 (fr) 1999-05-04 2000-11-09 Bionumerik Pharmaceuticals, Inc. Nouveaux analogues de la camptothecine fortement liphophiles
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
GB0119578D0 (en) 2001-08-10 2001-10-03 Pharmacia & Upjohn Spa Fluoro linkers

Also Published As

Publication number Publication date
JP4584538B2 (ja) 2010-11-24
KR100853141B1 (ko) 2008-08-20
US20030073698A1 (en) 2003-04-17
JP2004529114A (ja) 2004-09-24
US6403604B1 (en) 2002-06-11
EP1383772A2 (fr) 2004-01-28
ES2274020T3 (es) 2007-05-16
MXPA03007896A (es) 2004-06-07
CA2439787A1 (fr) 2002-09-12
DE60214359T2 (de) 2007-08-30
ATE338047T1 (de) 2006-09-15
CN1511159A (zh) 2004-07-07
NZ528115A (en) 2006-04-28
WO2002070525A3 (fr) 2003-02-20
CA2439787C (fr) 2011-05-24
EP1383772B1 (fr) 2006-08-30
CN1246323C (zh) 2006-03-22
KR20040002872A (ko) 2004-01-07
DE60214359D1 (en) 2006-10-12
IL157669A (en) 2010-11-30
US6825207B2 (en) 2004-11-30
WO2002070525A2 (fr) 2002-09-12

Similar Documents

Publication Publication Date Title
IL157669A0 (en) Nitrogen-based camptothecin derivatives
IL156967A0 (en) Camptothecin derivatives
ZA200005098B (en) Method for stabilizing pharmaceutical compositions by special use of an antioxidant.
PL367682A1 (en) Dolastatin 10 derivatives
PL343495A1 (en) Heterocyclically substituted amides used as calpain inhibitors
PL304649A1 (en) Novel derivatives of taxane and pharmaceutical agents
WO2004043954A3 (fr) Trans-9,10-dehydroepothilones c et d, leurs analogues et leurs procedes de production
CY2538B1 (en) Tetrahydropyrido compounds
IL160437A0 (en) INDENO [1,2-c] ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
HUP0402291A2 (hu) Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
DE69938192D1 (en) Imidazonaphthyridine
ATE260282T1 (de) Aromatische ester von camptothecinen und verfahren zur behandlung von krebserkrankungen
MXPA04003755A (es) Endoprotesis vasculares.
GB9907571D0 (en) Compounds
ZA886097B (en) Pharmaceutical composition for the treatment of psoriasis
AU2002218337A1 (en) Method for inducing cognition enhancement by use of trimethyl-bicyclo(2.2.1)heptane derivatives
MY125674A (en) Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
NO943765L (no) Aryloksybenzen-herbicidmidler
MXPA03010737A (es) Aril-8-azabiciclo(3.2.1) octanos para tratamiento de depresion.
EP1436279B8 (fr) Composes chimiques
HK1082727A1 (en) 2" oxo-voruscharin and derivatives thereof
ES2103237A1 (es) Nuevo compuesto derivado del cromeno
ZA200400824B (en) Pyridin-2-yl-methlyamine derivatives for treating opioid dependence.
NZ505085A (en) Pharmaceutical compositions comprising bipapcitide monocarboxylate and/or bipapcitide dicarboxylate for imaging and treating thrombi