IL156461A0 - Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide - Google Patents

Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

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Publication number
IL156461A0
IL156461A0 IL15646101A IL15646101A IL156461A0 IL 156461 A0 IL156461 A0 IL 156461A0 IL 15646101 A IL15646101 A IL 15646101A IL 15646101 A IL15646101 A IL 15646101A IL 156461 A0 IL156461 A0 IL 156461A0
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IL
Israel
Prior art keywords
pyran
fluorophenyl
pyrrole
tetrahydro
oxo
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IL15646101A
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English (en)
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Warner Lambert Co
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of IL156461A0 publication Critical patent/IL156461A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Catalysts (AREA)
IL15646101A 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide IL156461A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26050501P 2001-01-09 2001-01-09
PCT/IB2001/002729 WO2002055519A2 (en) 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Publications (1)

Publication Number Publication Date
IL156461A0 true IL156461A0 (en) 2004-01-04

Family

ID=22989433

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15646101A IL156461A0 (en) 2001-01-09 2001-12-27 Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
IL189358A IL189358A0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide
IL189357A IL189357A0 (en) 2001-01-09 2008-02-07 Novel compounds
IL189359A IL189359A0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL189358A IL189358A0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide
IL189357A IL189357A0 (en) 2001-01-09 2008-02-07 Novel compounds
IL189359A IL189359A0 (en) 2001-01-09 2008-02-07 Novel process for the synthesis of 5 - (4 - fluorophenyl) - 1 - [2 - ((2r, 4r)- 4 - hydroxy - 6 - oxo -tetrahydro - pyran - 2 - yl) - ethyl] - 2 - isopropyl- 4 - phenyl - 1h - pyrrole - 3 - carboxylic acid phenylamide

Country Status (25)

Country Link
US (7) US6476235B2 (zh)
EP (1) EP1353917B1 (zh)
JP (2) JP4190285B2 (zh)
KR (3) KR100833911B1 (zh)
CN (4) CN101024626A (zh)
AR (1) AR035680A1 (zh)
AT (1) ATE358126T1 (zh)
BR (1) BR0116739A (zh)
CA (1) CA2432064C (zh)
CY (1) CY1106590T1 (zh)
CZ (1) CZ20031893A3 (zh)
DE (1) DE60127583T2 (zh)
DK (1) DK1353917T3 (zh)
ES (1) ES2282200T3 (zh)
HK (2) HK1060572A1 (zh)
HU (1) HUP0302647A3 (zh)
IL (4) IL156461A0 (zh)
MX (1) MXPA03005284A (zh)
PL (1) PL365283A1 (zh)
PT (1) PT1353917E (zh)
RU (1) RU2244714C1 (zh)
TW (1) TWI293073B (zh)
WO (1) WO2002055519A2 (zh)
YU (1) YU49003A (zh)
ZA (1) ZA200304684B (zh)

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US7199261B2 (en) * 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
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KR100765555B1 (ko) * 2002-08-06 2007-10-09 워너-램버트 캄파니 엘엘씨 5-(4-플루오로페닐)-1-[2-((2ｒ,4ｒ)-4-히드록시-6-옥소-테트라히드로-피란-2-일)에틸]-2-이소프로필-4-페닐-1ｈ-피롤-3-카르복실산 페닐아미드의 제조 방법
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RU2330840C1 (ru) * 2004-04-16 2008-08-10 Пфайзер Продактс Инк. Способ получения аморфного кальций аторвастатина
ES2739493T3 (es) 2004-05-05 2020-01-31 Pfizer Prod Inc Formas de sal de de atorvastatina con benetamina
CZ299175B6 (cs) * 2004-06-17 2008-05-07 Zentiva, A. S Zpusob stanovení enantiomerní cistoty 2-(4-fluorfenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-fenyl-4[(fenylamino)-karbonyl]-1H-pyrrol-1-heptanové kyseliny a jejích solí
JP5000502B2 (ja) * 2004-07-16 2012-08-15 レツク・フアーマシユーテイカルズ・デー・デー アトルバスタチンカルシウムの酸化分解生成物
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HUP0302647A2 (hu) 2003-11-28
EP1353917B1 (en) 2007-03-28
CZ20031893A3 (cs) 2004-03-17
KR100677008B1 (ko) 2007-02-01
US6933393B2 (en) 2005-08-23
CA2432064C (en) 2007-09-11
US20070032663A1 (en) 2007-02-08
PL365283A1 (en) 2004-12-27
JP2004520351A (ja) 2004-07-08
US20030195353A1 (en) 2003-10-16
KR100582326B1 (ko) 2006-05-22
AR035680A1 (es) 2004-06-23
US7399773B2 (en) 2008-07-15
US6545153B1 (en) 2003-04-08
AU2002222430B2 (en) 2007-05-17
CN100351252C (zh) 2007-11-28
KR20060015698A (ko) 2006-02-17
IL189358A0 (en) 2008-06-05
US7183408B2 (en) 2007-02-27
CY1106590T1 (el) 2012-01-25
DE60127583D1 (de) 2007-05-10
HUP0302647A3 (en) 2009-03-30
DE60127583T2 (de) 2007-12-06
US20050239869A1 (en) 2005-10-27
ATE358126T1 (de) 2007-04-15
DK1353917T3 (da) 2007-06-18
YU49003A (sh) 2006-05-25
PT1353917E (pt) 2007-05-31
JP2008100989A (ja) 2008-05-01
TWI293073B (en) 2008-02-01
MXPA03005284A (es) 2003-09-25
US7371855B2 (en) 2008-05-13
RU2244714C1 (ru) 2005-01-20
EP1353917A2 (en) 2003-10-22
KR20030065594A (ko) 2003-08-06
IL189357A0 (en) 2008-06-05
CN101024626A (zh) 2007-08-29
KR20060114395A (ko) 2006-11-06
CA2432064A1 (en) 2002-07-18
HK1084114A1 (en) 2006-07-21
US6476235B2 (en) 2002-11-05
US20020133026A1 (en) 2002-09-19
CN1696129A (zh) 2005-11-16
WO2002055519A2 (en) 2002-07-18
WO2002055519A3 (en) 2002-09-19
US20070032664A1 (en) 2007-02-08
BR0116739A (pt) 2003-09-30
CN1907984A (zh) 2007-02-07
HK1060572A1 (en) 2004-08-13
ZA200304684B (en) 2004-06-28
IL189359A0 (en) 2008-06-05
US20070032662A1 (en) 2007-02-08
KR100833911B1 (ko) 2008-06-03
US7361771B2 (en) 2008-04-22
JP4190285B2 (ja) 2008-12-03
CN1489587A (zh) 2004-04-14
CN1222521C (zh) 2005-10-12
ES2282200T3 (es) 2007-10-16

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