IL155658A0 - Heteroarylacryloylaminoalkyl substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them - Google Patents
Heteroarylacryloylaminoalkyl substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising themInfo
- Publication number
- IL155658A0 IL155658A0 IL15565801A IL15565801A IL155658A0 IL 155658 A0 IL155658 A0 IL 155658A0 IL 15565801 A IL15565801 A IL 15565801A IL 15565801 A IL15565801 A IL 15565801A IL 155658 A0 IL155658 A0 IL 155658A0
- Authority
- IL
- Israel
- Prior art keywords
- heteroarylacryloylaminoalkyl
- preparation
- pharmaceutical preparations
- cardiac
- compounds
- Prior art date
Links
- 150000008331 benzenesulfonamides Chemical class 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001515 vagal effect Effects 0.000 abstract 2
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 102000016924 KATP Channels Human genes 0.000 abstract 1
- 108010053914 KATP Channels Proteins 0.000 abstract 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10054482A DE10054482A1 (de) | 2000-11-03 | 2000-11-03 | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP2001/012142 WO2002036565A1 (fr) | 2000-11-03 | 2001-10-20 | Derives de benzenesulfonamide substitues par heteroarylacryloylaminoalkyle, leur preparation, leur utilisation et preparations pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155658A0 true IL155658A0 (en) | 2003-11-23 |
Family
ID=7662010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15565801A IL155658A0 (en) | 2000-11-03 | 2001-10-20 | Heteroarylacryloylaminoalkyl substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them |
| IL155658A IL155658A (en) | 2000-11-03 | 2003-04-29 | Heteroarylacryloylaminoalkyl- substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL155658A IL155658A (en) | 2000-11-03 | 2003-04-29 | Heteroarylacryloylaminoalkyl- substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6472413B2 (fr) |
| EP (1) | EP1335902B1 (fr) |
| JP (1) | JP4281991B2 (fr) |
| AT (1) | ATE410414T1 (fr) |
| AU (2) | AU2002223631B2 (fr) |
| CA (1) | CA2427548C (fr) |
| DE (2) | DE10054482A1 (fr) |
| DK (1) | DK1335902T3 (fr) |
| ES (1) | ES2315314T3 (fr) |
| IL (2) | IL155658A0 (fr) |
| MX (1) | MXPA03003778A (fr) |
| PT (1) | PT1335902E (fr) |
| WO (1) | WO2002036565A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956846B2 (en) * | 2002-08-16 | 2005-10-18 | Utstarcom Incorporated | System and method for foreign agent control node redundancy in a mobile internet protocol network |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1493672C3 (de) * | 1964-08-01 | 1974-05-02 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1518816C3 (de) | 1965-03-24 | 1975-05-22 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| US4066639A (en) | 1965-05-06 | 1978-01-03 | Hoechst Aktiengesellschaft | Benzene-sulfonyl semicarbazides and process for preparing them |
| DE59401361D1 (de) | 1993-02-23 | 1997-02-06 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE4341655A1 (de) | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE19505397A1 (de) | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832009A1 (de) * | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| HK1040187B (zh) | 1998-09-10 | 2005-09-02 | 萨诺费－阿文蒂斯德国有限公司 | 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途 |
| DE19923086A1 (de) * | 1999-05-20 | 2000-11-23 | Aventis Pharma Gmbh | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
2000
- 2000-11-03 DE DE10054482A patent/DE10054482A1/de not_active Withdrawn
-
2001
- 2001-10-20 WO PCT/EP2001/012142 patent/WO2002036565A1/fr not_active Ceased
- 2001-10-20 PT PT01992700T patent/PT1335902E/pt unknown
- 2001-10-20 JP JP2002539325A patent/JP4281991B2/ja not_active Expired - Fee Related
- 2001-10-20 AU AU2002223631A patent/AU2002223631B2/en not_active Ceased
- 2001-10-20 ES ES01992700T patent/ES2315314T3/es not_active Expired - Lifetime
- 2001-10-20 CA CA2427548A patent/CA2427548C/fr not_active Expired - Fee Related
- 2001-10-20 AU AU2363102A patent/AU2363102A/xx active Pending
- 2001-10-20 DE DE60136088T patent/DE60136088D1/de not_active Expired - Lifetime
- 2001-10-20 EP EP01992700A patent/EP1335902B1/fr not_active Expired - Lifetime
- 2001-10-20 MX MXPA03003778A patent/MXPA03003778A/es active IP Right Grant
- 2001-10-20 AT AT01992700T patent/ATE410414T1/de active
- 2001-10-20 IL IL15565801A patent/IL155658A0/xx unknown
- 2001-10-20 DK DK01992700T patent/DK1335902T3/da active
- 2001-11-02 US US09/985,359 patent/US6472413B2/en not_active Expired - Lifetime
-
2003
- 2003-04-29 IL IL155658A patent/IL155658A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004513114A (ja) | 2004-04-30 |
| DE60136088D1 (de) | 2008-11-20 |
| AU2002223631B2 (en) | 2006-07-06 |
| AU2363102A (en) | 2002-05-15 |
| JP4281991B2 (ja) | 2009-06-17 |
| IL155658A (en) | 2010-04-15 |
| CA2427548C (fr) | 2010-11-16 |
| MXPA03003778A (es) | 2003-07-28 |
| DE10054482A1 (de) | 2002-05-08 |
| US20020123495A1 (en) | 2002-09-05 |
| WO2002036565A1 (fr) | 2002-05-10 |
| ATE410414T1 (de) | 2008-10-15 |
| ES2315314T3 (es) | 2009-04-01 |
| PT1335902E (pt) | 2009-01-19 |
| US6472413B2 (en) | 2002-10-29 |
| DK1335902T3 (da) | 2009-02-16 |
| EP1335902B1 (fr) | 2008-10-08 |
| EP1335902A1 (fr) | 2003-08-20 |
| CA2427548A1 (fr) | 2002-05-10 |
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