IL152728A0 - 2-substituted pregna-1,3,5 (10)-triene and chola-1,3,5(10)-triene derivatives and their biological activity - Google Patents
2-substituted pregna-1,3,5 (10)-triene and chola-1,3,5(10)-triene derivatives and their biological activityInfo
- Publication number
- IL152728A0 IL152728A0 IL15272801A IL15272801A IL152728A0 IL 152728 A0 IL152728 A0 IL 152728A0 IL 15272801 A IL15272801 A IL 15272801A IL 15272801 A IL15272801 A IL 15272801A IL 152728 A0 IL152728 A0 IL 152728A0
- Authority
- IL
- Israel
- Prior art keywords
- group
- triene
- chola
- carboxaldehyde
- hydrogen
- Prior art date
Links
- 230000004071 biological effect Effects 0.000 title 1
- MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20346200P | 2000-05-11 | 2000-05-11 | |
| PCT/GB2001/002103 WO2001085755A1 (en) | 2000-05-11 | 2001-05-11 | 2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL152728A0 true IL152728A0 (en) | 2003-06-24 |
Family
ID=22754111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15272801A IL152728A0 (en) | 2000-05-11 | 2001-05-11 | 2-substituted pregna-1,3,5 (10)-triene and chola-1,3,5(10)-triene derivatives and their biological activity |
| IL152728A IL152728A (en) | 2000-05-11 | 2002-11-10 | History of Pargan - 5,3,1 (10) - Trian and the whole - 5,3,1 (10) - Trian - 2 - Transformed and their biological activity |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL152728A IL152728A (en) | 2000-05-11 | 2002-11-10 | History of Pargan - 5,3,1 (10) - Trian and the whole - 5,3,1 (10) - Trian - 2 - Transformed and their biological activity |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1287017B1 (cs) |
| JP (1) | JP2003532737A (cs) |
| KR (1) | KR100740354B1 (cs) |
| CN (1) | CN100338088C (cs) |
| AT (1) | ATE301130T1 (cs) |
| AU (1) | AU784563B2 (cs) |
| CA (1) | CA2408751A1 (cs) |
| CZ (1) | CZ298835B6 (cs) |
| DE (1) | DE60112438T2 (cs) |
| DK (1) | DK1287017T3 (cs) |
| ES (1) | ES2247102T3 (cs) |
| IL (2) | IL152728A0 (cs) |
| NO (1) | NO323857B1 (cs) |
| NZ (1) | NZ523042A (cs) |
| WO (1) | WO2001085755A1 (cs) |
| ZA (1) | ZA200209060B (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| CA2430100A1 (en) * | 2000-11-27 | 2002-05-30 | Entremed, Inc. | Antiangiogenic agents |
| WO2002092100A1 (en) * | 2001-05-11 | 2002-11-21 | Marsden, John, Christopher | 17-(c(ch3) (ch2) o-3c (r4, r5) n (r6, r7))-substituted 19-nor-pregna-1, 3, 5(10)-triene derivatives and their medical use |
| DE602004024966D1 (de) | 2003-03-24 | 2010-02-25 | Sterix Ltd | Oestrogenderivate als steroid sulphatase inhibitoren |
| US7371741B2 (en) | 2003-05-28 | 2008-05-13 | Entremed, Inc. | Estradiol derivatives and pharmaceutical compositions using same |
| EP1756139A4 (en) | 2004-03-12 | 2009-07-29 | Entremed Inc | ANTI-ANGIOGENIC AGENTS |
| CA2646065C (en) | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
| JPS54112580A (en) * | 1978-02-23 | 1979-09-03 | Nec Corp | Electroless discharge lamp |
| JPS54112849A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of steroid derivative |
| JPS54112850A (en) * | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Steroid derivative and its preparation |
| JPS54117456A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Alkoxysteroid derivative |
| JPS54117455A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Novel 19-norsteroid derivative |
| JPS54117454A (en) * | 1978-03-02 | 1979-09-12 | Mitsubishi Chem Ind Ltd | Acylsteroid derivative |
| GB9804861D0 (en) * | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
-
2001
- 2001-05-11 JP JP2001582354A patent/JP2003532737A/ja active Pending
- 2001-05-11 WO PCT/GB2001/002103 patent/WO2001085755A1/en active IP Right Grant
- 2001-05-11 NZ NZ523042A patent/NZ523042A/en unknown
- 2001-05-11 IL IL15272801A patent/IL152728A0/xx active IP Right Grant
- 2001-05-11 ES ES01928120T patent/ES2247102T3/es not_active Expired - Lifetime
- 2001-05-11 AT AT01928120T patent/ATE301130T1/de not_active IP Right Cessation
- 2001-05-11 KR KR1020027015057A patent/KR100740354B1/ko not_active Expired - Fee Related
- 2001-05-11 CZ CZ20023719A patent/CZ298835B6/cs not_active IP Right Cessation
- 2001-05-11 EP EP01928120A patent/EP1287017B1/en not_active Expired - Lifetime
- 2001-05-11 DK DK01928120T patent/DK1287017T3/da active
- 2001-05-11 DE DE60112438T patent/DE60112438T2/de not_active Expired - Fee Related
- 2001-05-11 AU AU54984/01A patent/AU784563B2/en not_active Ceased
- 2001-05-11 CN CNB018124445A patent/CN100338088C/zh not_active Expired - Fee Related
- 2001-05-11 CA CA002408751A patent/CA2408751A1/en not_active Abandoned
-
2002
- 2002-11-07 ZA ZA200209060A patent/ZA200209060B/en unknown
- 2002-11-10 IL IL152728A patent/IL152728A/en not_active IP Right Cessation
- 2002-11-11 NO NO20025392A patent/NO323857B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ523042A (en) | 2004-05-28 |
| DK1287017T3 (da) | 2005-12-05 |
| HK1053843A1 (en) | 2003-11-07 |
| WO2001085755A1 (en) | 2001-11-15 |
| EP1287017B1 (en) | 2005-08-03 |
| AU5498401A (en) | 2001-11-20 |
| NO20025392L (no) | 2003-01-09 |
| NO20025392D0 (no) | 2002-11-11 |
| DE60112438T2 (de) | 2006-06-08 |
| CN1444597A (zh) | 2003-09-24 |
| ES2247102T3 (es) | 2006-03-01 |
| KR20030031899A (ko) | 2003-04-23 |
| AU784563B2 (en) | 2006-05-04 |
| JP2003532737A (ja) | 2003-11-05 |
| NO323857B1 (no) | 2007-07-16 |
| EP1287017A1 (en) | 2003-03-05 |
| CZ20023719A3 (cs) | 2003-04-16 |
| CZ298835B6 (cs) | 2008-02-20 |
| KR100740354B1 (ko) | 2007-07-26 |
| DE60112438D1 (de) | 2005-09-08 |
| CN100338088C (zh) | 2007-09-19 |
| ATE301130T1 (de) | 2005-08-15 |
| CA2408751A1 (en) | 2001-11-15 |
| IL152728A (en) | 2007-02-11 |
| ZA200209060B (en) | 2004-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |