IL152428A0 - Formulations and method of using nitric oxide mimetics against a malignant cell phenotype - Google Patents

Formulations and method of using nitric oxide mimetics against a malignant cell phenotype

Info

Publication number
IL152428A0
IL152428A0 IL15242801A IL15242801A IL152428A0 IL 152428 A0 IL152428 A0 IL 152428A0 IL 15242801 A IL15242801 A IL 15242801A IL 15242801 A IL15242801 A IL 15242801A IL 152428 A0 IL152428 A0 IL 152428A0
Authority
IL
Israel
Prior art keywords
formulations
nitric oxide
cell phenotype
malignant cell
oxide mimetics
Prior art date
Application number
IL15242801A
Other languages
English (en)
Original Assignee
Univ Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kingston filed Critical Univ Kingston
Publication of IL152428A0 publication Critical patent/IL152428A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL15242801A 2000-04-26 2001-04-26 Formulations and method of using nitric oxide mimetics against a malignant cell phenotype IL152428A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19975700P 2000-04-26 2000-04-26
US27746901P 2001-03-21 2001-03-21
PCT/CA2001/000566 WO2001080890A2 (fr) 2000-04-26 2001-04-26 Formulations et methodes d'utilisation d'agents mimetiques de l'oxyde nitrique contre un phenotype cellulaire malin

Publications (1)

Publication Number Publication Date
IL152428A0 true IL152428A0 (en) 2003-05-29

Family

ID=26895114

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15242801A IL152428A0 (en) 2000-04-26 2001-04-26 Formulations and method of using nitric oxide mimetics against a malignant cell phenotype
IL152428A IL152428A (en) 2000-04-26 2002-10-22 Nitric oxide mimetic compositions for use against a malignant cell phenotype

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152428A IL152428A (en) 2000-04-26 2002-10-22 Nitric oxide mimetic compositions for use against a malignant cell phenotype

Country Status (12)

Country Link
US (1) US6946484B2 (fr)
EP (1) EP1278547B1 (fr)
JP (1) JP2003531179A (fr)
AT (1) ATE281177T1 (fr)
AU (2) AU2001250221B2 (fr)
CA (1) CA2407466C (fr)
DE (1) DE60106905T2 (fr)
ES (1) ES2232613T3 (fr)
HK (1) HK1052468B (fr)
IL (2) IL152428A0 (fr)
MX (1) MXPA02010551A (fr)
WO (1) WO2001080890A2 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678391B2 (en) 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
AU2003208228A1 (en) * 2002-03-06 2003-09-16 Cellegy Pharmaceuticals, Inc Formulations and methods of using nitric oxide mimetics in cancer treatment
US20050119278A1 (en) * 2002-05-16 2005-06-02 Che-Ming Teng Anti-angiogenesis methods
US20050096370A1 (en) * 2003-04-07 2005-05-05 Bizbiotech Co., Ltd. Method for inhibiting tumor angiogenesis and tumor growth
ES2294543T3 (es) 2003-07-09 2008-04-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Heal Uso de sales de nitrilo para el tratamiento de afecciones cardiovasculares.
ES2365023T3 (es) 2004-04-21 2011-09-20 Enobia Pharma Inc. Conjugados de administración ósea y método de uso de los mismos para dirigir proteínas a hueso.
SE0401871D0 (sv) * 2004-07-15 2004-07-15 Glucogene Medical Hfm Ab New compositions
CA2580795A1 (fr) * 2004-09-22 2006-04-06 Tripath Imaging, Inc. Methodes et compositions permettant d'evaluer un pronostic de cancer du sein
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
WO2006128121A2 (fr) 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Particules liberant de l'oxyde nitrique pour therapie a base d'oxyde nitrique et applications biomedicales
US20070172847A1 (en) * 2005-11-15 2007-07-26 The Regents Of The University Of California Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses
US20070202155A1 (en) * 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
WO2007123777A2 (fr) * 2006-03-30 2007-11-01 Duke University Inhibition de l'activation hif-1 pour des réponses antitumorales et anti-inflammatoires
GB0607402D0 (en) 2006-04-12 2006-05-24 Barts & London Nhs Trust Therapeutic composition and use
US20070259026A1 (en) * 2006-04-20 2007-11-08 Robert Ang Vasodialating dressing for use with intravenous catheters
US8766512B2 (en) * 2009-03-31 2014-07-01 Sand 9, Inc. Integration of piezoelectric materials with substrates
US20100221247A1 (en) * 2008-09-29 2010-09-02 Robert Bender Agents and methods for treatment of cancer
ES2958410T3 (es) 2009-08-21 2024-02-08 Novan Inc Geles tópicos
EP2467173B8 (fr) 2009-08-21 2019-06-19 Novan, Inc. Pansements, procédés d'utilisation de ceux-ci et procédés de formation de ceux-ci
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
EP2658979B1 (fr) 2010-12-27 2018-02-14 Alexion Pharmaceuticals, Inc. Compositions contenant des peptides natriurétiques et leurs méthodes d'utilisation
WO2012118042A1 (fr) * 2011-02-28 2012-09-07 独立行政法人国立循環器病研究センター Agent médicinal pour l'inhibition de la métastase d'une tumeur maline
WO2012118829A2 (fr) 2011-02-28 2012-09-07 Novan, Inc. Xérogels libérant de l'oxyde nitrique modifiés par des groupements s-nitrosothiols tertiaires et procédés d'utilisation associés
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
USD949597S1 (en) 2014-06-15 2022-04-26 Bengt Johansson Flooring guard for pets
USD974802S1 (en) * 2013-06-16 2023-01-10 Bengt Johansson Flooring guard for pets
USD975470S1 (en) * 2014-06-15 2023-01-17 Bengt Johansson Flooring guard for pets
WO2016007873A1 (fr) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions et méthodes de traitement de la craniosynostose
ES2931337T3 (es) * 2014-07-31 2022-12-28 Univ Western Australia Un método para la identificación de combinaciones de inmunoterapia-fármacos usando un enfoque de red
CA2957552C (fr) * 2014-08-08 2024-01-16 Vindico Nanobiotechnology, Llc Compositions et procedes d'induction d'une embolisation microvasculaire des tumeurs a mediation par des nanoparticules
US10449236B2 (en) 2014-12-05 2019-10-22 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
CA2973883A1 (fr) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methodes de traitement d'un sujet atteint d'une deficience en phosphatase alcaline
US10456452B2 (en) 2015-07-02 2019-10-29 Poseida Therapeutics, Inc. Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
US11352612B2 (en) 2015-08-17 2022-06-07 Alexion Pharmaceuticals, Inc. Manufacturing of alkaline phosphatases
WO2017058822A1 (fr) 2015-09-28 2017-04-06 Alexion Pharmaceuticals, Inc. Identification de régimes posologiques efficaces pour une thérapie de l'hypophosphatasie de remplacement de l'enzyme phosphatase alcaline non spécifique à des tissus (tnsalp)
EP3368062A4 (fr) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. Méthodes de traitement de la craniosynostose chez un patient
WO2017155569A1 (fr) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez l'enfant
CA3019726A1 (fr) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Traitement d'une faiblesse musculaire a l'aide de phosphatases alcalines
WO2017173395A1 (fr) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez les adolescents et les adultes
ES2865481T3 (es) 2016-04-29 2021-10-15 Poseida Therapeutics Inc Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3500289B1 (fr) 2016-08-18 2024-10-09 Alexion Pharmaceuticals, Inc. Asfotase alfa le traitement de la trachéobronchomalacie
CN110719786A (zh) 2017-03-31 2020-01-21 阿雷克森制药公司 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法
EP3773684A1 (fr) 2018-03-30 2021-02-17 Alexion Pharmaceuticals, Inc. Production de glycoprotéines
CN113975264A (zh) * 2018-04-16 2022-01-28 上海岸阔医药科技有限公司 预防或治疗肿瘤疗法副作用的方法
CA3173631A1 (fr) 2021-02-12 2022-08-18 Walter C. Voegtli Polypeptides de phosphatase alcaline et leurs methodes d'utilisation

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434256A (en) 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5840759A (en) * 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
EP0722320B1 (fr) * 1993-10-08 2000-07-19 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Procede d'utilisation de composes degageant du monoxyde d'azote comme medicamentpour tradiosensibilisation des cellules hypoxiques
US5700830A (en) * 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
LV11542B (en) 1995-03-30 1997-02-20 Latvijas Organiskas Sintezes Instituts Substituted 1,3,9,11-tetraoxa-4,5,7,8-tetraazaundecadien-4,7-dioxides-5,7, preparation and use thereof
US6153186A (en) 1995-09-15 2000-11-28 Duke University Medical Center Red blood cells loaded with S-nitrosothiol and uses therefor
US5849790A (en) 1995-11-17 1998-12-15 The University Of South Florida (Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents
DE19732323C2 (de) * 1996-08-06 1999-08-19 Dunzendorfer Medikamentenkombination zur erhöhten Wirkstoffkonzentration in Geweben
US6057367A (en) 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
EP2292630B1 (fr) 1996-09-27 2015-11-25 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services 1-(2-carboxylato)-pyrrolidin-1-yl diazen-1-ium-1,2-diolates O2-substitués
AU8398398A (en) 1997-07-14 1999-02-10 Brigham And Women's Hospital Modification of nitric oxide activity to treat fas-induced pathologies
EP1060174B1 (fr) 1997-12-23 2004-09-22 Amersham Health AS Chelateurs liberant de l'oxyde nitrique et leur emploi a des fins therapeutiques
CA2330628A1 (fr) 1998-05-01 1999-11-11 Queen's University At Kingston Procede de diagnostic sur l'etat du systeme vasculaire
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
WO2000051597A1 (fr) 1999-03-05 2000-09-08 Merck Frosst Canada & Co. Methodes permettant d'inhiber l'activite de la cathepsine k pour le traitement des pathologies liees a une perte osseuse
US6171620B1 (en) 1999-04-27 2001-01-09 Health Research, Inc. Method of enhancing the efficacy of anti-tumor agents
AU2001233052A1 (en) 2000-01-26 2001-08-07 Cedars-Sinai Medical Center Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor
SE0000303D0 (sv) * 2000-01-31 2000-01-31 Xylogen Ab Novel compounds
JP2003527209A (ja) 2000-03-20 2003-09-16 ノボバスキュラー インコーポレーテッド 一酸化窒素供与体及び還元剤を含有するマトリックス並びにその使用
US20010038832A1 (en) 2000-04-11 2001-11-08 Benjamin Bonavida Nitric oxide and analogues thereof effectuate sensitization of neoplasm and immunologically undesired tissues to cytotoxicity
US7678391B2 (en) * 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
CA2410632A1 (fr) 2000-06-22 2001-12-27 David S. Garvey Taxanes nitroses et nitrosyles, compositions et procedes d'utilisation

Also Published As

Publication number Publication date
DE60106905T2 (de) 2005-12-01
AU2001250221B2 (en) 2006-07-06
WO2001080890A2 (fr) 2001-11-01
HK1052468A1 (en) 2003-09-19
HK1052468B (zh) 2005-06-03
CA2407466A1 (fr) 2001-11-01
EP1278547B1 (fr) 2004-11-03
ES2232613T3 (es) 2005-06-01
CA2407466C (fr) 2010-11-02
AU5022101A (en) 2001-11-07
WO2001080890A3 (fr) 2002-08-08
EP1278547A2 (fr) 2003-01-29
MXPA02010551A (es) 2003-09-25
DE60106905D1 (de) 2004-12-09
US6946484B2 (en) 2005-09-20
IL152428A (en) 2011-06-30
ATE281177T1 (de) 2004-11-15
JP2003531179A (ja) 2003-10-21
US20020040059A1 (en) 2002-04-04

Similar Documents

Publication Publication Date Title
IL152428A0 (en) Formulations and method of using nitric oxide mimetics against a malignant cell phenotype
MY135721A (en) Amidino compounds useful as nitric oxide synthase inhibitors
WO2001054679A3 (fr) Composition d'anesthesique et de vasodilatateur transdermique et procedes pour son administration topique
AU5984701A (en) Method of treating immune pathologies with low dose estrogen
WO2001024816A3 (fr) Compositions et procedes d'inhibition de la caseomorphine et de la gluteomorphine
AP2002002703A0 (en) Combinations of depeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diadetes mellitus.
AU7315301A (en) Compounds and compositions for delivering active agents
IL160222A0 (en) Opioid agonist formulations with releasable and sequestered antagonist
HK1125291A1 (en) Method of using guava extract and composition including guava extract
MXPA02010866A (es) Composiciones y metodos para proteger celulas durante la quimioterapia y radioterapia contra el cancer.
AU2001269688A1 (en) Combination containing an antifolate and methylmalonic acid lowering agent
GEP20043383B (en) Cell Adhesion-Inhibiting Antiinflammatory and Immune-Suppressive Compounds
BR9914163A (pt) Agente para melhorar a potência excretora da bexiga urinária, uso de um composto de amina do tipo não carbamato que tenha uma ação inibidora de acetilcolinesterase, e, método para melhorar a potência excretora da bexiga urinária
MXPA02011247A (es) Quimioterapia de combinacion.
MXPA03004209A (es) Composicion farmaceutica o cosmetica y uso de un inhbidor de proteina cinasa c con un inhibidor de metaloproteasas de la matriz para inhibir la migracion de celulas de langerhans.
MXPA02011431A (es) Composiciones y metodos para usar contra la inflamacion inducida por acne y enzimas que degradan la matriz dermica.
WO2000047231A3 (fr) Nouvelle inhibition antisens de rad51
WO2003106640A3 (fr) Procedes et compositions de ciblage cellulaire
ZA986720B (en) Photoresponsive sunscreen compositions
AP2000001926A0 (en) Voacamine as anti-malarial agent and anti-malarial agent containing voacamine.
EP1303520A4 (fr) Composes therapeutiques et procedes
DE60320283D1 (de) Zusammensetzungen mit Amphotericin B enthaltend weniger als 4% Verunreinigungen
MXPA03010407A (es) Prevencion de adiccion en gestion del dolor.
AU7548901A (en) Liposomal encapsulation of chelated actinium-225 and uses thereof
AU2204400A (en) Monte carlo simulation of neutron transport for use in radiotherapy