IL145701A0 - Purine derivatives having phosphodiesterase iv inhibition activity - Google Patents

Purine derivatives having phosphodiesterase iv inhibition activity

Info

Publication number
IL145701A0
IL145701A0 IL14570100A IL14570100A IL145701A0 IL 145701 A0 IL145701 A0 IL 145701A0 IL 14570100 A IL14570100 A IL 14570100A IL 14570100 A IL14570100 A IL 14570100A IL 145701 A0 IL145701 A0 IL 145701A0
Authority
IL
Israel
Prior art keywords
phosphodiesterase
inhibition activity
purine derivatives
purine
derivatives
Prior art date
Application number
IL14570100A
Other languages
English (en)
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/RU1999/000100 external-priority patent/WO2000059499A1/en
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of IL145701A0 publication Critical patent/IL145701A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14570100A 1999-04-02 2000-03-31 Purine derivatives having phosphodiesterase iv inhibition activity IL145701A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28547399A 1999-04-02 1999-04-02
PCT/RU1999/000100 WO2000059499A1 (en) 1999-04-05 1999-04-05 Use of succinic acid or salts thereof for the treatment of diabetes mellitus and wound healing
PCT/US2000/008525 WO2000059449A2 (en) 1999-04-02 2000-03-31 Purine derivatives having phosphodiesterase iv inhibition activity

Publications (1)

Publication Number Publication Date
IL145701A0 true IL145701A0 (en) 2002-07-25

Family

ID=23094386

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14570100A IL145701A0 (en) 1999-04-02 2000-03-31 Purine derivatives having phosphodiesterase iv inhibition activity

Country Status (12)

Country Link
US (1) US6413975B1 (zh)
EP (1) EP1169321A4 (zh)
JP (1) JP2002541078A (zh)
KR (1) KR20020065341A (zh)
CN (1) CN1377353A (zh)
AR (1) AR029347A1 (zh)
AU (1) AU4053800A (zh)
BR (1) BR0011182A (zh)
CA (1) CA2367143A1 (zh)
HU (1) HUP0200938A2 (zh)
IL (1) IL145701A0 (zh)
WO (1) WO2000059449A2 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030046397A (ko) * 2000-07-28 2003-06-12 슬로안-케테링인스티튜트퍼캔서리서치 세포증식성 질환 및 바이러스 감염의 치료 방법
CA2426952C (en) * 2000-11-02 2012-06-26 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US7825094B2 (en) * 2001-05-23 2010-11-02 Sloan-Kettering Institute For Cancer Research Method of treatment for cancers associated with elevated HER 2 levels
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
US20040001895A1 (en) * 2002-06-17 2004-01-01 Pfizer Inc. Combination treatment for depression and anxiety
KR20050067383A (ko) 2002-08-06 2005-07-01 아스트라제네카 아베 Ｔｉｅ2(ｔｅｋ) 활성을 갖는 축합 피리딘 및 피리미딘
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
WO2005058898A2 (en) * 2003-12-16 2005-06-30 Ranbaxy Laboratories Limited Purine compounds which can be used as phosphodiesterase (pde) type iv inhibitors
KR100677396B1 (ko) * 2004-11-20 2007-02-02 엘지전자 주식회사 음성인식장치의 음성구간 검출방법
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
UY30267A1 (es) * 2006-04-13 2007-11-30 Astrazeneca Ab Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones
CN101472926A (zh) * 2006-04-13 2009-07-01 阿斯利康(瑞典)有限公司 硫代黄嘌呤衍生物以及它们作为髓过氧化物酶抑制剂的用途
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
WO2007142577A1 (en) * 2006-06-05 2007-12-13 Astrazeneca Ab Pyrrolo[3,2-d]pyrimidin-4-one derivative as myeloperoxidase inhibitor
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
KR102712818B1 (ko) * 2018-12-06 2024-09-30 한국화학연구원 Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도
CN118206555A (zh) * 2024-03-15 2024-06-18 海赋药业(海南)有限责任公司 一种3,8-双取代腺嘌呤衍生物、制备方法及其应用

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3215696A (en) 1965-11-02 Substituted adenines -and preparation thereof
US2956998A (en) 1960-10-18 Adenine derivatives and process
US2903455A (en) 1959-09-08 Jdnviiiiaisnvhi jo
US2844577A (en) 1958-07-22 Certificate of correction
US2697709A (en) 1951-06-14 1954-12-21 Burroughs Wellcome Co Mercapto heterocycles and method of making
US2691654A (en) 1952-06-11 1954-10-12 Buroughs Wellcome & Co U S A I Amino heterocycles and method of making
US2966488A (en) 1956-07-30 1960-12-27 Shive William Substituted alkylaminopurines
US2957875A (en) 1957-11-18 1960-10-25 Upjohn Co Derivatives of purine
US3079378A (en) 1960-02-01 1963-02-26 Upjohn Co Acylated psicofuranosyladenines
NL262940A (zh) 1960-03-31
US3135753A (en) 1961-05-10 1964-06-02 Burroughs Wellcome Co Alkylthiopurines and method
FR1548252A (zh) 1961-10-13 1968-12-06
IL24679A (en) 1965-11-24 1971-10-20 Yissum Res Dev Co Derivatives of 3-methyl purine and methods of preparing the same
US3669979A (en) 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
US3952001A (en) 1970-07-01 1976-04-20 The Boots Company Limited 1-Carbamoyl-1,2,4-triazoles
JPS5121529A (ja) 1974-08-16 1976-02-20 Hitachi Ltd Pirorinsandometsukizeiseihimakuboshiho
USRE31429E (en) 1977-02-14 1983-10-25 Merck & Co., Inc. Process for preparation of 9-(dihalobenzyl)adenines
US4171440A (en) * 1977-10-20 1979-10-16 Merck & Co., Inc. Process for purification of 9-(2,6-dihalobenzyl)adenines
GB2041359B (en) 1979-01-10 1982-12-15 Ici Ltd Purine derivatives and their use in the defoliation of cotton plants
US4241063A (en) 1979-08-06 1980-12-23 Bristol-Myers Company Purine derivatives and their use as bronchodilators
EP0052959B1 (en) * 1980-11-14 1986-01-29 Takeda Chemical Industries, Ltd. Production of purine derivatives and intermediates therefor
US4407802A (en) 1981-09-28 1983-10-04 Merck & Co., Inc. 6-Amidino-9-substituted benzyl purines
US4361699A (en) 1981-09-28 1982-11-30 Merck & Co., Inc. Novel process for the preparation of N6 -alkyl-arprinocid
DE3316300A1 (de) 1982-05-07 1983-11-24 Kureha Kagaku Kogyo K.K., Tokyo Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff
US4492592A (en) 1983-06-06 1985-01-08 Shell Oil Company Combined desiccation of substantially supercritical CO2
JPS60260579A (ja) 1984-01-13 1985-12-23 Yoshitomi Pharmaceut Ind Ltd プリン誘導体
US4883801A (en) 1984-09-07 1989-11-28 The General Hospital Corporation Xanthine derivative pest control agents
GB8510758D0 (en) 1985-04-27 1985-06-05 Wellcome Found Compounds
HU215433B (hu) 1986-04-29 2000-05-28 Pfizer Inc. Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására
GB8618931D0 (en) 1986-08-02 1986-09-10 Euro Celtique Sa 6-thioxanthines
US5057517A (en) 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5091431A (en) 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
EP0363320A3 (de) 1988-10-06 1991-11-21 Ciba-Geigy Ag Substituierte 9H-Purine
US4971972A (en) 1989-03-23 1990-11-20 Schering Corporation Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
US5290782A (en) 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
ATE195739T1 (de) 1989-10-20 2000-09-15 Kyowa Hakko Kogyo Kk Kondensierte purinderivate
US5117830A (en) 1990-11-08 1992-06-02 Whitby Research, Inc. Method of determining viability of tissue
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5994629A (en) * 1991-08-28 1999-11-30 Novartis Ag Positive selection
DE69322254T2 (de) 1992-01-13 1999-04-29 Smithkline Beecham Corp., Philadelphia, Pa. 19101 Pyridyl-substituierte imidazole
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
WO1993025517A1 (en) 1992-06-15 1993-12-23 Celltech Limited Trisubstituted phenyl derivatives as selective phosphodiesterase iv inhibitors
JP3775684B2 (ja) 1992-07-28 2006-05-17 ローン−プーラン・ロレ・リミテツド 脂肪族−またはヘテロ原子−含有連結基によりアリールまたはヘテロアリールに連結されたフェニル含有化合物
GB9222253D0 (en) 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
JP3100984B2 (ja) 1992-12-02 2000-10-23 ファイザー・インク． 選択的ｐｄｅ▲下ｉ▼▲下ｖ▼阻害物質としてのカテコールジエーテル類
TW263495B (zh) 1992-12-23 1995-11-21 Celltech Ltd
GB9226830D0 (en) 1992-12-23 1993-02-17 Celltech Ltd Chemical compounds
GB9304920D0 (en) 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304919D0 (en) 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
DE4309969A1 (de) 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
FI951367A (fi) 1994-03-28 1995-09-29 Japan Energy Corp Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit)
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
US6057445A (en) * 1997-12-12 2000-05-02 Euro-Celtique S.A. Purine compounds having PDE IV inhibitory activity and methods of synthesis

Also Published As

Publication number Publication date
EP1169321A4 (en) 2002-10-30
WO2000059449A3 (en) 2001-01-04
CA2367143A1 (en) 2000-10-12
AU4053800A (en) 2000-10-23
JP2002541078A (ja) 2002-12-03
BR0011182A (pt) 2003-06-10
KR20020065341A (ko) 2002-08-13
CN1377353A (zh) 2002-10-30
EP1169321A2 (en) 2002-01-09
HUP0200938A2 (en) 2002-10-28
US6413975B1 (en) 2002-07-02
AR029347A1 (es) 2003-06-25
WO2000059449A2 (en) 2000-10-12

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