IL145701A0 - Purine derivatives having phosphodiesterase iv inhibition activity - Google Patents
Purine derivatives having phosphodiesterase iv inhibition activityInfo
- Publication number
- IL145701A0 IL145701A0 IL14570100A IL14570100A IL145701A0 IL 145701 A0 IL145701 A0 IL 145701A0 IL 14570100 A IL14570100 A IL 14570100A IL 14570100 A IL14570100 A IL 14570100A IL 145701 A0 IL145701 A0 IL 145701A0
- Authority
- IL
- Israel
- Prior art keywords
- phosphodiesterase
- inhibition activity
- purine derivatives
- purine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28547399A | 1999-04-02 | 1999-04-02 | |
PCT/RU1999/000100 WO2000059499A1 (fr) | 1999-04-05 | 1999-04-05 | Utilisation d'acide succinique ou de ses sels dans le traitement du diabete et la cicatrisation de blessures |
PCT/US2000/008525 WO2000059449A2 (fr) | 1999-04-02 | 2000-03-31 | Derives de purine possedant une activite d'inhibition de la phosphodiesterase iv |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145701A0 true IL145701A0 (en) | 2002-07-25 |
Family
ID=23094386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14570100A IL145701A0 (en) | 1999-04-02 | 2000-03-31 | Purine derivatives having phosphodiesterase iv inhibition activity |
Country Status (12)
Country | Link |
---|---|
US (1) | US6413975B1 (fr) |
EP (1) | EP1169321A4 (fr) |
JP (1) | JP2002541078A (fr) |
KR (1) | KR20020065341A (fr) |
CN (1) | CN1377353A (fr) |
AR (1) | AR029347A1 (fr) |
AU (1) | AU4053800A (fr) |
BR (1) | BR0011182A (fr) |
CA (1) | CA2367143A1 (fr) |
HU (1) | HUP0200938A2 (fr) |
IL (1) | IL145701A0 (fr) |
WO (1) | WO2000059449A2 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6946456B2 (en) * | 2000-07-28 | 2005-09-20 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
CN1501928A (zh) * | 2000-11-02 | 2004-06-02 | 斯隆-凯特林癌症研究所 | 结合hsp90的小分子组合物 |
FR2818642B1 (fr) * | 2000-12-26 | 2005-07-15 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion |
EP1404871A4 (fr) * | 2001-05-23 | 2006-10-04 | Sloan Kettering Inst Cancer | Methode de traitement de cancers associes a des niveaux de her-2 eleves |
AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
US20040001895A1 (en) * | 2002-06-17 | 2004-01-01 | Pfizer Inc. | Combination treatment for depression and anxiety |
WO2004013141A1 (fr) | 2002-08-06 | 2004-02-12 | Astrazeneca Ab | Pyridines condensees et pyrimidines a activite tie2 (tek) |
SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
WO2005058898A2 (fr) * | 2003-12-16 | 2005-06-30 | Ranbaxy Laboratories Limited | Inhibiteurs de la phosphodiesterase |
KR100677396B1 (ko) * | 2004-11-20 | 2007-02-02 | 엘지전자 주식회사 | 음성인식장치의 음성구간 검출방법 |
MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
TW200806667A (en) * | 2006-04-13 | 2008-02-01 | Astrazeneca Ab | New compounds |
CN101472926A (zh) * | 2006-04-13 | 2009-07-01 | 阿斯利康(瑞典)有限公司 | 硫代黄嘌呤衍生物以及它们作为髓过氧化物酶抑制剂的用途 |
JP2009539829A (ja) * | 2006-06-05 | 2009-11-19 | アストラゼネカ・アクチエボラーグ | ミエロペルオキシダーゼ阻害剤としてのピロロ[3,2−d]ピリミジン−4−オン誘導体 |
TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
TW200840566A (en) * | 2006-12-22 | 2008-10-16 | Esteve Labor Dr | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
KR20200068996A (ko) * | 2018-12-06 | 2020-06-16 | 한국화학연구원 | Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도 |
CN118206555A (zh) * | 2024-03-15 | 2024-06-18 | 海赋药业(海南)有限责任公司 | 一种3,8-双取代腺嘌呤衍生物、制备方法及其应用 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2903455A (en) | 1959-09-08 | Jdnviiiiaisnvhi jo | ||
US2956998A (en) | 1960-10-18 | Adenine derivatives and process | ||
US2844577A (en) | 1958-07-22 | Certificate of correction | ||
US3215696A (en) | 1965-11-02 | Substituted adenines -and preparation thereof | ||
US2697709A (en) | 1951-06-14 | 1954-12-21 | Burroughs Wellcome Co | Mercapto heterocycles and method of making |
US2691654A (en) | 1952-06-11 | 1954-10-12 | Buroughs Wellcome & Co U S A I | Amino heterocycles and method of making |
US2966488A (en) | 1956-07-30 | 1960-12-27 | Shive William | Substituted alkylaminopurines |
US2957875A (en) | 1957-11-18 | 1960-10-25 | Upjohn Co | Derivatives of purine |
US3079378A (en) | 1960-02-01 | 1963-02-26 | Upjohn Co | Acylated psicofuranosyladenines |
BE601946A (fr) | 1960-03-31 | |||
US3135753A (en) | 1961-05-10 | 1964-06-02 | Burroughs Wellcome Co | Alkylthiopurines and method |
FR1548252A (fr) | 1961-10-13 | 1968-12-06 | ||
IL24679A (en) | 1965-11-24 | 1971-10-20 | Yissum Res Dev Co | Derivatives of 3-methyl purine and methods of preparing the same |
US3669979A (en) | 1967-12-14 | 1972-06-13 | Gaf Corp | Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst |
US3952001A (en) | 1970-07-01 | 1976-04-20 | The Boots Company Limited | 1-Carbamoyl-1,2,4-triazoles |
JPS5121529A (ja) | 1974-08-16 | 1976-02-20 | Hitachi Ltd | Pirorinsandometsukizeiseihimakuboshiho |
USRE31429E (en) | 1977-02-14 | 1983-10-25 | Merck & Co., Inc. | Process for preparation of 9-(dihalobenzyl)adenines |
US4171440A (en) * | 1977-10-20 | 1979-10-16 | Merck & Co., Inc. | Process for purification of 9-(2,6-dihalobenzyl)adenines |
GB2041359B (en) | 1979-01-10 | 1982-12-15 | Ici Ltd | Purine derivatives and their use in the defoliation of cotton plants |
US4241063A (en) | 1979-08-06 | 1980-12-23 | Bristol-Myers Company | Purine derivatives and their use as bronchodilators |
EP0052959B1 (fr) * | 1980-11-14 | 1986-01-29 | Takeda Chemical Industries, Ltd. | Production de dérivés de purine et leurs intermédiaires |
US4407802A (en) | 1981-09-28 | 1983-10-04 | Merck & Co., Inc. | 6-Amidino-9-substituted benzyl purines |
US4361699A (en) | 1981-09-28 | 1982-11-30 | Merck & Co., Inc. | Novel process for the preparation of N6 -alkyl-arprinocid |
DE3316300A1 (de) | 1982-05-07 | 1983-11-24 | Kureha Kagaku Kogyo K.K., Tokyo | Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff |
US4492592A (en) | 1983-06-06 | 1985-01-08 | Shell Oil Company | Combined desiccation of substantially supercritical CO2 |
JPS60260579A (ja) | 1984-01-13 | 1985-12-23 | Yoshitomi Pharmaceut Ind Ltd | プリン誘導体 |
US4883801A (en) | 1984-09-07 | 1989-11-28 | The General Hospital Corporation | Xanthine derivative pest control agents |
GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
WO1987006576A1 (fr) | 1986-04-29 | 1987-11-05 | Pfizer Inc. | ANTIDEPRESSEUR INHIBITEUR DE PHOSPHODIESTERASE DE MPA-c INDEPENDANTE DU CALCIUM |
GB8618931D0 (en) | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
US5057517A (en) | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
US5091431A (en) | 1988-02-08 | 1992-02-25 | Schering Corporation | Phosphodiesterase inhibitors |
EP0363320A3 (fr) | 1988-10-06 | 1991-11-21 | Ciba-Geigy Ag | 9H-purine substituée |
US4971972A (en) | 1989-03-23 | 1990-11-20 | Schering Corporation | Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion |
US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
ATE195739T1 (de) | 1989-10-20 | 2000-09-15 | Kyowa Hakko Kogyo Kk | Kondensierte purinderivate |
US5117830A (en) | 1990-11-08 | 1992-06-02 | Whitby Research, Inc. | Method of determining viability of tissue |
US5177074A (en) | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
US5994629A (en) * | 1991-08-28 | 1999-11-30 | Novartis Ag | Positive selection |
MX9300141A (es) | 1992-01-13 | 1994-07-29 | Smithkline Beecham Corp | Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
JP3264492B2 (ja) | 1992-01-13 | 2002-03-11 | スミスクライン・ビーチャム・コーポレイション | ピリジル置換イミダゾール |
EP0607373B1 (fr) | 1992-06-15 | 1997-03-19 | Celltech Therapeutics Limited | Derives a groupe phenyle trisubstitue utilises comme inhibiteurs selectifs de la phosphodiesterase iv |
IL106517A0 (en) | 1992-07-28 | 1994-08-26 | Rhone Poulenc Rorer Ltd | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group |
GB9222253D0 (en) | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
DE69332762T2 (de) | 1992-12-02 | 2003-08-14 | Pfizer Inc., New York | Cathecoldiether als selektive pde iv hemmungsmittel |
GB9226830D0 (en) | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
TW263495B (fr) | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
GB9304919D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
FI951367A (fi) | 1994-03-28 | 1995-09-29 | Japan Energy Corp | Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit) |
US6066641A (en) * | 1994-12-13 | 2000-05-23 | Euro-Celtique S.A. | Aryl thioxanthines |
US5869486A (en) | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
JP2002508379A (ja) * | 1997-12-12 | 2002-03-19 | ユーロ−セルティーク,エス.エイ. | 2−チオキサンチンを経た3−置換アデニン |
-
2000
- 2000-03-31 CN CN00808330A patent/CN1377353A/zh active Pending
- 2000-03-31 AR ARP000101488A patent/AR029347A1/es unknown
- 2000-03-31 HU HU0200938A patent/HUP0200938A2/hu unknown
- 2000-03-31 BR BR0011182-1A patent/BR0011182A/pt not_active IP Right Cessation
- 2000-03-31 CA CA002367143A patent/CA2367143A1/fr not_active Abandoned
- 2000-03-31 IL IL14570100A patent/IL145701A0/xx unknown
- 2000-03-31 KR KR1020017012857A patent/KR20020065341A/ko not_active Application Discontinuation
- 2000-03-31 JP JP2000609014A patent/JP2002541078A/ja active Pending
- 2000-03-31 EP EP00919929A patent/EP1169321A4/fr not_active Withdrawn
- 2000-03-31 WO PCT/US2000/008525 patent/WO2000059449A2/fr active Search and Examination
- 2000-03-31 AU AU40538/00A patent/AU4053800A/en not_active Abandoned
- 2000-03-31 US US09/539,571 patent/US6413975B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR029347A1 (es) | 2003-06-25 |
US6413975B1 (en) | 2002-07-02 |
KR20020065341A (ko) | 2002-08-13 |
WO2000059449A2 (fr) | 2000-10-12 |
AU4053800A (en) | 2000-10-23 |
BR0011182A (pt) | 2003-06-10 |
EP1169321A2 (fr) | 2002-01-09 |
JP2002541078A (ja) | 2002-12-03 |
CN1377353A (zh) | 2002-10-30 |
EP1169321A4 (fr) | 2002-10-30 |
CA2367143A1 (fr) | 2000-10-12 |
WO2000059449A3 (fr) | 2001-01-04 |
HUP0200938A2 (en) | 2002-10-28 |
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