IL143779A0 - Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation - Google Patents

Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation

Info

Publication number
IL143779A0
IL143779A0 IL14377900A IL14377900A IL143779A0 IL 143779 A0 IL143779 A0 IL 143779A0 IL 14377900 A IL14377900 A IL 14377900A IL 14377900 A IL14377900 A IL 14377900A IL 143779 A0 IL143779 A0 IL 143779A0
Authority
IL
Israel
Prior art keywords
piperidine
inhibitors
fibril formation
piperazine derivatives
abeta
Prior art date
Application number
IL14377900A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL143779A0 publication Critical patent/IL143779A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/08—Diarylmethoxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL14377900A 1999-02-10 2000-02-08 Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation IL143779A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9902938.1A GB9902938D0 (en) 1999-02-10 1999-02-10 Organic compounds
PCT/EP2000/001000 WO2000047571A1 (en) 1999-02-10 2000-02-08 Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation

Publications (1)

Publication Number Publication Date
IL143779A0 true IL143779A0 (en) 2002-04-21

Family

ID=10847440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14377900A IL143779A0 (en) 1999-02-10 2000-02-08 Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation

Country Status (20)

Country Link
US (1) US20020002170A1 (xx)
EP (1) EP1150971A1 (xx)
JP (1) JP2002536441A (xx)
KR (1) KR20010102006A (xx)
CN (1) CN1337960A (xx)
AR (1) AR022542A1 (xx)
AU (1) AU2803200A (xx)
BR (1) BR0008068A (xx)
CA (1) CA2362389A1 (xx)
CO (1) CO5140091A1 (xx)
CZ (1) CZ20012868A3 (xx)
GB (1) GB9902938D0 (xx)
HU (1) HUP0200133A3 (xx)
ID (1) ID29283A (xx)
IL (1) IL143779A0 (xx)
NO (1) NO20013832L (xx)
PE (1) PE20001460A1 (xx)
SK (1) SK11372001A3 (xx)
TR (1) TR200101924T2 (xx)
WO (1) WO2000047571A1 (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053127B1 (en) * 2002-09-16 2006-05-30 Nalco Company Quaternized amido cyclic amine surfactant
DE602004028228D1 (de) * 2003-03-26 2010-09-02 Merck Sharp & Dohme Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
KR20060066057A (ko) * 2003-06-30 2006-06-15 다이이찌 세이야꾸 가부시기가이샤 복소환 메틸 설폰 유도체
CN106866657A (zh) * 2017-04-25 2017-06-20 成都倍特药业有限公司 一种麦角新碱的制备方法
CA3082757A1 (en) 2017-11-24 2019-05-31 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives
GB9701628D0 (en) * 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives

Also Published As

Publication number Publication date
CA2362389A1 (en) 2000-08-17
NO20013832D0 (no) 2001-08-06
WO2000047571A1 (en) 2000-08-17
NO20013832L (no) 2001-09-27
BR0008068A (pt) 2001-11-13
SK11372001A3 (sk) 2001-12-03
HUP0200133A2 (en) 2002-06-29
AR022542A1 (es) 2002-09-04
PE20001460A1 (es) 2001-01-03
CZ20012868A3 (cs) 2001-10-17
HUP0200133A3 (en) 2003-01-28
TR200101924T2 (tr) 2002-01-21
CN1337960A (zh) 2002-02-27
JP2002536441A (ja) 2002-10-29
EP1150971A1 (en) 2001-11-07
KR20010102006A (ko) 2001-11-15
CO5140091A1 (es) 2002-03-22
ID29283A (id) 2001-08-16
US20020002170A1 (en) 2002-01-03
AU2803200A (en) 2000-08-29
GB9902938D0 (en) 1999-03-31

Similar Documents

Publication Publication Date Title
EG24136A (en) Piperazine derivatives useful as ccr5 antagonists
IL148698A0 (en) INHIBITORS OF FACTOR Xa
EG24533A (en) Piperdine derivatives useful as CCR 5 antagonists
PL339173A1 (en) Derivatives of benzamidine as inhibitors of factor xa
EE200300007A (et) Heterotsüklilised tetrahüdropüridino- või piperidinoderivaadid
AU5041300A (en) Inhibitors of factor xa
HK1066537A1 (en) Piperazine compounds as tachykinins inhibitors
AU5283700A (en) Inhibitors of factor xa
IL148818A0 (en) Piperazine derivatives as 5-ht1b
AU3857300A (en) Inhibitors of factor xa
PL355654A1 (en) Piperidine and piperazine derivatives which function as 5-ht2a
EE200200277A (et) 4-karboksüamino-2-etüül-1,2,3,4-tetrahüdrokinoliini kristall kui CETP inhibiitor
DK1131308T3 (da) Piperazin- og piperidinderivater
IL145301A0 (en) 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of cns disorders
HK1053657A1 (en) Novel heterocyclic compounds and salts thereof andmedicinal use of the same
PL352296A1 (en) Crystalline derivatives of 1-methylocarbapeneme
AU6392701A (en) Piperazine and piperidine compounds
PL349769A1 (en) New amidinobenzylamine derivatives and their use as thrombin inhibitors
AU2001294824A1 (en) Piperazine based inhibitors of factor xa
IL143779A0 (en) Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation
HUP0203855A3 (en) Substituted piperazine derivatives as mtp inhibitors
HUP0105102A3 (en) Heterocyclic derivatives as inhibitors of factor xa and pharmaceutical compositions containing them
AU3836600A (en) N-substituted piperidine derivatives
GB0023334D0 (en) Spirotricyclic substituted azacycloalkane derivatives and uses thereof
IL150010A0 (en) Heterocyclic derivatives