IL143779A0 - Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation - Google Patents
Piperidine and piperazine derivatives as inhibitors of the abeta fibril formationInfo
- Publication number
- IL143779A0 IL143779A0 IL14377900A IL14377900A IL143779A0 IL 143779 A0 IL143779 A0 IL 143779A0 IL 14377900 A IL14377900 A IL 14377900A IL 14377900 A IL14377900 A IL 14377900A IL 143779 A0 IL143779 A0 IL 143779A0
- Authority
- IL
- Israel
- Prior art keywords
- piperidine
- inhibitors
- fibril formation
- piperazine derivatives
- abeta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/08—Diarylmethoxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9902938.1A GB9902938D0 (en) | 1999-02-10 | 1999-02-10 | Organic compounds |
PCT/EP2000/001000 WO2000047571A1 (en) | 1999-02-10 | 2000-02-08 | Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation |
Publications (1)
Publication Number | Publication Date |
---|---|
IL143779A0 true IL143779A0 (en) | 2002-04-21 |
Family
ID=10847440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14377900A IL143779A0 (en) | 1999-02-10 | 2000-02-08 | Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation |
Country Status (20)
Country | Link |
---|---|
US (1) | US20020002170A1 (xx) |
EP (1) | EP1150971A1 (xx) |
JP (1) | JP2002536441A (xx) |
KR (1) | KR20010102006A (xx) |
CN (1) | CN1337960A (xx) |
AR (1) | AR022542A1 (xx) |
AU (1) | AU2803200A (xx) |
BR (1) | BR0008068A (xx) |
CA (1) | CA2362389A1 (xx) |
CO (1) | CO5140091A1 (xx) |
CZ (1) | CZ20012868A3 (xx) |
GB (1) | GB9902938D0 (xx) |
HU (1) | HUP0200133A3 (xx) |
ID (1) | ID29283A (xx) |
IL (1) | IL143779A0 (xx) |
NO (1) | NO20013832L (xx) |
PE (1) | PE20001460A1 (xx) |
SK (1) | SK11372001A3 (xx) |
TR (1) | TR200101924T2 (xx) |
WO (1) | WO2000047571A1 (xx) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053127B1 (en) * | 2002-09-16 | 2006-05-30 | Nalco Company | Quaternized amido cyclic amine surfactant |
DE602004028228D1 (de) * | 2003-03-26 | 2010-09-02 | Merck Sharp & Dohme | Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten |
KR20060066057A (ko) * | 2003-06-30 | 2006-06-15 | 다이이찌 세이야꾸 가부시기가이샤 | 복소환 메틸 설폰 유도체 |
CN106866657A (zh) * | 2017-04-25 | 2017-06-20 | 成都倍特药业有限公司 | 一种麦角新碱的制备方法 |
CA3082757A1 (en) | 2017-11-24 | 2019-05-31 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
US6060483A (en) * | 1996-06-27 | 2000-05-09 | Pharmacia & Upjohn S.P.A. | Antineurodegenerative ergoline derivatives |
GB9701628D0 (en) * | 1997-01-27 | 1997-03-19 | Pharmacia & Upjohn Spa | Imino-aza-anthracyclinone derivatives |
-
1999
- 1999-02-10 GB GBGB9902938.1A patent/GB9902938D0/en not_active Ceased
-
2000
- 2000-02-02 CO CO00006270A patent/CO5140091A1/es unknown
- 2000-02-08 WO PCT/EP2000/001000 patent/WO2000047571A1/en not_active Application Discontinuation
- 2000-02-08 HU HU0200133A patent/HUP0200133A3/hu unknown
- 2000-02-08 CZ CZ20012868A patent/CZ20012868A3/cs unknown
- 2000-02-08 PE PE2000000089A patent/PE20001460A1/es not_active Application Discontinuation
- 2000-02-08 IL IL14377900A patent/IL143779A0/xx unknown
- 2000-02-08 CN CN00802995A patent/CN1337960A/zh active Pending
- 2000-02-08 SK SK1137-2001A patent/SK11372001A3/sk unknown
- 2000-02-08 AU AU28032/00A patent/AU2803200A/en not_active Abandoned
- 2000-02-08 ID IDW00200101601A patent/ID29283A/id unknown
- 2000-02-08 JP JP2000598491A patent/JP2002536441A/ja active Pending
- 2000-02-08 TR TR2001/01924T patent/TR200101924T2/xx unknown
- 2000-02-08 AR ARP000100544A patent/AR022542A1/es unknown
- 2000-02-08 EP EP00906300A patent/EP1150971A1/en not_active Withdrawn
- 2000-02-08 CA CA002362389A patent/CA2362389A1/en not_active Abandoned
- 2000-02-08 KR KR1020017010056A patent/KR20010102006A/ko not_active Application Discontinuation
- 2000-02-08 BR BR0008068-3A patent/BR0008068A/pt not_active Application Discontinuation
-
2001
- 2001-07-16 US US09/906,249 patent/US20020002170A1/en not_active Abandoned
- 2001-08-06 NO NO20013832A patent/NO20013832L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2362389A1 (en) | 2000-08-17 |
NO20013832D0 (no) | 2001-08-06 |
WO2000047571A1 (en) | 2000-08-17 |
NO20013832L (no) | 2001-09-27 |
BR0008068A (pt) | 2001-11-13 |
SK11372001A3 (sk) | 2001-12-03 |
HUP0200133A2 (en) | 2002-06-29 |
AR022542A1 (es) | 2002-09-04 |
PE20001460A1 (es) | 2001-01-03 |
CZ20012868A3 (cs) | 2001-10-17 |
HUP0200133A3 (en) | 2003-01-28 |
TR200101924T2 (tr) | 2002-01-21 |
CN1337960A (zh) | 2002-02-27 |
JP2002536441A (ja) | 2002-10-29 |
EP1150971A1 (en) | 2001-11-07 |
KR20010102006A (ko) | 2001-11-15 |
CO5140091A1 (es) | 2002-03-22 |
ID29283A (id) | 2001-08-16 |
US20020002170A1 (en) | 2002-01-03 |
AU2803200A (en) | 2000-08-29 |
GB9902938D0 (en) | 1999-03-31 |
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