IL142288A0 - An in vitro activity assay for human hepatitis b virus (hbv) dna polymerase, and its use for screening for inhibitors of hbv dna polymerase - Google Patents

An in vitro activity assay for human hepatitis b virus (hbv) dna polymerase, and its use for screening for inhibitors of hbv dna polymerase

Info

Publication number
IL142288A0
IL142288A0 IL14228899A IL14228899A IL142288A0 IL 142288 A0 IL142288 A0 IL 142288A0 IL 14228899 A IL14228899 A IL 14228899A IL 14228899 A IL14228899 A IL 14228899A IL 142288 A0 IL142288 A0 IL 142288A0
Authority
IL
Israel
Prior art keywords
dna polymerase
hbv
virus
inhibitors
screening
Prior art date
Application number
IL14228899A
Other languages
English (en)
Original Assignee
Government Of The Republic Of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government Of The Republic Of filed Critical Government Of The Republic Of
Publication of IL142288A0 publication Critical patent/IL142288A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
IL14228899A 1998-09-29 1999-03-13 An in vitro activity assay for human hepatitis b virus (hbv) dna polymerase, and its use for screening for inhibitors of hbv dna polymerase IL142288A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/SG1998/000077 WO2000018958A2 (en) 1998-09-29 1998-09-29 An in vitro activity assay for human hepatits b virus (hbv) dna polymerase, the use of such an assay to assay activity of various serum samples and to screen for inhibitors of the hbv dna polymerase and a method of producing hbv dna polymerase
PCT/SG1999/000017 WO2000018968A1 (en) 1998-09-29 1999-03-13 An in vitro activity assay for human hepatitis b virus (hbv) dna polymerase, and its use for screening for inhibitors of hbv dna polymerase

Publications (1)

Publication Number Publication Date
IL142288A0 true IL142288A0 (en) 2002-03-10

Family

ID=20429877

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14228899A IL142288A0 (en) 1998-09-29 1999-03-13 An in vitro activity assay for human hepatitis b virus (hbv) dna polymerase, and its use for screening for inhibitors of hbv dna polymerase
IL142288A IL142288A (en) 1998-09-29 2001-03-27 Method for DNA POLYMERASE review of viral hepatitis in humans

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142288A IL142288A (en) 1998-09-29 2001-03-27 Method for DNA POLYMERASE review of viral hepatitis in humans

Country Status (23)

Country Link
US (1) US6593082B1 (hu)
EP (1) EP1117843A1 (hu)
JP (1) JP2002525130A (hu)
KR (1) KR100445958B1 (hu)
CN (1) CN1197978C (hu)
AR (1) AR030012A1 (hu)
AU (2) AU9372698A (hu)
BR (1) BR9914099A (hu)
CA (1) CA2344282A1 (hu)
HK (1) HK1039161A1 (hu)
HR (1) HRP20010230B1 (hu)
HU (1) HUP0103735A3 (hu)
IL (2) IL142288A0 (hu)
IS (1) IS5900A (hu)
MY (1) MY123274A (hu)
NO (1) NO20011510L (hu)
NZ (1) NZ510704A (hu)
PL (1) PL347026A1 (hu)
RU (1) RU2202620C2 (hu)
TR (1) TR200100899T2 (hu)
UA (1) UA75028C2 (hu)
WO (2) WO2000018958A2 (hu)
YU (1) YU23601A (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7893501A (en) * 2000-07-14 2002-01-30 Replidyne Inc Novel dna polymerase iii holoenzyme delta subunit nucleic acid molecules and proteins
AUPS037002A0 (en) * 2002-02-07 2002-02-28 Melbourne Health Viral variants and uses therefor
KR20030075638A (ko) * 2002-03-20 2003-09-26 (주) 비엔씨바이오팜 Ｂ형 간염바이러스의 프라이밍 저해제의 스크리닝 방법
TW200643171A (en) 2005-06-07 2006-12-16 Temasek Life Sciences Lab Ltd Porcine circovirus type 2 vaccines
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
WO2008097926A2 (en) 2007-02-02 2008-08-14 Yale University Transient transfection with rna
US9249423B2 (en) * 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
ES2651308T3 (es) 2009-10-16 2018-01-25 Glaxo Group Limited Inhibidores antisentido de HBV
CN104316682B (zh) * 2014-10-10 2015-12-30 三峡大学 一种s-腺苷甲硫氨酸脱羧酶的活性检测方法及其应用
RU2763173C1 (ru) * 2020-07-27 2021-12-28 Федеральное бюджетное учреждение науки "Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" (ФБУН НИИ эпидемиологии и микробиологии имени Пастера) Способ выявления ДНК вируса гепатита В в биологическом материале при низкой вирусной нагрузке на основе двухэтапной ПЦР с детекцией по трем мишеням в режиме реального времени

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492817A (en) * 1993-11-09 1996-02-20 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
US5360714A (en) 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
WO1994005812A1 (en) 1992-09-02 1994-03-17 The Scripps Research Institute Coupled isothermal polynucleotide amplification and translation system
US5709998A (en) 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
WO1996010649A1 (en) 1994-09-30 1996-04-11 Southwest Foundation For Biomedical Research Isolated human hepatitis b virus polymerase and uses thereof

Also Published As

Publication number Publication date
KR100445958B1 (ko) 2004-08-25
YU23601A (sh) 2005-07-19
HUP0103735A2 (hu) 2002-01-28
BR9914099A (pt) 2001-07-31
EP1117843A1 (en) 2001-07-25
CN1197978C (zh) 2005-04-20
WO2000018968A8 (en) 2002-11-07
MY123274A (en) 2006-05-31
NO20011510D0 (no) 2001-03-23
HUP0103735A3 (en) 2005-12-28
HRP20010230B1 (en) 2006-05-31
US6593082B1 (en) 2003-07-15
IS5900A (is) 2001-03-19
JP2002525130A (ja) 2002-08-13
KR20010083879A (ko) 2001-09-03
PL347026A1 (en) 2002-03-11
WO2000018968A1 (en) 2000-04-06
HRP20010230A2 (en) 2002-06-30
HK1039161A1 (zh) 2002-04-12
AU2969499A (en) 2000-04-17
WO2000018958A2 (en) 2000-04-06
CN1320167A (zh) 2001-10-31
CA2344282A1 (en) 2000-04-06
RU2202620C2 (ru) 2003-04-20
TR200100899T2 (tr) 2001-07-23
NZ510704A (en) 2002-10-25
UA75028C2 (en) 2006-03-15
AU772819B2 (en) 2004-05-06
NO20011510L (no) 2001-05-28
AR030012A1 (es) 2003-08-13
IL142288A (en) 2006-12-31
AU9372698A (en) 2000-04-17

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