IL139163A - Method of predicting the ability of compounds to modulate the biological activity of receptors - Google Patents
Method of predicting the ability of compounds to modulate the biological activity of receptorsInfo
- Publication number
- IL139163A IL139163A IL13916399A IL13916399A IL139163A IL 139163 A IL139163 A IL 139163A IL 13916399 A IL13916399 A IL 13916399A IL 13916399 A IL13916399 A IL 13916399A IL 139163 A IL139163 A IL 139163A
- Authority
- IL
- Israel
- Prior art keywords
- receptor
- modulate
- ability
- assays
- biological activity
- Prior art date
Links
- 230000004071 biological effect Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 238000000423 cell based assay Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Collating Specific Patterns (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Photoreceptors In Electrophotography (AREA)
- Percussion Or Vibration Massage (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8275698P | 1998-04-23 | 1998-04-23 | |
| US9965698P | 1998-09-09 | 1998-09-09 | |
| US11534599P | 1999-01-08 | 1999-01-08 | |
| PCT/US1999/006664 WO1999054728A2 (en) | 1998-04-23 | 1999-03-26 | Method of predicting receptor modulating activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL139163A0 IL139163A0 (en) | 2001-11-25 |
| IL139163A true IL139163A (en) | 2005-09-25 |
Family
ID=27374331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13916399A IL139163A (en) | 1998-04-23 | 1999-03-26 | Method of predicting the ability of compounds to modulate the biological activity of receptors |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1073891B1 (de) |
| JP (1) | JP2002512368A (de) |
| KR (1) | KR100637955B1 (de) |
| AT (1) | ATE335994T1 (de) |
| AU (1) | AU769917B2 (de) |
| CA (1) | CA2329738C (de) |
| DE (1) | DE69932712T2 (de) |
| IL (1) | IL139163A (de) |
| WO (1) | WO1999054728A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660468B1 (en) | 1998-10-27 | 2003-12-09 | Board Of Trustees Of The University Of Arkansas | Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction |
| WO2002000716A2 (en) * | 2000-06-28 | 2002-01-03 | Bristol-Myers Squibb Company | Cell lines and cell-based assays for identification of androgen receptor modulators |
| EP1360501A2 (de) * | 2000-07-12 | 2003-11-12 | Karo Bio USA, Inc. | Verfahren zur identifizierung von konformation-empfindlichen bindenden peptiden und ihre verwendung |
| DE10040289A1 (de) * | 2000-08-17 | 2002-02-28 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung und Ermittlung geeigneter Effektoren von Zielmolekülen mit Substanzbibliotheken |
| US6586190B2 (en) | 2000-08-18 | 2003-07-01 | Syngenta Participations Ag | Parallel high throughput method and kit |
| WO2004035614A1 (en) * | 2001-07-11 | 2004-04-29 | Karo Bio Ab | Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof |
| AU2003205605A1 (en) * | 2002-01-18 | 2003-07-30 | Karo Bio Ab | Conformation-specific, protein kinase binding peptides and related methods and products |
| EP1353182A3 (de) * | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Verfahren zur Vorhersage von Zell-basierten Assay Resultaten mit Hilfe von Bindungsprofilen |
| EP1637885A1 (de) * | 2004-09-16 | 2006-03-22 | Vivalis | Screeningverfahren von Konformation empfindlichen bindenden Peptiden |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| RU2500685C2 (ru) | 2006-11-10 | 2013-12-10 | Кара Терапеутикс, Инк | Синтетические пептидные амиды |
| PL4054201T3 (pl) | 2007-04-18 | 2024-08-12 | Dolby International Ab | Systemy kodowania |
| US20140072058A1 (en) | 2010-03-05 | 2014-03-13 | Thomson Licensing | Coding systems |
| EP2480888B1 (de) | 2009-09-25 | 2016-11-30 | XOMA Technology Ltd. | Screening-verfahren |
| WO2011083147A1 (en) | 2010-01-08 | 2011-07-14 | Cemm-Forschungsinstitut Für Molekulare Medizin Gmbh | Wave1 inhibition in the medical intervention of inflammatory diseases and/or infections caused by a pathogen |
| WO2011131626A1 (en) | 2010-04-19 | 2011-10-27 | Medizinische Universität Innsbruck | Tmem195 encodes for tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity |
| US9446039B2 (en) | 2012-08-27 | 2016-09-20 | Cemm Forschungszentrum Für Molekulare Medizin Gmbh | Aminoheteroaryl compounds as MTH1 inhibitors |
| ES2753386T3 (es) | 2013-03-13 | 2020-04-08 | Forma Therapeutics Inc | Derivados de 2-hidroxi-1-{4-[(4-fenil)fenil]carbonil}piperazin-1-il}etano-1-ona y compuestos relacionados como inhibidores de sintasa de ácido graso (FASN) para el tratamiento del cáncer |
| CN105044330B (zh) * | 2015-08-28 | 2017-12-22 | 宁波瑞源生物科技有限公司 | 一种减少体外检测中生物样本假阳性的封闭液及其应用 |
| CN106778032B (zh) * | 2016-12-14 | 2019-06-04 | 南京邮电大学 | 药物设计中配体分子海量特征筛选方法 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7457796A (en) * | 1995-10-23 | 1997-05-15 | Tularik Inc. | Rip: novel human protein involved in tumor necrosis factor signal transduction, and screening assays |
| WO1997031646A1 (en) * | 1996-02-28 | 1997-09-04 | University Of Colorado | Steroid receptor antagonist co-modulator and methods for using same |
-
1999
- 1999-03-26 CA CA002329738A patent/CA2329738C/en not_active Expired - Fee Related
- 1999-03-26 AT AT99914190T patent/ATE335994T1/de not_active IP Right Cessation
- 1999-03-26 AU AU32091/99A patent/AU769917B2/en not_active Ceased
- 1999-03-26 EP EP99914190A patent/EP1073891B1/de not_active Expired - Lifetime
- 1999-03-26 KR KR1020007011794A patent/KR100637955B1/ko not_active Expired - Fee Related
- 1999-03-26 IL IL13916399A patent/IL139163A/xx not_active IP Right Cessation
- 1999-03-26 DE DE69932712T patent/DE69932712T2/de not_active Expired - Fee Related
- 1999-03-26 WO PCT/US1999/006664 patent/WO1999054728A2/en not_active Ceased
- 1999-03-26 JP JP2000545020A patent/JP2002512368A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073891B1 (de) | 2006-08-09 |
| KR20010042966A (ko) | 2001-05-25 |
| WO1999054728A3 (en) | 2000-02-10 |
| CA2329738A1 (en) | 1999-10-28 |
| AU769917B2 (en) | 2004-02-12 |
| EP1073891A2 (de) | 2001-02-07 |
| JP2002512368A (ja) | 2002-04-23 |
| CA2329738C (en) | 2008-10-07 |
| IL139163A0 (en) | 2001-11-25 |
| AU3209199A (en) | 1999-11-08 |
| WO1999054728A2 (en) | 1999-10-28 |
| ATE335994T1 (de) | 2006-09-15 |
| DE69932712D1 (de) | 2006-09-21 |
| KR100637955B1 (ko) | 2006-10-23 |
| DE69932712T2 (de) | 2007-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |