IL137929A0 - Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes - Google Patents
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymesInfo
- Publication number
- IL137929A0 IL137929A0 IL13792999A IL13792999A IL137929A0 IL 137929 A0 IL137929 A0 IL 137929A0 IL 13792999 A IL13792999 A IL 13792999A IL 13792999 A IL13792999 A IL 13792999A IL 137929 A0 IL137929 A0 IL 137929A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- compounds useful
- dependent enzymes
- thiadiazole compounds
- activity dependent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/033,937 US6162791A (en) | 1998-03-02 | 1998-03-02 | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
| PCT/CA1999/000160 WO1999045027A1 (en) | 1998-03-02 | 1999-02-23 | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137929A0 true IL137929A0 (en) | 2001-10-31 |
Family
ID=21873323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13792999A IL137929A0 (en) | 1998-03-02 | 1999-02-23 | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6162791A (tr) |
| EP (1) | EP1058690A1 (tr) |
| JP (1) | JP2002505339A (tr) |
| KR (1) | KR20010041406A (tr) |
| CN (1) | CN1291993A (tr) |
| AU (1) | AU741295B2 (tr) |
| BR (1) | BR9908441A (tr) |
| CA (1) | CA2322838A1 (tr) |
| EA (1) | EA200000892A1 (tr) |
| HU (1) | HUP0101899A3 (tr) |
| IL (1) | IL137929A0 (tr) |
| PL (1) | PL342661A1 (tr) |
| TR (1) | TR200002527T2 (tr) |
| WO (1) | WO1999045027A1 (tr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833369B2 (en) * | 1997-06-24 | 2004-12-21 | Janssen Pharmaceutica, Nv | Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives |
| US6468977B1 (en) * | 1998-03-02 | 2002-10-22 | Apotex Inc. | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
| US6245788B1 (en) * | 1999-03-31 | 2001-06-12 | The Procter & Gamble Company | Viral treatment |
| US6258831B1 (en) | 1999-03-31 | 2001-07-10 | The Procter & Gamble Company | Viral treatment |
| US6340696B1 (en) | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
| EP1201136A1 (en) | 2000-10-31 | 2002-05-02 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Food grade transglutaminase inhibitor and uses thereof |
| DE10054687A1 (de) * | 2000-11-03 | 2002-05-16 | N Zyme Biotec Gmbh | Inhibitoren von Transglutaminasen |
| CA2379375A1 (en) * | 2002-03-28 | 2003-09-28 | Apotex Inc. | Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases |
| ZA200601274B (en) * | 2003-10-15 | 2007-05-30 | Sumitomo Chemical Co | 1,2,4-thiadiazole compounds and pests controlling composition containing the same |
| CN101374836A (zh) * | 2005-12-27 | 2009-02-25 | 托莱多大学 | 毒蕈碱激动剂及其使用方法 |
| EP2296471A4 (en) | 2008-05-15 | 2012-03-14 | Univ Toledo | MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS |
| MX2012013031A (es) | 2010-05-12 | 2012-12-17 | Univ Vanderbilt | Potenciadores alostericos mglur4 de sulfona heterociclica, composiciones y metodos para tratar disfuncion neurologica. |
| US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
| CA3183740A1 (en) | 2020-06-10 | 2021-12-16 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| US11851422B2 (en) | 2021-07-09 | 2023-12-26 | Aligos Therapeutics, Inc. | Anti-viral compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874864A (en) * | 1988-05-24 | 1989-10-17 | Pfizer Inc. | Benzamide protease inhibitors |
| DE3910358A1 (de) * | 1989-03-31 | 1990-10-04 | Bayer Ag | Thiadiazol-substituierte acrylsaeureester und neue zwischenprodukte |
| DE4026904A1 (de) * | 1990-08-25 | 1992-02-27 | Bayer Ag | Verfahren zur herstellung von 3-alkoxy-2-heteroazolyl-amino-acrylsaeureestern |
| JP2808877B2 (ja) * | 1990-09-29 | 1998-10-08 | 大正製薬株式会社 | エポキシスクシナム酸誘導体およびその中間体 |
| DE4142191A1 (de) * | 1991-12-20 | 1993-06-24 | Bayer Ag | Verfahren zur herstellung von 3-alkoxy-acrylestern |
| US5498616A (en) * | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6004933A (en) * | 1997-04-25 | 1999-12-21 | Cortech Inc. | Cysteine protease inhibitors |
-
1998
- 1998-03-02 US US09/033,937 patent/US6162791A/en not_active Expired - Fee Related
-
1999
- 1999-02-23 CA CA002322838A patent/CA2322838A1/en not_active Abandoned
- 1999-02-23 BR BR9908441-4A patent/BR9908441A/pt not_active IP Right Cessation
- 1999-02-23 KR KR1020007009539A patent/KR20010041406A/ko not_active Application Discontinuation
- 1999-02-23 JP JP2000534569A patent/JP2002505339A/ja active Pending
- 1999-02-23 HU HU0101899A patent/HUP0101899A3/hu unknown
- 1999-02-23 WO PCT/CA1999/000160 patent/WO1999045027A1/en not_active Application Discontinuation
- 1999-02-23 AU AU26067/99A patent/AU741295B2/en not_active Ceased
- 1999-02-23 EP EP99906005A patent/EP1058690A1/en not_active Withdrawn
- 1999-02-23 EA EA200000892A patent/EA200000892A1/ru unknown
- 1999-02-23 IL IL13792999A patent/IL137929A0/xx unknown
- 1999-02-23 CN CN99803568A patent/CN1291993A/zh active Pending
- 1999-02-23 TR TR2000/02527T patent/TR200002527T2/tr unknown
- 1999-02-23 PL PL99342661A patent/PL342661A1/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL342661A1 (en) | 2001-07-02 |
| CA2322838A1 (en) | 1999-09-10 |
| EP1058690A1 (en) | 2000-12-13 |
| HUP0101899A3 (en) | 2001-12-28 |
| TR200002527T2 (tr) | 2001-01-22 |
| CN1291993A (zh) | 2001-04-18 |
| BR9908441A (pt) | 2000-10-31 |
| JP2002505339A (ja) | 2002-02-19 |
| AU2606799A (en) | 1999-09-20 |
| WO1999045027A1 (en) | 1999-09-10 |
| EA200000892A1 (ru) | 2001-02-26 |
| US6162791A (en) | 2000-12-19 |
| AU741295B2 (en) | 2001-11-29 |
| KR20010041406A (ko) | 2001-05-15 |
| HUP0101899A2 (hu) | 2001-11-28 |
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