IL137351A0 - Heterocyclic topoisomerase poisons - Google Patents
Heterocyclic topoisomerase poisonsInfo
- Publication number
- IL137351A0 IL137351A0 IL13735198A IL13735198A IL137351A0 IL 137351 A0 IL137351 A0 IL 137351A0 IL 13735198 A IL13735198 A IL 13735198A IL 13735198 A IL13735198 A IL 13735198A IL 137351 A0 IL137351 A0 IL 137351A0
- Authority
- IL
- Israel
- Prior art keywords
- heterocyclic
- topoisomerase poisons
- poisons
- topoisomerase
- heterocyclic topoisomerase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/023,147 US6063801A (en) | 1998-02-12 | 1998-02-12 | Heterocyclic topoisomerase poisons |
| PCT/US1999/002966 WO1999041241A1 (en) | 1998-02-12 | 1999-02-12 | Heterocyclic topoisomerase poisons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137351A0 true IL137351A0 (en) | 2001-07-24 |
Family
ID=21813388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13735198A IL137351A0 (en) | 1998-02-12 | 1998-02-12 | Heterocyclic topoisomerase poisons |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6063801A (ja) |
| EP (1) | EP1054870A1 (ja) |
| JP (1) | JP2002503653A (ja) |
| CN (1) | CN1290253A (ja) |
| AU (1) | AU748778B2 (ja) |
| CA (1) | CA2318347A1 (ja) |
| IL (1) | IL137351A0 (ja) |
| PL (1) | PL342262A1 (ja) |
| WO (1) | WO1999041241A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136911A0 (en) * | 1997-12-31 | 2001-06-14 | Univ Rutgers | Heterocyclic topoisomerase poisons |
| US6063801A (en) * | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6803369B1 (en) * | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| AU2003228649A1 (en) * | 2002-04-23 | 2003-11-10 | U.S.Genomics, Inc. | Compositions and methods related to two-arm nucleic acid probes |
| AU2006279537A1 (en) | 2005-08-15 | 2007-02-22 | Irm Llc | Compounds and compositions as TPO mimetics |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| CN105237480B (zh) * | 2015-08-14 | 2017-12-05 | 三峡大学 | 一种2‑三氟甲基苯并咪唑化合物及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE26065E (en) | 1966-07-19 | Folybenzimidazoles and their preparation | ||
| US26065A (en) * | 1859-11-08 | Improvement in cotton-gins | ||
| US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
| CH420044A (de) * | 1964-09-01 | 1967-03-15 | Ciba Geigy | Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien |
| DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| SU1530628A1 (ru) | 1987-11-20 | 1989-12-23 | Ленинградский Технологический Институт Им.Ленсовета | Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК |
| JP2700475B2 (ja) * | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
| US5807874A (en) | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| BR9608476A (pt) * | 1995-05-17 | 1999-08-17 | Univ Rutgers | Composto processo para inibir o crescimento de uma célula tumoral de mam¡fero e composicão terapéutica |
| US5767142A (en) * | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| CN1067070C (zh) * | 1996-02-12 | 2001-06-13 | 新泽西州州立大学(拉特格斯) | 用作拓扑异构酶抑制剂的甲氧檗因类似物 |
| US5770617A (en) * | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| TR199900636T2 (xx) * | 1996-09-23 | 1999-10-21 | Rutgers, The State University Of New Jersey | Anti-t�m�r ajanlar� olarak ikameli/katk�l� heterosayk�llar. |
| US6063801A (en) | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
-
1998
- 1998-02-12 US US09/023,147 patent/US6063801A/en not_active Expired - Lifetime
- 1998-02-12 IL IL13735198A patent/IL137351A0/xx unknown
-
1999
- 1999-02-12 EP EP99906928A patent/EP1054870A1/en not_active Withdrawn
- 1999-02-12 CN CN99802929A patent/CN1290253A/zh active Pending
- 1999-02-12 WO PCT/US1999/002966 patent/WO1999041241A1/en not_active Application Discontinuation
- 1999-02-12 AU AU26724/99A patent/AU748778B2/en not_active Ceased
- 1999-02-12 JP JP2000531436A patent/JP2002503653A/ja active Pending
- 1999-02-12 CA CA002318347A patent/CA2318347A1/en not_active Abandoned
- 1999-02-12 PL PL99342262A patent/PL342262A1/xx not_active Application Discontinuation
-
2000
- 2000-01-14 US US09/484,402 patent/US6221892B1/en not_active Expired - Lifetime
-
2001
- 2001-02-28 US US09/796,500 patent/US6399642B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1054870A1 (en) | 2000-11-29 |
| US6399642B2 (en) | 2002-06-04 |
| CA2318347A1 (en) | 1999-08-19 |
| US6221892B1 (en) | 2001-04-24 |
| US20010009919A1 (en) | 2001-07-26 |
| PL342262A1 (en) | 2001-06-04 |
| JP2002503653A (ja) | 2002-02-05 |
| AU748778B2 (en) | 2002-06-13 |
| US6063801A (en) | 2000-05-16 |
| AU2672499A (en) | 1999-08-30 |
| WO1999041241A1 (en) | 1999-08-19 |
| CN1290253A (zh) | 2001-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL346155A1 (en) | 1h-imidazopyridine derivatives | |
| PL345540A1 (en) | Thiobenzimidazole derivatives | |
| GB9800575D0 (en) | Heterocyclic compounds | |
| HK1022310A1 (en) | Benzosulfone derivatives | |
| GB9815880D0 (en) | Heterocycles | |
| GB9910384D0 (en) | Alpha-ketoamide derivatives | |
| GB9804426D0 (en) | Heterocycles | |
| HK1046400A1 (en) | Substituted 2-dialkylaminoalkylbiphenyl derivatives | |
| IL137351A0 (en) | Heterocyclic topoisomerase poisons | |
| GB9810354D0 (en) | Heterocycles | |
| EG23802A (en) | 2-Phenylpyran-4-one derivatives | |
| GB9827729D0 (en) | Thieno-indole derivatives | |
| AP2001002327A0 (en) | 1-Trifluoromethyl-4-hydroxy-7- piperidinylaminomethy lchroman derivatives | |
| IL141602A0 (en) | Bridged heterocyclic derivatives | |
| EP1061912A4 (en) | PHENANTHROFURANDERIVATE | |
| GB9821898D0 (en) | Heterocycles | |
| IL139276A0 (en) | Cyclohexenondioxthio chromanoyl derivatives | |
| HK1042478A1 (zh) | 2-氧代-2h-喹啉衍生物 | |
| GB9810175D0 (en) | Phosphate-medicated cyclization | |
| GB9812410D0 (en) | Heterocyclic derivatives | |
| GB9809351D0 (en) | Heterocyclic derivatives | |
| GB9816279D0 (en) | Arylthiazolidinedione derivatives | |
| SI1051395T1 (sl) | N-hidroksiformamidni derivati | |
| GB9925002D0 (en) | Test | |
| GB9800571D0 (en) | Heterocyclic compounds |