IL136308A0 - Antipicornaviral compounds and methods for their use and preparation - Google Patents
Antipicornaviral compounds and methods for their use and preparationInfo
- Publication number
- IL136308A0 IL136308A0 IL13630898A IL13630898A IL136308A0 IL 136308 A0 IL136308 A0 IL 136308A0 IL 13630898 A IL13630898 A IL 13630898A IL 13630898 A IL13630898 A IL 13630898A IL 136308 A0 IL136308 A0 IL 136308A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- methods
- antipicornaviral compounds
- antipicornaviral
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/991,739 US5962487A (en) | 1997-12-16 | 1997-12-16 | Antipicornaviral compounds and methods for their use and preparation |
| PCT/US1998/026583 WO1999031122A1 (en) | 1997-12-16 | 1998-12-15 | Antipicornaviral compounds and methods for their use and preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136308A0 true IL136308A0 (en) | 2001-05-20 |
Family
ID=25537509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13630898A IL136308A0 (en) | 1997-12-16 | 1998-12-15 | Antipicornaviral compounds and methods for their use and preparation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5962487A (xx) |
| EP (1) | EP1037905A1 (xx) |
| JP (1) | JP2002508389A (xx) |
| KR (1) | KR20010033236A (xx) |
| AU (1) | AU762682B2 (xx) |
| BR (1) | BR9813651A (xx) |
| CA (1) | CA2312940A1 (xx) |
| HU (1) | HUP0100149A3 (xx) |
| IL (1) | IL136308A0 (xx) |
| IS (1) | IS5510A (xx) |
| NO (1) | NO20003067L (xx) |
| NZ (1) | NZ505034A (xx) |
| PL (1) | PL341435A1 (xx) |
| WO (1) | WO1999031122A1 (xx) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| SI1073672T1 (en) * | 1998-04-30 | 2004-02-29 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, their preparation and use |
| CN1198838C (zh) * | 1998-04-30 | 2005-04-27 | 阿格罗尼制药公司 | 抗小rna病毒化合物及其制备方法和用途 |
| US6143079A (en) * | 1998-11-19 | 2000-11-07 | Asm America, Inc. | Compact process chamber for improved process uniformity |
| US6369226B1 (en) | 1999-06-21 | 2002-04-09 | Agouron Pharmaceuticals, Inc. | Substituted benzamide inhibitors of rhinovirus 3C protease |
| ES2230135T3 (es) * | 1999-08-04 | 2005-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis. |
| PE20010517A1 (es) * | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
| US6355807B1 (en) * | 1999-08-24 | 2002-03-12 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| PE20020157A1 (es) | 1999-12-03 | 2002-02-22 | Agouron Pharma | Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis |
| EP1261611A2 (en) * | 2000-02-29 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
| PA8515201A1 (es) * | 2000-04-14 | 2002-10-24 | Agouron Pharma | Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis |
| HUP0301331A3 (en) | 2000-06-14 | 2004-03-01 | Agouron Pharmaceuticals Inc La | Antipicornaviral compounds process for their preparation and compositions containing them, their pharmaceutical uses, and intermediates for their synthesis |
| US6653295B2 (en) | 2000-12-13 | 2003-11-25 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus NS3 protease |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| KR101208266B1 (ko) | 2002-03-22 | 2012-12-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤미아스텔린 유도체 및 이의 용도 |
| US7094783B2 (en) * | 2002-06-26 | 2006-08-22 | Bristol-Myers Squibb Company | Bicyclic pyrimidinones as coagulation cascade inhibitors |
| US20030125548A1 (en) * | 2002-09-13 | 2003-07-03 | Dorit Arad | Molecules derived from mechanism based drug design |
| WO2005066123A1 (en) * | 2003-12-31 | 2005-07-21 | Taigen Biotechnology | Protease inhibitors |
| US7462594B2 (en) * | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
| ES2640814T3 (es) | 2008-05-21 | 2017-11-06 | Genesis Technologies Limited | Inhibidores selectivos de caspasa y usos de los mismos |
| US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
| ES2665301T3 (es) | 2011-04-15 | 2018-04-25 | Genesis Technologies Limited | Inhibidores selectivos de cisteína proreasa y usos de los mismos |
| US9474759B2 (en) | 2011-09-27 | 2016-10-25 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
| JP2013180983A (ja) * | 2012-03-01 | 2013-09-12 | Tokyo Univ Of Agriculture & Technology | Ｎ置換アミド化合物の製造方法 |
| US9309284B2 (en) | 2012-05-02 | 2016-04-12 | Kansas State University Reasearch Foundation | Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses |
| WO2021188620A1 (en) * | 2020-03-17 | 2021-09-23 | Cocrystal Pharma Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
| WO2022156692A1 (zh) * | 2021-01-22 | 2022-07-28 | 中国人民解放军军事科学院军事医学研究院 | 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0668870A1 (en) * | 1991-06-14 | 1995-08-30 | Chiron Corporation | Inhibitors of picornavirus proteases |
| US5514778A (en) * | 1993-07-01 | 1996-05-07 | Eli Lilly And Company | Anti-picornaviral agents |
| IL112759A0 (en) * | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
| IT1269511B (it) * | 1994-05-17 | 1997-04-01 | Univ Degli Studi Milano | Derivati di acidi ammino-solfonici , loro impiego nella sintesi di pseudopeptidi e procedimento per la loro preparazione |
| AU722704B2 (en) * | 1996-05-14 | 2000-08-10 | Agouron Pharmaceuticals, Inc. | Inhibitors of picornavirus 3c proteases and methods for their use and preparation |
-
1997
- 1997-12-16 US US08/991,739 patent/US5962487A/en not_active Expired - Fee Related
-
1998
- 1998-12-15 CA CA002312940A patent/CA2312940A1/en not_active Abandoned
- 1998-12-15 PL PL98341435A patent/PL341435A1/xx unknown
- 1998-12-15 AU AU18262/99A patent/AU762682B2/en not_active Ceased
- 1998-12-15 WO PCT/US1998/026583 patent/WO1999031122A1/en not_active Application Discontinuation
- 1998-12-15 IL IL13630898A patent/IL136308A0/xx unknown
- 1998-12-15 BR BR9813651-8A patent/BR9813651A/pt not_active IP Right Cessation
- 1998-12-15 HU HU0100149A patent/HUP0100149A3/hu unknown
- 1998-12-15 EP EP98963184A patent/EP1037905A1/en not_active Withdrawn
- 1998-12-15 NZ NZ505034A patent/NZ505034A/en unknown
- 1998-12-15 KR KR1020007006647A patent/KR20010033236A/ko not_active Application Discontinuation
- 1998-12-15 JP JP2000539045A patent/JP2002508389A/ja not_active Withdrawn
-
2000
- 2000-05-25 IS IS5510A patent/IS5510A/is unknown
- 2000-06-15 NO NO20003067A patent/NO20003067L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999031122A1 (en) | 1999-06-24 |
| AU1826299A (en) | 1999-07-05 |
| JP2002508389A (ja) | 2002-03-19 |
| KR20010033236A (ko) | 2001-04-25 |
| CA2312940A1 (en) | 1999-06-24 |
| BR9813651A (pt) | 2000-10-03 |
| US5962487A (en) | 1999-10-05 |
| HUP0100149A3 (en) | 2001-12-28 |
| EP1037905A1 (en) | 2000-09-27 |
| NO20003067D0 (no) | 2000-06-15 |
| IS5510A (is) | 2000-05-25 |
| HUP0100149A2 (hu) | 2001-06-28 |
| WO1999031122A9 (en) | 1999-09-30 |
| NZ505034A (en) | 2003-07-25 |
| AU762682B2 (en) | 2003-07-03 |
| PL341435A1 (en) | 2001-04-09 |
| NO20003067L (no) | 2000-08-15 |
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